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Volumn 7, Issue 2, 1998, Pages 109-117

G protein subunits and cell proliferation

Author keywords

Extracellular response kinase; G protein; Jun N terminal kinase; Oncogene; Proliferation; Rac; Ras; Rho; Transformation

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; PROTEIN KINASE; PROTEIN SUBUNIT;

EID: 0031802475     PISSN: 1424862X     EISSN: 14248638     Source Type: Journal    
DOI: 10.1159/000014536     Document Type: Article
Times cited : (21)

References (52)
  • 2
    • 85003117994 scopus 로고
    • The G-protein family and their interaction with receptors
    • Johnson GL, Dhanasekaran N: The G-protein family and their interaction with receptors. Endocrinol Rev 1989;3:317-331.
    • (1989) Endocrinol Rev , vol.3 , pp. 317-331
    • Johnson, G.L.1    Dhanasekaran, N.2
  • 3
    • 0024342820 scopus 로고
    • Diversity of G-protein family: Sequences from five additional a subunits in the mouse
    • Strathman M, Wilkie TM, Simon MI: Diversity of G-protein family: Sequences from five additional a subunits in the mouse. Proc Natl Acad Sci USA 1989;86:7407-7409.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 7407-7409
    • Strathman, M.1    Wilkie, T.M.2    Simon, M.I.3
  • 4
    • 0029011084 scopus 로고
    • G protein couple receptor systems involved in cell growth and oncogenesis
    • Dhanasekaran N, Heasley LE, Johnson GL: G protein couple receptor systems involved in cell growth and oncogenesis. Endocrinol Rev 1995; 16:259-270.
    • (1995) Endocrinol Rev , vol.16 , pp. 259-270
    • Dhanasekaran, N.1    Heasley, L.E.2    Johnson, G.L.3
  • 6
    • 0024614795 scopus 로고
    • The cyclic AMP-mediated stimulation of cell proliferation
    • Dumont JE, Jauniaux JC, Roger PP: The cyclic AMP-mediated stimulation of cell proliferation. Trends Biochem Sci 1989;17:67-71.
    • (1989) Trends Biochem Sci , vol.17 , pp. 67-71
    • Dumont, J.E.1    Jauniaux, J.C.2    Roger, P.P.3
  • 7
    • 0023522307 scopus 로고
    • Altered Gs and adenylate cyclase activity in human GH-secreting pituitary adenomas
    • Vallar L, Spada A, Giannattasio G: Altered Gs and adenylate cyclase activity in human GH-secreting pituitary adenomas. Nature 1987;330: 566-568.
    • (1987) Nature , vol.330 , pp. 566-568
    • Vallar, L.1    Spada, A.2    Giannattasio, G.3
  • 9
    • 0018641464 scopus 로고
    • Transformation of NIH/3T3 mouse cells by DNA of Rous sarcoma virus
    • Copeland NG, Zelenetz AD, Cooper GM: Transformation of NIH/3T3 mouse cells by DNA of Rous sarcoma virus. Cell 1979;17:993-1002.
    • (1979) Cell , vol.17 , pp. 993-1002
    • Copeland, N.G.1    Zelenetz, A.D.2    Cooper, G.M.3
  • 10
    • 0025284399 scopus 로고
    • Increased mitogenic responsiveness of Swiss 3T3 cells expressing constitutively active Gsa
    • Zachary I, Masters SB, Bourne HR: Increased mitogenic responsiveness of Swiss 3T3 cells expressing constitutively active Gsa. Biochem Bio-phys Res Commun 1990; 168:1184-1193.
    • (1990) Biochem Bio-Phys Res Commun , vol.168 , pp. 1184-1193
    • Zachary, I.1    Masters, S.B.2    Bourne, H.R.3
  • 11
    • 0025826856 scopus 로고
    • A mutant a subunit of Gi2 induces neoplastic transformation of Rat-1 cells
    • Pace AM, Wong YH, Bourne HR: A mutant a subunit of Gi2 induces neoplastic transformation of Rat-1 cells. Proc Natl Acad Sci USA 1991; 88:7031-7035.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 7031-7035
    • Pace, A.M.1    Wong, Y.H.2    Bourne, H.R.3
  • 13
    • 0026693669 scopus 로고
    • Enhanced phospholipase C stimulation and transformation in NIH3T3 cells expressing Q209LGq-a-subunits
    • De Vivo M, Chen J, Iyengar R: Enhanced phospholipase C stimulation and transformation in NIH3T3 cells expressing Q209LGq-a-subunits. J Biol Chem 1992;267:18263-18266.
