Self-association of CIITA and its transactivation potential

Molecular and Cellular Biology

Volumn 21, Issue 15, 2001, Pages 4919-4928

  Sisk, T J ^a   Roys, S ^a   Chang, C H ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2 TRANSACTIVATOR; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELLULAR DISTRIBUTION; COMPLEX FORMATION; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE FUNCTION; HUMAN; HUMAN CELL; KIDNEY CELL; PRIORITY JOURNAL; PROTEIN INTERACTION; TRANSACTIVATION;

AMINO ACID MOTIFS; AMINO ACIDS; BLOTTING, WESTERN; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; GENES, DOMINANT; GENES, MHC CLASS II; GUANOSINE TRIPHOSPHATE; HUMANS; INTERLEUKIN-4; LUCIFERASES; MUTATION; NUCLEAR PROTEINS; PLASMIDS; PRECIPITIN TESTS; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; PROTEIN BIOSYNTHESIS; PROTEIN STRUCTURE, TERTIARY; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 0034960167     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.15.4919-4928.2001     Document Type: Article

References (45)

1. Human B cell variants immunoselected against a single Ia antigen subset have lost expression of several Ia antigen subsets
2. Expression and functional analysis of Apaf-1 isoforms. Extra Wd-40 repeat is required for cytochrome c binding and regulated activation of procaspase-9
3. Human CARDY protein is a novel CED-4/Adaf-1 cell death family member that activates NF-κB
4. The MHC class II transactivator (CIITA) requires conserved leucine charged domains for interactions with the conserved W box promoter element
5. Class II, transactivator (CIITA) is sufficient for the inducible expression of major histocompatibility complex class II genes
6. Activation and transdominant suppression of MHC class II and HLA-DMB promoters by a series of C-terminal class II transactivator deletion mutants
7. Importance of acidic, proline/serine/threonine-rich, and GTP-binding regions in the major histocompatibility complex class II transactivator: Generation of transdominant-negative mutants
8. A defect in the nuclear translocation of CIITA causes a form of type II bare lymphocyte syndrome
9. A trans-acting class II regulatory gene unlinked to the MHC controls expression of HLA class II genes
10. Associations and interactions between bare lymphocyte syndrome factors
11. Functional complementation of major histocompatibility complex class II regulatory mutants by the purified X-box-binding protein RFX
12. Binding and cooperative interactions between two B-cell-specific transcriptional coactivators
13. The class II trans-activator CIITA interacts with the TBP-associated factor TAFII32
14. Interactions between the class II transactivator and CREB binding protein increase transcription of major histocompatibility complex class II genes
15. A novel role for the major histocompatibility complex class II transactivator CIITA in the repression of IL-4 production
16. Combined immunodeficiency with defective expression in MHC class II genes
17. CIITA leucine-rich repeats control nuclear localization, in vivo recruitment to the major histocompatibility complex (MHC) class II enhanceosome, and MHC class II gene transactivation
18. GTP binding by class II transactivator: Role in nuclear import
19. Efficient transactivation by retinoic acid receptors in yeast requires retinoid X receptors
20. Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB
21. An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways
22. Ets-1 activates the DRA promoter in B cells
23. Structural diversity of leucine-rich repeat proteins
24. Involvement of CREB binding protein in expression of major histocompatibility complex class II genes via interaction with the class II transactivator
25. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
26. CCAAT-binding factor NF-Y and RFX are required for in vivo assembly of a nucleoprotein complex that spans 250 base pairs: The invariant chain promoter as a model
27. Two distinct domains within CIITA mediate self-association: Involvement of the GTP-binding and leucine-rich repeat domains
28. Formation of a regulatory factor X/X2 box-binding protein/nuclear factor-Y multiprotein complex on the conserved regulatory regions of HLA class II genes
29. Regulation of MHC class II genes: Lessons from a disease
30. CIITA is a transcriptional coactivator that is recruited to MHC class II promoters by multiple synergistic interactions with an enhanceosome complex
31. Adenylate cyclase in Saccharomyces cerevisiae is a peripheral membrane protein
32. CREB regulates MHC class II expression in a CIITA-dependent manner
33. Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma
34. Function of major histocompatibility complex class II promoters requires cooperative binding between factors RFX and NF-Y
35. The primary structure of human ribonuclease/angiogenin inhibitor (RAI) discloses a novel highly diversified protein superfamily with a common repetitive module
36. Specific complex formation between the type II bare lymphocyte syndrome-associated transactivators CIITA and RFX5
37. MHC class II transactivator inhibits IL-4 gene transcription by competing with NF-AT to bind the coactivator CREB binding protein (CBP)/p300
38. Acetylation by PCAF enhances CIITA nuclear accumulation and transactivation of major hisocompatibility complex class II genes
39. Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)
40. Regulation of MHC class II expression by interferon-γ-mediated by the transactivator gene CIITA
41. A functionally essential domain of RFX5 mediates activation of major histocompatibility complex class II promoters by promoting cooperative binding between RFX and NF-Y
42. CCAAT box binding protein NF-Y facilitates in vivo recruitment of upstream DNA binding transcription factors
43. CIITA-dependent and-independent class II MHC expression revealed by a dominant negative mutant
44. Transcriptional scaffold: CIITA interacts with NF-Y, RFX, and CREB to cause stereospecific regulation of the class II major histocompatibility complex promoter
45. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3