WY-14,643-mediated promotion of hepatocarcinogenesis in connexin32-wild-type and connexin32-null mice

Carcinogenesis

Volumn 24, Issue 9, 2003, Pages 1561-1565

  Moennikes, Oliver ^a   Stahl, Sabine ^a   Bannasch, Peter ^b   Buchmann, Albrecht ^a   Schwarz, Michael ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CONNEXIN 32; DIETHYLNITROSAMINE; GLUCOSE 6 PHOSPHATASE; GLUTAMATE AMMONIA LIGASE; PEROXISOME PROLIFERATOR; PIRINIXIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BENIGN TUMOR; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; FROZEN SECTION; GENE MUTATION; GENE OVEREXPRESSION; GENOTYPE; LIVER CARCINOGENESIS; LIVER INJURY; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PHENOTYPIC VARIATION; PRECANCER; PRIORITY JOURNAL; TUMOR PROMOTION; TUMOR VOLUME; WILD TYPE;

ANIMALS; CARCINOGENS; COCARCINOGENESIS; CONNEXINS; LIVER NEOPLASMS, EXPERIMENTAL; MALE; MICE; MICE, INBRED C3H; MICE, MUTANT STRAINS; MUTATION; PYRIMIDINES;

EID: 0141590651     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/bgg099     Document Type: Article

References (31)

