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Volumn 17, Issue 11, 1996, Pages 2441-2448

Decreased connexin32 and a characteristic enzyme phenotype in clofibrate-induced preneoplastic lesions not shared with spontaneously occurring lesions in the rat liver

Author keywords

[No Author keywords available]

Indexed keywords

CLOFIBRATE; GAMMA GLUTAMYLTRANSFERASE; GAP JUNCTION PROTEIN; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUTATHIONE TRANSFERASE; LIVER ENZYME; SUCCINATE DEHYDROGENASE;

EID: 10544245672     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/17.11.2441     Document Type: Article
Times cited : (15)

References (59)
  • 1
    • 0020361679 scopus 로고
    • Correlative histochemislry of some enzymes of carbohydrate metabolism in preneoplastic and neoplastic lesions in rat liver
    • Hacker, H.J., Moore, M., Mayer, D. and Bannasch, P. (1982) Correlative histochemislry of some enzymes of carbohydrate metabolism in preneoplastic and neoplastic lesions in rat liver. Carcinoogenesis, 3, 1265-1272.
    • (1982) Carcinoogenesis , vol.3 , pp. 1265-1272
    • Hacker, H.J.1    Moore, M.2    Mayer, D.3    Bannasch, P.4
  • 2
    • 0024906387 scopus 로고
    • Medium term bioassay system for detection of carcinogens and modifiers of hepatocarcinogens utilizing the GST-P positive liver cell focus as an end-point maker
    • Ito, N., Tatematsu, M., Hasegawa, R. and Tsuda, H. (1989) Medium term bioassay system for detection of carcinogens and modifiers of hepatocarcinogens utilizing the GST-P positive liver cell focus as an end-point maker. Toxicol. Pathol., 17, 630-640.
    • (1989) Toxicol. Pathol. , vol.17 , pp. 630-640
    • Ito, N.1    Tatematsu, M.2    Hasegawa, R.3    Tsuda, H.4
  • 3
    • 0024490605 scopus 로고
    • Glutathione transferases as markers of preneoplasia
    • Sato, K. (1989) Glutathione transferases as markers of preneoplasia. Adv. Cancer Res., 52, 205-255.
    • (1989) Adv. Cancer Res. , vol.52 , pp. 205-255
    • Sato, K.1
  • 4
    • 0023268283 scopus 로고
    • Immunohistochemically demonstrated altered expression of cytochrome P-450 molecular forms and epoxide hydrolase in N-ethylhydroxyethylnitrosamine-induced rat kidney and liver lesions
    • Tsuda, H., Moore, M.A., Asamoto, M., Inoue, T., Fukushima, S., Ito, N., Satoh, K., Amerizad, Z. and Oesch, F. (1987) Immunohistochemically demonstrated altered expression of cytochrome P-450 molecular forms and epoxide hydrolase in N-ethylhydroxyethylnitrosamine-induced rat kidney and liver lesions. Carcinogenesis, 8, 711-718.
    • (1987) Carcinogenesis , vol.8 , pp. 711-718
    • Tsuda, H.1    Moore, M.A.2    Asamoto, M.3    Inoue, T.4    Fukushima, S.5    Ito, N.6    Satoh, K.7    Amerizad, Z.8    Oesch, F.9
  • 5
    • 0027093420 scopus 로고
    • Effects of modifying agents on conformity of enzyme phenotype and proliferative potential in focal preneoplastic and neoplastic liver cell lesions in rats
    • Tsuda, H., Ozaki, K., Uwagawa, S., Yamaguchi, S., Hakoi, K., Aoki, T., Kato, T., Sato, K. and Ito, N. (1992) Effects of modifying agents on conformity of enzyme phenotype and proliferative potential in focal preneoplastic and neoplastic liver cell lesions in rats. Jpn J. Cancer Res., 83, 1154-1165.
    • (1992) Jpn J. Cancer Res. , vol.83 , pp. 1154-1165
    • Tsuda, H.1    Ozaki, K.2    Uwagawa, S.3    Yamaguchi, S.4    Hakoi, K.5    Aoki, T.6    Kato, T.7    Sato, K.8    Ito, N.9
  • 6
    • 0027752793 scopus 로고
    • Number of simultaneously expressed enzyme alterations correlates with progression of N-ethyl-N-hydroxyethylnitrosamine-induced hepatocarcinogenesis in rats
    • Yamaguchi, S., Hakoi, K., Ozaki, K., Kato, T., Danai, T., Nagao, S., Takahashi, H., Matsumoto, K. and Tsuda, H. (1993) Number of simultaneously expressed enzyme alterations correlates with progression of N-ethyl-N-hydroxyethylnitrosamine-induced hepatocarcinogenesis in rats. Jpn J. Cancer Res., 84, 1237-1244,.
