Early-life handling stimulation and environmental enrichment: Are some of their effects mediated by similar neural mechanisms?

Pharmacology Biochemistry and Behavior

Volumn 73, Issue 1, 2002, Pages 233-245

  Fernández Teruel, Alberto ^a   Giménez Llort, Lydia ^a   Escorihuela, Rosa M ^a   Gil, Luis ^a   Aguilar, Raúl ^a   Steimer, Thierry ^b   Tobea, Adolf ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b Institutions Universitaires de Psychiatrie   (Switzerland)

Author keywords

Age related deficits; Anxiety; Early experience; Environmental enrichment; Hippocampus; Learning; Memory; Neonatal handling; Neural plasticity; Stress

Indexed keywords

AGING; ANXIETY; AVOIDANCE BEHAVIOR; COGNITION; COGNITIVE DEFECT; ENVIRONMENTAL ENRICHMENT; EXPERIENCE; FEAR; HIPPOCAMPUS; LEARNING; MEMORY; NEWBORN; NONHUMAN; PLASTICITY; PRIORITY JOURNAL; REVIEW; RODENT; STIMULATION; STRESS; ANIMAL; ENVIRONMENT; EXPLORATORY BEHAVIOR; MOTIVATION; PHYSIOLOGY; RAT;

RODENTIA;

ANIMALS; ANIMALS, NEWBORN; ENVIRONMENT; EXPLORATORY BEHAVIOR; HANDLING (PSYCHOLOGY); LEARNING; RATS;

EID: 0035985577     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(02)00787-6     Document Type: Article

References (133)

