메뉴 건너뛰기




Volumn 3, Issue 4, 2003, Pages 471-483

Advances in combined radiation therapy for the management of rectal cancer

Author keywords

Adjuvant therapy; Combined modality therapy; Radiation therapy; Rectal cancer

Indexed keywords

AMIFOSTINE; BEVACIZUMAB; CAPECITABINE; CELECOXIB; CHLOROETHYLNITROSOUREA DERIVATIVE; FLUOROURACIL; FOLINIC ACID; GEFITINIB; GEMCITABINE; IRINOTECAN; LEVAMISOLE; LOMUSTINE; METHYL N (2 CHLOROETHYL) N' CYCLOHEXYL N NITROSOUREA; OXALIPLATIN; RALTITREXED; UFT; UNCLASSIFIED DRUG; VINCRISTINE;

EID: 0042510801     PISSN: 14737140     EISSN: None     Source Type: Journal    
DOI: 10.1586/14737140.3.4.471     Document Type: Review
Times cited : (2)

References (117)
  • 2
    • 0020617786 scopus 로고
    • Patterns of recurrence of rectal cancer after potentially curative surgery
    • Rich T, Gunderson LL, Lew R et al. Patterns of recurrence of rectal cancer after potentially curative surgery. Cancer 52, 1317-1329 (1983).
    • (1983) Cancer , vol.52 , pp. 1317-1329
    • Rich, T.1    Gunderson, L.L.2    Lew, R.3
  • 3
    • 0020554732 scopus 로고
    • Patterns of recurrence in adenocarcinoma of the rectum and rectosigmoid treated with surgery alone: Indications in treatment planning with adjuvant radiation
    • Mendenhall WM, Million RR, Pfaff WW. Patterns of recurrence in adenocarcinoma of the rectum and rectosigmoid treated with surgery alone: indications in treatment planning with adjuvant radiation. Int. J Radiat. Oncol. Biol. Phys. 9, 977-985 (1983).
    • (1983) Int. J Radiat. Oncol. Biol. Phys. , vol.9 , pp. 977-985
    • Mendenhall, W.M.1    Million, R.R.2    Pfaff, W.W.3
  • 4
    • 0021325541 scopus 로고
    • Patterns of pelvic recurrence following definitive resections of rectal cancer
    • Piliphen SJ, Heilweil M, Quan SH et al. Patterns of pelvic recurrence following definitive resections of rectal cancer. Cancer 53, 1354-1362 (1984).
    • (1984) Cancer , vol.53 , pp. 1354-1362
    • Piliphen, S.J.1    Heilweil, M.2    Quan, S.H.3
  • 5
    • 0021792174 scopus 로고
    • Prolongation of the disease-free survival in surgically treated rectal carcinoma
    • Gastrointestinal Tumor Study Group
    • Gastrointestinal Tumor Study Group. Prolongation of the disease-free survival in surgically treated rectal carcinoma. N. Engl. J. Med. 312, 465-1472 (1985).
    • (1985) N. Engl. J. Med. , vol.312 , pp. 465-1472
  • 6
    • 0026071185 scopus 로고
    • Effective surgical adjuvant therapy for high-risk rectal carcinoma
    • Krook JE, Moertel CG, Gunderson LL et al. Effective surgical adjuvant therapy for high-risk rectal carcinoma. N. Engl. J. Med. 324, 709-715 (1991).
    • (1991) N. Engl. J. Med. , vol.324 , pp. 709-715
    • Krook, J.E.1    Moertel, C.G.2    Gunderson, L.L.3
  • 7
    • 84944371744 scopus 로고
    • Adjuvant therapy for patients with colon and rectal cancer
    • National Institutes of Health Consensus Conference
    • National Institutes of Health Consensus Conference. Adjuvant therapy for patients with colon and rectal cancer. JAMA 264, 1444-1450 (1990).
    • (1990) JAMA , vol.264 , pp. 1444-1450
  • 8
    • 0023836214 scopus 로고
    • Postoperative adjuvant chemotherapy or radiation therapy for rectal cancer: Results from NSABP protocol R-01
    • Fisher B, Wolmark N, Rockette H et al. Postoperative adjuvant chemotherapy or radiation therapy for rectal cancer: results from NSABP protocol R-01. J. Natl Cancer Inst. 80, 21-29 (1988).
    • (1988) J. Natl Cancer Inst. , vol.80 , pp. 21-29
    • Fisher, B.1    Wolmark, N.2    Rockette, H.3
  • 9
    • 0034162884 scopus 로고    scopus 로고
    • Randomized trial of postoperative adjuvant chemotherapy with or without radiation for carcinoma of the rectum: National Surgical Adjuvant Breast and Bowel Project Protocol R-02
    • Wolmark N, Wieand S, Hyams DM et al. Randomized trial of postoperative adjuvant chemotherapy with or without radiation for carcinoma of the rectum: National Surgical Adjuvant Breast and Bowel Project Protocol R-02. J. Natl Cancer Inst. 92, 388-396 (2000).
    • (2000) J. Natl Cancer Inst. , vol.92 , pp. 388-396
    • Wolmark, N.1    Wieand, S.2    Hyams, D.M.3
  • 10
    • 0026603462 scopus 로고
    • Radiation therapy and 5-FU with or without semustine for the treatment of patients with surgical adjuvant adenocarcinoma of the rectum
    • Gastrointestinal Tumor Study Group
    • Gastrointestinal Tumor Study Group. Radiation therapy and 5-FU with or without semustine for the treatment of patients with surgical adjuvant adenocarcinoma of the rectum. J. Clin. Oncol. 10, 549-557 (1992).
    • (1992) J. Clin. Oncol. , vol.10 , pp. 549-557
  • 11
    • 0028136295 scopus 로고
    • Improving adjuvant therapy for rectal cancer by combining protracted-infusion 5-FU with radiation therapy after curative surgery
    • O'Connell MJ, Martenson JA, Wieand HS et al. Improving adjuvant therapy for rectal cancer by combining protracted-infusion 5-FU with radiation therapy after curative surgery. N. Engl. J. Med. 331, 502-507 (1994).
