Autologous glioma cell vaccine admixed with interleukin-4 gene transfected fibroblasts in the treatment of recurrent glioblastoma: Preliminary observations in a patient with a favorable response to therapy

Journal of Neuro-Oncology

Volumn 64, Issue 1, 2003, Pages 13-20

  Okada, Hideho ^a,b   Lieberman, Frank S ^a   Edington, Howard D ^a   Witham, Timothy F ^a   Wargo, Mark J ^b   Cai, Quan ^a   Elder, Elaine H ^a   Whiteside, Theresa L ^a   Schold Jr , S Clifford ^a,b   Pollack, Ian F ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

Author keywords

Cancer vaccine; Gliomas; Immunotherapy; Interleukin 4; Retroviral vectors

Indexed keywords

AUTOLOGOUS GLIOMA CELL VACCINE; CANCER VACCINE; CD4 ANTIGEN; CD8 ANTIGEN; CORTICOSTEROID; GANCICLOVIR; INTERLEUKIN 4; RETROVIRUS VECTOR; T6 ANTIGEN; TEMOZOLOMIDE; THALIDOMIDE; THYMIDINE KINASE; UNCLASSIFIED DRUG;

ADOPTIVE IMMUNOTHERAPY; ADULT; ALLERGIC ENCEPHALITIS; BEAM THERAPY; BRAIN BIOPSY; CANCER IMMUNOTHERAPY; CANCER SURVIVAL; CASE REPORT; CELL INFILTRATION; CELLULAR IMMUNITY; CLINICAL TRIAL; CONFERENCE PAPER; CONTRAST ENHANCEMENT; CRANIOTOMY; CYTOKINE PRODUCTION; DISEASE COURSE; DOSE RESPONSE; DRUG EFFICACY; DRUG RESPONSE; DRUG WITHDRAWAL; EXCISION; FIBROBLAST; GENE EXPRESSION; GENETIC TRANSFECTION; GLIOBLASTOMA; GLIOMA CELL; HERPES SIMPLEX VIRUS; HUMAN; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; INJECTION SITE; IRRADIATION; LETHARGY; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PHASE 1 CLINICAL TRIAL; RECURRENT CANCER; SKIN TEST; TEMPORAL LOBE; TRANSGENE; TREATMENT OUTCOME; VACCINATION; VACCINE PRODUCTION;

EID: 0043065333     PISSN: 0167594X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1024969422010     Document Type: Conference Paper

References (32)

