Structural and functional characteristics of a dominant-negative isoform of porcine MHC class II transactivator

European Journal of Immunogenetics

Volumn 30, Issue 4, 2003, Pages 259-270

  Quinn, Gary ^a,b   Bower, R ^a   Dos Santos Cruz, G ^a   Giovino, M ^b   Xu, Y ^b   Patience, C ^a   Schuurman, H J ^a,b  

^a Imutran Ltd   (United Kingdom)

^b Immerge Biotherapeutics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GUANINE NUCLEOTIDE BINDING PROTEIN; HLA ANTIGEN CLASS 2; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2 TRANSACTIVATOR; MESSENGER RNA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DNA SEQUENCE; DOMINANT GENE; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; MONONUCLEAR CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MOTIF; SEQUENCE HOMOLOGY; SPLEEN CELL; SWINE; VASCULAR ENDOTHELIUM; XENOTRANSPLANTATION;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; GENES, DOMINANT; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PROTEIN ISOFORMS; SEQUENCE HOMOLOGY; SPLEEN; SWINE; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS;

ANIMALIA; SUIDAE; SUS SCROFA;

EID: 0042881122     PISSN: 09607420     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2370.2003.00397.x     Document Type: Article

References (40)

1. Accolla, R.S. (1983) Human B cell variants immunoselected against a single Ia antigen subset have lost expression of several Ia antigen subsets. Journal of Experimental Medicine, 157, 1053.
2. Barbieri, G., Deffrennes, V., Prod'homme, T., Vedrenne, J., Baton, F., Cortes, C., Fischer, A., Bono, M.R., Lisowska-Grospierre, B., Charron, D. et al. (2002) Isoforms of class II transactivator protein. International Immunology, 14, 839.
3. Bontron, S., Ucla, C., Mach, B. & Steimle, V. (1997) Efficient repression of endogenous major histocompatibility complex class II expression through dominant negative CIITA mutants isolated by a functional selection strategy. Molecular Cell Biology, 17, 4249.
4. Chang, C.H. & Flavell, R.A. (1995) Class II transactivator regulates the expression of multiple genes involved in antigen presentation. Journal of Experimental Medicine, 181, 765.
5. Chang, C.H., Guerder, S., Hong, S.C., van Ewijk, W. & Flavell, R.A. (1996) Mice lacking the MHC class II transactivator (CIITA) show tissue-specific impairment of MHC class II expression. Immunity, 4, 167.
6. Chin, K.C., Mao, C., Skinner, C., Riley, J.L., Wright, K.L., Moreno, C.S., Stark, G.R., Boss, J.M. & Ting, J.P. (1994) Molecular analysis of G1B and G3A IFN gamma mutants reveals that defects in CIITA or RFX result in defective class II MHC and Ii gene induction. Immunity, 8, 687.
7. Chin, K.C., Li, G.G. & Ting, J.P. (1997) Importance of acidic, proline/serine/threonine-rich, and GTP-binding regions in the major histocompatibility complex class II transactivator: generation of transdominant-negative mutants. Proceedings of the National Academy of Sciences of the USA, 94, 2501.
8. Cozzi, E. & White, D.J. (1995) The generation of transgenic pigs as potential organ donors for humans. Nature Medicine, 9, 964.
9. Cressman, D.E., O'Connor, W.J., Greer, S.F., Zhu, X.S. & Ting, J.P. (2001) Mechanisms of nuclear import and export that control the subcellular localization of class ii transactivator. Journal of Immunology, 167, 3626.
10. Davis, T.A., Craighead, N., Williams, A.J., Scadron, A., June, C.H. & Lee, K.P. (1996) Primary porcine endothelial cells express membrane-bound B7 (CD86) and a soluble factor that co-stimulate cyclosporin A-resistant and CD28-dependent human T cell proliferation. International Immunology, 8, 1099.
11. DeSandro, A.M., Nagarajan, U.M. & Boss, J.M. (2000) Associations and interactions between bare lymphocyte syndrome factors. Molecular Cell Biology, 20, 6587.
12. Fabre, J.W. (1996) The role of polymorphic donor peptides in allograft recognition and rejection. Immunological Review, 154, 21.
13. Hake, S.B., Masternak, K., Kammerbauer, C., Janzen, C., Reith, W. & Steimle, V. (2000) CIITA leucine-rich repeats control nuclear localization, in vivo recruitment to the major histocompatibility complex (MHC) class II enhanceosome, and MHC class II gene transactivation. Molecular Cell Biology, 20, 7716.
14. Harton, J.A., Cressman, D.E., Chin, K.C., Der, C.J. & Ting, J.P. (1999) GTP binding by class II transactivator: role in nuclear import. Science, 285, 1402.
15. Holling, T.M., van der Stoep, N., Quinten, E. & van den Elsen, P.J. (2002) Activated human T cells accomplish MHC class II expression through T cell-specific occupation of class II transactivator promoter III. Journal of Immunology, 168, 763.
16. Kozak, M. (1987) An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Research, 15, 8125.
17. Linhoff, M.W., Harton, J.A., Cressman, D.E., Martin, B.K. & Ting, J.P. (2001) Two distinct domains within CIITA mediate self association: involvement of the GTP-binding and leucine-rich repeat domains. Molecular Cell Biology, 21, 3001.