    • (1994) N. Engl. J. Med. , vol.331 , pp. 502-507
    • O'Connell, M.J.1    Martenson, J.A.2    Wieand, H.S.3
  • 12
    • 0036534143 scopus 로고    scopus 로고
    • Adjuvant therapy in rectal cancer: Analysis of stage, sex and local control: Final report of Intergroup 0114
    • Tepper JE, O'Connell MJ, Niedzwiecki DR et al. Adjuvant therapy in rectal cancer: analysis of stage, sex and local control: final report of Intergroup 0114. J. Clin. Oncol. 20, 1744-1750 (2002).
    • (2002) J. Clin. Oncol. , vol.20 , pp. 1744-1750
    • Tepper, J.E.1    O'Connell, M.J.2    Niedzwiecki, D.R.3
  • 13
    • 3042760073 scopus 로고    scopus 로고
    • Intergroup 0144: Phase III trial of 5-FU-based chemotherapy regimens plus radiotherapy (XRT) in postoperative adjuvant rectal cancer. Bolus 5-FU versus prolonged venous infusion (PVI) before and after XRT + PVI versus bolus 5-FU + leucovorin (LV) + levamisole (LEV) before and after XRT + bolus 5-FU + LV
    • (Abstract 1006)
    • Smalley SR, Benedetti J, Williamson S et al. Intergroup 0144: Phase III trial of 5-FU-based chemotherapy regimens plus radiotherapy (XRT) in postoperative adjuvant rectal cancer. Bolus 5-FU versus prolonged venous infusion (PVI) before and after XRT + PVI versus bolus 5-FU + leucovorin (LV) + levamisole (LEV) before and after XRT + bolus 5-FU + LV. Proc. Am. Soc. Clin. Oncol. (2003) (Abstract 1006).
    • (2003) Proc. Am. Soc. Clin. Oncol.
    • Smalley, S.R.1    Benedetti, J.2    Williamson, S.3
  • 14
    • 0036533844 scopus 로고    scopus 로고
    • Randomized trial of postoperative adjuvant therapy in Stage II and III rectal cancer to define the optimal sequence of chemotherapy and radiotherapy: A preliminary report
    • Lee J-H, Lee J-H, Ahn J-H et al. Randomized trial of postoperative adjuvant therapy in Stage II and III rectal cancer to define the optimal sequence of chemotherapy and radiotherapy: a preliminary report. J. Clin. Oncol. 20, 1751-1758 (2002).
    • (2002) J. Clin. Oncol. , vol.20 , pp. 1751-1758
    • Lee, J.-H.1    Lee, J.-H.2    Ahn, J.-H.3
  • 15
    • 0033007459 scopus 로고    scopus 로고
    • Prognostic factors in Stage T3N0 rectal cancer: Do all patients require postoperative irradiation and chemotherapy?
    • Willett CG, Badizaadegan K, Ancukiewicz M et al. Prognostic factors in Stage T3N0 rectal cancer: do all patients require postoperative irradiation and chemotherapy? Dis. Colon Rectum , 167-173 (1999).
    • (1999) Dis. Colon Rectum , pp. 167-173
    • Willett, C.G.1    Badizaadegan, K.2    Ancukiewicz, M.3
  • 16
    • 0033220455 scopus 로고    scopus 로고
    • T3N0 rectal cancer: Results following sharp mesorectal excision and no adjuvant therapy
    • Merchant NB, Guillem JG, Paty PB et al. T3N0 rectal cancer: results following sharp mesorectal excision and no adjuvant therapy. J. Gastrointest. Surg. 3, 6-647 (1999).
    • (1999) J. Gastrointest. Surg. , vol.3 , pp. 6-647
    • Merchant, N.B.1    Guillem, J.G.2    Paty, P.B.3
  • 17
    • 0022644238 scopus 로고
    • Recurrence and survival after total mesorectal excision for rectal cancer
    • Heald RJ, Ryall RDH. Recurrence and survival after total mesorectal excision for rectal cancer. Lancet 1, 1479-1482 (1986).
    • (1986) Lancet , vol.1 , pp. 1479-1482
    • Heald, R.J.1    Ryall, R.D.H.2
  • 18
    • 0031859317 scopus 로고    scopus 로고
    • Rectal cancer: The Basingstoke experience of total mesorectal excision, 1978-1997
    • Heald RJ, Moran BJ, Ryall RD et al. Rectal cancer: the Basingstoke experience of total mesorectal excision, 1978-1997. Arch. Surg. 133, 894-899 (1998).
    • (1998) Arch. Surg. , vol.133 , pp. 894-899
    • Heald, R.J.1    Moran, B.J.2    Ryall, R.D.3
  • 19
    • 0033399087 scopus 로고    scopus 로고
    • Total mesorectal excision with autonomic nerve preservation: A new foundation for the evaluation of multi-disciplinary adjuvant therapy in the management of rectal cancers
    • Kafka NJ, Enker WE. Total mesorectal excision with autonomic nerve preservation: a new foundation for the evaluation of multi-disciplinary adjuvant therapy in the management of rectal cancers. Ann. Chir 53, 996-1002 (1999).
    • (1999) Ann. Chir. , vol.53 , pp. 996-1002
    • Kafka, N.J.1    Enker, W.E.2
  • 20
    • 0033822558 scopus 로고    scopus 로고
    • Selective total mesorectal excision for rectal cancer
    • Leong AFPK. Selective total mesorectal excision for rectal cancer. Dis. Colon Rectum 43, 1237-12 (2000).