1. Further evidence for the dissociation of locomotor activity and head-dipping in rats
2. The effects of early experience on subsequent emotionality and resistance to stress
3. Effects of early experiences on emotional and physiological reactivity in the rat
4. Effects of early experience on adrenocortical reactivity
5. Learned fear, emotional reactivity and fear of heights: A factor analytic map from a large F2 intercross of Roman rat strains
6. Effects of infantile stimulation on elderly Roman rats performance in a working memory version of the Morris water maze
7. Do early-life events permanently alter behavioral and hormonal responses to stressors
8. Psychobiology of novelty seeking and drug seeking behavior
9. Time courses of effects of differential experience on brain measures and behavior of rats
10. A study of some enriching variables in a free environment for rats
11. 3H-flunitrazepam binding in rat brain
12. The anxiolytic action of benzodiazepines is not present in handling-habituated rats
13. Two-way active avoidance as an animal model of anxiety: Negative correlation between plasma-corticosterone levels and avoidance performance
14. Neonatal stress and long-term modulation of GABA receptors in rat brain
15. Genetic determinants of individual differences in avoidance learning: Behavioral and endocrine characteristics
16. Effects of enriched and restricted early environments on the learning ability of bright and dull rats
17. Early stimulation of rodents: A critical review of present interpretations
18. Environmental therapy in hypothyroid and other disadvantaged animal populations
19. Infantile stimulation and adult exploratory behavior: Effects of handling upon tactual variation seeking
20. Novelty-seeking in rats. Biobehavioral characteristics and possible relationship with the sensation-seeking trait in man
21. Effects of exposure to stressors in early life upon later behavioural and biological processes
22. Interactive effects of age and duration of infantile experiences upon weight gain and mortality in the rat
23. Effects of environmental complexity and social grouping upon modification of emotional behavior
24. Effects of preweaning and postweaning manipulations upon problem-solving behavior
25. Effects of handling in infancy upon adult behavior and adrenocortical activity: Suggestions for a neuroendocrine mechanism
26. Long-term effects of preweaning and post-weaning free-environment experience on rats problem-solving behavior
27. Infantile stimulation induces brain lateralization in rats
28. The relationship between adrenal steroids and enrichment-induced brain growth
29. Genetic selection and differential stress responses
30. Inconsistency of early handling and its effect upon emotionality in the rat
31. Beneficial effects of infantile stimulation on coping (avoidance) behavior in rats are prevented by perinatal blockade of benzodiazepine receptors with Ro 15-1788
32. Infantile stimulation and the role of the benzodiazepine receptor system in adult acquisition of two-way avoidance behavior
33. Environmental enrichment reverses the detrimental action of early inconsistent stimulation and increases the beneficial effects of postnatal handling on shuttlebox learning in adult rats
34. Effects of training, early handling and perinatal flumazenil on shuttle box acquisition in Roman low-avoidance rats: Toward overcoming a genetic deficit
35. Environmental enrichment and postnatal handling prevent spatial learning deficits in aged hypoemotional (Roman high-avoidance) and hyperemotional (Roman low-avoidance) rats
36. Early environmental stimulation produces long-lasting changes on beta-adrenoceptor transduction system
37. Inbred Roman high- and low-avoidance rats: Differences in anxiety, novelty-seeking, and shuttlebox behaviors
38. Genetic learning deficiency does not hinder environment-dependent brain growth
39. Factor analysis shows that female rat behavior is characterised primarily by activity, male rats are driven by sex and anxiety
40. Infantile stimulation and perinatal administration of Ro 15-1788: Additive anxiety-reducing effects in rats
41. Infantile (handling) stimulation and behavior in young Roman high- and low-avoidance rats
42. The early acquisition of two-way (shuttle-box) avoidance as an anxiety-mediated behavior: Psychopharmacological validation
43. Early stimulation effects on novelty-induced behavior in two psychogenetically-selected rat lines with divergent emotionality profiles
44. Differential effects of early stimulation and/or perinatal flumazenil treatment in young low- and high-avoidance rats
45. Postnatal handling, perinatal flumazenil, and adult behavior of the Roman rat lines
46. Neonatal handling and environmental enrichment effects on emotionality, novelty/reward seeking, and age-related cognitive and hippocampal impairments: Focus on the Roman rat lines
47. Phospholipase C (PLC) beta1 levels in brain cortical membranes from RHA/Verh and RLA/Verh rats: Effects of aging and neonatal handling
48. Postnatal handling reduces anxiety as measured by emotionality rating and hyponeophagia tests in female rats
49. The ontogeny of exploration in the rat: Habituation and effects of handling
50. Validity of head-dipping as a measure of exploration in a modified hole-board
51. The nature of the effect of free-environment experience in the rat
52. Crucial periods for free-environmental experience in the rat
53. Receptor blockade reveals a correspondence between hippocampal-dependent behavior and experience-dependent synaptic enhancement
54. Strain, sex, and environment effects on appetitively and aversively motivated learning tasks
55. Handling in infancy, brain laterality and muricide in rats
56. Genetic and environmental influences on reactive and spontaneous locomotor activities in rats
57. Different effects of acute neonatal stressors and long-term postnatal handling on stress-induced changes in behavior and in ornithine decarboxylase activity of adult rats
58. Enrichment and early handling protect against age-related deficits. A behavioral and histological study in RHA/Verh and RLA/Verh rats
59. Sex differences in emotional behavior in the rat: Correlation between open field defecation and active avoidance
60. Altered synaptic transmission in dentate gyrus of rats reared in complex environments: Evidence from hippocampal slices maintained in vitro
61. Early postnatal stimulation influences passive avoidance behaviour of adult rats
62. Rats housed in a complex environment exhibit greater hilar LTP than individually housed littermates