18. Martin, U., Kiessig, V., Blusch, J.H., Haverich, A., vonder Helm, K., Herden, T. & Steinhoff, G. (1998) Expression of pig endogenous retrovirus by primary porcine endothelial cells and infection of human cells. Lancet, 352, 692.
19. Masternak, K., Muhlethaler-Mottet, A., Villard, J., peretti, M. & Reith, W. (2000) Molecular genetics of the Bare lymphocyte syndrome. Review of Immunogenetics, 2, 267.
20. Muhlethaler-Mottet, A., Otten, L.A., Steimle, V. & Mach, B. (1997) Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA. EMBO Journal, 16, 2851.
21. Muhlethaler-Mottet, A., Di Berardino, W., Otten, L.A. & Mach, B. (1998) Activation of the MHC class II transactivator CIITA by interferon-gamma requires cooperative interaction between Star1 and USF-1. Immunity, 8, 157.
22. Murray, A.G., Khodadoust, M.M., Poher, J.S. & Bothwell, A.L. (1994) Porcine aortic endothelial cells activate human T cells: direct presentation of MHC antigens and costimulation by ligands for human CD2 and CD28. Immunity, 1, 57.
23. Nickerson, K., Sisk, T.J., Inohara, N., Yee, C.S., Kennell, J., Cho, M.C. & Yannie, P.J. (2001) Dendritic cell-specific MHC class II transactivator contains a caspase recruitment domain that confers potent transactivation activity. Journal of Biological Chemistry, 276, 19089.
24. Palvimo, J.J., Kallio, P.J., Ikonen, T., Mehto, M. & Janne, O.A. (1993) Dominant negative regulation of trans-activation by the rat androgen receptor: roles of the N-terminal domain and heterodimer formation. Molecular Endocrinology, 7, 1399.
25. Piskurich, J.F., Wang, Y., Linhoff, M.W., White, L.C. & Ting, J.P. (1998) Identification of distinct regions of 5′ flanking DNA that mediate constitutive, IFN-gamma, STAT1, and TGF-beta-regulated expression of the class II transactivator gene. Journal of Immunology, 160, 233.
26. Quan, V., Towey, M., Sacks, S. & Kelly, A.P. (1999) Absence of MHC class II gene expression in a patient with a single amino acid substitution in the class II transactivator protein CIITA. Immunogenetics, 49, 957.
27. Quinn, G., Ochiya, T., Terada, M. & Yoshida, T. (2000) Mouse flt-1 promoter directs endothelial-specific expression in the embryoid body model of embryogenesis. Biochemistry and Biophysics Research Communications, 276, 1089.
28. Raval, A., Weissman, J.D., Howcroft, T.K. & Singer, D.S. (2003) The GTP-binding domain of class II transactivator regulates its nuclear export. Journal of Immunology, 170, 922.
29. Sisk, T.J., Gourley, T., Roys, S. & Chang, C.H. (2000) MHC class II transactivator inhibits IL-4 gene transcription by competing with NF-AT to bind the coactivator CREB binding protein (CBP)/p300. Journal of Immunology, 165, 2511.
30. Sisk, T.J., Roys, S. & Chang, C. (2001) Self association of CIITA and its transactivation potential. Molecular Cell Biology, 21, 4919.
31. Steimle, V.L., Otten, A., Zufferey, M. & Mach, B. (1993) Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome). Cell, 75, 135.
32. Tosi, G., Jabrane-Ferrat, N. & Peterlin, B.M. (2002) Phosphorylation of CIITA directs its oligomerization, accumulation and increased activity on MHCII promoters. EMBO Journal, 21, 5467.
33. Watson, C.A., Petzelbauer, P., Zhou, J., Pardi, R. & Bender, J.R. (1995) Contact-dependent endothelial class II HLA gene activation induced by NK cells is mediated by IFN-γ-dependent and -independent mechanisms. Journal of Immunology, 154, 3222.
34. Wong, A.W., Ghosh, N., McKinnon, K.P., Reed, W., Piskurich, J.F., Wright, K.L. & Ting, J.P. (2002) Regulation and specificity of MHC2TA promoter usage in human primary T lymphocytes and cell line. Journal of Immunology, 169, 3112.
35. Yen, P.M., Liu, Y., Palvimo, J.J., Trifiro, M., Whang, J., Pinsky, L., Janne, O.A. & Chin, W.W. (1997) Mutant and wild-type androgen receptors exhibit cross-talk on androgen-, glucocorticoid-, and progesterone-mediated transcription. Molecular Endocrinology, 11, 162.
36. Yun, S., Gustafsson, K. & Fabre, J.W. (1997) Suppression of MHC class II expression by human class II trans-activator constructs lacking the N-terminal domain. International Immunology, 9, 1545.
37. Yun, S., Gustafsson, K. & Fabre, J.W. (1998) Suppression of human anti-porcine T-cell immune responses by major histocompatibility complex class II transactivator constructs lacking the amino terminal domain. Transplantation, 66, 103.
38. Zhou, H. & Glimcher, L.H. (1995) Human MHC class II gene transcription directed by the carboxyl terminus of CIITA, one of the defective genes in type II MHC combined immune deficiency. Immunity, 2, 545.
39. Zhou, H., Su, H.S., Zhang, X., Douhan, J. & 3rd & Glimcher, L.H. (1997) CIITA-dependent and -independent class II MHC expression revealed by a dominant negative mutant. Journal of Immunology, 158, 4741.
40. Zhu, X.S., Linhoff, M.W., Li, G., Chin, K.C., Maity, S.N. & Ting, J.P. (2000) Transcriptional scaffold: CIITA interacts with NF-Y, RFX, and CREB to cause stereospecific regulation of the class II major histocompatibility complex promoter. Molecular Cell Biology, 20, 605.