    • (2000) Dis. Colon Rectum , vol.43 , pp. 1237-1312
    • Leong, A.F.P.K.1
  • 21
    • 0033504794 scopus 로고    scopus 로고
    • Safety and efficacy of low anterior resection for rectal cancer: 681 consecutive cases from a specialty service
    • Enker WE, Merchant N, Cohen AM et al. Safety and efficacy of low anterior resection for rectal cancer: 681 consecutive cases from a specialty service. Ann. Surg. 230, 544-552 (1999).
    • (1999) Ann. Surg. , vol.230 , pp. 544-552
    • Enker, W.E.1    Merchant, N.2    Cohen, A.M.3
  • 22
    • 0035975394 scopus 로고    scopus 로고
    • Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer
    • Kapiteijn E, Marijnen CA, Nagtegaal ID et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N. Engl. J. Med. 345, 638-646 (2001).
    • (2001) N. Engl. J. Med. , vol.345 , pp. 638-646
    • Kapiteijn, E.1    Marijnen, C.A.2    Nagtegaal, I.D.3
  • 23
    • 0033819376 scopus 로고    scopus 로고
    • Current protocols and outcome of local therapy for rectal cancer
    • Bleday R, Steele G Jr. Current protocols and outcome of local therapy for rectal cancer. Surg. Oncol. Clin. North Am. 9, 751-758 (2000).
    • (2000) Surg. Oncol. Clin. North Am. , vol.9 , pp. 751-758
    • Bleday, R.1    Steele G., Jr.2
  • 24
    • 0033497440 scopus 로고    scopus 로고
    • Long-term follow-up of patients with rectal cancer managed by local excision with and without adjuvant irradiation
    • Chakravarti A, Compton C, Shellito P et al. Long-term follow-up of patients with rectal cancer managed by local excision with and without adjuvant irradiation. Ann. Surg. 230, 49-54 (1999).
    • (1999) Ann. Surg. , vol.230 , pp. 49-54
    • Chakravarti, A.1    Compton, C.2    Shellito, P.3
  • 25
    • 0036785852 scopus 로고    scopus 로고
    • Long-tem results of local excision for rectal cancer
    • Paty PB, Nash GM, Baron P et al. Long-tem results of local excision for rectal cancer. Ann. Surg. 236, 522-530 (2002).
    • (2002) Ann. Surg. , vol.236 , pp. 522-530
    • Paty, P.B.1    Nash, G.M.2    Baron, P.3
  • 26
    • 0345466299 scopus 로고    scopus 로고
    • Sphincter-sparing treatment for distal rectal adenocarcinoma
    • Steele GD, Herndon JE, Bleday R et al. Sphincter-sparing treatment for distal rectal adenocarcinoma. Ann. Surg. Oncol. 6, 433-441 (1999).
    • (1999) Ann. Surg. Oncol. , vol.6 , pp. 433-441
    • Steele, G.D.1    Herndon, J.E.2    Bleday, R.3
  • 27
    • 0033971075 scopus 로고    scopus 로고
    • Anal sphincter conservation for patients with adenocarcinoma of the distal rectum: Long-term results of radiation therapy oncology group protocol 89-02
    • Russell AH, Harris J, Rosenberg PJ et al. Anal sphincter conservation for patients with adenocarcinoma of the distal rectum: long-term results of radiation therapy oncology group protocol 89-02. Int. J. Radiat. Oncol. Biol Phys. 46, 313-322 (2000).
    • (2000) Int. J. Radiat. Oncol. Biol Phys. , vol.46 , pp. 313-322
    • Russell, A.H.1    Harris, J.2    Rosenberg, P.J.3
  • 28
    • 0033842677 scopus 로고    scopus 로고
    • Transanal excision for low rectal cancers is curative in early-stage disease with favorable histology
    • Blair S, Ellehorn JD. Transanal excision for low rectal cancers is curative in early-stage disease with favorable histology. Am. Surg. 66, 817-820 (2000).
    • (2000) Am. Surg. , vol.66 , pp. 817-820
    • Blair, S.1    Ellehorn, J.D.2
  • 29
    • 1842377447 scopus 로고    scopus 로고
    • Improved survival with preoperative radiotherapy in resectable rectal cancer. Swedish Rectal Cancer Trial
    • No authors listed
    • No authors listed. Improved survival with preoperative radiotherapy in resectable rectal cancer. Swedish Rectal Cancer Trial. N. Engl. J. Med. 336, 980-987 (1997).
    • (1997) N. Engl. J. Med. , vol.336 , pp. 980-987
  • 30
    • 0031978182 scopus 로고    scopus 로고
    • Preoperative irradiation affects functional results after surgery for rectal cancer: Results from a randomized study
    • Dahlberg M, Glimelius B, Graf W et al. Preoperative irradiation affects functional results after surgery for rectal cancer: results from a randomized study. Dis. Colon Rectum 41, 543-549 (1998).
    • (1998) Dis. Colon Rectum , vol.41 , pp. 543-549
    • Dahlberg, M.1    Glimelius, B.2    Graf, W.3
  • 31
    • 0026664189 scopus 로고
    • Does preoperative radiation therapy enhance the probability of local control and survival in high-risk distal rectal cancer
    • Mendenhall WM, Bland KI, Copeland EM et al. Does preoperative radiation therapy enhance the probability of local control and survival in high-risk distal rectal cancer. Ann. Surg. 215, 696-706 (1992).
    • (1992) Ann. Surg. , vol.215 , pp. 696-706
    • Mendenhall, W.M.1    Bland, K.I.2    Copeland, E.M.3
  • 33
    • 0029093508 scopus 로고
    • Preoperative infusional chemoirradiation for Stage T3 rectal cancer
    • Rich TA, Skipper JM, Ajani JA et al. Preoperative infusional chemoirradiation for Stage T3 rectal cancer. Int. J. Radiat. Oncol. Biol. Phys. 32, 1025-1029 (1995).