63. Strain of foster mother determines long-term effects of early handling: Evidence for maternal mediation
64. The effects of experimental variations on problem solving in the rat
65. Genetic and experiential manipulation of fear-related behavior in Japanese quail chicks (Coturnix coturnix japonica)
66. Differential rearing experience, gender and radial maze performance
67. More hippocampal neurons in adult mice living in an enriched environment
68. Influence of environmental enrichment and sex on predator stress response in rats
69. Post-weaning handling attenuates isolation-rearing induced disruptions of prepulse inhibition in rats
70. Relations between brain chemistry and problem-solving among rats in enriched and impoverished environments
71. Psychological stress and environmental adaptation in enriched vs. impoverished housed rats
72. A further study of infantile handling and adult avoidance learning
73. Infantile experience and resistance to physiological stress
74. Genetic and ontogenetic determinants of adult behavior in the rat
75. Infantile experiences, strain differences, and avoidance learning
76. The effects of early shock and handling on later avoidance conditioning
77. Infantile experience and the maturation of the pituitary adrenal axis
78. Physiological and behavioral effects of infantile stimulation
79. Subchronic MK-801 treatment to juvenile rats attenuates environmental effects on adult spatial learning
80. Pain avoidance behavior of rats reared in restricted and enriched environments
81. Behavioral effects of environmental enrichment in randomly bred mice
82. Short- and long-periods of neonatal maternal separation differentially affect anxiety and feeding in adults rats: Gender-dependent effects
83. Effects of neonatal handling on age-related impairments associated with the hippocampus
84. The effects of neonatal handling on the development of the adrenocortical response to stress: Implications for neuropathology and cognitive deficits in later life
85. Environmental influence on behavior and nerve growth factor in the brain
86. Environmental influences on the central nervous system and their implications for the aging rat
87. Environmental manipulation differentially alters c-Fos expression in amygdaloid nuclei following aversive conditioning
88. Postnatal handling reduces emotionality ratings and accelerates two-way active avoidance in female rats
89. Effects of postnatal handling of rats on emotional, HPA-axis, and prolactin reactivity to novelty and conflict
90. Brief exposure to an enriched environment improves performance on the Morris water task and increases hippocampal cytosolic protein kinase C activity in young rats
91. Pre-weaning non-handling of rats disrupts latent inhibition in males, and results in persisting sex- and area-dependent increases in dopamine and serotonin turnover
92. Effects of neonatal stimulation on later cognitive function and hippocampal nerve growth factor
93. Effects of environmental enrichment on cognitive function and hippocampal NGF in the non-handled rats
94. Learning induces changes in the central cholinergic system of the rat in a sexually dimorphic pattern
95. Environmental enrichment and neurotransmitter receptors
96. Effects of environmental enrichment on gene expression in the brain
97. Environmental enrichment selectively increases 5-HT1A receptor mRNA expression and binding in the rat hippocampus
98. Growth hormone and environmental complexity effects on behavior in the rat
99. Experience-dependent changes in exploratory behavior in the adult rat (Rattus norvegicus): Overall activity level and interactions with objects
100. Object interactions in juvenile rats (Rattus norvegicus): Effects of different experimental histories
101. Responsiveness of brain size to individual experience: Behavioural and evolutionary implications
102. Psychobiology of plasticity: Effects of training and experience on brain and behavior
103. Environmental enrichment in BALB/c mice: Effects in classical tests of anxiety and exposure to a predatory odor
104. Differential effects of alkylating agents on the multiple muscarinic receptor subtypes linked to the activation of phospholipase C by carbachol in rat brain cortical membranes
105. The role and mechanisms of action of glucocorticoid involvement in memory storage
106. Effects of early protein malnutrition and environmental stimulation upon the reactivity to diazepam in two animal models of anxiety
107. Enhancement of hippocampal field potentials in rats exposed to a novel, complex environment
108. Effects of aging on environmental modulation of hippocampal evoked responses
109. Effects of neonatal thyroid hormone stimulation and differential preweaning rearing on spatial discrimination learning in rats
110. Effects of environmental enrichment on open field-activity and Hebb-Williams problem-solving in rats
111. Long-term behavioural and neuroendocrine changes in Roman high-(RHA/Verh) and low-(RLA/Verh) avoidance rats following neonatal handling
112. Neonatal handling reduces emotional reactivity and susceptibility to learned helplessness. Involvement of catecholaminergic systems
113. Interaction of genotype and environment as determinants of corticosteroid response to stress
114. Neonatal nonhandling and in utero prenatal stress reduce the density of NADPH-diaphorase-reactive neurons in the fascia dentata and Ammon's horn of rats
115. Nesting material as environmental enrichment has no adverse effects on behavior and physiology of laboratory mice
116. Neural consequences of environmental enrichment
117. Greater efficacy of preweaning than postweaning environmental enrichment on maze learning in adult rats
118. Insensitivity of the analysis of variance to heredity-environment interaction
119. Effects of fear conditioning on subsequent avoidance behavior and movement
120. Long-lasting effect of early handling on the peripheral benzodiazepine receptor
121. Restricted daily exposure to environmental enrichment increases the diversity of exploration
122. Early handling increases hippocampal long-term potentiation in young rats
123. Infantile handling and associative processes of rats
124. Infantile handling and the facilitation of discrimination and reversal learning
125. The effects of free and restricted environmental experience on problem-solving behavior in the rat
126. The effects of early postnatal stimulation on Morris water-maze acquisition in adult mice: Genetic and maternal factors
127. Enrichment-dependent differences in novelty exploration in rats can be explained by habituation