No association between non-violent suicidal behavior and the serotonin transporter promoter polymorphism

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 116 B, Issue 1, 2003, Pages 72-76

  Courtet, Philippe ^a   Buresi, Catherine ^b   Abbar, Mocrane ^c   Baud, Patrick ^b   Boulenger, Jean Philippe ^d   Castelnau, Didier ^a   Mouthon, Dominique ^b   Malafosse, Alain ^b  

^a LAPEYRONIE HOSPITAL   (France)

^b GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^c DEPARTMENT OF NEUROLOGY   (France)

^d INSERM   (France)

Author keywords

Association study; Nonviolent suicidal behavior; Polymorphism; Serotonin transporter

Indexed keywords

SEROTONIN; SEROTONIN TRANSPORTER;

ADULT; ALLELE; ARTICLE; CAUCASIAN; CONTROLLED STUDY; ETHNIC DIFFERENCE; FEMALE; GENE; GENE EXPRESSION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION; SEROTONIN TRANSPORTER GENE; SEROTONINERGIC SYSTEM; STATISTICAL ANALYSIS; SUICIDAL BEHAVIOR; SUICIDE ATTEMPT; VIOLENCE;

EID: 0042827375     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.10756     Document Type: Article

References (30)

1. Abbar M, Courtet P, Bellivier F, Leboyer M, Boulenger JP, Castelnau D, Ferreira M, Lambercy C, Mouthon D, Paoloni-Giacobino A, Vessaz M, Malafosse A, Buresi C. 2001. Suicide attempts and the tryptophan hydroxylase gene. Mol Psychiatry 6:268-273.
2. Armitage P, Berry G. 1987. Statistical methods in medical research. Oxford: Oxford: Blackwell Scientific Publications. p 371-407.
3. Asberg M. 1997. Neurotransmitters and suicidal behavior. The evidence from cerebrospinal fluid studies. Ann N Y Acad Sci 836:158-181.
4. Asberg M, Träskman L, Thoren P. 1976. 5-HIAA in the cerebrospinal fluid. A biochemical suicide predictor? Arch Gen Psychiatry 33:1193-1197.
5. Bellivier F, Szoke A, Henry C, Lacoste J, Bottos C, Nosten-Bertrand M, Hardy P, Rouillon F, Launay J, Laplanche J, Leboyer M. 2000. Possible association between serotonin transporter gene polymorphism and violent suicidal behavior in mood disorders. Biol Psychiatry 48:319-322.
6. Bondy B, Erfurth A, Jonge S, Kruger M, Meyer H. 2000. Possible association of the short allele of the serotonin transporter promoter gene polymorphism (5-HTTLPR) with violent suicide. Mol Psychiatry 5: 193-195.
7. Brent DA, Bridge J, Johnson BA, Connolly J. 1996. Suicidal behavior runs in families. A controlled family study of adolescent suicide victims. Arch Gen Psychiatry 53:1145-1152.
8. Coccaro EF. 1992. Impulsive aggression and central serotonergic system function in humans: an example of a dimensional brain-behavior relationship. Int Clin Psychopharmacol 7:3-12.
9. Collier DA, Stöber G, Li T, Heils A, Catalano M, Di Bella D. et al. 1996. A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders. Mol Psychiatry 1:453-460.
10. Courtet P, Baud P, Abbar M, Boulenger JP, Castelnau D, Mouthon D, Malafosse A, Buresi C. 2001. Association between violent suicidal behavior and the low activity allele of the serotonin transporter gene. Mol Psychiatry 6:338-341.
11. Du L, Faludi G, Palkovits M, Demeter E, Bakish D, Lapierre YD, et al. 1999. Frequency of long allele in serotonin transporter gene is increased in depressed suicide victims. Biol Psychiatry 46:196-201.
12. Gelernter J, Cubells JF, Kidd JR, Pakstis AJ, Kidd KK. 1999. Population studies of polymorphism of the serotonin transporter protein gene. Am J Med Genet 88:61-66.
13. Gorwood P, Batel P, Ades J, Hamon M, Boni C. 2000. Serotonin transporter gene polymorphisms, alcoholism, and suicidal behavior. Biol Psychiatry 48:259-264.
14. Heils A, Teufel A, Petri S, Stober G, Riederer P, Bengel D. et al. 1996. Allelic variation of human serotonin transporter gene expression. J Neurochem 66:2621-2624.
15. Lesch KP, Wolozin BL, Estler HC, Murphy DL, Riederer P. 1993. Isolation of a cDNA encoding the human brain serotonin transporter. J Neural Transm 91:67-72.
16. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S. et al. 1996. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274:1527-1531.
17. Lester D. 1995. The concentration of neurotransmitter metabolites in the cerebrospinal fluid of suicidal individuals: a meta-analysis. Pharmacopsychiatry 28:45-50.
18. Linkowski P, de Maertelaer V, Mendlewicz J. 1985. Suicidal behavior in major depressive illness. Acta Psychiatr Scand 72:233-238.
19. Malone KM, Haas GL, Sweeney JA, Mann JJ. 1995. Major depression and the risk of attempted suicide. J Affect Disord 34:173-185.
20. Mann JJ. 1998. The neurobiology of suicide. Nat Med 4:25-30.
21. Mann JJ, McBride PA, Brown RP, Linnoila M, Leon AC, DeMeo M, Mieczkowski T, Myers JB, Stanley M. 1992. Relationship between central and peripheral serotonin indexes in depressed and suicidal psychiatric inpatients. Arch Gen Psychiatry 49:442-446.
22. Mann JJ, Huang YY, Underwood MD, Kassir SA, Oppenheim S, Kelly TM, Dwork AJ, Arango V. 2000. A serotonin transporter gene promoter polymorphism (5-HTTLPR) and prefrontal cortical binding in major depression and suicide. Arch Gen Psychiatry 57:729-738.
23. Nielsen DA, Goldman D, Virkkunen M, Tokola R, Rawlings R, Linnoila M. 1994. Suicidality and 5-hydroxyindoleacetic acid concentration associated with a tryptophan hydroxylase polymorphism. Arch Gen Psychiatry 51:34-38.
24. Nurnberger JI, Blehar MC, Kaufman CA, York-Cooler C, Simpson SG, Harkavy-Freedman J, Severe JB, Malaspina D, Reich T. 1994. Diagnostic interview for genetic studies. Arch Gen Psychiatry 51:849-864.
25. Risch NJ. 2000. Searching for genetic determinants in the new millennium. Nature 405:847-856.
26. Roy A. 1993. Features associated with suicide attempts in depression: a partial replication. J Affect Disord 27:35-38.
27. Roy A, Segal NL, Sarchiapone M. 1995. Attempted suicide among living co-twins of twin suicide victims. Am J Psychiatry 152:1075-1076.
28. Roy A, Rylander G, Sarchiapone M. 1997. Genetic studies of suicidal behavior. Psychiatr Clin North Am 20:595-611.
29. Russ MJ, Lachman HM, Kashdan T, Saito T, Bajmakovic-Kacila S. 2000. Analysis of catechol-O-methyltransferase and 5-hydroxytryptamine transporter polymorphisms in patients at risk for suicide. Psychiatry Res 93:73-78.
30. Verkes RJ, Van der Mast RC, Hengeveld MW, Tuyl JP, Zwinderman AH, Van Kempen GM. 1998. Reduction by paroxetine of suicidal behavior in patients with repeated suicide attempts but not major depression. Am J Psychiatry 155:543-547.