    • (1993) Jpn J. Cancer Res. , vol.84 , pp. 1237-1244
    • Yamaguchi, S.1    Hakoi, K.2    Ozaki, K.3    Kato, T.4    Danai, T.5    Nagao, S.6    Takahashi, H.7    Matsumoto, K.8    Tsuda, H.9
  • 7
    • 0343058567 scopus 로고
    • Hepatocyte gap junctions are permeable to a second messenger, inositol 1,4,5-triphosphate and tocalcium ions
    • Saez, J.C., Conner, J.A., Spray, D.C. and Bennett, M.V.L. (1989) Hepatocyte gap junctions are permeable to a second messenger, inositol 1,4,5-triphosphate and tocalcium ions. Proc. Natl Acad. Sci. USA, 86, 2708-2712.
    • (1989) Proc. Natl Acad. Sci. USA , vol.86 , pp. 2708-2712
    • Saez, J.C.1    Conner, J.A.2    Spray, D.C.3    Bennett, M.V.L.4
  • 8
    • 0025941882 scopus 로고
    • Aberrant expression and function of gap junctions during carcinogenesis
    • Yamasaki, H. (1991) Aberrant expression and function of gap junctions during carcinogenesis. Environ. Health Perspect., 93, 191-197.
    • (1991) Environ. Health Perspect. , vol.93 , pp. 191-197
    • Yamasaki, H.1
  • 9
    • 0025939902 scopus 로고
    • Alterations in intercellular communication during the stage of promotion
    • Klaunig, J.E. (1991) Alterations in intercellular communication during the stage of promotion. Proc. Soc. Exp. Biol. Med., 198, 688-692.
    • (1991) Proc. Soc. Exp. Biol. Med. , vol.198 , pp. 688-692
    • Klaunig, J.E.1
  • 10
    • 0024467324 scopus 로고
    • Changes in gap junction protein (connexin 32) gene expression during rat liver carcinogenesis
    • Fitzgerald, D.J., Mesnil, M., Oyamada, M., Tsuda, H., Ito, N. and Yamasaki, H. (1989) Changes in gap junction protein (connexin 32) gene expression during rat liver carcinogenesis. J. Cell Biochem., 41, 97-102.
    • (1989) J. Cell Biochem. , vol.41 , pp. 97-102
    • Fitzgerald, D.J.1    Mesnil, M.2    Oyamada, M.3    Tsuda, H.4    Ito, N.5    Yamasaki, H.6
  • 11
    • 0023911132 scopus 로고
    • Expression of the c-raf protooncogene: γ-glutamyltranspeptidase and gap junction protein in rat liver neoplasms
    • Beer, D.C., Neveu, M.J., Paul, D.L., Rapp, U.R. and Pitot, H.C. (1986) Expression of the c-raf protooncogene: γ-glutamyltranspeptidase and gap junction protein in rat liver neoplasms. Cancer Res., 48, 1610-1617.
    • (1986) Cancer Res. , vol.48 , pp. 1610-1617
    • Beer, D.C.1    Neveu, M.J.2    Paul, D.L.3    Rapp, U.R.4    Pitot, H.C.5
  • 12
    • 0022776965 scopus 로고
    • Reduced number of gap junctions in rat hepatocarcinomas detected by monoclonal antibody
    • Janssen-Timmen, U., Traub, O., Dermietzel, R., Rabes, H.M. and Wilecke, K. (1986) Reduced number of gap junctions in rat hepatocarcinomas detected by monoclonal antibody. Carcinogenesis, 7, 1475-1482.
    • (1986) Carcinogenesis , vol.7 , pp. 1475-1482
    • Janssen-Timmen, U.1    Traub, O.2    Dermietzel, R.3    Rabes, H.M.4    Wilecke, K.5
  • 13
    • 0028815251 scopus 로고
    • Cell proliferation and advancement of hepatocarcinogenesis in the rat are associated with a decrease in connexin32 expression
    • Tsuda, H., Asamoto, M., Baba, H. et al. (1995) Cell proliferation and advancement of hepatocarcinogenesis in the rat are associated with a decrease in connexin32 expression. Carcinogenesis, 16, 101-105.
