Correlation between delayed neuronal cell death and selective decrease in phosphatidylinositol 4-kinase expression in the CA1 subfield of the hippocampus after transient forebrain ischemia

Journal of Cerebral Blood Flow and Metabolism

Volumn 23, Issue 8, 2003, Pages 962-971

  Furuta, Yudai ^a   Uehara, Takashi ^a   Nomura, Yasuyuki ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Apoptosis; Brain ischemia; Down regulation; Neuron; PI 4 kinase

Indexed keywords

MESSENGER RNA; PHOSPHATIDYLINOSITOL KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN ISCHEMIA; BRAIN PERFUSION; BRAIN REGION; CONTROLLED STUDY; CORRELATION ANALYSIS; DIFFERENTIAL DISPLAY; DOWN REGULATION; FOREBRAIN; GENE CONTROL; GENE ISOLATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HYPOXIA; MALE; NERVE CELL NECROSIS; NEUROBLASTOMA CELL; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

EID: 0042570694     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.WCB.0000073948.29308.F8     Document Type: Article

References (39)

1. Abe K, Aoki M, Kawagoe J, Yoshida T, Hattori A, Korure K, Itoyama Y (1995) Ischemic delayed neuronal death. A mitochondrial hypothesis. Stroke 26:1478-1489
2. Alvarez-Tejado M, Naranjo-Suárez S, Jiménez C, Carrera AC, Landázuri MO, del Peso L (2001) Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis. J Biol Chem 276:22368-22374
3. Araya R, Uehara T, Nomura Y (1998) Hypoxia induces apoptosis in human neuroblastoma SK-N-MC cells by caspase activation accompanying cytochrome c release from mitochondria. FEBS Lett 439:168-172
4. Asahi M, Hoshimaru M, Uemura Y, Tokime T, Kojima M, Ohtsuka T, Matsuura N, Aoki T, Shibahara K, Kikuchi H (1997) Expression of interleukin-1 beta converting enzyme gene family and bcl-2 gene family in the rat brain following permanent occlusion of the middle cerebral artery. J Cereb Blood Flow Metab 17:11-18
5. Azuma T, Koths K, Flanagan L, Kwiatkowski D (2000) Gelsolin in complex with phosphatidylinositol 4,5-bisphosphate inhibits caspase-3 and -9 to retard apoptotic progression. J Biol Chem 275: 3761-3766
6. Chen J, Zhu RL, Nakayama M, Kawaguchi K, Jin K, Stetler RA, Simon RP, Graham SH (1996) Expression of the apoptosis-effector gene, Bax, is up-regulated in vulnerable hippocampal CA1 neurons following global ischemia. J Neurochem 67:64-71
7. Chen J, Graham SH, Nakayama M, Zhu RL, Jin K, Stetler RA, Simon RP (1997) Apoptosis repressor genes Bcl-2 and Bcl-x-long are expressed in the rat brain following global ischemia. J Cereb Blood Flow Metab 17:2-10
8. Choi DW (1996) Ischemia-induced neuronal apoptosis. Curr Opinion Neurobiol 8:667-672
9. Czech MP (2000) PIP2 and PIP3: complex roles at the cell surface. Cell 100:603-406
10. Ferrer I, Tortosa A, Macaya A, Sierra A, Moreno D, Munell F, Blanco R, Squier W (1994) Evidence of nuclear DNA fragmentation following hypoxia-ischemia in the infant rat brain, and transient forebrain ischemia in the adult gerbil. Brain Pathol 4:115-122
11. Honda A, Nogami M, Yokozeki T, Yamazaki M, Nakamura H, Watanabe H, Kawamoto K, Nakayama K, Morris AJ, Frohman MA, Kanaho Y (1999) Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation. Cell 99:521-532
12. Jorgensen MB, Deckert J, Wright DC, Gehlert DR (1989) Delayed c-fos proto-oncogene expression in the rat hippocampus induced by transient global cerebral ischemia: an in situ hybridization study. Brain Res 484:393-398
13. Juurlink BH, Sweeney MI (1997) Mechanisms that result in damage during and following cerebral ischemia. Neurosci Biobehav Rev 21:121-128
14. Kirino T (1982) Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res 239:57-69
15. Ko HS, Uehara T, Nomura Y (2002) Role of ubiquilin associated with protein-disulfide isomerase in the endoplasmic reticulum in stress-induced apoptotic cell death. J Biol Chem 277:35386-35392
16. Kothakota S, Azuma T, Reinhard C, Klippel A, Tang J, Chu K, McGarry TJ, Kirschner MW, Koths K, Kwiatkowski DJ, Williams LT (1997) Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis. Science 278:294-298
17. Koya RC, Fujita H, Shimizu S, Ohtsu M, Takimoto M, Tsujimoto Y, Kuzumaki N (2000) Gelsolin inhibits apoptosis by blocking mitochondrial membrane potential loss and cytochrome c release. J Biol Chem 275:15343-15349
