Immunostimulatory CpG motifs trigger a T helper-1 immune response to human immunodeficiency virus type-1 (HIV-1) gp160 envelope proteins

Clinical Chemistry and Laboratory Medicine

Volumn 37, Issue 3, 1999, Pages 199-204

  Deml, Ludwig ^a   Schirmbeck, Reinhold ^b   Reimann, Jörg ^b   Wolf, Hans ^a   Wagner, Ralf ^a,c  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b UNIVERSITY OF ULM   (Germany)

^c Klinikum Regensburg   (Germany)

Author keywords

Aluminium hydroxide; CpG motifs; HIV gp160

Indexed keywords

ALUMINUM HYDROXIDE; BACTERIAL DNA; GAMMA INTERFERON; GLYCOPROTEIN GP 160; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; INTERLEUKIN 5; OLIGODEOXYNUCLEOTIDE; VIRUS ENVELOPE PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; B LYMPHOCYTE; CELLULAR IMMUNITY; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; FEMALE; HELPER CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOMODULATION; IN VIVO STUDY; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE;

ADJUVANTS, IMMUNOLOGIC; AIDS VACCINES; ANIMALS; CPG ISLANDS; DNA PRIMERS; HIV ENVELOPE PROTEIN GP160; MICE; MICE, INBRED BALB C; OLIGODEOXYRIBONUCLEOTIDES; T-LYMPHOCYTES, CYTOTOXIC; TH1 CELLS; TUMOR CELLS, CULTURED;

ANIMALIA; BACTERIA (MICROORGANISMS); HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0032944291     PISSN: 14346621     EISSN: None     Source Type: Journal    
DOI: 10.1515/CCLM.1999.037     Document Type: Conference Paper

References (33)