1. Dranoff G: Cancer gene therapy: Connecting basic research with clinical inquiry. [Review] [85 refs]. J Clin Oncol 16: 2548-2556, 1998
2. Sampson JH, Archer GE, Ashley DM, Fuchs HE, Hale LP, Dranoff G, Bigner DD: Subcutaneous vaccination with irradiated cytokine-producing tumor cells stimulates CD8+ cell-mediated immunity against tumors located in the immunologically privileged central nervous system. Proc Natl Acad Sci USA 93: 10399-10404, 1996
3. Dranoff G: The use of gene transfer in cancer immunotherapy. [Review] [48 refs]. Forum 8: 357-364, 1998
4. Soiffer R, Lynch T, Mihm M, Jung K, Rhuda C, Schmollinger JC, Hodi FS, Liebster L, Lam P, Mentzer S, Singer S, Tanabe KK, Cosimi AB, Duda R, Sober A, Bhan A, Daley J, Neuberg D, Parry G, Rokovich J, Richards L, Drayer J, Berns A, Clift S, Dranoff G: Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte-macrophage colony-stimulating factor generated potent antitumor immunity in patients with metastatic melanoma. Proc Natl Acad Sci USA 95: 13141-13146, 1998
5. Golumbek PT, Lazenby AJ, Levitsky HI, Jaffee LM, Karasuyama HB, Baker M, Pardoll DM: Treatment of established renal cancer by tumor cells engineered to secrete interleukin-4. Science 254: 713-716, 1991
6. Pericle F, Giovarelli M, Colombo MP, Ferrari G, Musinani P, Modesti A, Cavallo F, Di Pierri F, Novelli F, Forni G: An efficient Th2-type memory follows CD8+ lymphocyte-driven and eosinophil-mediated rejection of a spontaneous mouse mammary adenocarcinoma engineered to release IL-4. J Immunol 153: 5659-5673, 1994
7. Schuler T, Qin Z, Ibe S, Noben-Trauth N, Blankenstein T: TH1-associated and cytotoxic T lymphocyte-mediated tumor immunity is impaired in IL-4-deficient mice. J Exp Med 189: 803-810, 1999
8. Pippin BA, Rosenstein M, Jacob WF, Chiang Y, Lotze MT: Local IL-4 delivery enhances immune reactivity to murine tumors: Gene theraphy in combination with IL-2. Cancer Gene Ther 1: 35-42, 1994
9. Stoppacciaro A, Paglia P, Lambardi L, Parmiani G, Baroni G, Colombo MP: Genetic modification of a carcinoma with the IL-4 gene increases the influx of dendritic cells relative to other cytokines. Eur J Immunol 27: 2375-2382, 1997
10. Lotze MT, Rubin JT, Carty S, Edington H, Ferson P, Landreneau R, Pippin, Posner, M, Rosenfelder D, Watson C: Gene theraphy of cancer: A pilot study of IL-4-gene-modified fibroblasts admixed with autologous tumro to elicit an immune response. Hum Gene Ther 5: 41-55, 1994
11. Suminami Y, Elder Em, Lotze MT, Whiteside TL: In situ interleukin-4 gene expression in cancer patients treated with genetically modified tumor vaccine. J Immunother 17: 238-248, 1995
12. Saas P, Walker PR, Hahne M, Quiquerez AL, Schnuriger V, Perrin G, French L, Van Meir EG, De Tribolet N, Tschopp TJ, Dietrich PY: Fas ligand expression by astrocytoma in vivo: Maintaining immune privilege in the brain? J Clin Invest 99: 1173-1178, 1997
13. Weller M, Fontana A, The failure of current immunotheraphy for malignant glioma. Tumor-derived TGF-beta. T-cells apoptosis, and the immune privilege of the brain. Brain Res 21: 128-151, 1995
14. Wiendel H, Mitsdoerffer M, Hofmeister V, Wischhuyse J, Bornemann A, Meyermann R, Weiss EH, Melms A, Weller M: A functional role of HLA-G expression in human gliomas: An alternative strategy of immune escape. J Immunol 168: 4772-4780, 2002
15. Wischhusen J, Jung G, Radovanovoc I, Beier C, Steibach JP, Rimner A, Huang H, Schulz JB, Ohgaki H, Aguzzi A, Rammensee HG, Weller M: Identification of CD70-mediated apoptosis of immune effector cells as a novel immune escape pathway of human glioblastoma. Cancer Res 62: 2592-2599, 2002
16. Lampson LA: Beyond inflammation: Site-directed immunotheraphy. [Review] [32 refs]. Immunol Today 19: 17-22, 1998
17. Lampson LA: Immunobiology of brain tumors: Antigens, effectors, and delivery to sites of microscopic tumor in the brain. In: Black PM, Loeffler JS (eds) Cancer of the Nervous System. Blackwell, Oxford, 1997, pp 874-906
