Human acid sphingomyelinase: Assignment of the disulfide bond pattern

European Journal of Biochemistry

Volumn 270, Issue 6, 2003, Pages 1076-1088

  Lansmann, Stephanie ^a   Schuette, Christina G ^b   Bartelsen, Oliver ^a   Hoernschemeyer, Joerg ^a   Linke, Thomas ^a   Weisgerber, Judith ^a   Sandhoff, Konrad ^a  

^a UNIVERSITY OF BONN   (Germany)

^b MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

Author keywords

Disulfide bonds; Enzymatic and chemical cleavage; Human acid sphingomyelinase; MALDI MS; PSD

Indexed keywords

CERAMIDE; PHOSPHORYLCHOLINE; SPHINGOMYELIN; SPHINGOMYELIN PHOSPHODIESTERASE; TRYPSIN;

ARTICLE; DISULFIDE BOND; ENZYME ASSAY; ENZYME PURIFICATION; ENZYME STRUCTURE; GLYCOSYLATION; HUMAN; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; PEPTIDE ANALYSIS; PLACENTA; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

AMINO ACID SEQUENCE; CERAMIDES; DISULFIDES; GLYCOSYLATION; HUMANS; INDICATORS AND REAGENTS; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; NIEMANN-PICK DISEASES; OPEN READING FRAMES; PEPTIDES; PHOSPHINES; PHOSPHORYLCHOLINE; PLACENTA; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOMYELINS;

UNIDENTIFIED BACULOVIRUS;

EID: 0344643423     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1033.2003.03435.x     Document Type: Article

References (27)

