Helper T cell differentiation and the problem of cellular inheritance

Immunologic Research

Volumn 27, Issue 2-3, 2003, Pages 463-467

  Reiner, Steven L ^a,b   Mullen, Alan C ^a   Hutchins, Anne S ^a   Pearce, Erika L ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Cell cycle; Epigenetic; GATA 3; IL 4; T bet

Indexed keywords

CYTOKINE; CYTOSINE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR T BET; UNCLASSIFIED DRUG;

AUTOIMMUNE DISEASE; CELL CYCLE; CELL DIFFERENTIATION; CELL LINEAGE; CELL MATURATION; CELL STRUCTURE; CHROMATIN STRUCTURE; DNA METHYLATION; DNA REPLICATION; GENE CONTROL; GENE EXPRESSION REGULATION; GENE LOCUS; GENE SILENCING; GENE STRUCTURE; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; GENOME ANALYSIS; GENOMICS; HELPER CELL; HUMAN; INFECTION; INFLAMMATION; NONHUMAN; OUTCOMES RESEARCH; PLASTICITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; QUALITATIVE ANALYSIS; REGULATORY MECHANISM; REVIEW; STEM CELL; STRUCTURE ANALYSIS; TH1 CELL; TH2 CELL;

ANIMALS; CELL DIFFERENTIATION; CYTOKINES; GENE EXPRESSION REGULATION; HUMANS; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 0141456218     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1385/IR:27:2-3:463     Document Type: Review

References (26)

1. Reiner SL: Helper T cell differentiation, inside and out. Curr Opin Immunol 2001;13:351-355.
2. Mullen AC, High FA, Hutchins AS, Lee HW, Villarino AV, Livingston DM, et al.: Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science 2001;292:1907-1910.
3. Murphy EE, Terres G, Macatonia SE, Hsieh CS, Mattson J, Lanier L, et al.: B7 and interleukin 12 cooperate for proliferation and interferon gamma production by mouse T helper clones that are unresponsive to B7 costimulation. J Exp Med 1994;180:223-231.
4. Kennedy MK, Picha KS, Shanebeck KD, Anderson DM, Grabstein KH: Interleukin-12 regulates the proliferation of Th1, but not Th2 or Th0, clones. Eur J Immunol 1994;24:2271-2278.
5. Mullen AC, Hutchins AS, Villarino AV, Lee HW, High FA, Cereb N, et al.: Cell cycle controlling the silencing and functioning of mammalian activators. Curr Biol 2001;11:1695-1699.
6. Ouyang W, Ranganath SH, Weindel K, Bhattacharya D, Murphy TL, Sha WC, Murphy KM: Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism. Immunity 1998;9:745-755.
7. Yang J, Zhu H, Murphy TL, Ouyang W, Murphy KM: IL-18-stimulated GADD45 beta required in cytokine-induced, but not TCR-induced, IFN-γ production. Nat Immunol 2001;2:157-164.
8. Glimcher LH, Murphy KM: Lineage commitment in the immune system: the T helper lymphocyte grows up. Genes Dev 2000;14:1693-1711.
9. Murphy KM, Ouyang W, Farrar JD, Yang J, Ranganath S, Asnagli H, et al.: Signaling and transcription in T helper development. Annu Rev Immunol 2000;18:451-494.
10. Bird JJ, Brown DR, Mullen AC, Moskowitz NH, Mahowald MA, Sider JR, et al.: Helper T cell differentiation is controlled by the cell cycle. Immunity 1998;9:229-237.
11. Richards EJ, Elgin SCR: Epigenetic codes for heterochromatin formation and silencing: rounding up the usual suspects. Cell 2002;108:489-500.
12. Grogan JL, Mohrs M, Harmon B, Lacy DA, Sedat JW. Locksley RM: Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets. Immunity 2001;14:205-215.
13. Agarwal S, Rao A: Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation. Immunity 1998;9:765-775.
14. Mullen AC, Hutchins AS, High FA, Lee HW, Sykes KJ, Chodosh LA, Reiner SL: H1x is induced by and genetically interacts with T-bet to promote heritable T(H)1 gene induction. Nat Immunol 2002;3:652-658.
15. Hutchins AS, Mullen AC, Lee HW, Sykes KJ, High FA, Hendrich BD, et al.: Gene silencing quantitatively controls the function of a developmental trans-activator. Mol Cell 2002;10:81-91.
16. Fields PE, Kim ST, Flavell RA: Cutting edge: changes in histone acetylation at the IL-4 and IFN-γ Loci Accompany Th1/Th2 Differentiation. J Immunol 2002;169:647-650.
17. Avni O, Lee D, Macian F, Szabo S J, Glimcher LH, Rao A: T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes. Nat Immunol 2002;3:643-651.
18. Lee DU, Agarwal S, Rao A: Th2 lineage commitment and efficient IL-4 production involves extended demethylation of the IL-4 gene. Immunity 2002;16:649-660.
19. Szabo SJ, Kim ST, Costa GL, Zhang X, Fathman CG, Glimcher LH: A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 2000;100(6):655-669.
20. Ferber IA, Lee HJ, Zonin F, Heath V, Mui A, Arai N, O'Garra A: GATA-3 significantly downregulates IFN-γ production from developing Th1 cells in addition to inducing IL-4 and IL-5 levels. Clin Immunol 1999;91:134-144.
21. Ouyang W, Lohning M, Gao Z, Assenmacher M, Ranganath S, Radbruch A, Murphy KM: Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment. Immunity 2000;12:27-37.
22. Szabo SJ, Sullivan BM, Stemmann C, Satoskar AR, Sleckman BP, Glimcher LH: Distinct effects of T-bet in TH1 lineage commitment and IFN-γ production in CD4 and CD8 T cells. Science 2002;295:338-342.
23. Finotto S, Neurath MF, Glickman JN, Qin S, Lehr HA, Green FH, et al.: Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science 2002;295:336-338.
24. Zhu J, Guo L, Min B, Watson CJ, Hu-Li J, Young HA, et al.: Growth factor independent-1 induced by IL-4 regulates Th2 cell proliferation. Immunity 2002;16:733-744.
25. Ben-Sasson SZ, Gerstel R, Hu-Li J, Paul WE: Cell division is not a "clock" measuring acquisition of competence to produce IFN-γ or IL-4. J Immunol 2001;166:112-120.
26. Laouar Y, Crispe IN: Functional flexibility in T cells: independent regulation of CD4+ T cell proliferation and effector function in vivo. Immunity 2000;13:291-301.