Adenosine A1 and A(2A) receptor antagonists stimulate motor activity: Evidence for an increased effectiveness in aged rats

Neuroscience Letters

Volumn 251, Issue 3, 1998, Pages 201-204

  Popoli, Patrizia ^a   Reggio, Rosaria ^a   Pèzzola, Antonella ^a   Fuxe, Kjell ^b   Ferré, Sergi ^b  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Adenosine A(2A) receptors; Adenosine A1 receptors; Aging; Motor activity; Rats

Indexed keywords

5 AMINO 2 (2 FURYL) 7 (2 PHENYLETHYL)PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; 8 CYCLOPENTYLTHEOPHYLLINE; ADENOSINE A1 RECEPTOR ANTAGONIST; ADENOSINE A2A RECEPTOR ANTAGONIST; METHYLXANTHINE; RECEPTOR SUBTYPE; 8-CYCLOPENTYL-1,3-DIMETHYLXANTHINE; ADENOSINE A2A RECEPTOR; ADENOSINE RECEPTOR; DRUG DERIVATIVE; PYRIMIDINE DERIVATIVE; THEOPHYLLINE; TRIAZOLE DERIVATIVE;

ADOLESCENT; AGED; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DOSE RESPONSE; DRUG MECHANISM; MALE; MINIMUM INHIBITORY CONCENTRATION; MOTOR ACTIVITY; MOTOR NERVE CONDUCTION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; RECEPTOR BLOCKING; ANIMAL; COMPARATIVE STUDY; DRUG ANTAGONISM; DRUG EFFECT; PHYSIOLOGY; WISTAR RAT;

AGING; ANIMALS; MALE; MOTOR ACTIVITY; PYRIMIDINES; RATS; RATS, WISTAR; RECEPTOR, ADENOSINE A2A; RECEPTORS, PURINERGIC P1; THEOPHYLLINE; TRIAZOLES;

EID: 0032584389     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(98)00533-3     Document Type: Article

References (20)

1. 3H]NECA in rat striatal membranes. Mol. Pharmacol. 29:1986;331-337.
2. 2A adenosine receptor binding in aged striatum, hippocampus and cortex of the rat. NeuroReport. 6:1995;1583-1588.
3. Emerich D.F., McDermott P., Krueger P., Banks M., Zhao J., Marszalowski J., Frydel B., Winn S.R., Sanberg P.R. Locomotion of aged rats: relationship to neurochemical but not morphological changes in nigrostriatal dopaminergic neurons. Brain Res. Bull. 32:1993;477-486.
4. 2 receptors induces catalepsy. Neurosci. Lett. 130:1991;162-164.
5. 1 receptors. NeuroReport. 6:1994;73-76.
6. Ferré S., Fredholm B.B., Morelli M., Popoli P., Fuxe K. Adenosine-dopamine receptor-receptor interactions in the basal ganglia. Trends Neurosci. 20:1997;482-487.
7. 2-adenosine antagonist in vitro and in vivo. FEBS Lett. 323:1993;141-144.
8. 2A receptor antagonist with anticataleptic activity. Eur. J. Pharmacol. 256:1994;263-268.
9. 2A receptor. Nature. 388:1997;674-678.
10. Marshall J.F., Joyce J.N. Basal ganglia dopamine receptor autoradiography and age-related movement disorders. Ann. N.Y. Acad. Sci. 515:1988;215-225.
11. Nikodijevic O., Jacobson K.A., Daly J.W. Effects of combinations of methylxanthines and adenosine analogs on locomotor activity in control and chronic caffeine-treated mice. Drug Dev. Res. 30:1993;104-110.
12. 1 agonists in dopamine-denervated rats. Eur. J. Neurosci. 8:1996;1176-1181.
13. 2 receptors induces rotational behaviour in response to dopaminergic stimulation in intact rats. Eur. J. Pharmacol. 257:1994;21-25.
14. 1 receptor stimulation in rodents. Neurosci. Lett. 218:1996;209-213.
15. Popoli, P., Betto, P., Rimondini, R., Reggio R., Pèzzola A., Ricciarello G., Fuxe, K. and Ferré, S., Age-related alteration of the adenosine/dopamine balance in the rat striatum, Brain Res., (1998) in press.
16. 2A receptor antagonists as new agents for the treatment of Parkinson's disease. Trends Pharmacol. Sci. 18:1997;338-344.
17. 2 receptor in the rat striatum. Neurosci. Lett. 158:1993;121-124.
18. 2A receptors underlies the behavioural activating effect of caffeine and is associated with reduced expression of messenger RNA for NGFI-A and NGFI-B in caudate-putamen and nucleus acumbens. Neuroscience. 79:1997;753-764.
19. 6-cyclopentyl adenosine and 8-cyclopenthyl-1,3-dipropylxanthine on N-methyl-D-aspartate induced seizures in mice. Eur. J. Pharmacol. 249:1993;265-270.
20. 2A adenosine receptor antagonist. J. Pharmacol. Exp. Ther. 276:1996;398-404.