    • (1995) Carcinogenesis , vol.16 , pp. 101-105
    • Tsuda, H.1    Asamoto, M.2    Baba, H.3
  • 14
    • 0029450996 scopus 로고
    • Peroxisome proliferators: Potential role of altered hepatocyte growth and differentiation in tumor development
    • Cattley, R.C., Miller, R.T. and Corton, J.C. (1995) Peroxisome proliferators: potential role of altered hepatocyte growth and differentiation in tumor development (Review). Prog. Clin. Biol. Res., 391, 295-303.
    • (1995) Prog. Clin. Biol. Res. , vol.391 , pp. 295-303
    • Cattley, R.C.1    Miller, R.T.2    Corton, J.C.3
  • 15
    • 0028141931 scopus 로고
    • Phenotypic alteration of hepatocellular foci in rats treated with clofibrate and phenobarbital
    • Hasegawa, R., Yoshida, T., Mizoguchi, Y., Futakuchi, M., Kim, D.J., Cui, L. and Ito, N. (1994) Phenotypic alteration of hepatocellular foci in rats treated with clofibrate and phenobarbital. Cancer Lett., 83, 89-95.
    • (1994) Cancer Lett. , vol.83 , pp. 89-95
    • Hasegawa, R.1    Yoshida, T.2    Mizoguchi, Y.3    Futakuchi, M.4    Kim, D.J.5    Cui, L.6    Ito, N.7
  • 16
    • 0028311721 scopus 로고
    • Relationship of peroxisome proliferator-induced cellular effects to hepatocarcinogenesis
    • Popp, J.A., Cattley, R.C., Miller, R.T. and Marsman, D.S. (1994) Relationship of peroxisome proliferator-induced cellular effects to hepatocarcinogenesis (Review). Prog. Clin. Biol. Res., 387, 193-207.
    • (1994) Prog. Clin. Biol. Res. , vol.387 , pp. 193-207
    • Popp, J.A.1    Cattley, R.C.2    Miller, R.T.3    Marsman, D.S.4
  • 17
    • 0023202190 scopus 로고
    • Peroxisome proliferation and hepatocarcinogenesis
    • Rao, M.S. and Reddy, J.K. (1987) Peroxisome proliferation and hepatocarcinogenesis (Review). Carcinogenesis, 8, 631-636.
    • (1987) Carcinogenesis , vol.8 , pp. 631-636
    • Rao, M.S.1    Reddy, J.K.2
  • 18
    • 0024418166 scopus 로고
    • Evaluation of liver cell proliferation during ciprolibrate-induced hepatocarcinogenesis
    • Yeldandi, A.V., Milano, M., Subbarao, V., Reddy, J.K. and Rao, M.S. (1989) Evaluation of liver cell proliferation during ciprolibrate-induced hepatocarcinogenesis. Cancer Lett., 47, 21-27.
    • (1989) Cancer Lett. , vol.47 , pp. 21-27
    • Yeldandi, A.V.1    Milano, M.2    Subbarao, V.3    Reddy, J.K.4    Rao, M.S.5
  • 19
    • 0021051308 scopus 로고
    • Carcinogenesis by hepatic peroxisome proliferators: Evaluation of the risk of the hypolipidemic drugs and industrial plasticizers to humans
    • Reddy, J.K. and Lalwani, N.D. (1983) Carcinogenesis by hepatic peroxisome proliferators: evaluation of the risk of the hypolipidemic drugs and industrial plasticizers to humans. CRC Crit. Rev. Toxicol., 12, 1-58.
    • (1983) CRC Crit. Rev. Toxicol. , vol.12 , pp. 1-58
    • Reddy, J.K.1    Lalwani, N.D.2
  • 20
    • 0016174586 scopus 로고
    • Semipermeable membranes for improving the histochemical demonstration of enzyme activities in tissue sections. VI. Glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase
    • Meijer, A.E.F.H. and de Vries, G.P. (1974) Semipermeable membranes for improving the histochemical demonstration of enzyme activities in tissue sections. VI. Glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase. Histochemistry, 40, 349-359.
    • (1974) Histochemistry , vol.40 , pp. 349-359
    • Meijer, A.E.F.H.1    De Vries, G.P.2
  • 22
    • 0021262406 scopus 로고
    • The placental form of glutathione S-transferase as a new marker protein for preneoplasia in rat chemical hepatocarcinogenesis
    • Sato, K., Kitahara, A., Satoh, K., Ishikawa, T., Tatematsu, M. and Ito, N. (1984) The placental form of glutathione S-transferase as a new marker protein for preneoplasia in rat chemical hepatocarcinogenesis. Jpn J. Cancer Res., 75, 199-202.