    • (1992) J Biol Chem , vol.267 , pp. 18263-18266
    • De Vivo, M.1    Chen, J.2    Iyengar, R.3
  • 14
    • 0026725897 scopus 로고
    • Mutant a subunit of the Gq protein induces malignant transformation in NIH3T3 cells
    • Kalinec G, Nagaradi AJ, Hermouet S, Xu N, Gutkind JS: Mutant a subunit of the Gq protein induces malignant transformation in NIH3T3 cells. Mol Cell Biol 1992;12:4687-4693.
    • (1992) Mol Cell Biol , vol.12 , pp. 4687-4693
    • Kalinec, G.1    Nagaradi, A.J.2    Hermouet, S.3    Xu, N.4    Gutkind, J.S.5
  • 16
    • 0027217195 scopus 로고
    • A mutant a subunit of G12 potentiates eicosanoid pathway and is highly mitogenic in NIH3T3 cells
    • Xu N, Bradley L, Ambudkar I, Gutkind JS: A mutant a subunit of G12 potentiates eicosanoid pathway and is highly mitogenic in NIH3T3 cells. Proc Natl Acad Sci USA 1993;90: 11354-11358.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 11354-11358
    • Xu, N.1    Bradley, L.2    Ambudkar, I.3    Gutkind, J.S.4
  • 18
    • 0028173803 scopus 로고
    • Activated mutant of Ga13 induces Egr-1, c-fos, and transformation in NIH3T3 cells
    • Vara Prasad MVVS, Shore SK, Dhanasekaran N: Activated mutant of Ga13 induces Egr-1, c-fos, and transformation in NIH3T3 cells. Oncogene 1994;9:2425-2429.
    • (1994) Oncogene , vol.9 , pp. 2425-2429
    • Vara Prasad, M.1    Shore, S.K.2    Dhanasekaran, N.3
  • 19
    • 0028100892 scopus 로고
    • Mutant a subunits of G12 and G13 proteins induce neoplastic transformation of Rat-1 fibroblasts
    • Voyno-Yasenetskaya T, Pace AM, Bourne HR: Mutant a subunits of G12 and G13 proteins induce neoplastic transformation of Rat-1 fibroblasts. Oncogene 1994;9:2559-2565.
    • (1994) Oncogene , vol.9 , pp. 2559-2565
    • Voyno-Yasenetskaya, T.1    Pace, A.M.2    Bourne, H.R.3
  • 20
    • 0028998475 scopus 로고
    • Mutant a subunit of Gz transforms Swiss 3T3 cells
    • Wong YH, Chan JSC, Yung LY, Bourne HR: Mutant a subunit of Gz transforms Swiss 3T3 cells. Oncogene 1995;10:1927-1933.
    • (1995) Oncogene , vol.10 , pp. 1927-1933
    • Wong, Y.H.1    Chan, J.2    Yung, L.Y.3    Bourne, H.R.4
  • 21
    • 0029119740 scopus 로고
    • Cell cycle control in mammalian cells: Role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs)
    • Grana X, Reddy EP: Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs). Oncogene 1995; 11: 211-219.
    • (1995) Oncogene , vol.11 , pp. 211-219
    • Grana, X.1    Reddy, E.P.2
  • 22
    • 0027104056 scopus 로고
    • Mitogenic pathways regulated by G protein oncogenes
    • Gupta SK, Gallego C, Johnson GL: Mitogenic pathways regulated by G protein oncogenes. Mol Biol Cell 1992;3:123-128.
    • (1992) Mol Biol Cell , vol.3 , pp. 123-128
    • Gupta, S.K.1    Gallego, C.2    Johnson, G.L.3
  • 23
    • 0027772672 scopus 로고
    • Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3',5' monophosphate
    • Wu J, Dent P, Wolfman A, Weber MJ, Sturgill TW: Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3',5' monophosphate. Science 1993;262: 1065-1069.
    • (1993) Science , vol.262 , pp. 1065-1069
    • Wu, J.1    Dent, P.2    Wolfman, A.3    Weber, M.J.4    Sturgill, T.W.5
  • 24
    • 0028973270 scopus 로고
    • Dual effect of P-adrenergic receptors on mitogen activated protein kinase. Evidence for a Py-dependent activation and a GascAMP-mediated inhibition
    • Crespo P, Cachero TG, Xu N, Gutkind JS: Dual effect of P-adrenergic receptors on mitogen activated protein kinase. Evidence for a Py-dependent activation and a GascAMP-mediated inhibition. J Biol Chem 1995;270:25259-25265.
