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+ dendritic cells to selectively deplete this subset and show that they were involved in CTL priming to intracellular pathogens.
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+ CTL following exposure to vaccinia virus via different routes
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These authors used a recombinant vaccinia virus bearing the US11 gene that inhibits endogenous MHC class I-restricted presentation to discriminate between direct and indirect presentation during CTL priming.
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+ CTL following exposure to vaccinia virus via different routes. J. Immunol. 169:2002;4222-4229 These authors used a recombinant vaccinia virus bearing the US11 gene that inhibits endogenous MHC class I-restricted presentation to discriminate between direct and indirect presentation during CTL priming.
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Mueller S.N., Jones C.M., Smith C.M., Heath W.R., Carbone F.R. Rapid cytotoxic T lymphocyte activation occurs in the draining lymph nodes after cutaneous herpes simplex virus infection as a result of early antigen presentation and not the presence of virus. J. Exp. Med. 195:2002;651-656.
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Cutting Edge: Conventional CD8alpha(+) Dendritic Cells Are Preferentially Involved in CTL Priming After Footpad Infection with Herpes Simplex Virus-1
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Smith CM, Belz GT, Wilson NS, Villadangos JA, Shortman K, Carbone FR, Heath WR: Cutting Edge: Conventional CD8alpha(+) Dendritic Cells Are Preferentially Involved in CTL Priming After Footpad Infection with Herpes Simplex Virus-1. J Immunol 2003, 170:4437-4440.
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The CD8alpha(+) dendritic cell is responsible for inducing peripheral self-tolerance to tissue-associated antigens
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+ dendritic cell subset selectively endocytoses dying cells in culture and in vivo
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+ dendritic cells selectively take up antigen from dying cells for class I-restricted cross-presentation, which potentially explains their selective involvement in this event.
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Vaginal submucosal dendritic cells, but not langerhans cells, induce protective Th1 responses to herpes simplex virus-2
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This study examined dendritic cell involvement in helper T cell priming during vaginal infection and makes the surprising point that this event does not involve the major dendritic cell population in the mucosa.
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Zhao X., Deak E., Soderberg K., Linehan M., Spezzano D., Zhu J., Knipe D.M., Iwasaki A. Vaginal submucosal dendritic cells, but not langerhans cells, induce protective Th1 responses to herpes simplex virus-2. J. Exp. Med. 197:2003;153-162 This study examined dendritic cell involvement in helper T cell priming during vaginal infection and makes the surprising point that this event does not involve the major dendritic cell population in the mucosa.
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