    • (1984) Jpn J. Cancer Res. , vol.75 , pp. 199-202
    • Sato, K.1    Kitahara, A.2    Satoh, K.3    Ishikawa, T.4    Tatematsu, M.5    Ito, N.6
  • 23
    • 0021797851 scopus 로고
    • Purification, induction and distribution of placental glutathione transferase: A new marker enzyme for preneoplastic cells in the rat chemical carcinogenesis
    • Satoh, K., Kitahara, A., Soma, Y., Inaba, Y., Hayama, I. and Sato, K. (1985) Purification, induction and distribution of placental glutathione transferase: a new marker enzyme for preneoplastic cells in the rat chemical carcinogenesis. Proc. Natl Acad. Sci. USA, 82, 3964-3968.
    • (1985) Proc. Natl Acad. Sci. USA , vol.82 , pp. 3964-3968
    • Satoh, K.1    Kitahara, A.2    Soma, Y.3    Inaba, Y.4    Hayama, I.5    Sato, K.6
  • 24
    • 0025784401 scopus 로고
    • Sequential changes of gap-junctional intercellular communications during multistage rat liver carcinogenesis: Direct measurement of communication in vivo
    • Krutovskikh, V.A., Oyamada, M. and Yamasaki, H. (1991) Sequential changes of gap-junctional intercellular communications during multistage rat liver carcinogenesis: direct measurement of communication in vivo. Carcinogenesis, 12, 1701-1706.
    • (1991) Carcinogenesis , vol.12 , pp. 1701-1706
    • Krutovskikh, V.A.1    Oyamada, M.2    Yamasaki, H.3
  • 25
    • 0027848777 scopus 로고
    • Gap junction intercellular communication and cell proliferation during rat liver carcinogenesis
    • Yamasaki, H., Krutovskikh, V., Mesnil, M., Columbano, A., Tsuda, H. and Ito, N. (1993) Gap junction intercellular communication and cell proliferation during rat liver carcinogenesis. Environ. Health Perspect., 101 (Suppl. 5), 191-198.
    • (1993) Environ. Health Perspect. , vol.101 , Issue.5 SUPPL. , pp. 191-198
    • Yamasaki, H.1    Krutovskikh, V.2    Mesnil, M.3    Columbano, A.4    Tsuda, H.5    Ito, N.6
  • 26
    • 0024942575 scopus 로고
    • Observations on altered hepatocellular foci in National Toxicology Program two-year carcinogenicity studies in rats
    • Harada, T., Maronpot, R.R., Morris, R.W. and Boorman, G.A. (1989) Observations on altered hepatocellular foci in National Toxicology Program two-year carcinogenicity studies in rats. Toxicol. Pathol., 17, 690-706.
    • (1989) Toxicol. Pathol. , vol.17 , pp. 690-706
    • Harada, T.1    Maronpot, R.R.2    Morris, R.W.3    Boorman, G.A.4
  • 27
    • 0024910273 scopus 로고
    • Documenting foci of hepatocellular alteration in two-year carcinogenicity studies: Current practices of the National Toxicology Program
    • Maronpot, R.R., Harada, T., Murthy, A.S. and Boorman, G.A. (1989) Documenting foci of hepatocellular alteration in two-year carcinogenicity studies: current practices of the National Toxicology Program (Review). Toxicol. Pathol., 17, 675-683.
    • (1989) Toxicol. Pathol. , vol.17 , pp. 675-683
    • Maronpot, R.R.1    Harada, T.2    Murthy, A.S.3    Boorman, G.A.4
  • 28
    • 0027517501 scopus 로고
    • Glutathione S-transferase isoenzyme patterns in different subtypes of enzyme-altered rat liver foci treated with the peroxisome proliferator nafenopin or with phenobarbital
    • Grasl-Kraupp, B., Waldhor, T., Huber, W. and Schulte-Hermann, R. (1993) Glutathione S-transferase isoenzyme patterns in different subtypes of enzyme-altered rat liver foci treated with the peroxisome proliferator nafenopin or with phenobarbital. Carcinogenesis, 14, 2407-2412.
    • (1993) Carcinogenesis , vol.14 , pp. 2407-2412
    • Grasl-Kraupp, B.1    Waldhor, T.2    Huber, W.3    Schulte-Hermann, R.4
  • 29
    • 0028356399 scopus 로고
    • Inhibition of cell proliferation by ciprofibrate in glutathione S-transferase P1-1-positive rat hepatic hyperplastic nodules
    • Chen, Z.Y., Liu, Y.E., He, C.Y., White, C.C. and Eaton, D.L. (1994) Inhibition of cell proliferation by ciprofibrate in glutathione S-transferase P1-1-positive rat hepatic hyperplastic nodules. Cancer Res., 54, 2622-2629.