1. Bruzzone, R., White, T.W. and Paul, D.L. (1996) Connections with connexins: the molecular basis of direct intercellular signaling. Eur. J. Biochem., 238, 1-27.
2. Kumar, N.M. and Gilula, N.B. (1996) The gap junction communication channel. Cell, 84, 381-388.
3. Yamasaki, H. and Naus, C.C. (1996) Role of connexin genes in growth control. Carcinogenesis, 17, 1199-1213.
4. Trosko, J.E. and Ruch, R.J. (1998) Cell-cell communication in carcinogenesis. Front. Biosci., 3, 208-236.
5. Plum, A., Hallas, G. and Magin, T. (2000) Unique and shared functions of different connexins in mice. Curr. Biol., 10, 1083-109.
6. Temme, A., Buchmann, A., Gabriel, H.D., Nelles, E., Schwarz, M. and Willecke, K. (1997) High incidence of spontaneous and chemically induced liver tumors in mice deficient for connexin32. Curr. Biol., 7, 713-716.
7. Moennikes, O., Buchmann, A., Ott, T., Willecke, K. and Schwarz, M. (1999) The effect of connexin32 null mutation on hepatocarcinogenesis in different mouse strains. Carcinogenesis, 20, 1379-1382.
8. Moennikes, O., Buchmann, A., Romualdi, A., Ott, T., Werringloer, J., Willecke, K. and Schwarz, M. (2000) Lack of phenobarbital mediated promotion of hepatocarcinogenesis in connexin32 null mice. Cancer Res., 60, 5087-5091.
9. Qi, C., Zhu, Y. and Reddy, J.K. (2000) Peroxisome proliferator-activated receptors, coactivators and downstream targets. Cell. Biochem. Biophys., 32, 187-204.
10. Rao, M.S. and Reddy, J.K. (1987) Peroxisome proliferation and hepatocarcinogenesis. Carcinogenesis, 8, 631-636.
11. Glauert, H.P., Beer, D., Rao, M.S., Schwarz, M., Xu, Y.D., Goldsworthy, T.L., Coloma, J. and Pitot, H.C. (1986) Induction of altered hepatic foci in rats by the administration of hypolipidemic peroxisome proliferators alone or following a single dose of diethylnitrosamine. Cancer Res., 46, 4601-4606.
12. Cattley, R.C. and Popp, J.A. (1989) Differences in the promoting activities of the peroxisome proliferator WY-14,643 and phenobarbital in rat liver. Cancer Res., 49, 3246-3251.
13. Gonzales, F.J., Peters, J.M. and Cattley, R.C. (1998) Mechanism of action of the nongenotoxic peroxisome proliferators: role of the peroxisome proliferator activated receptor α. J. Natl Cancer Inst., 90, 1702-1709.
14. Nelles, E., Buetzler, C., Jung, D. et al. (1996) Defective propagation of signals generated by sympathetic nerve stimulation in the liver of connexin32-deficient mice. Proc. Natl Acad. Sci. USA, 93, 9565-9570.
15. Wachstein, M. and Meisel, E. (1957) Histochemistry of hepatic phosphatases at a physiological pH. Am. J. Clin. Pathol., 27, 13-23.
16. Loeppen, S., Schneider, D., Gaunitz, F., Gebhardt, R., Kurek, R., Buchmann, A. and Schwarz, M. (2002) Overexpression of glutamine synthetase is associated with β-catenin-mutations in mouse liver tumors during promotion of hepatocarcinogenesis by phenobarbital. Cancer Res., 62, 5685-5688.
17. Schwarz, M., Buchmann, A., Schulte, M., Pearson, D. and Kunz, W. (1989) Heterogeneity of enzyme-altered foci in rat liver. Toxicol. Lett., 49, 297-317.
18. Buchmann, A., Bauer-Hofmann, R., Mahr, J., Drinkwater, N.R., Luz, A. and Schwarz, M. (1991) Mutational activation of the c-Ha-ras gene in liver tumors of different rodent strains: correlation with susceptibility to hepatocarcinogenesis. Proc. Natl Acad. Sci. USA, 88, 911 915.
19. Aydinlik, H., Nguyen, T.D., Moennikes, O., Buchmann, A. and Schwarz, M. (2001) Selective pressure during tumor promotion by phenobarbital leads to clonal outgrowth of β-catenin-mutated mouse liver tumors. Oncogene, 20, 7812-7816.
20. Peters, J.M., Cattley, R.C. and Gonzalez, F.J. (1997) Role of PPAR alpha in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy-14,643. Carcinogenesis, 18, 2029-2033.
21. Marsman, D.S., Cattley, R.C., Conway, J.G. and Popp, J.A. (1988) Relationship of the hepatic peroxisome proliferation and replicative DNA synthesis to the hepatocarcinogenicity of the peroxisome proliferators di(2-ethylhexyl)phtalate and [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (Wy-14,643) in rats. Cancer Res., 48, 6739-6744.
22. Pitot, H.C. (1990) Altered hepatic foci: their role in murine hepatocarcinogenesis. Ann. Rev. Pharm. Tox., 30, 465-500.
23. Gebhardt, R., Tanaka, T. and Williams, G. (1989) Glutamine synthetase heterogeneous expression as a marker for the cellular lineage of preneoplastic and neoplastic liver populations. Carcinogenesis, 10, 1917-1923.
24. Bannasch, P., Klimek, F. and Mayer, D. (1997) Early bioenergetic changes in hepatocarcinogenesis: preneoplastic phenotypes mimic responses to insulin and thyroid hormone. J. Bioenerget. Biomem., 29, 303-313.
25. Grasl-Kraupp, B., Huber, W., Gerbracht, U. and Schulte-Hermann, R. (1990) Tumor promotion by the peroxisome proliferator nafenopin involving a specific subtype of altered foci in rat liver. Cancer Res., 50, 3701-3708.
26. Marsman, D.S. and Popp, J.A. (1994) Biological potential of basophilic hepatocellular foci and hepatic adenoma induced by the peroxisome proliferator, Wy-14,643. Carcinogenesis, 15, 111-117.
27. Leibold, E., Greim, H. and Schwarz, L.R. (1994) Inhibition of intercellular communication of rat hepatocytes by nafenopin: involvement of protein kinase C. Carcinogenesis, 15, 1265-1269.
28. Tsuda, H., Asamoto, M., Iwahori, Y. et al. (1996) Decreased connexin32 and a characteristic enzyme phenotype in clofibrate-induced preneoplastic lesions not shared with spontaneously occurring lesions in the rat liver. Carcinogenesis, 17, 2441-2448.
29. Dragan, Y.P. and Pitot, H.C. (1992) The role of the stages of initiation and promotion in phenotypic diversity during hepatocarcinogenesis in the rat. Carcinogenesis, 13, 739-750.
30. Polakis, P. (2000) Wnt signaling and cancer. Genes Dev., 14, 1837-1851.
31. Schwarz, M., Wanke, I., Wulbrand, U., Moennikes, O. and Buchmann, A. (2003) Role of Connexin32 and β-Catenin in tumor promotion in mouse liver. Toxicol. Pathol., 31, 99-102.