Potent maturation of monocyte-derived dendritic cells after cd40l lentiviral gene delivery

Journal of Immunotherapy

Volumn 26, Issue 5, 2003, Pages 451-460

  Koya, Richard C ^a   Kasahara, Nori ^a   Favaro, Patricia M B ^a   Lau, Roy ^a   Ta, Huy Q ^b   Weber, Jeffrey S ^b   Stripecke, Renata ^b  

^a Institute for Genetic Medicine   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

CD40L; Dendritic cells; Gene therapy; Immunotherapy; Lentiviral vectors; Melanoma

Indexed keywords

B7 ANTIGEN; CD4 ANTIGEN; CD40 LIGAND; CD8 ANTIGEN; CD83 ANTIGEN; GLYCOPROTEIN GP 100; GREEN FLUORESCENT PROTEIN; HLA A2 ANTIGEN; INTERLEUKIN 12; LENTIVIRUS VECTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; RECOMBINANT GAMMA INTERFERON; TUMOR ANTIGEN;

ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; CANCER IMMUNOTHERAPY; CELL MATURATION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; GENE TARGETING; GENE TRANSFER; GENETIC TRANSDUCTION; HELPER CELL; HUMAN; HUMAN CELL; IMMUNITY; IMMUNIZATION; LENTIVIRINAE; MONOCYTE; PHENOTYPE; PRIORITY JOURNAL;

ANTIBODIES, MONOCLONAL; CD4-POSITIVE T-LYMPHOCYTES; CD40 LIGAND; CELL LINE; COCULTURE TECHNIQUES; DENDRITIC CELLS; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTORS, RECOMBINANT; HUMANS; IMMUNOPHENOTYPING; INTERLEUKIN-12; LENTIVIRUS; MONOCYTES; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0141483730     PISSN: 15249557     EISSN: 15374513     Source Type: Journal    
DOI: 10.1097/00002371-200309000-00008     Document Type: Article

References (36)

1. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature. 1998; 392:245-252.
2. Kirk CJ, Mule JJ. Gene-modified dendritic cells for use in tumor vaccines. Hum Gene Ther. 2000; 11:797-806.
3. Schuler G, Steinman RM. Dendritic cells as adjuvants for immune-mediated resistance to tumors. J Exp Med. 1997; 186:1183-1187.
4. Romani N, Gruner S, Brang D, et al. Proliferating dendritic cell progenitors in human blood. J Exp Med. 1994; 180:83-93.
5. Sallusto F, Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J Exp Med. 1994; 179:1109-1118.
6. Pierre P, Turley SJ, Gatti E, et al. Developmental regulation of MHC class II transport in mouse dendritic cells. Nature. 1997; 388:787-792.
7. Caux C, Massacrier C, Vanbervliet B, et al. Interleukin 10 inhibits T cell alloreaction induced by human dendritic cells. Int Immunol. 1994; 6:1177-1185.
8. Cella M, Scheidegger D, Palmer-Lehmann K, et al. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J Exp Med. 1996; 184:747-752.
9. Schoenberger SP, Toes RE, van der Voort El, et al. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature. 1998; 393:480-483.
10. Banchereau J, Bazan F, Blanchard D, et al. The CD40 antigen and its ligand. Annu Rev Immunol. 1994; 12:881-922.
11. Mackey MF, Gunn JR, Maliszewsky C, et al. Dendritic cells require maturation via CD40 to generate protective antitumor immunity. J Immunol. 1998; 161:2094-2098.
12. Kuniyoshi JS, Kuniyoshi CJ, Lim AM, et al. Dendritic cell secretion of IL-15 is induced by recombinant huCD40LT and augments the stimulation of antigen-specific cytolytic T cells. Cell Immunol. 1999; 193:48-58.
13. Lau R, Wang F, Jeffery G, et al. Phase I trial of Intravenous peptide-pulsed dendritic cells in patients with metastatic melanoma. J Immunother. 2001; 24:66-78.
14. Aicher A, Westermann J, Cayeux S, et al. Successful retroviral mediated transduction of a reporter gene in human dendritic cells: feasibility of therapy with gene-modified antigen presenting cells. Exp Hematol. 1997; 25:39-44.
15. Arthur JF, Butterfield LH, Roth MD, et al. A comparison of gene transfer methods in human dendritic cells. Cancer Gene Ther. 1997; 4:17-25.
16. Henderson RA, Nimgaonkar MT, Watkins SC, et al. Human dendritic cells genetically engineered to express high levels of the human epithelial tumor antigen mucin (MUC-1). Cancer Res. 1996; 56:3763-3770.
17. Szabolcs P, Gallardo HF, Ciocon DH, et al. Retrovirally transduced human dendritic cells express a normal phenotype and potent T-cell stimulatory capacity. Blood. 1997; 90:2160-2167.
18. Van Tendeloo VF, Snoeck HW, Lardon F, et al. Nonviral transfection of distinct types of human dendritic cells: high-efficiency gene transfer by electroporation into hematopoietic progenitor-but not monocyte-derived dendritic cells. Gene Ther. 1998; 5:700-707.
19. Kikuchi T, Hackett NR, Crystal RG. Cross-strain protection against clinical and laboratory strains of Pseudomonas aeruginosa mediated by dendritic cells genetically modified to express CD40 ligand and pulsed with specific strains of Pseudomonas aeruginosa. Hum Gene Ther. 2001; 12:1251-1263.
20. Kikuchi T, Worgall S, Singh R, et al. Dendritic cells genetically modified to express CD40 ligand and pulsed with antigen can initiate antigen-specific humoral immunity independent of CD4+ T cells. Nat Med. 2000; 6:1154-1159.
21. Ranieri E, Herr W, Gambotto A, et al. Dendritic cells transduced with an adenovirus vector encoding Epstein-Barr virus latent membrane protein 2B: a new modality for vaccination. J Virol. 1999; 73:10416-10425.
22. Molnar-Kimber KL, Sterman DH, Chang M, et al. Impact of preexisting and induced humoral and cellular immune responses in an adenovirus-based gene therapy phase I clinical trial for localized mesothelioma. Hum Gene Ther. 1998; 9:2121-2133.
23. Jooss K, Yang Y, Fisher KJ, et al. Transduction of dendritic cells by DNA viral vectors directs the immune response to transgene products in muscle fibers. J Virol. 1998; 72:4212-4223.
24. Korst RJ, Mahtabifard A, Yamada R, et al. Effect of adenovirus gene transfer vectors on the immunologic functions of mouse dendritic cells. Mol Ther. 2002; 5:307-315.
25. Case SS, Price MA, Jordan CT, et al. Stable transduction of quiescent CD34(+)CD38(−) human hematopoietic cells by HIV-1-based lentiviral vectors. Proc Natl Acad Sci USA. 1999; 96:2988-2993.
26. Stripecke R, Cardoso AA, Pepper KA, et al. Lentiviral vectors for efficient delivery of CD80 and granulocyte-macrophage colony-stimulating factor in human acute lymphoblastic leukemia and acute myeloid leukemia cells to induce antileukemic immune responses. Blood. 2000; 96:1317-1326.
27. Dyall J, Latouche JB, Schnell S, et al. Lentivirus-transduced human monocyte-derived dendritic cells efficiently stimulate antigen-specific cytotoxic T lymphocytes. Blood. 2001; 97:114-121.
28. Gruber A, Kan-Mitchell J, Kuhen KL, et al. Dendritic cells transduced by multiply deleted HIV-1 vectors exhibit normal phenotypes and functions and elicit an HIV-specific cytotoxic T-lymphocyte response in vitro. Blood. 2000; 96:1327-1333.
29. Schroers R, Sinha I, Segall H, et al. Transduction of human PBMC-derived dendritic cells and macrophages by an HIV-1-based lentiviral vector system. Mol Ther. 2000; 1:171-179.
30. Koya RC, Kasahara N, Pullarkat V, et al. Transduction of acute myeloid leukemia cells with third generation self-inactivating lentiviral vectors expressing CD80 and GM-CSF: effects on proliferation, differentiation, and stimulation of allogeneic and autologous anti-leukemia immune responses. Leukemia. 2002; 16:1645-1654.
31. Zufferey R, Donello JE, Trono D, et al. Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors. J Virol. 1999; 73:2886-2892.
32. Vieira PL, de Jong EC, Wierenga EA, et al. Development of Th1-inducing capacity in myeloid dendritic cells requires environmental instruction. J Immunol. 2000; 164:4507-4512.
33. Dull T, Zufferey R, Kelly M, et al. A third-generation lentivirus vector with a conditional packaging system. J Virol. 1998; 72:8463-8471.
34. Zufferey R, Dull T, Mandel RJ, et al. Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery. J Virol. 1998; 72:9873-9880.
35. Koppi TA, Tough-Bement T, Lewinsohn DM, et al. CD40 ligand inhibits Fas/CD95-mediated apoptosis of human blood-derived dendritic cells. Eur J Immunol. 1997; 27:3161-3165.
36. Nieda M, Kikuchi A, Nicol A, et al. Dendritic cells rapidly undergo apoptosis in vitro following culture with activated CD4+ Valpha24 natural killer T cells expressing CD40L. Immunology. 2001; 102:137-145.