    • (1994) Cancer Res. , vol.54 , pp. 2622-2629
    • Chen, Z.Y.1    Liu, Y.E.2    He, C.Y.3    White, C.C.4    Eaton, D.L.5
  • 30
    • 0024377254 scopus 로고
    • Modulation of diethylnitrosamine-inhiated placental glutathione S-transferase positive preneoplastic and neoplastic lesions by clofibrate, a hepatic peroxisome proliferator
    • Hosokawa, S., Tatematsu, M., Aoki, T., Nakanowatari, J., Igarashi, T. and Ito, N. (1989) Modulation of diethylnitrosamine-inhiated placental glutathione S-transferase positive preneoplastic and neoplastic lesions by clofibrate, a hepatic peroxisome proliferator. Carcinogenesis, 10, 2237-2241.
    • (1989) Carcinogenesis , vol.10 , pp. 2237-2241
    • Hosokawa, S.1    Tatematsu, M.2    Aoki, T.3    Nakanowatari, J.4    Igarashi, T.5    Ito, N.6
  • 31
    • 0022617474 scopus 로고
    • Hepatic foci of cellular and enzymatic alteration and nodules in rats treated with clofibrate or diethylnitrosamine followed by phenobarbital: Their rate of onset and their reversibility
    • Greaves, P., Irisarri, E. and Monro, A.M. (1986) Hepatic foci of cellular and enzymatic alteration and nodules in rats treated with clofibrate or diethylnitrosamine followed by phenobarbital: their rate of onset and their reversibility. J Natl Cancer Inst., 76, 475-484.
    • (1986) J Natl Cancer Inst. , vol.76 , pp. 475-484
    • Greaves, P.1    Irisarri, E.2    Monro, A.M.3
  • 32
    • 0022485360 scopus 로고
    • Analysis of peroxisome proliferator-induced preneoplastic and neoplastic lesions of rat liver for placental form of glutathione S-transferase and gamma-glutamyltranspeptidase
    • Rao, M.S., Tatematsu, M., Subbarao, V., Ito, N. and Reddy, J.K. (1986) Analysis of peroxisome proliferator-induced preneoplastic and neoplastic lesions of rat liver for placental form of glutathione S-transferase and gamma-glutamyltranspeptidase. Cancer Res., 46, 5287-5290.
    • (1986) Cancer Res. , vol.46 , pp. 5287-5290
    • Rao, M.S.1    Tatematsu, M.2    Subbarao, V.3    Ito, N.4    Reddy, J.K.5
  • 33
    • 0023221711 scopus 로고
    • Absence of γ-glutamyl transpeptidase activity in neoplastic lesions induced in the liver of male F-344 rats by di-(2-ethyyhexyl)phthalate, a peroxisome proliferator
    • Rao, M.S., Usuda, N., Subbarao, V. and Reddy, J.K. (1987) Absence of γ-glutamyl transpeptidase activity in neoplastic lesions induced in the liver of male F-344 rats by di-(2-ethyyhexyl)phthalate, a peroxisome proliferator. Carcinogenesis, 8, 1347-1350.
    • (1987) Carcinogenesis , vol.8 , pp. 1347-1350
    • Rao, M.S.1    Usuda, N.2    Subbarao, V.3    Reddy, J.K.4
  • 34
    • 0023792924 scopus 로고
    • Lack of expression of glutathione-S-transferasc P, γ-glutamyl transpeptidase, and α-fetoprotein messenger RNAs in liver tumors induced by peroxisome proliferators
    • Rao, M.S., Nemali, M.R., Usuda, N., Scarpelli, D.G., Makino, T., Pitot, H.C. and Reddy, J.K. (1988) Lack of expression of glutathione-S-transferasc P, γ-glutamyl transpeptidase, and α-fetoprotein messenger RNAs in liver tumors induced by peroxisome proliferators. Cancer Res., 48, 4919-4925.
    • (1988) Cancer Res. , vol.48 , pp. 4919-4925
    • Rao, M.S.1    Nemali, M.R.2    Usuda, N.3    Scarpelli, D.G.4    Makino, T.5    Pitot, H.C.6    Reddy, J.K.7
  • 35
    • 0025157081 scopus 로고
    • Modulatory interaction between initial clofibrate treatment and subsequent administration of 2-acetylaminofluorene or sodium phenobarbital on glutathione S-transferase positive lesion development
    • Mutai, M., Tatematsu, M., Aoki, T., Wada, S. and Ito, N. (1990) Modulatory interaction between initial clofibrate treatment and subsequent administration of 2-acetylaminofluorene or sodium phenobarbital on glutathione S-transferase positive lesion development. Cancer Lett., 49, 127-132.