    • (1995) Int. J. Radiat. Oncol. Biol. Phys. , vol.32 , pp. 1025-1029
    • Rich, T.A.1    Skipper, J.M.2    Ajani, J.A.3
  • 34
    • 0029057685 scopus 로고
    • Preoperative radiation and chemotherapy in the treatment of adenocarcinoma of the rectum
    • Chan RS, Tyler DS, Anscher MS et al. Preoperative radiation and chemotherapy in the treatment of adenocarcinoma of the rectum. Ann. Surg. 221, 779-787 (1995).
    • (1995) Ann. Surg. , vol.221 , pp. 779-787
    • Chan, R.S.1    Tyler, D.S.2    Anscher, M.S.3
  • 35
    • 0026558968 scopus 로고
    • Enhancement of radiation-induced downstaging of rectal cancer by 5-FU and high-dose leucovorin chemotherapy
    • Minsky BD, Cohen AM, Kemeny N et al. Enhancement of radiation-induced downstaging of rectal cancer by 5-FU and high-dose leucovorin chemotherapy. J. Clin. Oncol. 10, 79-84 (1992).
    • (1992) J. Clin. Oncol. , vol.10 , pp. 79-84
    • Minsky, B.D.1    Cohen, A.M.2    Kemeny, N.3
  • 36
    • 0031671241 scopus 로고    scopus 로고
    • Sphincter prevention with preoperative radiation therapy and coloanal anastomosis
    • Wagman R, Minsky BD, Cohen AM et al. Sphincter prevention with preoperative radiation therapy and coloanal anastomosis. Int. J. Radiat. Oncol. Biol. Phys. , 51-57 (1998).
    • (1998) Int. J. Radiat. Oncol. Biol. Phys. , pp. 51-57
    • Wagman, R.1    Minsky, B.D.2    Cohen, A.M.3
  • 37
    • 0028887770 scopus 로고
    • Conservative surgery for low rectal cancer after high dose radiation
    • Rouonet P, Fabre J, Dubois J et al. Conservative surgery for low rectal cancer after high dose radiation. Am. Surg. 221, 67-73 (1995).
    • (1995) Am. Surg. , vol.221 , pp. 67-73
    • Rouonet, P.1    Fabre, J.2    Dubois, J.3
  • 38
    • 0032006959 scopus 로고    scopus 로고
    • High dose preoperative radiation and the challenge of sphincter-preservation surgery for cancer of the distal rectum
    • Mohiuddin M, Rozine W, Marks G et al. High dose preoperative radiation and the challenge of sphincter-preservation surgery for cancer of the distal rectum. Int. J Radiat. Oncol. Biol. Phys. , 569-574 (1998).
    • (1998) Int. J Radiat. Oncol. Biol. Phys. , pp. 569-574
    • Mohiuddin, M.1    Rozine, W.2    Marks, G.3
  • 39
    • 0033984573 scopus 로고    scopus 로고
    • Preoperative radiochemotherapy in rectal cancer: Long-term results of a Phase II trial
    • Bosset JF, Magnin V, Maingon P et al. Preoperative radiochemotherapy in rectal cancer: long-term results of a Phase II trial. Int. J. Radiat. Oncol. Biol. Phys. 46, 323-327 (2000).
    • (2000) Int. J. Radiat. Oncol. Biol. Phys. , vol.46 , pp. 323-327
    • Bosset, J.F.1    Magnin, V.2    Maingon, P.3
  • 40
    • 0034010640 scopus 로고    scopus 로고
    • Sphincter-sparing surgery after preoperative radiotherapy for low rectal cancers: Feasibility, oncologic results and quality of life outcomes
    • Allal AS, Bieri S, Pelloni A et al. Sphincter-sparing surgery after preoperative radiotherapy for low rectal cancers: feasibility, oncologic results and quality of life outcomes. Br. J. Cancer 82, 1131-1137 (2000).
    • (2000) Br. J. Cancer , vol.82 , pp. 1131-1137
    • Allal, A.S.1    Bieri, S.2    Pelloni, A.3
  • 41
    • 22144462216 scopus 로고    scopus 로고
    • Does the addition of chemotherapy to preoperative radiation increase acute toxicity in patients with rectal cancer: Report of 22921 EORTC Phase III trial
    • (Abstract 1179)
    • Bosset J-F, Calais G, Daban A et al. Does the addition of chemotherapy to preoperative radiation increase acute toxicity in patients with rectal cancer: report of 22921 EORTC Phase III trial. Proc. Am. Soc. Clin. Oncol. (2003) (Abstract 1179).
    • (2003) Proc. Am. Soc. Clin. Oncol.
    • Bosset, J.-F.1    Calais, G.2    Daban, A.3
  • 42
    • 0034000894 scopus 로고    scopus 로고
    • Preoperative chemoradiation in fixed distal rectal cancer: Dose time factors for pathologic complete response
    • Mohiuddin M, Regine WF, John WJ et al. Preoperative chemoradiation in fixed distal rectal cancer: dose time factors for pathologic complete response. Int. J. Radiat. Oncol. Biol. Phys. 46, 883-888 (2000).
    • (2000) Int. J. Radiat. Oncol. Biol. Phys. , vol.46 , pp. 883-888
    • Mohiuddin, M.1    Regine, W.F.2    John, W.J.3
  • 43
    • 0032812135 scopus 로고    scopus 로고
    • Influence of the interval between preoperative radiation therapy and surgery on downstaging and on the rate of sphincter-sparing surgery for rectal cancer: The Lyon R90-01 randomized trial
    • Francois Y, Nemoz CJ, Baulieux J et al. Influence of the interval between preoperative radiation therapy and surgery on downstaging and on the rate of sphincter-sparing surgery for rectal cancer: the Lyon R90-01 randomized trial. J. Clin. Oncol. 17, 2396-22 (1999).
