Unique reciprocal changes of hepatocellular membrane transporter expression and fluidity in rats with selective biliary obstruction

Hepatology Research

Volumn 26, Issue 2, 2003, Pages 157-163

  Kanno, Keishi ^a   Tazuma, Susumu ^a   Niida, Shumpei ^b,c   Chayama, Kazuaki ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

^c NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

Author keywords

Bile acid; Cholestasis; Hepatocellular transporter; Membrane fluidity

Indexed keywords

CARRIER PROTEIN; GLYCOPROTEIN P; MEMBRANE PROTEIN; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; PROTEIN BSEP; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT LIGATION; BILE SECRETION; CELL MEMBRANE FLUIDITY; CELL MEMBRANE TRANSPORT; CHOLESTASIS; CONTROLLED STUDY; EXTRAHEPATIC BILE DUCT OBSTRUCTION; HISTOPATHOLOGY; HYPERBILIRUBINEMIA; LIVER CELL MEMBRANE; MALE; MOLECULAR BIOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RAT STRAIN; REGULATORY MECHANISM; UPREGULATION;

EID: 0043170767     PISSN: 13866346     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1386-6346(03)00084-6     Document Type: Article

References (35)

1. Muller M. Transcriptional control of hepatocanalicular transporter gene expression. Semin Liver Dis 2000;20:323-37.
2. Cohen DE. Hepatocellular transport and secretion of biliary lipids. Curr Opin Lipidol 1999;10:295-302.
3. Kullak-Ublick GA, Beuers U, Paumgartner G. Hepatobiliary transport J Hepatol 2000;32:3-18.
4. Borst P, Evers R, Kool M, Wijnholds J. A family of drug transporters: the multidrug resistance-associated proteins. J Natl Cancer Inst 2000;92:1295-302.
5. Borst P, Zelcer N, Holvoort AV. ABC transporters in lipid transport. Biochim Biophys Acta 2000;1486:128-44.
6. Trauner M, Arrese M, Soroka CJ, et al. The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis. Gastroenterology 1997;113:255-64.
7. Kubitz R, Wettstein M, Warskulat U, Haussinger D. Regulation of the multidrug resistance protein 2 in the rat liver by lipopolysaccharide and dexamethasone. Gastroenterology 1999;116:401-10.
8. Dombrowski F, Kubitz R, Chittattu A, Wettstein M, Saha N, Haussinger D. Electron-microscopic demonstration of multidrug resistance protein 2 (Mrp2) retrieval from canalicular membrane in response to hyperosmolarity and lipopolysaccharide. Biochem J 2000;348:183-8.
9. Vos TA, Hooiveld GJEJ, Koning H, et al. Up-regulation of the multidrug resistance genes, Mrp1 and Mdr1b, and down-regulation of the organic anion transporter, Mrp2, and the bile salt transporter, Spgp, in endotoxemic rat liver. Hepatology 1998;28:1637-44.
10. Kagawa T, Watanabe N, Sato M, et al. Differential expression of multidrug resistance (mdr) and canalicular multispecific organic anion transporter (cMOAT) genes following extrahepatic biliary obstruction in rats. Biochem Mol Biol Int 1998;44:443-52.
11. Lee JM, Trauner M, Soroka CJ, Stieger B, Meier PJ, Boyer JL. Expression of the bile salt export pump is maintained after chronic cholestasis in the rat. Gastroenterology 2000;118:163-72.
12. Paulusma CC, Kothe MJ, Bakker CT, Bosma PJ, van Bokhoven I, van Marle J, et al. Zonal down-regulation and redistribution of the multidrug resistance protein 2 during bile duct ligation in rat liver. Hepatology 2000;31:684-92.
13. Hirohashi T, Suzuki H, Ito K, et al. Hepatic expression of multidrug resistance-associated protein-like proteins maintained in Eisai hyperbilirubinemic rats. Mol Pharmacol 1998;53:1068-75.
14. Soroka CJ, Lee JM, Azzaroli F, Boyer JL. Cellular localization and up-regulation of multidrug resistance-associated protein 3 in hepatocytes and cholangiocytes during obstructive cholestasis in rat liver. Hepatplogy 2001;33:783-91.
15. Donner MG, Keppler D. Up-regulation of basolateral multidrug resistance protein 3 (Mrp3) in cholestatic rat liver. Hepatology 2001;34:351-9.