18. Okada H, Villa LA, Attanucci J, Erff M, Fellows WK, Lotze MT, Pollack IF, Chambers WH: Cytokine gene therapy of gliomas: Effective induction of therapeutic immunity to intracranial tumors by peripheral immunization with interleukin-4 transduced glioma cells. Gene Ther 8: 1157-1166, 2001
19. Elder EM, Lotze MT, Whiteside TL: Successful culture and selection of cytokine gene-modified human dermal fibroblasts for the biologic therapy of patients with cancer. Hum Gene Ther 7: 479-487, 1996
20. Okada H, Giezeman-Smits KM, Tahara H, Attanucci J, Fellows WK, Lotze MT, Chambers WH, Bozik ME: Effective cytokine gene therapy against an intracranial glioma using a retrovirally transduced IL-4 plus HSV-TK tumor vaccine. Gene Ther 6: 219-226, 1999
21. Giezeman-Smits KM, Okada H, Brissette-Storkus SC, Villa LA, Attanucci J, Lotze MT, Pollack IF, Bozik ME, Chambers WH: Cytokine gene therapy of gliomas: Induction of reactive CD4+ cells by interleukin-4 transfected 9L gliosarcoma is essential for protective immunity. Cancer Res 60: 2449-2457, 2000
22. Okada H, Pollack IF, Lotze MT, Lunsford LD, Kondziolka D, Lieberman FS, Schiff D, Attanucci J, Edington H, Chambers WH, Robbins PD, Baar J, Kinzler D, Whiteside TL, Elder EM: Gene therapy of malignant gliomas: A phase I study of IL4HSV-TK gene-modified autologous tumor to elicit an immune response (clinical protocol). Hum Gene Ther 11: 637-653, 2000
23. Okada H, Attanucci J, Tahara H, Pollack IF, Bozik ME, Chambers WH, Lotze MT: Characterization and transduction of a retroviral vector encoding human interleukin-4 and the herpes simplex-thymidine kinase for glioma tumor vaccine therapy. Cancer Gene Ther 7: 486-494, 2000
24. Herr W, Linn B, Leister N, Wandel E, Meyer Zum Buschenfelde KH, Wolfel T: The use of computer - Assisted video image analysis for the quantification of CD8+ T lymphocytes producing tumor necrosis factor alpha sopots in response to peptide antigens. J Immunol Methods 203: 141-152, 1997
25. Kalman B, Lublin FD: Immunopathogenic mechanisms in experimental allergic encephalomyelitis. [Review]. Curr Opin Neurol Neurosurg 6: 182-188, 1993
26. Schmidt S, Linington C, Zipp F, Sotgiu S, De Wall Malefyt R, Wekerle H, Hohlfeld R: Multiple sclerosis: Comparison of the human T-cell response to S100 beta and myelin basic protein reveal oparallels to rat experimental autoimmune panencepohalitis. Brain 120: 1437-1445, 1997
27. Bigner DD, Pitts OM, Wikstrand CJ: Induction of lethal experimental allergic encephalomyelitis in non-human primates and guinea pigs with human glioblastoma multiforme tissue. J Neurosurg 55: 32-42, 1981
28. Herr W, Ranieri E, Olson W, Zarour H, Gesualdo L, Storkus WJ: Mature dendritic cells pulsed with free-thaw cell lysates define as effective in vitro vaccine designed to elicit EBV-specific CD4(+) and CD8(+) T lymphocyte responses. Blood 96, 1857-1864, 2000
29. Zarour HM, Kirkwood JM, Kierstead LS, Herr W, Brusic V, Slingluff CLJ, Sidney J, Sette A, Storkus WJ: Melan-A/MART-1(51-73) represents an immunogenic HLA-DR4-restricted epitope recognized by melanoma-reactive CD4(+) T cells. Proc Natl Acad Sci USA 97: 400-405, 2000
30. Okano F, Storkus WJ, Chambers WH, Pollack IF, Okada H: Identification of a novel HLA-A*0201 restricted cytotoxic T lymphocyte epitope in a human glioma asociated antigen, interleukin-13 receptor 2 chain. Clin Cancer Res 8: 2851-2855, 2002
31. Debinski W, Gibo DM, Hulet SW, Connor JR, Gillespie GY: Receptor for interleukin 13 is a marker and therapeutic target for human high-grade gliomas. Clin Cancer Res 5: 985-990, 1999
32. Debinski W, Slagle B, Gibo DM, Powers SK, Gillespie GY: Expression of a restrictive receptor for interleukin 13 is associated with glial transformation. J Neurooncol 48: 103-111, 2000