    • (1999) J. Clin. Oncol. , vol.17 , pp. 2396-2422
    • Francois, Y.1    Nemoz, C.J.2    Baulieux, J.3
  • 44
    • 8044239624 scopus 로고    scopus 로고
    • A clinical trial to evaluate the worth of preoperative multimodality therapy in patients with operable carcinoma of the rectum. A progress report of the National Surgical Adjuvant Breast and Bowel Project protocol R-03
    • Hyams DM, Mamounas EP, Petrelli N et al. A clinical trial to evaluate the worth of preoperative multimodality therapy in patients with operable carcinoma of the rectum. A progress report of the National Surgical Adjuvant Breast and Bowel Project protocol R-03. Dis. Colon Rectum , 131-139 (1997).
    • (1997) Dis. Colon Rectum , pp. 131-139
    • Hyams, D.M.1    Mamounas, E.P.2    Petrelli, N.3
  • 45
    • 0035045845 scopus 로고    scopus 로고
    • Adjuvant versus neoadjuvant radiochemotherapy for locally advanced rectal cancer: A progress report of a Phase III randomized trial
    • Sauer R, Fietkau R, Wittekind C et al. Adjuvant versus neoadjuvant radiochemotherapy for locally advanced rectal cancer: a progress report of a Phase III randomized trial. Strahlenther Onkol. 177, 173-181 (2001).
    • (2001) Strahlenther Onkol. , vol.177 , pp. 173-181
    • Sauer, R.1    Fietkau, R.2    Wittekind, C.3
  • 46
    • 0033000021 scopus 로고    scopus 로고
    • The incidence and clinical consequences of treatment-related bowel injury
    • Miller AR, Martenson JA, Nelson H et al. The incidence and clinical consequences of treatment-related bowel injury. Int. J. Radiat. Oncol. Biol. Phys. 43, 817-825 (1999).
    • (1999) Int. J. Radiat. Oncol. Biol. Phys. , vol.43 , pp. 817-825
    • Miller, A.R.1    Martenson, J.A.2    Nelson, H.3
  • 47
    • 0036006937 scopus 로고    scopus 로고
    • The dose-volume relationship of acute small bowel toxicity from concurrent 5-FU-based chemotherapy and radiation therapy for rectal cancer
    • Baglan KL, Frazier RC, Yan D et al. The dose-volume relationship of acute small bowel toxicity from concurrent 5-FU-based chemotherapy and radiation therapy for rectal cancer. Int. J. Radiat. Oncol. Biol. Phys. 52, 176-183 (2002).
    • (2002) Int. J. Radiat. Oncol. Biol. Phys. , vol.52 , pp. 176-183
    • Baglan, K.L.1    Frazier, R.C.2    Yan, D.3
  • 48
    • 0021873195 scopus 로고
    • Treatment planning for colorectal cancer: Radiation and surgical techniques and value of small-bowel films
    • Gunderson LL, Russell AH, Llewellyn HJ et al. Treatment planning for colorectal cancer: radiation and surgical techniques and value of small-bowel films. Int. J. Radiat. Oncol. Biol. Phys. 11, 1379-1393 (1985).
    • (1985) Int. J. Radiat. Oncol. Biol. Phys. , vol.11 , pp. 1379-1393
    • Gunderson, L.L.1    Russell, A.H.2    Llewellyn, H.J.3
  • 49
    • 0027397872 scopus 로고
    • Pelvic radiation therapy in rectal cancer: Technical considerations
    • Minsky BD. Pelvic radiation therapy in rectal cancer: technical considerations. Semin. Radiat. Oncol. 3, 42-47 (1993).
    • (1993) Semin. Radiat. Oncol. , vol.3 , pp. 42-47
    • Minsky, B.D.1
  • 50
    • 0032784713 scopus 로고    scopus 로고
    • Technical advances in the treatment of patients with rectal cancer
    • Willett CG. Technical advances in the treatment of patients with rectal cancer. Int. J. Radiat. Oncol. Biol. Phys. 45, 1107-1108 (1999).
    • (1999) Int. J. Radiat. Oncol. Biol. Phys. , vol.45 , pp. 1107-1108
    • Willett, C.G.1
  • 51
    • 0030826232 scopus 로고    scopus 로고
    • Efficacy of a belly board device with CT-simulation in reducing small bowel volume within pelvic irradiation fields
    • Das IJ, Lanciano RM, Movsas B et al. Efficacy of a belly board device with CT-simulation in reducing small bowel volume within pelvic irradiation fields. Int. J. Radiat. Oncol. Biol. Phys. 39, 67-76 (1997).
    • (1997) Int. J. Radiat. Oncol. Biol. Phys. , vol.39 , pp. 67-76
    • Das, I.J.1    Lanciano, R.M.2    Movsas, B.3
  • 52
    • 0343049020 scopus 로고    scopus 로고
    • Influence of treatment technique on dose-volume histogram and normal tissue complication probability for small bowel and bladder. A prospective study using a 3D planning system and a radiobiological model in patients receiving postoperative pelvic radiation
    • Kolbl O, Richter S, Flentje M. Influence of treatment technique on dose-volume histogram and normal tissue complication probability for small bowel and bladder. A prospective study using a 3D planning system and a radiobiological model in patients receiving postoperative pelvic radiation. Strahlenther Onkol. 176, 105-111 (2000).
    • (2000) Strahlenther Onkol. , vol.176 , pp. 105-111
    • Kolbl, O.1    Richter, S.2    Flentje, M.3
  • 53
    • 0036658220 scopus 로고    scopus 로고
    • Concurrent boost radiotherapy as preoperative treatment for locally advanced rectal carcinoma: A new beam arrangement
    • Capirci C, Valvo F, Salviato S et al. Concurrent boost radiotherapy as preoperative treatment for locally advanced rectal carcinoma: a new beam arrangement. Tumori 88, 325-330 (2002).
    • (2002) Tumori , vol.88 , pp. 325-330
    • Capirci, C.1    Valvo, F.2    Salviato, S.3
  • 54
    • 0000975098 scopus 로고    scopus 로고
    • The potential benefit of intensity modulated radiation therapy (IMRT) for rectal cancer
    • Robertson JM, Yan D, Girimonte PE et al. The potential benefit of intensity modulated radiation therapy (IMRT) for rectal cancer. Int. J. Radiat. Oncol. Biol. Phys. 45(Suppl. 3), 248 (1999).