    • (1995) J Biol Chem , vol.270 , pp. 25259-25265
    • Crespo, P.1    Cachero, T.G.2    Xu, N.3    Gutkind, J.S.4
  • 25
    • 0026640629 scopus 로고
    • MAP kinase is constitutively activated in gip2 and src transformed Rat 1a fibroblasts
    • Gupta SK, Gallego C, Johnson GL, Heasley LE: MAP kinase is constitutively activated in gip2 and src transformed Rat 1a fibroblasts. J Biol Chem 1992;267:7987-7990.
    • (1992) J Biol Chem , vol.267 , pp. 7987-7990
    • Gupta, S.K.1    Gallego, C.2    Johnson, G.L.3    Heasley, L.E.4
  • 26
    • 0026353851 scopus 로고
    • GTPase deficient Gai2 oncogene gip2 inhibits adeny-lyl cyclase and attenuates receptor-stimulated phospholipase-A2 activity
    • Lowndes JM, Gupta SK, Osawa S, Johnson GL: GTPase deficient Gai2 oncogene gip2 inhibits adeny-lyl cyclase and attenuates receptor-stimulated phospholipase-A2 activity. J Biol Chem 1991;266:14193-14197.
    • (1991) J Biol Chem , vol.266 , pp. 14193-14197
    • Lowndes, J.M.1    Gupta, S.K.2    Osawa, S.3    Johnson, G.L.4
  • 27
    • 0027240231 scopus 로고
    • Involvement of Ras and Raf in the mitogen activated protein (MAP) kinases kinase and MAP kinase
    • Winitz S, Russel M, Qian NX, Gardner A, Dwyer L, Johnson GL: Involvement of Ras and Raf in the mitogen activated protein (MAP) kinases kinase and MAP kinase. J Biol Chem 1993;268:19196-19199.
    • (1993) J Biol Chem , vol.268 , pp. 19196-19199
    • Winitz, S.1    Russel, M.2    Qian, N.X.3    Gardner, A.4    Dwyer, L.5    Johnson, G.L.6
  • 28
  • 29
    • 0028240869 scopus 로고
    • Ras dependent activation of MAP kinase pathway is mediated by G-protein Py-subunits
    • Crespo P, Xu N, Simonds WF, Gutkind JS: Ras dependent activation of MAP kinase pathway is mediated by G-protein Py-subunits. Nature 1994;369:418-420.
    • (1994) Nature , vol.369 , pp. 418-420
    • Crespo, P.1    Xu, N.2    Simonds, W.F.3    Gutkind, J.S.4
  • 30
    • 0028670476 scopus 로고
    • Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by GPy activation of p21ras
    • Koch WJ, Hawes BE, Allen LF, Lef-kowitz RJ: Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by GPy activation of p21ras. Proc Natl Acad Sci USA 1994;91:12706-12710.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 12706-12710
    • Koch, W.J.1    Hawes, B.E.2    Allen, L.F.3    Lef-Kowitz, R.J.4
  • 31
    • 0029095717 scopus 로고
    • Mitogen-activated protein kinase activation requires two signal inputs from the human anaphylatoxin C5a receptor
    • Buhl AM, Osawa S, Johnson GL: Mitogen-activated protein kinase activation requires two signal inputs from the human anaphylatoxin C5a receptor. J Biol Chem 1995;270: 19828-19832.
    • (1995) J Biol Chem , vol.270 , pp. 19828-19832
    • Buhl, A.M.1    Osawa, S.2    Johnson, G.L.3
  • 32
    • 0029670821 scopus 로고    scopus 로고
    • Go protein a-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism
    • van Biesen T, Hawes BE, Raymond JR, Luttrell LM, Koch WJ, Lefko-witz RJ: Go protein a-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism. J Biol Chem 1996;271:1266-1269.
    • (1996) J Biol Chem , vol.271 , pp. 1266-1269
    • Van Biesen, T.1    Hawes, B.E.2    Raymond, J.R.3    Luttrell, L.M.4    Koch, W.J.5    Lefko-Witz, R.J.6
  • 33
    • 0026500077 scopus 로고
    • Activation of phospholipase C by the a subunits of Gq and G11 proteins in transfected Cos-7 cells
    • Wu D, Lee CH, Rhee SG, Simon MI: Activation of phospholipase C by the a subunits of Gq and G11 proteins in transfected Cos-7 cells. J Biol Chem 1992;267:1811-1817.