    • (1990) Cancer Lett. , vol.49 , pp. 127-132
    • Mutai, M.1    Tatematsu, M.2    Aoki, T.3    Wada, S.4    Ito, N.5
  • 36
    • 0025220542 scopus 로고
    • Effects of hypolipidemic drugs nafenopin and clofibrate on phenotypic expression and cell death (apoptosis) in altered foci of rat liver
    • Gerbracht, U., Bursch, W., Kraus, P., Putz, B., Reinacher, M., Timmermann, T.I. and Schulte-Hermann, R. (1990) Effects of hypolipidemic drugs nafenopin and clofibrate on phenotypic expression and cell death (apoptosis) in altered foci of rat liver. Carcinogenesis, 11, 617-624.
    • (1990) Carcinogenesis , vol.11 , pp. 617-624
    • Gerbracht, U.1    Bursch, W.2    Kraus, P.3    Putz, B.4    Reinacher, M.5    Timmermann, T.I.6    Schulte-Hermann, R.7
  • 37
    • 0024314929 scopus 로고
    • Differences between the promoting activities of the peroxisome proliferator WY-14,643 and phenobarbital in rat liver
    • Cattley, R.C. and Popp, J.A. (1989) Differences between the promoting activities of the peroxisome proliferator WY-14,643 and phenobarbital in rat liver. Cancer Res., 49, 3246-3251.
    • (1989) Cancer Res. , vol.49 , pp. 3246-3251
    • Cattley, R.C.1    Popp, J.A.2
  • 38
    • 0023860215 scopus 로고
    • Demonstration of glucose-6-phosphatase and peroxisomal catalase activity by ultrastructural cytochemistry in oval cells from livers of carcinogen-treated rats
    • Plenat, F., Braun, L. and Fausto, N. (1988) Demonstration of glucose-6-phosphatase and peroxisomal catalase activity by ultrastructural cytochemistry in oval cells from livers of carcinogen-treated rats. Am. J. Pathol., 130, 91-102.
    • (1988) Am. J. Pathol. , vol.130 , pp. 91-102
    • Plenat, F.1    Braun, L.2    Fausto, N.3
  • 39
    • 0028173749 scopus 로고
    • Biological potential of basophilic hepatocellular foci and hepatic adenoma induced by the peroxisome proliferator, Wy-14643
    • Marsman, D.S. and Popp, J.A. (1994) Biological potential of basophilic hepatocellular foci and hepatic adenoma induced by the peroxisome proliferator, Wy-14643. Carcinogenesis, 15, 111-117.
    • (1994) Carcinogenesis , vol.15 , pp. 111-117
    • Marsman, D.S.1    Popp, J.A.2
  • 40
    • 0023901129 scopus 로고
    • Enzyme histochemical and morphological phenotype of amphophilic foci and amphophilic/tigroid cell adenomas in rat liver after combined treatment with dehydroepiadrosterone and N-nitrosomorpholine
    • Weber, E., Moore, M.A. and Bannasch, P. (1988) Enzyme histochemical and morphological phenotype of amphophilic foci and amphophilic/tigroid cell adenomas in rat liver after combined treatment with dehydroepiadrosterone and N-nitrosomorpholine. Carcinogenesis, 9, 1049-1054.
    • (1988) Carcinogenesis , vol.9 , pp. 1049-1054
    • Weber, E.1    Moore, M.A.2    Bannasch, P.3
  • 41
    • 0019161983 scopus 로고
    • Influence of starvation and clolibrate administration on oxidative phosphorylation by rat liver mitochondria
    • Rasheed, B.K., Chhabra, S. and Kurup, C.K. (1980) Influence of starvation and clolibrate administration on oxidative phosphorylation by rat liver mitochondria. Biochem. J., 190, 191-198.
    • (1980) Biochem. J. , vol.190 , pp. 191-198
    • Rasheed, B.K.1    Chhabra, S.2    Kurup, C.K.3
  • 43
    • 0029069304 scopus 로고
    • Inhibition of rat liver gap junction intercellular communication by tumor-promoting agents in vivo. Association with aberrant localization of connexin proteins
    • Krutovskikh, V.A., Mesnil, M., Mazzoleni, G. and Yamasaki, H. (1995) Inhibition of rat liver gap junction intercellular communication by tumor-promoting agents in vivo. Association with aberrant localization of connexin proteins. Lab. Invest., 72, 571-577.