1. Burton DR, Montefiori DC. The antibody response in HIV-1 infection. AIDS 1997; 11 Suppl A:S87-98.
2. Poignard P, Klasse PJ, Sattentau QJ. Antibody neutralisation of HIV-1. Immunology Today 1996; 17:239-46.
3. Wilson CC, Kalams SA, Wilkes BM, Ruhl DJ, Gao F, Hahn BH, et al. Overlapping epitopes in human immunodeficiency virus type 1 gp120 presented by HLA A, B, and C molecules: effects of viral variation on cytotoxic T-lymphocyte recognition. J Virol 1997; 71:1256-64.
4. Cox JC, Coulter AR. Adjuvants - a classification and review of their modes of action. Vaccine 1997; 15:248-56.
5. Chu RS, Targoni OS, Krieg AM, Lehmann PV, Harding CV. CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity. J Exp Med 1997; 186:1623-31.
6. Karagouni EE, Hadjipetrou Kourounakis L. Regulation of isotype immunoglobulin production by adjuvants in vivo. Scand J Immunol 1990; 31:745-54.
7. Tokunaga T, Yamamoto H, Shimada S, Abe H, Fukuda T, Fujisawa Y, et al. Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity. J Natl Cancer Inst 1984; 72:955-62.
8. Yamamoto S, Yamamoto T, Shimada S, Kuramoto E, Yano O, Kataoka T, et al. DNA from bacteria, but not from vertebrates, induces interferons, activates natural killer cells and inhibits tumor growth. Microbiol Immunol 1992; 36:983-97.
9. Sun S, Cai Z, Langlade Demoyen P, Kosaka H, Brunmark A, Jackson MR, et al. Dual function of Drosophila cells as APCs for naive CD8+ T cells: implications for tumor immunotherapy. Immunity 1996; 4:555-64.
10. Krieg AM, Yi AK, Matson S, Waldschmidt TJ, Bishop GA, Teasdale R, et al. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 1995; 374:546-9.
11. Bird AP. CpG-rich islands and the function of DNA methylation. Nature 1986; 321:209-13.
12. Stacey KJ, Sweet MJ, Hume DA. Macrophages ingest and are activated by bacterial DNA. J Immunol 1996; 157:2116-22.
13. Ballas ZK, Rasmussen WL, Krieg AM. Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA. J Immunol 1996; 157:1840-5.
14. Klinman DM, Yi AK, Beaucage SL, Conover J, Krieg AM. CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma. Proc Natl Acad Sci USA 1996; 93:2879-83.
15. Sato Y, Roman M, Tighe H, Lee D, Corr M, Nguyen MD, et al. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science 1996; 273:352-4.
16. Raz E, Tighe H, Sato Y, Corr M, Dudler JA, Roman M, et al. Preferential induction of a Th1 immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization. Proc Natl Acad Sci USA 1996; 93:5141-5.
17. Takahashi H, Cohen J, Hosmalin A, Cease KB, Houghten R, Cornette JL, et al. An immunodominant epitope of the human immunodeficiency virus envelope glycoprotein gp160 recognized by class I major histocompatibility complex molecule-restricted murine cytotoxic T lymphocytes. Proc Natl Acad Sci USA 1988; 85:3105-9.
18. Modrow S, Hoflacher B, Mertz R, Wolf H. Carrier-bound synthetic peptides. Use as antigen in HIV-1 ELISA tests and in antiserum production. J Immunol Methods 1989; 118:1-7.
19. gag virus-like particles by an Epstein-Barr virus gp220/350-derived transmembrane domain. Virology 1997; 235:10-25.
20. gag retrovirus-like particles. Virology 1994; 200:162-75.
21. Zhao Q, Matson S, Herrera CJ, Fisher E, Yu H, Krieg AM. Comparison of cellular binding and uptake of antisense phosphodiester, phosphorothioate, and mixed phosphorothioate and methylphosphonate oligonucleotides. Antisense Res Dev 1993; 3:53-66.
22. Reimann J, Bellan A, Conradt P. Development of autoreactive L3T4+ T cells from double-negative (L3T4-/Ly-2-) Thy-1+ spleen cells of normal mice. Eur J Immunol 1988; 18:989-99.
23. Lipford GB, Bauer M, Blank C, Reiter R, Wagner H, Heeg K. CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: a new class of vaccine adjuvants. Eur J Immunol 1997; 27:2340-4.
24. Deml L, Schirmbeck R, Reimann J, Wolf H, Wagner R. Recombinant human immunodeficiency Pr55gag virus-like particles presenting chimeric envelope glycoproteins induce cytotoxic T-cells and neutralizing antibodies. Virology 1997; 235:26-39.
25. Hu R, Oyaizu N, Kalyanaraman VS, Pahwa S. HIV-1 gp160 as a modifier of Th1 and Th2 cytokine response: gp160 suppresses interferon-gamma and interleukin-2 production concomitantly with enhanced interleukin-4 production in vitro. Clin Immunol Immunopathol 1994; 73:245-51.
26. Roman M, Martin Orozco E, Goodman JS, Nguyen MD, Sato Y, Ronaghy A, et al. Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants. Nat Med 1997; 3:849-54.
27. Moldoveanu Z, Love-Homan L, Huang WQ, Krieg AM. CpG DNA, a novel immune enhancer for systemic and mucosal immunisation with influenza virus. Vaccine 1998; 16:1216-24.
28. Davis HL, Weeranta R, Waldschmidt TJ, Tygrett L, Schorr J, Krieg AM. CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen. J Immunol 1998; 160:870-6.
29. Krieg AM. An innate immune defense mechanism based on the recognition of CpG motifs in microbial DNA. J Lab Clin Med 1996; 128:128-33.
30. Klinman D, Yi A, Beaucage S, Conover J, Krieg A. CpG motifs present in bacterial DNA rapidly induce lymphocytesto secrete interleukin 6, interleukin 12, and interferon gamma. Proc Natl Acad Sci USA 1996, 93 (7):2879-83.
31. Halpern MD, Kurlander RJ, Pisetsky DS. Bacterial DNA induces murine interferon-gamma production by stimulation of interleukin-12 and tumor necrosis factor-alpha. Cell Immunol 1996; 167:72-8.
32. Brinkmann V, Geiger T, Alkan S, Heusser CH. Interferon alpha increases the frequency of interferon gamma-producing human CD4+ T cells. J Exp Med 1993; 178:1655-63.
33. Trinchieri G. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol 1995; 13:251-76.