18. Krayev AS, Markusheva TV, Kramerov DA, Ryskov AP, Skryabin KG, Bayev AA, Georgiev GP (1982) Ubiquitous transposon-like repeats B1 and B2 of the mouse genome: B2 sequencing. Nucleic Acids Res 10:7461-7475
19. Lindvall O, Ernfors P, Bengzon J, Kokaia Z, Smith ML, Siesjo BK, Persson H (1992) Differential regulation of mRNAs for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the adult rat brain following cerebral ischemia and hypoglycemic coma. Proc Natl Acad Sci U S A 89:648-652
20. 2 sequences are induced in the hippocampal CA1 region after transient global cerebral ischemia. J Biol Chem 274:28674-28681
21. MacManus JP, Linnik MD (1997) Gene expression induced by cerebral ischemia: an apoptotic perspective. J Cereb Blood Flow Metab 17: 815-832
22. Nakagawa T, Goto K, Kondo H (1996) Cloning, expression, and localization of 230-kDa phosphatidylinositol 4-kinase. J Biol Chem 271:12088-12094
23. Narita K, Kubota M, Nakane M, Kitahara S, Nakagomi T, Tamura A, Hisaki H, Ueta N (2000) Therapeutic time window in the penumbra during permanent focal ischemia in rats: changes of free fatty acids and glycerophospholipids. Neurol Res 22:393-400
24. Nitatori T, Sato N, Waguri S, Karasawa Y, Araki H, Shibanai K, Kominami E, Uchiyama Y (1995) Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis. J Neurosci 15:1001-1011
25. Nowak TS (1985) Synthesis of a stress protein following transient ischemia in the gerbil. J Neurochem 45:1635-1641
26. Petito CK, Feldmann E, Pulsinelli WA, Plum F (1987) Delayed hippocampal damage in humans following cardiorespiratory arrest. Neurology 37:1281-1286
27. Pulsinelli WA, Brierley JB, Plum F (1982) Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann Neurol 11:491-498
28. Raucher D, Stauffer T, Chen W, Shen K, Guo S, York JD, Sheetz MP, Meyer T (2000) Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion. Cell 100:221-228
29. Strosznajder J (1989) Prolonged ischemia differently affects phospholipase C acting against phosphatidylinositol and phosphatidylinositol 4,5-bisphosphate in brain subsynaptosomal fraction. FEBS Lett 257:110-112
30. Sun HQ, Yamamoto M, Mejillano M, Yin H (1999) Gelsolin, a multifunctional actin regulatory protein. J Biol Chem 274:33179-33182
31. Tanaka S, Uehara T, Nomura Y (2000) Up-regulation of proteindisulfide isomerase in response to hypoxia/brain ischemia and its protective effect against apoptotic cell death. J Biol Chem 275:10388-10393
32. Toker A (1998) The synthesis and cellular roles of phosphatidylinositol 4,5-bisphosphate. Curr Opin Cell Biol 10:254-261
33. Tsuda M, Kitagawa K, Imaizumi K, Wanaka A, Tohyama M, Takagi T (1996) Induction of SPI-3 mRNA, encoding a serine protease inhibitor, in gerbil hippocampus after transient forebrain ischemia. Brain Res Mol Brain Res 35:314-318
34. Tsuda M, Imaizumi K, Katayama T, Kitagawa K, Wanaka A, Tohyama M, Takagi T (1997) Expression of zinc transporter gene, ZnT-1, is induced after transient forebrain ischemia in the gerbil. J Neurosci 17:6678-6684
35. Uehara T, Matsuno J, Kaneko M, Nishiya T, Fujimuro M, Yokosawa H, Nomura Y (1999a) Transient nuclear factor κB (NF-κB) activation stimulated by interleukin-1β may be partly dependent on proteasome activity, but not phosphorylation and ubiquitination of the IκBα molecule, in C6 glioma cells. Regulation of NF-κB linked to chemokine production. J Biol Chem 274:15875-15882
36. Uehara T, Kaneko M, Tanaka S, Okuma Y, Nomura Y (1999b) Possible involvement of p38 MAP kinase in HSP70 expression induced by hypoxia in rat primary astrocytes. Brain Res 823:226-230
37. Uehara T, Kikuchi Y, Nomura Y (1999c) Caspase activation accompanying cytochrome c release from mitochondria is possibly involved in nitric oxide-induced neuronal apoptosis in SH-SY5Y cells. J Neurochem 72:196-205
38. Vereb G, Balla A, Gergely P, Wymann MP, Gülkan H, Suer S, Heimeyer LMG Jr (2001) The ATP-binding site of brain phosphatidylinositol 4-kinase PI4K230 as revealed by 5′-p-fluorosulfonylbenzoyladenosine. Int J Biochem Cell Biol 33:249-259
39. Wang X, Yue TL, Barone FC, White RF, Clark RK, Willette RN, Sulpizio A, Aiyar NV, Ruffolo RR Jr, Feuerstein GZ (1995) Discovery of adrenomedullin in rat ischemic cortex and evidence for its role in exacerbating focal brain ischemic damage. Proc Natl Acad Sci U S A 92:11480-11484