    • (1995) Lab. Invest. , vol.72 , pp. 571-577
    • Krutovskikh, V.A.1    Mesnil, M.2    Mazzoleni, G.3    Yamasaki, H.4
  • 44
    • 0028094681 scopus 로고
    • Transgenic hepatocarcinogenesis in the rat
    • Hully, J.R. et al. (1994) Transgenic hepatocarcinogenesis in the rat. Am. J. Pathol., 145, 386-397.
    • (1994) Am. J. Pathol. , vol.145 , pp. 386-397
    • Hully, J.R.1
  • 45
    • 0024314929 scopus 로고
    • Differences between the promoting activities of the peroxisome proliferator WY-14,643 and phenobarbital in rat liver
    • Conway, J.G., Cattley, R.C., Popp, J.A. and Butterworth, B.E. (1989) Differences between the promoting activities of the peroxisome proliferator WY-14,643 and phenobarbital in rat liver. Cancer Res., 49, 3246-3251.
    • (1989) Cancer Res. , vol.49 , pp. 3246-3251
    • Conway, J.G.1    Cattley, R.C.2    Popp, J.A.3    Butterworth, B.E.4
  • 46
    • 0025832995 scopus 로고
    • Age-related susceptibility to the carcinogenic effect of the peroxisome proliferator WY-14,643 in rat liver
    • Cattley, R.C., Marsman, D.S. and Popp, J.A. (1991) Age-related susceptibility to the carcinogenic effect of the peroxisome proliferator WY-14,643 in rat liver. Carcinogenesis, 12, 469-473.
    • (1991) Carcinogenesis , vol.12 , pp. 469-473
    • Cattley, R.C.1    Marsman, D.S.2    Popp, J.A.3
  • 47
    • 0027732501 scopus 로고
    • Elevated 8-hydroxydeoxyguanosine in hepatic DNA of rats following exposure to peroxisome proliferators: Relationship to carcinogenesis and nuclear localization
    • Cattley, R.C. and Glover, S.E. (1993) Elevated 8-hydroxydeoxyguanosine in hepatic DNA of rats following exposure to peroxisome proliferators: relationship to carcinogenesis and nuclear localization. Carcinogenesis, 14, 2495-2499.
    • (1993) Carcinogenesis , vol.14 , pp. 2495-2499
    • Cattley, R.C.1    Glover, S.E.2
  • 48
    • 0024323931 scopus 로고
    • Formation of 8-hydroxydeoxyguanosine in liver DNA of rats following long-term exposure to a peroxisome proliferator
    • Kasai, H., Okada, Y., Nishimura, S., Rao, M.S. and Reddy, J.K. (1989) Formation of 8-hydroxydeoxyguanosine in liver DNA of rats following long-term exposure to a peroxisome proliferator. Cancer Res., 49, 2603-2605.
    • (1989) Cancer Res. , vol.49 , pp. 2603-2605
    • Kasai, H.1    Okada, Y.2    Nishimura, S.3    Rao, M.S.4    Reddy, J.K.5
  • 49
    • 0027217582 scopus 로고
    • Analysis of activated protooncogenes in B6C3F1 mouse liver tumors induced by ciprolibrate, a potent peroxisome proliferator
    • Hegi, M.E., Fox, T.R., Belinsky, S.A., Devereux, T.R. and Anderson, M.W. (1993) Analysis of activated protooncogenes in B6C3F1 mouse liver tumors induced by ciprolibrate, a potent peroxisome proliferator. Carcinogenesis, 14, 145-149.
    • (1993) Carcinogenesis , vol.14 , pp. 145-149
    • Hegi, M.E.1    Fox, T.R.2    Belinsky, S.A.3    Devereux, T.R.4    Anderson, M.W.5
  • 50
    • 0023845912 scopus 로고
    • DNA strand breaks induced by hydrogen peroxide in isolated rat hepatocytes
    • Olson, M.J. (1988) DNA strand breaks induced by hydrogen peroxide in isolated rat hepatocytes. J. Toxicol. Environ. Health, 23, 407-423.
    • (1988) J. Toxicol. Environ. Health , vol.23 , pp. 407-423
    • Olson, M.J.1
  • 51
    • 0022560394 scopus 로고
    • Tumor-initiating and promoting activities of di(2-ethylhexyl)-phthalate in vivo and in vitro
    • Ward, J.M., Diwan, B.A., Oshima, M., Hu, H., Shuller, H.M. and Rice, J.M. (1986) Tumor-initiating and promoting activities of di(2-ethylhexyl)-phthalate in vivo and in vitro. Environ. Health Perspect., 65, 279-291.