    • (1999) Int. J. Radiat. Oncol. Biol. Phys. , vol.45 , Issue.SUPPL. 3 , pp. 248
    • Robertson, J.M.1    Yan, D.2    Girimonte, P.E.3
  • 55
    • 0034306879 scopus 로고    scopus 로고
    • Reduction of small and large bowel irradiation using an optimized intensity-modulated pelvic radiotherapy technique in patients with prostate cancer
    • Nutting CM, Convery DJ, Cosgrove VP et al. Reduction of small and large bowel irradiation using an optimized intensity-modulated pelvic radiotherapy technique in patients with prostate cancer. Int. J. Radiat. Oncol. Biol. Phys. 48, 649-656 (2000).
    • (2000) Int. J. Radiat. Oncol. Biol. Phys. , vol.48 , pp. 649-656
    • Nutting, C.M.1    Convery, D.J.2    Cosgrove, V.P.3
  • 56
    • 0034212424 scopus 로고    scopus 로고
    • Prospective trial of preoperative concomitant boost radiotherapy with continuous infusion 5-fluorouracil for locally advanced rectal cancer
    • Janjan NA, Crane CN, Feig BW et al. Prospective trial of preoperative concomitant boost radiotherapy with continuous infusion 5-fluorouracil for locally advanced rectal cancer. Int. J. Radiat. Oncol. Biol. Phys. 47, 713-718 (2000).
    • (2000) Int. J. Radiat. Oncol. Biol. Phys. , vol.47 , pp. 713-718
    • Janjan, N.A.1    Crane, C.N.2    Feig, B.W.3
  • 57
    • 0027442334 scopus 로고
    • Adjuvant postoperative accelerated hyperfractionated radiotherapy in rectal cancer: A feasibility study
    • Coucke PA, Cuttat JF, Mirimanoff RO. Adjuvant postoperative accelerated hyperfractionated radiotherapy in rectal cancer: a feasibility study. Int. J. Radiat. Oncol. Biol. Phys. 27, 885-889 (1993).
    • (1993) Int. J. Radiat. Oncol. Biol. Phys. , vol.27 , pp. 885-889
    • Coucke, P.A.1    Cuttat, J.F.2    Mirimanoff, R.O.3
  • 58
    • 0028927446 scopus 로고
    • The rationale to switch from postoperative hyperfractionated accelerated radiotherapy to preoperative hyperfractionated accelerated radiotherapy in rectal cancer
    • Coucke PA, Sartorelli B, Cuttat JF et al. The rationale to switch from postoperative hyperfractionated accelerated radiotherapy to preoperative hyperfractionated accelerated radiotherapy in rectal cancer. Int. J. Radiat. Oncol. Biol. Phys. 32, 181-188 (1995).
    • (1995) Int. J. Radiat. Oncol. Biol. Phys. , vol.32 , pp. 181-188
    • Coucke, P.A.1    Sartorelli, B.2    Cuttat, J.F.3
  • 59
    • 0037111297 scopus 로고    scopus 로고
    • Preoperative hyperfractionated radiotherapy for locally advanced rectal cancers: A Phase I-IIs trial
    • Allal AS, Bieri S, Brundler MA et al. Preoperative hyperfractionated radiotherapy for locally advanced rectal cancers: a Phase I-IIs trial. Int. J. Radiat. Oncol. Biol. Phys. 54, 1076-1081 (2002).
    • (2002) Int. J. Radiat. Oncol. Biol. Phys. , vol.54 , pp. 1076-1081
    • Allal, A.S.1    Bieri, S.2    Brundler, M.A.3
  • 60
    • 0000593543 scopus 로고
    • In vitro study on the anti-oxidant activities of amifostine (wr-2721)
    • Ohnishi ST, Ohnishi T. Glick JH et al. In vitro study on the anti-oxidant activities of amifostine (wr-2721). Proc. Am. Assoc. Cancer Res. 33, 419 (1992).
    • (1992) Proc. Am. Assoc. Cancer Res. , vol.33 , pp. 419
    • Ohnishi, S.T.1    Ohnishi, T.2    Glick, J.H.3
  • 61
    • 0021914053 scopus 로고
    • Alkaline phophatase promotes radioprotection and accumulation of WR-1065 in V79-171 cellls incubated in medium containing WR-2721
    • Calabro-Jones PM, Fahey RC, Smoluk GD, et al. Alkaline phophatase promotes radioprotection and accumulation of WR-1065 in V79-171 cellls incubated in medium containing WR-2721. Int. J Radiat. Oncol. Biol. Phys. 47, 23-27 (1985).
    • (1985) Int. J Radiat. Oncol. Biol. Phys. , vol.47 , pp. 23-27
    • Calabro-Jones, P.M.1    Fahey, R.C.2    Smoluk, G.D.3
  • 62
    • 0026596470 scopus 로고
    • Use of radiation with or without WR-2721 in advanced rectal cancer
    • Liu T, Liu Y, He S et al. Use of radiation with or without WR-2721 in advanced rectal cancer. Cancer 69, 2820-2825 (1992).
    • (1992) Cancer , vol.69 , pp. 2820-2825
    • Liu, T.1    Liu, Y.2    He, S.3
  • 63
    • 0043177761 scopus 로고    scopus 로고
    • Randomized Phase III trial of chemoradiation treatment +/- amifostine in patients with colorectal cancer
    • (Abstract 1176)
    • Antonadou D, Athanassiou H, Sarris G et al. Randomized Phase III trial of chemoradiation treatment +/- amifostine in patients with colorectal cancer. Proc. Am. Soc. Clin. Oncol. (2003) (Abstract 1176).
    • (2003) Proc. Am. Soc. Clin. Oncol.
