The protective effect of alstonia scholaris r. br. on hepatotoxin-induced acute liver damage

American Journal of Chinese Medicine

Volumn 24, Issue 2, 1996, Pages 153-164

  Lin, Song Chow ^a   Lin, Chun Ching ^a   Lin, Yun Ho ^b   Supriyatna, S ^c   Pan, Shiow Lin ^a  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^c PADJADJARAN UNIVERSITY   (Indonesia)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; AMINOTRANSFERASE; ANALGESIC AGENT; ASPARTATE AMINOTRANSFERASE; CARBON TETRACHLORIDE; GALACTOSAMINE; PARACETAMOL; PLANT EXTRACT;

ANIMAL; ARTICLE; BLOOD; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECT; INJURY; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER; MALE; MOUSE; PATHOLOGY; RAT; TRADITIONAL MEDICINE; WISTAR RAT;

ACETAMINOPHEN; ALANINE TRANSAMINASE; ANALGESICS, NON-NARCOTIC; ANIMALS; ASPARTATE AMINOTRANSFERASES; CARBON TETRACHLORIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; GALACTOSAMINE; INJECTIONS, INTRAPERITONEAL; LIVER; MALE; MEDICINE, TRADITIONAL; MICE; PLANT EXTRACTS; RATS; RATS, WISTAR; TRANSAMINASES;

EID: 0030341526     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X96000207     Document Type: Article

References (25)

1. Black, M. Acetaminophen hepatotoxicity. Ann. Rev. Med. 35:577, 1984.
2. Chiu. H.F., C.C. Lin, C.C. Yang and F. Yang The pharmacological and pathological studies on several hepatic protective crude drugs from Taiwan (I). Am. J. Chin. Med. 16(3-4): 127-137, 1988.
3. Chiu, H.F., C.C. Lin, C.C. Yang and F. Yang. The pharmacological and pathological studies on several hepatic protective crude drugs from Taiwan (II). Am. J. Chin. Med. 17(1-2):17-23, 1989.
4. Clark, R., R.P.H. Thompson, V. Borirakchanyavat, B. Widdop, A.R. Division, R. Goulding and R. Williams. Hepatic damage and death from overdose of paracetamol. Lancet. 1(794):66-70, 1973.
5. Clawson, G. A. Mechanism of carbon tetrachloride hepatotoxicity. Pathol. Immunopath. Res. 8:104-112, 1989.
6. Dumont, J.M., M.F. Maignan and D. Perrissoud. Protective effect of malotilate against galactosamine intoxication in the rat. Arch. Int. Pharmacodyn. Ther. 289:269-310, 1987.
7. Dwivedi, Y., R. Rastogi, N.K. Garg and B.N. Dhawan. Picroliv and its components kutkoside and picroside I protect liver against galactosamine-induced damage in rats. Pharmacol. Toxicol. 71:381387,1992.
8. El-Mojfy, S.K., M.C. Scruffon, .A. Serroni, C. Nicolini and J.L. Farber. Early reversible plasma membrane injury in galactosamine induced liver cell death. Am. J. Pathol. 79:579-596,1975.
9. Hinson, J.A. Biochemical toxicology of acetaminophen. Rev. Biochem. Toxicol. 2:103-129,1980.
10. Hoffmann, K.J., A.J. Streeter, D.B. Axworth and T.A. Baillie. Structural characterization of the major covalent adduct formed in vitro and in vivo between acetaminophen and mouse liver proteins. Mol. Pharmol. 27:566-573,1985.
11. Jeffrey, A.B. and H.R. Barry. Role of free radicals in toxic hepatic injury. II. Are free radicals the cause of toxin-induced liver injury? Clin. Toxicol. 31:173-196,1993.
12. John, T. and H. Rosemary. Animal models of fulminant hepatic failure. Digestive Disease and Science. 36:770-774,1991.
13. Jollow, D.J., J.R. Mitchell, W.Z. Potter, D.C. Davis, J.R. Gillette and B.B. Brodie Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo. J. Pharmacol. Exp. Ther. 18,: 195-202,1973.
14. Keppler, D. and K. Decker. Studies on the mechanism of galactosamine hepatitis. J. Biochem. 10:219-225,1969.
15. Keppler, D., R. Lesch; W. Reutter and K. Decker. Experimental hepatitis induced by D-galactosamine. Exp. Mol. Path. 9:279-290,1968.
16. Lin, C.C., H.F. Chiu, M.H. Ten, C.C. Wu and M.F. Chen. The pharmacological and pathological studies on Taiwan folk medicine (III) -The effects of Bupleurum kaoi and cultivated Bupleurum falcatum var. komarowi. Am. J. Chin. Med. 18:105-112, 1990a.
17. Lin, C.C., M.H. Yen, H.F. Chiu and C.H. Chang. The pharmacological and pathological studies on Taiwan folk medicine (IV) - The effects of Echinops grijisii and E. latifolius. Am. J. Chin. Med. 18:113-120, 1990b.
18. MacDonal, J.R., J.H. Beckstead and E.A. Smuckler. An ultrastructural and histochemical study of the prominent inflammatory responses in D(+)-galactosamine hepatotoxicity. Brit. J. Exp. Path. 68:189-199,1987.
19. Mitchell, J.R. Acetaminophen toxicity. N. Engl. J. Med. 319:1601-1602, 1988.
20. Mitchell, J.R., D.J. Jollow; W.Z. Potter, J.R. Gillette and B.B. Brodie. Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione. J. Pharmacol. Exp Ther. 187:211-217,1973.
21. Nelson, S.D. Molecular mechanisms of the hepatotoxicity caused by acetaminophen. Seminar in Liver Disease. 10:267-278,1990.
22. Orrego, H., F J. Carmichael, M.J. Phillips, H. Kalant, J. Khanna and Y Israel. Protection by propylthiouracil against carbon tetrachloride-incuced liver damage. Gastroenterology, 1:821-826,1976.
23. Potter, D.W. and J A Hinson. Reactions of N-acetyl-p-benzoquinone-imine with reduced glutathione, acetaminophen, and NADPH. Mol. Pharmacol. 30:33-41,1986.
24. Williams, A.T. and R.F. Burk. Carbon tetrachloride hepatoxicity: an example of free radical-mediated injury. Seminar in Liver Disease, 10:279-284,1990.
25. Wormser, U. and G. Zbinden. Quantitative and qualitative change of serum proteolytic activity in rats with liver damage induced by galactosamine. Arch. Toxicol. 59:111-114, 1986.