16. Yasumiba S, Tazuma S, Ochi H, Kajiyama G. Modifying hepatic phospholipid synthesis associates with biliary phospholipid secretion rate in a transport-independent manner in rats. Dig Dis Sci 2001;46:1290-8.
17. Hyogo H, Tazuma S, Kajiyama G. Biliary excretory function is regulated by canalicular membrane fluidity associated with phospholipids fatty acyl chains in the bilayer: implications for the pathophysiology of cholestasis. J Gastroenterol Hepatol 2000;15:887-94.
18. Yasumiba S, Tazuma S, Ochi H, Chayama K, Kajiyama G. Cyclosprin A reduces canalicular membrane fluidity and regulates transporter function in rats. Biochem J 2001;354:591-6.
19. Adler RD, Wannagat F-J, Robert KO. Bile secretion in selective biliary obstruction. Gastroenterology 1977;73:129-36.
20. Wannagat F-J, Adler RD, Robert KO. Bile acid-induced increase in bile acid-independent flow and plasma membrane NaK-ATPase activity in rat liver. J Clin Invest 1978;61:297-307.
21. Bellentani S, Ferrari A, Villa E, Manenti F. Study of the long-term effects of selective biliary obstruction (SBO). Res Exp Med (Berl) 1981;178:229-35.
22. Gant TW, Silverman JA, Bisgaard HC, Burt RK, Marino PA, Thorgeirsson SS. Regulation of 2-acetylamino-fluorene-and 3-methylcholanthrene-mediated induction of multidrug resistance and cytochrome P450IA gene family expression in primary hepatocyte cultures and rat liver. Mol Carcinog 1991;4:499-509.
23. Takenaka O, Horie T, Kobayashi K, Suzuki H, Sugiyama Y. Kinetic analysis of hepatobiliary transport for conjugated metabolites in the perfused liver of mutant rats (EHBR) with hereditary conjugated hyperbilirubinemia. Pharm Res 1995;12:1746-55.
24. Jorg K, Daniel R, Yunhai C, Dietrich K. Characterization of the human multidrug resistance protein isoform MRP3 localized to basolateral hepatocyte membrane. Hepatology 1999;29:1156-63.
25. Lomberd M, Bomford A, Hynes M, Naoumov NV, Roberts S, Crowe J, et al. Regulation of the hepatic transferrin receptor in hereditary hemochromatosis. Hepatology 1989;9:1-5.
26. Gotoh S, Todaka N, Yan Y, Fukamachi Y, Abe T, Higashi K. Studies on the multidrug resistance gene expression in the liver of rats associated with different susceptibility of hepatocarcinogenesis. J Uoch 1999;21:265-76.
27. Lentz BR, Moore BM, Barrow DA. Light-scattering effects in the measurement of membrane microviscosity with diphenylhexatriene. Biophys J 1979;25:489-94.
28. Kawato S, Kinoshita K, Ikegami A. Dynamic structure of lipid bilayers studied by nanosecond fluorescence techniques. Biochemistry 1977;16:2319-24.
29. Hyogo H, Tazuma S, Nishioka T, et al. Phospholipid alterations in hepatocyte membranes and transporter protein changes in cholestatic rat model. Dig Dis Sci 2001;46:2089-97.
30. Hirohashi T, Suzuki H, Takikawa H, Sugiyama Y. ATP-dependent transport of bile salts by rat multidrug resistance-associated protein 3 (Mrp3). J Biol Chem 2000;275:2905-10.
31. Asamoto Y, Tazuma S, Ochi H, Chayama K, Suzuki H. Bile-salt hydrophobicity is a key factor regulating rat liver plasma-membrane communication: relation to bilayer structure, fluidity and transporter expression and function. Biochem J 2001;359:605-10.
32. Mills PR, Meier PJ, Smith DJ, Ballatori N, Boyer JL, Gordon ER. The effect of changes in the fluid state of rat liver plasma membrane on transport of taurocholate. Hepatology 1987;7:61-6.
33. Dipple I, Houslay MD. The activity of glucagon-stimulated adenylate cyclase from rat liver plasma membranes is modulated by the fluidity of its lipid environment. Biochem J 1998;174:179-90.
34. Shachter D. Fluidity and function of hepatocyte plasma membranes. Hepatology 1984;4:140-51.
35. Rosario J, Sutherland E, Zaccaro L, Simon FR. Ethinylestradiol administration selectively alters liver sinusoidal membrane lipid fluidity and protein composition. Biochemistry 1988;27:3939-46.