Role of interferons in LPS hypersensitivity

Journal of Endotoxin Research

Volumn 9, Issue 5, 2003, Pages 308-312

  Freudenberg, Marina A ^a   Kalis, Christoph ^a   Chvatchko, Yolande ^b   Merlin, Thomas ^a   Gumescheimer, Marina ^a   Galanos, Chris ^a  

^a MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

^b SERONO PHARMACEUTICAL RES INSTITUTE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BACTERIUM LIPOPOLYSACCHARIDE; BETA INTERFERON; GAMMA INTERFERON; INTERFERON; INTERLEUKIN 12; INTERLEUKIN 18; STAT4 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL COUNT; CONTROLLED STUDY; CYTOKINE PRODUCTION; GRAM NEGATIVE BACTERIUM; HOST; HYPERSENSITIVITY; IMMUNE RESPONSE; INFECTION; MICROORGANISM; MOUSE; NONHUMAN; PROTEIN INDUCTION; SENSITIZATION; SIGNAL TRANSDUCTION;

ACUTE-PHASE PROTEINS; ANIMALS; CARRIER PROTEINS; GRAM-NEGATIVE BACTERIA; HYPERSENSITIVITY; INTERFERONS; LIPOPOLYSACCHARIDES; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT;

ANIMALIA; BACTERIA (MICROORGANISMS); NEGIBACTERIA;

EID: 0141446362     PISSN: 09680519     EISSN: None     Source Type: Journal    
DOI: 10.1179/096805103225002566     Document Type: Article

References (28)

1. Poltorak A, He X, Smirnova I et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 1998; 282: 2085-2088.
2. Kalis C, Kanzler B, Lembo A et al. Toll-like receptor 4 expression levels determine the degree of LPS-susceptibility in mice. Eur J Immunol 2003; 33: 798-805.
3. Nagai Y, Akashi S, Nagafuku M et al. Essential role of MD-2 in LPS responsiveness and TLR4 distribution. Nat Immunol 2002; 3: 667-672.
4. da Silva Correia J, Soldau K, Christen U, Tobias PS, Ulevitch RJ. Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex: transfer from CD14 to TLR4 and MD-2. J Biol Chem 2001; 276: 21129-21135.
5. Freudenberg MA, Merlin T, Gumenscheimer M, Kalis C, Landmann R, Galanos C. Role of lipopolysaccharide susceptibility in the innate immune response to Salmonella typhimurium infection: LPS, a primary target for recognition of Gram-negative bacteria. Microbes Infect 2001; 3: 1213-1222.
6. Jack RS, Fan X, Bernheiden M et al. Lipopolysaccharide-binding protein is required to combat a murine Gram-negative bacterial infection. Nature 1997; 389: 742-745.
7. Galanos C, Freudenberg MA, Matsuura M, Coumbos A. Hypersensitivity to endotoxin and mechanisms of host-response. Prog Clin Biol Res 1988; 272: 295-308.
8. Freudenberg MA, Salomao R, Sing A, Mitov I, Galanos C. Reconciling the concepts of endotoxin sensitization and tolerance. Prog Clin Biol Res 1998; 397: 261-268.
9. Merlin T, Gumenscheimer M, Galanos C, Freudenberg MA. TNF-alpha hyper-responses to Gram-negative and Gram-positive bacteria in Propionibacterium acnes primed or Salmonella typhimurium infected mice. J Endotoxin Res 2001; 7: 157-163.
10. Galanos C, Gumenscheimer M, Muhlradt P, Jirillo E, Freudenberg M. MALP-2, a Mycoplasma lipopeptide with classical endotoxic properties: end of an era of LPS monopoly? J Endotoxin Res 2000; 6: 471-476.
11. Katschinski T, Galanos C, Coumbos A, Freudenberg MA. Gamma interferon mediates Propionibacterium acnes-induced hypersensitivity to lipopolysaccharide in mice. Infect Immun 1992; 60: 1994-2001.
12. Doughty L, Nguyen K, Durbin J, Biron C. A role for IFN-alpha beta in virus infection-induced sensitization to endotoxin. J Immunol 2001; 166: 2658-2664.
13. Okamura H, Tsutsui H, Kashiwamura S, Yoshimoto T, Nakanishi K. Interleukin-18: a novel cytokine that augments both innate and acquired immunity. Adv Immunol 1998; 70: 281-312.
14. Trinchieri G. Interleukin-12: a cytokine at the interface of inflammation and immunity. Adv Immunol 1998; 70: 83-243.
15. Freudenberg MA, Merlin T, Kalis C, Chvatchko Y, Stuebig H, Galanos C. A murine, IL-12 independent pathway of IFN-γ induction by Gram-negative bacteria based on STAT4 activation by type I IFN and IL-18 signaling. J Immunol 2002; 169: 1665-1668.
16. Biron CA. Interferons alpha and beta as immune regulators - a new look. Immunity 2001; 14: 661-664.
17. Sing A, Merlin T, Knopf HP et al. Bacterial induction of beta interferon in mice is a function of the lipopolysaccharide component. Infect Immun 2000; 68: 1600-1607.
18. Poltorak A, Merlin T, Nielsen PJ et al. A point mutation in the IL-12R beta 2 gene underlies the IL-12 unresponsiveness of Lps-defective C57BL/10ScCr mice. J Immunol 2001; 167: 2106-2111.
19. Kaisho T, Akira S. Toll-like receptors as adjuvant receptors. Biochim Biophys Acta 2002; 1589: 1-13.
20. Toshchakov V, Jones BW, Perera PY et al. TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages. Nat Immunol 2002; 3: 392-398.
21. Yaegashi Y, Nielsen P, Sing A, Galanos C, Freudenberg MA. Interferon beta, a cofactor in the interferon gamma production induced by Gram-negative bacteria in mice. J Exp Med 1995; 181: 953-960.
22. Merlin T, Sing A, Nielsen PJ, Galanos C, Freudenberg MA. Inherited IL-12 unresponsiveness contributes to the high LPS resistance of the Lps(d) C57BL/10ScCr mouse. J Immunol 2001; 166: 566-573.
23. Xu X, Sun YL, Hoey T. Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain. Science 1996; 273: 794-797.
24. + T lymphocytes. J Immunol 1998; 160: 3642-3647.
25. Lawless VA, Zhang S, Ozes ON et al. Stat4 regulates multiple components of IFN-gamma-inducing signaling pathways. J Immunol 2000; 165: 6803-6808.
26. Rogge L, D'Ambrosio D, Biffi M et al. The role of Stat4 in species-specific regulation of Th cell development by type I IFNs. J Immunol 1998; 161: 6567-6574.
27. Farrar JD, Smith JD, Murphy TL, Leung S, Stark GR, Murphy KM. Selective loss of type I interferon-induced STAT4 activation caused by a minisatellite insertion in mouse Stat2. Nat Immunol 2000; 1: 65-69.
28. Nguyen KB, Cousens LP, Doughty LA, Pien GC, Durbin JE, Biron CA. Interferon alpha/beta-mediated inhibition and promotion of interferon gamma: STAT1 resolves a paradox. Nat Immunol 2000; 1: 70-76.