    • (1986) Environ. Health Perspect. , vol.65 , pp. 279-291
    • Ward, J.M.1    Diwan, B.A.2    Oshima, M.3    Hu, H.4    Shuller, H.M.5    Rice, J.M.6
  • 52
    • 0026014061 scopus 로고
    • Increased susceptibility of aged rats to hepatocarcinogenesis by the peroxisome proliferator nafenopin and the possible involvement of altered liver foci occurring spontaneously
    • Kraupp, G.B., Huber, W., Taper, H. and Schulte, H.R. (1991) Increased susceptibility of aged rats to hepatocarcinogenesis by the peroxisome proliferator nafenopin and the possible involvement of altered liver foci occurring spontaneously. Cancer Res., 51, 666-671.
    • (1991) Cancer Res. , vol.51 , pp. 666-671
    • Kraupp, G.B.1    Huber, W.2    Taper, H.3    Schulte, H.R.4
  • 53
    • 0028021454 scopus 로고
    • Initiator-specific promotion of hepatocarcinogenesis by WY-14,643 and clofibrate
    • Cattley, R.C., Kato, M., Popp, J.A., Teets, V.J. and Voss, K.S. (1994) Initiator-specific promotion of hepatocarcinogenesis by WY-14,643 and clofibrate. Carcinogenesis, 15, 1763-1766.
    • (1994) Carcinogenesis , vol.15 , pp. 1763-1766
    • Cattley, R.C.1    Kato, M.2    Popp, J.A.3    Teets, V.J.4    Voss, K.S.5
  • 55
    • 0025179132 scopus 로고
    • Reversible alteration in the expression of the gap junctional protein connexin 32 during tumor promotion in rat liver and its role during cell proliferation
    • Neveu, M.J., Hully, J.R., Paul, D.L. and Pitot, H.C. (1990) Reversible alteration in the expression of the gap junctional protein connexin 32 during tumor promotion in rat liver and its role during cell proliferation. Cancer Commun., 2, 21-31.
    • (1990) Cancer Commun. , vol.2 , pp. 21-31
    • Neveu, M.J.1    Hully, J.R.2    Paul, D.L.3    Pitot, H.C.4
  • 56
    • 0027093421 scopus 로고
    • Differential changes in expression of gap junction proteins connexin 26 and 32 during hepatocarcinogenesis in rats
    • Sakamoto, H., Oyamada, M., Enomoto, K. and Mori, M. (1992) Differential changes in expression of gap junction proteins connexin 26 and 32 during hepatocarcinogenesis in rats. Jpn J. Cancer Res., 83, 1210-1215.
    • (1992) Jpn J. Cancer Res. , vol.83 , pp. 1210-1215
    • Sakamoto, H.1    Oyamada, M.2    Enomoto, K.3    Mori, M.4
  • 57
    • 0025668577 scopus 로고
    • Aberrant expression of gap junction gene in primary human hepatocellular carcinomas: Increased expression of cardiac-type gap junction gene connexin 43
    • Oyamada, M., Krutovskikh, V.A., Mesnil, M., Partensky, C. Berger, F. and Yamasaki, H. (1990) Aberrant expression of gap junction gene in primary human hepatocellular carcinomas: increased expression of cardiac-type gap junction gene connexin 43. Mol. Carcinogenesis, 3, 273-278.
    • (1990) Mol. Carcinogenesis , vol.3 , pp. 273-278
    • Oyamada, M.1    Krutovskikh, V.A.2    Mesnil, M.3    Partensky, C.4    Berger, F.5    Yamasaki, H.6
  • 58
    • 0028177936 scopus 로고
    • Multiple mechanisms are responsible for altered expression of gap junction genes during oncogenesis in rat liver
    • Neveu, M.J., Hully, J.R., Babcock, K.L., Hertzberg, E.L., Nicholson, B.J., Paul, D.L. and Pitot, H.C. (1994) Multiple mechanisms are responsible for altered expression of gap junction genes during oncogenesis in rat liver. J Cell Sci., 107, 83-95.
    • (1994) J Cell Sci. , vol.107 , pp. 83-95
    • Neveu, M.J.1    Hully, J.R.2    Babcock, K.L.3    Hertzberg, E.L.4    Nicholson, B.J.5    Paul, D.L.6    Pitot, H.C.7


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