Solution structure for Pandinus toxin K-α (PiTX-Kα), a selective blocker of A-type potassium channels

Biochemistry

Volumn 36, Issue 10, 1997, Pages 2763-2771

  Tenenholz, T C ^a   Rogowski, R S ^a   Collins, J H ^a,b   Blaustein, M P ^a   Weber, D J ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHARYBDOTOXIN; PEPTIDE; POTASSIUM CHANNEL; SCORPION VENOM;

ALPHA HELIX; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; DISULFIDE BOND; NUCLEAR MAGNETIC RESONANCE; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN PURIFICATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; PROTEIN TERTIARY STRUCTURE; SYNAPTOSOME;

AMINO ACID SEQUENCE; ANIMALS; BRAIN CHEMISTRY; CHARYBDOTOXIN; CONSERVED SEQUENCE; HYDROGEN BONDING; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEUROTOXINS; POTASSIUM CHANNEL BLOCKERS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RATS; RECOMBINANT PROTEINS; SCORPION VENOMS; SEQUENCE ALIGNMENT; SYNAPTOSOMES;

EID: 0030891188     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9628432     Document Type: Article

References (59)

1. Aiyar, J., Withka, J. M., Rizzi, J. P., Singleton, D. H., Andrews, G. C., Lin, W., Boyd, J., Hanson, D. C., Simon, M., Dethlefs, B., Lee, C., Hall, J. E., Gutman, G. A., & Chandy, K. G. (1995) Neuron 15, 1169-1181.
2. Anderson, C. S., MacKinnon, R., Smith, C., & Miller, C. (1988) J. Gen. Physiol. 91, 317-333.
3. Bartschat, D. K., & Blaustein M. P. (1985) J. Physiol. 361, 419-440.
4. Basus, V. J. (1989) Methods Enzymol. 177, 132-149.
5. Bax, A., & Davis, D. G. (1985) J. Magn. Reson. 65, 355-360.
6. Benishin, C. G., Sorensen, R. G., Brown, W. E., Kruger, B. K., & Blaustein, M. P. (1988) Mol. Pharmacol. 34, 152-159.
7. Blaustein, M. P., Rogowski, R. S., Schneider, M. J., & Krueger, B. K. (1991) Mol. Pharmacol. 40, 932-942.
8. Bontemps, F., Roumestand, C., Gilquin, B., Menez, A., & Toma, F. (1991) Science 254, 1521-1523.
9. Bontemps, F., Gilquin, B., Roumestand, C., Menez, A., & Toma, F. (1992) Biochemistry 31, 7756-7764.
10. Brunger, A. T. (1992) X-PLOR Version 3.1, Yale University Press, New Haven, CT.
11. Crest, M., Jacquet, G., Gola, M., Zerrouk, H., Benslimane, A., Rochat, H., Mansuelle, P., & Martin-Eauclaire, M. (1992) J. Biol. Chem. 267, 1640-1647.
12. Dreyer, F. (1990) Rev. Physiol. Biochem. Pharmacol. 115, 94-123.
13. Fernandez, I., Romi, R., Szendeffy, S., Martin-Eauclaire, M. F., Rochat, H., Van Rietschoten, J., Pons, M., & Giralt, E. (1994) Biochemistry 33, 14256-14263.
14. Ferrin, T. E., Huang, C. C., Jarvis, L. E., & Langridge, R. (1988) J. Mol. Graphics 6, 13-27.
15. Garcia, M. L., Garcia-Calvo, M., Hidalgo, P., Lee, A., & MacKinnon, R. (1994) Biochemistry 33, 6834-6839.
16. Garcia-Calvo, M., Leonard, R. J., Novick, J., Stevens, S. P., Schmalhofer, W., Kaczorowski, G. J., & Garcia, M. L. (1993) J. Biol. Chem. 268, 18866-18874.
17. Goldstein, S. A., & Miller, C. (1993) Biophys. J. 65, 1613-1619.
18. Goldstein, S. A., Pheasant, D. J., & Miller, C. (1994) Neuron 12, 1377-1388.
19. Griesinger, C., & Ernst, R. R. (1987) J. Magn. Reson. 75, 261.
20. Griesinger, C., Sørensen, O. W., & Ernst, R. R. (1985) J. Am. Chem. Soc. 107, 6394-6396.
21. Griesinger, C., Sørensen, O. W., & Ernst, R. R. (1987) J. Magn. Reson. 75, 474-492.
22. Griesinger, C., Otting, G., Wüthrich, K., & Ernst, R. R. (1988) J. Am. Chem. Soc. 110, 7870.
23. Hidalgo, P., & MacKinnon, R. (1995) Science 268, 307-310.