    • (1992) J Biol Chem , vol.267 , pp. 1811-1817
    • Wu, D.1    Lee, C.H.2    Rhee, S.G.3    Simon, M.I.4
  • 34
    • 0024673503 scopus 로고
    • S-phase induction and transformation of quiescent NIH 3T3 cells by microinjection of phospholipase C
    • Smith MR, Ryu SH, Suh PG, Rhee SG, Kung HF: S-phase induction and transformation of quiescent NIH 3T3 cells by microinjection of phospholipase C. Proc Natl Acad Sci USA 1989;86:3659-3663.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 3659-3663
    • Smith, M.R.1    Ryu, S.H.2    Suh, P.G.3    Rhee, S.G.4    Kung, H.F.5
  • 35
    • 0030896268 scopus 로고    scopus 로고
    • The pathway connecting m2 receptors to the nucleus involves small GTP-binding proteins acting on divergent MAP kinase cascades
    • Gutkind JS, Crespo P, Xu N, Tera-moto H, Coso OA: The pathway connecting m2 receptors to the nucleus involves small GTP-binding proteins acting on divergent MAP kinase cascades. Life Sci 1997;60: 999-1006.
    • (1997) Life Sci , vol.60 , pp. 999-1006
    • Gutkind, J.S.1    Crespo, P.2    Xu, N.3    Tera-Moto, H.4    Coso, O.A.5
  • 37
    • 0029130292 scopus 로고
    • Team blue sees red
    • Bourne H: Team blue sees red. Nature 1995;376:727-729.
    • (1995) Nature , vol.376 , pp. 727-729
    • Bourne, H.1
  • 40
    • 0030153427 scopus 로고    scopus 로고
    • Signaling by G12 class of G proteins
    • Dhanasekaran N, Dermott JM: Signaling by G12 class of G proteins. Cell Signal 1996;8:235-245.
    • (1996) Cell Signal , vol.8 , pp. 235-245
    • Dhanasekaran, N.1    Dermott, J.M.2
  • 41
    • 0029143947 scopus 로고
    • Activation of Jun kinase/ stress activated protein kinase by GTPase-deficient mutants of Ga12 and Ga13
    • Vara Prasad MVVS, Dermott JM, Heasley LE, Johnson GL, Dhanase-karan N: Activation of Jun kinase/ stress activated protein kinase by GTPase-deficient mutants of Ga12 and Ga13. J Biol Chem 1995;270: 18655-18659.
    • (1995) J Biol Chem , vol.270 , pp. 18655-18659
    • Vara Prasad, M.1    Dermott, J.M.2    Heasley, L.E.3    Johnson, G.L.4    Dhanase-Karan, N.5
  • 42
    • 0029666415 scopus 로고    scopus 로고
    • Ga12 stimulates c-Jun NH2-terminal kinase through small G proteins Ras and Rac
    • Collins LR, Minden A, Karin M, Brown JH: Ga12 stimulates c-Jun NH2-terminal kinase through small G proteins Ras and Rac. J Biol Chem 1996;271:17349-17353.
    • (1996) J Biol Chem , vol.271 , pp. 17349-17353
    • Collins, L.R.1    Minden, A.2    Karin, M.3    Brown, J.H.4
  • 43
    • 0029664963 scopus 로고    scopus 로고
    • Ga12 and Ga13 regulate extracellular signal-regulated kinase and c-Jun kinase pathways by different mechanisms in COS-7 cells
    • 13 regulate extracellular signal-regulated kinase and c-Jun kinase pathways by different mechanisms in COS-7 cells. J Biol Chem 1996;271:21081-21087.
    • (1996) J Biol Chem , vol.271 , pp. 21081-21087
    • Voyno-Yasenetskaya, T.A.1    Faure, M.P.2    Ahn, N.G.3    Bourne, H.R.4
  • 44
    • 0030614474 scopus 로고    scopus 로고
    • Dependence of activated Ga12-induced G1 to S phase cell cycle progression on both ras/mitogen-activated protein kinase and Ras/Rac1/Jun N-terminal kinase cascades in NIH3T3 fibroblasts
    • Misui H, Takuwa N, Kurokawa K, Exton JH, Takuwa Y: Dependence of activated Ga12-induced G1 to S phase cell cycle progression on both ras/mitogen-activated protein kinase and Ras/Rac1/Jun N-terminal kinase cascades in NIH3T3 fibroblasts. J Biol Chem 1997;272:4904-4910.