    • Antonadou, D.1    Athanassiou, H.2    Sarris, G.3
  • 64
    • 0033817226 scopus 로고    scopus 로고
    • Intermittent use of amifostine during postoperative radiochemotherapy and acute toxicity in rectal cancer patients
    • Dunst J, Semlin S, Pigorsch S et al. Intermittent use of amifostine during postoperative radiochemotherapy and acute toxicity in rectal cancer patients. Strahlenther Onkol. 176, 416-421 (2000).
    • (2000) Strahlenther Onkol. , vol.176 , pp. 416-421
    • Dunst, J.1    Semlin, S.2    Pigorsch, S.3
  • 65
    • 0036984492 scopus 로고    scopus 로고
    • Early results from a Phase I-II radiation dose-escalation study with concurrent amifostine and infusional 5-fluorouracil chemotherapy for preoperative treatment of unresectable or locally recurrent rectal cancer
    • Myerson R, Zobeiri I, Birnbaum E et al. Early results from a Phase I-II radiation dose-escalation study with concurrent amifostine and infusional 5-fluorouracil chemotherapy for preoperative treatment of unresectable or locally recurrent rectal cancer. Semin. Oncol. 29(Suppl. 19), 29-33 (2002).
    • (2002) Semin. Oncol. , vol.29 , Issue.SUPPL. 19 , pp. 29-33
    • Myerson, R.1    Zobeiri, I.2    Birnbaum, E.3
  • 66
    • 0008590833 scopus 로고    scopus 로고
    • Oxaliplatin: In vitro and in vivo evidence of its radiosensitizing activity - Preclinical observations relevant to ongoing clinical trials
    • (Abstract)
    • Blackstock A, Hess S. Oxaliplatin: in vitro and in vivo evidence of its radiosensitizing activity - preclinical observations relevant to ongoing clinical trials. Proc. Am. Assoc. Cancer Res. 41, 53 (2000) (Abstract).
    • (2000) Proc. Am. Assoc. Cancer Res. , vol.41 , pp. 53
    • Blackstock, A.1    Hess, S.2
  • 67
    • 0035340318 scopus 로고    scopus 로고
    • Addition of oxaliplatin to continuous fluorouracil, 1-folinic acid and concomitant radiotherapy in rectal cancer: The Lyon R 97-03 Phase I trial
    • Freyer G, Bossard N, Romestaing P et al. Addition of oxaliplatin to continuous fluorouracil, 1-folinic acid and concomitant radiotherapy in rectal cancer: the Lyon R 97-03 Phase I trial. J. Clin. Oncol. 19, 2433-2438 (2001).
    • (2001) J. Clin. Oncol. , vol.19 , pp. 2433-2438
    • Freyer, G.1    Bossard, N.2    Romestaing, P.3
  • 68
    • 0037445116 scopus 로고    scopus 로고
    • Preoperative concurrent chemoradiotherapy in locally advanced rectal cancer with high-dose radiation and oxaliplatin-containing regimen: The Lyon R0-04 Phase II trial
    • Gérard J-P, Chapet O, Nemoz C et al. Preoperative concurrent chemoradiotherapy in locally advanced rectal cancer with high-dose radiation and oxaliplatin-containing regimen: the Lyon R0-04 Phase II trial. J Clin. Oncol. 21, 1119-1124 (2003).
    • (2003) J. Clin. Oncol. , vol.21 , pp. 1119-1124
    • Gérard, J.-P.1    Chapet, O.2    Nemoz, C.3
  • 69
    • 0042955225 scopus 로고    scopus 로고
    • Raltitrexed and oxaliplatin preliminary results of a Phase II study of chemoradiation with preoperative treatment of Stage II/III resectable rectal cancer
    • (Abstract)
    • Valentini V, Morganti AG, Romestaing P et al. Raltitrexed and oxaliplatin preliminary results of a Phase II study of chemoradiation with preoperative treatment of Stage II/III resectable rectal cancer. Proc. Am. Soc. Clin. Oncol. 21, 151 (2002) (Abstract).
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21 , pp. 151
    • Valentini, V.1    Morganti, A.G.2    Romestaing, P.3
  • 70
    • 0012722437 scopus 로고    scopus 로고
    • A Phase I-II study of weekly oxaliplatin, 5-FU continuous infusion and preoperative radiotherapy in locally advanced rectal cancer
    • Schele C, Frisco ML, Puriarella S et al. A Phase I-II study of weekly oxaliplatin, 5-FU continuous infusion and preoperative radiotherapy in locally advanced rectal cancer. Proc. Am. Soc. Clin. Oncol. 21 (2002).
    • (2002) Proc. Am. Soc. Clin. Oncol. , pp. 21
    • Schele, C.1    Frisco, M.L.2    Puriarella, S.3
  • 71
    • 0043177758 scopus 로고    scopus 로고
    • ECOG 1297: A Phase I study of preoperative radiation therapy (RT) with concurrent protracted continuous infusion 5-FU and dose escalating oxaliplatin followed by surgery, adjuvant 5-FU and leucovorin for locally advanced (T3/4) rectal adenocarcinoma
    • (Abstract 1094)
    • Rosenthal DI, Catalano D, Haller DG et al. ECOG 1297: a Phase I study of preoperative radiation therapy (RT) with concurrent protracted continuous infusion 5-FU and dose escalating oxaliplatin followed by surgery, adjuvant 5-FU and leucovorin for locally advanced (T3/4) rectal adenocarcinoma. Proc. Am. Soc. Clin. Oncol. (2003) (Abstract 1094).
    • (2003) Proc. Am. Soc. Clin. Oncol.
    • Rosenthal, D.I.1    Catalano, D.2    Haller, D.G.3
  • 72
    • 0030900289 scopus 로고    scopus 로고
    • SN-38, a metabolite of the camptothecan derivative CPT-11, potentiates the cytotoxic effect of radiation in human colon adenocarcinoma cells grown as spheroids
    • Omura M, Torigoe S, Kubota N. SN-38, a metabolite of the camptothecan derivative CPT-11, potentiates the cytotoxic effect of radiation in human colon adenocarcinoma cells grown as spheroids. Radiother. Oncol. 43, 197-201 (1997).