24. Howell, M. L., & Blumenthal, K. M. (1989) J. Biol. Chem. 264, 15268-15273.
25. Huang, C. C., Pettersen, E. F., Klein, T. E., Ferrin, T. E., & Langridge, R. (1991) J. Mol. Graphics 9, 230-236.
26. Johnson, B. A., & Sugg, E. E. (1992) Biochemistry 31, 8151-8159.
27. Kadowaki, H., Kadowaki, T., Wondisford, F., & Taylor, S. (1989) Gene 76, 161-166.
28. Kammann, M., Laufs, J., Schell, J., & Gronenborn, B. (1989) Nucleic Acids Res. 17, 5404.
29. Kessler, H., Greisinger, C., Kerssebaum, R., Wagner, K., & Ernst, R. R. (1987) J. Am. Chem. Soc. 109, 607-609.
30. Krezel, A. M., Kasibhatla, C., Hidalgo, P., MacKinnon, R., & Wagner, G. (1995) Protein Sci. 4, 1478-1489.
31. Laskowski, R. A., MacArthur, M. W., Moss, D. S., & Thornton, J. M. (1993) J. Appl. Crystallogr. 26, 283-291.
32. Lebreton, F., Delepierre, M., Ramirez, A. N., Balderas, C., & Possani, D. (1994) Biochemistry 33, 11135-11149.
33. MacKinnon, R. (1991) Nature 500, 232-235.
34. MacKinnon, R., & Miller, C. (1988) J. Gen. Physiol. 91, 335-349.
35. Macura, S., & Ernst, R. R. (1980) Mol. Phys. 41, 95.
36. Martins, J. C., Ahang, W., Tartar, A., Lazdunski, M., & Borremans, F. A. M. (1990) FEBS Lett. 260, 249-253.
37. Miller, C. (1990) Biochemistry 29, 5320-5325.
38. Miller, C. (1995) Neuron 15, 5-10.
39. Miller, C., Moczydlowski, E., Latorre, R., & Phillips, M. (1985) Nature 313, 316-318.
40. Nilges, M., Clore, G. M., & Gronenborn, A. M. (1988) FEBS Lett. 229, 317-324.
41. Park, C. S., & Miller, C. (1992a) Biochemistry 31, 7749-7755.
42. Park, C. S., & Miller, C. (1992b) Neuron 9, 307-313.
43. Park, C. S., Hausdorff, S. F., & Miller, C. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 2046-2050.
44. Piantini, U., Sørensen, O. W., & Ernst, R. R. (1982) J. Am. Chem. Soc. 104, 6800.
45. Piotto, M., Saudek, V., & Sklenar, V. (1992) J. Biomol. NMR 2, 661-665.
46. Possani, L. D., Martin, B. M., & Svendensen, I. (1982) Carlsberg Res. Commun. 47, 285-289.
47. Powers, R., Garret, D. S., March, C. J., Frieden, E. A., Gronenborn, A. M., & Clore, G. M. (1993) Biochemistry 32, 6744-6762.
48. Rance, M., Sørensen, O. W., Bodenhausen, G., Wagner, G., Ernst, R. R., & Wüthrich, K. (1983) Biochem. Biophys. Res. Commun. 117, 479.
49. Rogowski, R. S., Krueger, B. K., Collins, J. H., & Blaustein, M. P. (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 1475-1479.
50. Rogowski, R. S., Collins, J. H., O'Neil, T. J., Gustafson, T. A., Werkman, T. A., Rogawski, M. A., Tenenholz, T. C., Weber, D. J., & Blaustein, M. P. (1996) Mol. Pharmacol. 50, 1167-1177.
51. Schneider, M. J., Rogowski, R. S., Krueger, B. K., & Blaustein, M. P. (1989) FEBS Lett. 250, 433-436.
52. Smith, C. D. (1989) Ph.D. Thesis, Brandeis University, Waltham, MA.
53. Stampe, P., Kolmakova-Partensky, L., & Miller, C. (1994) Biochemistry 33, 443-450.
54. Stocker, M., & Miller, C. (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 9509-9513.
55. Tenenholz, T. C, Rogowski, R. S., Amburgey, J. C., Collins, J. H., Gustafson, T. A., Blaustein, M. P., & Weber, D. J. (1996) Biophys. J. 70, A59
56. Vallette, F., Mege, E., Reiss, A., & Adesnik, M. (1989) Nucleic Acids Res. 17, 723-732.
57. Werkman, T. R., Kawamura, T., Yokoyama, S., Higashida, H., & Rogawski, M. A. (1992) Neuroscience 50, 935-946.
58. Wishart, D. S., Sykes, B. D., & Richards, F. M. (1992) Biochemistry 31, 1647-1651.
59. Wüthrich, K. (1986) NMR of Proteins and Nucleic Acids, John Wiley, New York.