    • (1997) J Biol Chem , vol.272 , pp. 4904-4910
    • Misui, H.1    Takuwa, N.2    Kurokawa, K.3    Exton, J.H.4    Takuwa, Y.5
  • 45
    • 0028973505 scopus 로고    scopus 로고
    • Ga12 and Ga13 stimulate Rho-dependent stress fiber formation and focal adhesion assembly
    • Buhl AM, Johnson NL, Dhanaseka-ran N, Johnson GL: Ga12 and Ga13 stimulate Rho-dependent stress fiber formation and focal adhesion assembly. J Biol Chem 1996;270: 24631-24634.
    • (1996) J Biol Chem , vol.270 , pp. 24631-24634
    • Buhl, A.M.1    Johnson, N.L.2    Dhanaseka-Ran, N.3    Johnson, G.L.4
  • 46
    • 0000201075 scopus 로고    scopus 로고
    • Ga13 stimulates Na+-H+ exchange through distinct Cdc42-de-pendent and RhoA-dependent pathways
    • Hooley R, Yu C-Y, Symons M, Barber DL: Ga13 stimulates Na+-H+ exchange through distinct Cdc42-de-pendent and RhoA-dependent pathways. J Biol Chem 1996;271:6152-6158.
    • (1996) J Biol Chem , vol.271 , pp. 6152-6158
    • Hooley, R.1    Yu, C.-Y.2    Symons, M.3    Barber, D.L.4
  • 47
    • 0031015426 scopus 로고    scopus 로고
    • Vascular system defects and impaired cell chemokine-sis as a result of Ga13 deficiency
    • Offermanns S, Mancino V, Revel J-P, Simon MI: Vascular system defects and impaired cell chemokine-sis as a result of Ga13 deficiency. Science 1997;275:533-536.
    • (1997) Science , vol.275 , pp. 533-536
    • Offermanns, S.1    Mancino, V.2    Revel, J.-P.3    Simon, M.I.4
  • 48
  • 49
    • 0030047481 scopus 로고    scopus 로고
    • Signaling from G protein coupled receptors to c-Jun kinase involves Py subunits of heterotrimeric G proteins acting on a Ras and Rac 1-dependent pathway
    • Coso OA, Teramoto H, Simonds WF, Gutkind SJ: Signaling from G protein coupled receptors to c-Jun kinase involves Py subunits of heterotrimeric G proteins acting on a Ras and Rac 1-dependent pathway. J Biol Chem 1996;271:3963-3966.
    • (1996) J Biol Chem , vol.271 , pp. 3963-3966
    • Coso, O.A.1    Teramoto, H.2    Simonds, W.F.3    Gutkind, S.J.4
  • 50
    • 0029778177 scopus 로고    scopus 로고
    • Role of c-Src tyrosine kinase in G protein-coupled receptor-and GPy-mediated activation of mitogen-activated protein kinases
    • Luttrel LM, Hawes BE, van Biesen T, Luttrell DK, Lansing TJ, Lefko-witz RJ: Role of c-Src tyrosine kinase in G protein-coupled receptor-and GPy-mediated activation of mitogen-activated protein kinases. J Biol Chem 1996;271:19443-19450.
    • (1996) J Biol Chem , vol.271 , pp. 19443-19450
    • Luttrel, L.M.1    Hawes, B.E.2    Van Biesen, T.3    Luttrell, D.K.4    Lansing, T.J.5    Lefko-Witz, R.J.6
  • 51
    • 0029943493 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase is an early intermediate in the GPy-mediated mitogen-activated protein kinase signaling pathway
    • Hawes BE, Luttrell LM, van Biesen T, Lefkowitz RJ: Phosphatidylinositol 3-kinase is an early intermediate in the GPy-mediated mitogen-activated protein kinase signaling pathway. J Biol Chem 1996;271:12133-12136.
    • (1996) J Biol Chem , vol.271 , pp. 12133-12136
    • Hawes, B.E.1    Luttrell, L.M.2    Van Biesen, T.3    Lefkowitz, R.J.4
  • 52
    • 0030872062 scopus 로고    scopus 로고
    • Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi and Gq pathways on cal-cium/calmodulin, PYK2 and Src kinase
    • Rocca GJD, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ: Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi and Gq pathways on cal-cium/calmodulin, PYK2 and Src kinase. J Biol Chem 1997;272:19125-19132.
    • (1997) J Biol Chem , vol.272 , pp. 19125-19132
    • Rocca, G.1    Van Biesen, T.2    Daaka, Y.3    Luttrell, D.K.4    Luttrell, L.M.5    Lefkowitz, R.J.6


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