1. Schuchman, E.H. & Desnick, R.J. (1995) Niemann-Pick disease types A and B: Acid sphingomyelinase deficiencies. In The Metabolic and Molecular Bases of Inherited Disease, 7th edn. (Scriver, C.R., Beaudet, A.L., Sly, W.S. & Valle, D., eds), pp. 2601-2624. McGraw Hill, New York.
2. Quintern, L.E., Weitz, G., Nehrkorn, H., Tager, J.M., Schram, A.W. & Sandhoff, K. (1987) Acid sphingomyelinase from human urine: purification and characterization. Biochim. Biophys. Acta 922, 323-336.
3. Quintern, L.E., Schuchman, E.H., Levran, O., Suchi, M., Ferlinz, K., Reinke, H., Sandhoff, K. & Desnick, R.J. (1989) Isolation of cDNA clones encoding human acid sphingomyelinase: occurrence of alternatively processed transcripts. EMBO J. 8, 2469-2473.
4. Schuchman, E.H., Suchi, M., Takahashi, T., Sandhoff, K. & Desnick, R.J. (1991) Human acid sphingomyelinase. Isolation, nucleotide sequence and expression of the full-length and alternatively spliced cDNAs. J. Biol. Chem. 266, 8531-8539.
5. Hurwitz, R., Ferlinz, K, Vielhaber, G. & Sandhoff, K. (1994) Processing of human acid sphingomyelinase in normal and I-cell fibroblasts. J. Biol. Chem. 269, 5440-5445.
6. Lansmann, S., Ferlinz, K., Hurwitz, R., Bartelsen, O., Glombitza, G. & Sandhoff, K. (1996) Purification of acid sphingomyelinase from human placenta: Characterization and N-terminal sequence. FEBS Lett. 399, 227-231.
7. Ferlinz, K., Hurwitz, R., Mozcall, H., Lansmann, S., Schuchman, E.A. & Sandhoff, K. (1997) Functional characterization of the N-glycosylation sites of human acid sphingomyelinase by site directed mutagenesis. Eur. J. Biochem. 243, 511-517.
8. Spiegel, S., Foster, D. & Kolesnick, R. (1996) Signal transduction through lipid second messengers. Curr. Opin. Cell Biol. 8, 159-167.
9. Hannun, Y.A. (1996) Functions of ceramide in coordinating cellular responses to stress. Science 274, 1855-1859.
10. Huwiler, A., Kolter, T., Pfeilschifter, J. & Sandhoff, K. (2000) Physiology and pathophysiology of sphingolipid metabolism and signaling. Biochim. Biophys. Acta 1485, 63-99.
11. Kirschnek, S., Paris, F., Weller, M., Grassme, H., Ferlinz, K., Riehle, A., Fuks, Z., Kolesnick, R. & Gulbins, E (2000) CD95-mediated apoptosis in vivo involves acid sphingomyelinase. J. Biol. Chem. 275, 27316-27323.
12. Klein, A., Henseler, M., Klein, C., Suzuki, K., Harzer, K. & Sandhoff, K. (1994) Sphingolipid activator protein (sap-D) stimulates the lysosomal degradation of ceramide in vivo. Biochem. Biophys. Res. Com. 200, 1440-1448.
13. Ponting, C.P. (1994) Acid sphingomyelinase posesses a domain homologous to its activator proteins: saposins B and D. Protein Sci. 3, 359-361.
14. Vaccaro, A.M., Savioli, R., Barca, A., Tatti, M., Ciaffoni, F., Maras, B., Siciliano, R., Zappacosta, F., Amoresano, A. & Pucci, P. (1995) Structural analysis of saposin C and B. Complete localization of disulfide bridges. J. Biol. Chem. 270, 9953-9960.
15. Tatti, M, Salvioli, R., Ciaffoni, F., Pucci, P., Andolfo, A., Amoresano, A. & Vaccaro, A.M. (1999) Structural and membrane-binding properties of saposin D. Eur. J. Biochem. 263, 486-494.
16. Bartelsen, O., Lansmann, S., Nettersheim, M., Lemm, T., Ferlinz, K. & Sandhoff, K (1998) Expression of recombinant human acid sphingomyelinase in insect Sf21 cells: purification, processing and enzymatic characterization. J. Biotechnol. 63, 29-40.
17. Smith, P.K., Krohn, R.I., Hermanson, G.T., Mallia, A.K., Gartner, F.H., Provenzano, M.D., Fujimoto, E.K., Goeke, N.M., Olson, B.J. & Klenk, D.C. (1985) Measurement of protein using bicinchoninic acid. Anal. Biochem. 150, 76-85.
18. Patterson, S.D. & Katta, V. (1994) Prompt fragmentation of disulfide-linked peptides during matrix-assisted laser desorption ionization mass spectrometry. Anal. Chem. 66, 3727-3732.
19. O'Dowd, B.F., Cumming, D.A., Gravel, R.A. & Mahuran, D. (1988) Oligosaccharide structure and amino acid sequence of the major glycopeptides of mature human beta-hexosaminidase. Biochemistry 27, 5216-5226.
20. Kornfeld, R. & Kornfeld, S. (1985) Assembly of asparagine-linked oligosaccharides. Annu. Rev. Biochem. 54, 631-664.
21. Wu, J. & Watson, J.T. (1997) A novel methodology for assignment of disulfide bond pairings in proteins. Protein Sci. 6, 391-398.
22. Schuette, C.G., Lemm, T., Glombitza, G.J. & Sandhoff, K. (1998) Complete localization of disulfide bonds in GM2 activator protein. Protein Sci. 7, 1039-1045.
23. Kaufmann, R., Hirsch, D. & Sprengler, B. (1994) Sequencing of peptides in a time-of-flight mass spectrometer: Evaluation of post source decay following matrix-assisted laser desorption ionization (MALDI). Int. J. Mass Spectrom. Ion Proc. 86, 137-154.
24. He, X., Miranda, S.R., Xiong, X., Dagan, A., Gatt, S. & Schuchman, E.H. (1999) Characterization of human acid sphingo-myelinase purified from the media of overexpressing Chinese hamster ovary cells. Biochim. Biophys. Acta 1432, 251-264.
25. Ida, H., Rennert, O.M., Eto, Y. & Chan, W.Y. (1993) Cloning of a human acid sphingomyehnase cDNA with a new mutation that renders the enzyme inactive. J. Biochem. 114, 15-20.
26. Faull, K.F., Higginson, J., Waring, A.J., Johnson, J., To, T., Whitelegge, J.P., Stevens, R.L., Fluharty, C.B. & Fluharty, A.L. (2000) Disulfide connectivity in cerebroside sulfate activator is not necessary for biological activity or alpha-helical content but is necessary for trypsin resistance and strong ligand binding. Arch. Biochem. Biophys. 376, 266-274.
27. Hurwitz, R., Ferlinz, K. & Sandhoff, K. (1994) The tricyclic antidepressant desipramine causes proteolytic degradation of lysosomal sphingomyelinase in human fibroblasts. Biol. Chem. Hoppe Seyler 375, 447-450.