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Volumn 10, Issue 18, 2003, Pages 1891-1915

Current progress in the chemistry and pharmacology of akuammiline alkaloids

Author keywords

Akuammiline; Bisindole; Echitamine; Indole; Isolation; Monoterpene alkaloids; Pharmacology; Strictamine

Indexed keywords

AKUAMMICINE; AKUAMMILINE; AKUAMMILINE ALKALOID; AKUAMMINE; ALSTONINE; AMPICILLIN; ANTIAMEBIC AGENT; ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; ANTILEISHMANIAL AGENT; ANTIMALARIAL AGENT; ANTIPYRETIC AGENT; CORYMINE; ECHITAMINE; ECHITAMINIC ACID; ERIPINE; INDOLE ALKALOID; MORPHINE; PICRATIDINE; PICRILINE; PLANT EXTRACT; PSEUDOAKUAMMIGINE; RAUSUTRANINE; RAUWOLFIA ALKALOID; RHAZIMINE; RHAZYA STRICTA EXTRACT; STRICTAMINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VINCA ALKALOID; VINGRAMINE;

EID: 0042924098     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/0929867033457016     Document Type: Review
Times cited : (220)

References (168)
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    • For Martin's approach, see references [17] and [18]. With the exception of the Wieland-Gumlich aldehyde and strychnine, over 40 total syntheses of pentacyclic Strychnos alkaloids have been accomplished, for a premium review, see: Bonjoch, J.; Solé, D. Chem. Rev. 2000, 100, 3455.
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    • Alkaloids with the pleiocarpamine skeleton compose a related family of bases that differ from akuammiline alkaloids in the regioselective closure of ring E between N-1 and C-16. The total syntheses of (±)-2,7-dihydropleiocarpamine, (± -16-epi-pleiocarpamine, and (±)-nor-mavacurine have been reported in addition to the partial synthesis of (+)-16-epi-pleiocarpamine, and the elaboration of pattern structures
    • Alkaloids with the pleiocarpamine skeleton compose a related family of bases that differ from akuammiline alkaloids in the regioselective closure of ring E between N-1 and C-16. The total syntheses of (±)-2,7-dihydropleiocarpamine, (± -16-epi-pleiocarpamine, and (±)-nor-mavacurine have been reported in addition to the partial synthesis of (+)-16-epi-pleiocarpamine, and the elaboration of pattern structures: Bennasar, M.-L.; Zulaica, E.; Jiménez, J.-M.; Bosch, J. J. Org. Chem. 1993, 58, 7756.
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    • The search of chemical abstracts was executed on SciFinder. The authors of this Review ask to be excused for the involuntary absence of any references regarding the isolation of akuammiline alkaloids within the period covered.
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    • Also named 2-methoxy-1,2-dihydrorhazimine.
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    • For a detailed discussion on the anti-inflammatory activity found in extracts from the seeds of P. nitida, see reference [73].
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    • Diversity-oriented libraries of analogues of indole alkaloids yohimbine (antihypertensive), indolactam V (protein kinase C activator), and galanthamine (acetylcholinesterase inhibitor) have been synthesized. Respectively: Atuegbu, A.; Maclean, D.; Nguyen, C.; Gordon, E. M.; Jacobs, J. W. Bioorg. Med. Chem. 1996, 4, 1097.
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    • For example, dendrobatid alkaloids isolated from dart-poison frogs are indolizidine derivatives, while azaazulene-based acids have been attributed a variety of biological properties. Respectively
    • For example, dendrobatid alkaloids isolated from dart-poison frogs are indolizidine derivatives, while azaazulene-based acids have been attributed a variety of biological properties. Respectively: Garraffo, H.; Spande, T. F.; Daly, J. W. J. Nat. Prod. 1993, 56, 357.
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    • Its analogue dihydropseudoakuammigine has also been prepared in different reducing conditions Academic Press, New York
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    • 5]-enkephalin
    • 5]-enkephalin.
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    • Structure of nociceptin:
    • Structure of nociceptin:


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.