    • (1997) Radiother. Oncol. , vol.43 , pp. 197-201
    • Omura, M.1    Torigoe, S.2    Kubota, N.3
  • 73
    • 0042175557 scopus 로고    scopus 로고
    • Chemoradiation with CPT-11, 5FU in neoadjuvant treatment of locally advanced or recurrent adenocarcinoma of the rectum: A Phase I/II study update
    • (Abstract 1052)
    • Mitchell E, Anne P, Fry R et al. Chemoradiation with CPT-11, 5FU in neoadjuvant treatment of locally advanced or recurrent adenocarcinoma of the rectum: a Phase I/II study update. Proc. Am. Soc. Clin. Oncol. (2003) (Abstract 1052).
    • (2003) Proc. Am. Soc. Clin. Oncol.
    • Mitchell, E.1    Anne, P.2    Fry, R.3
  • 74
    • 0347298702 scopus 로고    scopus 로고
    • Phase II trial of preoperative 3D conformal radiotherapy, protracted venows infusion 5-fluorouracil and weekly CPT-11, followed by surgery for ultrasound-staged T3 rectal cancer
    • Mehra VK, Cho C, Ford JM et al. Phase II trial of preoperative 3D conformal radiotherapy, protracted venows infusion 5-fluorouracil and weekly CPT-11, followed by surgery for ultrasound-staged T3 rectal cancer. Int. J. Radiat. Oncol. Biol. Phys. 55, 132-137 (2003).
    • (2003) Int. J. Radiat. Oncol. Biol. Phys. , vol.55 , pp. 132-137
    • Mehra, V.K.1    Cho, C.2    Ford, J.M.3
  • 75
    • 0031671255 scopus 로고    scopus 로고
    • Open, randomized, multicenter trial of raltitrexed versus fluofouracil plus high-dose leucovorin in patients with advanced colorectal cancer
    • Cocconi G, Cunningham D, Van Cutsem E et al. Open, randomized, multicenter trial of raltitrexed versus fluofouracil plus high-dose leucovorin in patients with advanced colorectal cancer. J. Clin. Oncol. 16, 2943-2952 (1998).
    • (1998) J. Clin. Oncol. , vol.16 , pp. 2943-2952
    • Cocconi, G.1    Cunningham, D.2    Van Cutsem, E.3
  • 76
    • 0038157031 scopus 로고    scopus 로고
    • Raltitrexed plus radiotherapy for the treatment of unresectable/recurrent rectal cancer: A Phase I study
    • James RD, Botwood N, Vernon CC et al. Raltitrexed plus radiotherapy for the treatment of unresectable/recurrent rectal cancer: a Phase I study. Ann. Oncol. 14, 570-573 (2003).
    • (2003) Ann. Oncol. , vol.14 , pp. 570-573
    • James, R.D.1    Botwood, N.2    Vernon, C.C.3
  • 77
    • 0034773727 scopus 로고    scopus 로고
    • Preoperative chemoradiation with raltitrexed (Tomudex) for T2/N+ and T3/N+ rectal cancers: A Phase I study
    • Valentini V, Doglietto GB, Morganti AG et al. Preoperative chemoradiation with raltitrexed (Tomudex) for T2/N+ and T3/N+ rectal cancers: a Phase I study. Eur. J. Cancer 37, 2050-2055 (2001).
    • (2001) Eur. J. Cancer , vol.37 , pp. 2050-2055
    • Valentini, V.1    Doglietto, G.B.2    Morganti, A.G.3
  • 78
    • 0033371543 scopus 로고    scopus 로고
    • Phase II study of raltitrexed (Tomudex) in chemotherapy-pretreated patients with advanced colorectal cancer
    • Tomudex Cooperative Study Group
    • Sato A, Kurihara M, Horikoshi N et al. Phase II study of raltitrexed (Tomudex) in chemotherapy-pretreated patients with advanced colorectal cancer. Tomudex Cooperative Study Group. Anticancer Drugs 10, 741-748 (1999).
    • (1999) Anticancer Drugs , vol.10 , pp. 741-748
    • Sato, A.1    Kurihara, M.2    Horikoshi, N.3
  • 79
    • 0037236085 scopus 로고    scopus 로고
    • Oxaliplatin plus raltitrexed in the treatment of patients with advanced colorectal cancer: A Phase II study
    • Martoni A, Mini E, Pinto C et al. Oxaliplatin plus raltitrexed in the treatment of patients with advanced colorectal cancer: a Phase II study. Anticancer Res. 23, 687-691 (2003).
    • (2003) Anticancer Res. , vol.23 , pp. 687-691
    • Martoni, A.1    Mini, E.2    Pinto, C.3
  • 80
    • 0026324313 scopus 로고
    • Action of 2′,2′-difluorodeoxycytidine on DNA synthesis
    • Huang P, Chubb S, Hertel LW et al. Action of 2′,2′-difluorodeoxycytidine on DNA synthesis. Cancer Res. 51, 6110-6117 (1991).
    • (1991) Cancer Res. , vol.51 , pp. 6110-6117
    • Huang, P.1    Chubb, S.2    Hertel, L.W.3
  • 81
    • 0027076297 scopus 로고
    • Phase II study of gemcitabine in advanced colorectal adenocarcinoma
    • Moore DF Jr, Pazdur R, Daugherty K et al. Phase II study of gemcitabine in advanced colorectal adenocarcinoma. Invest. New Drugs 10, 323-325 (1992).
    • (1992) Invest. New Drugs , vol.10 , pp. 323-325
    • Moore D.F., Jr.1    Pazdur, R.2    Daugherty, K.3
  • 82
    • 0032428290 scopus 로고    scopus 로고
    • Phase II trial of 150-minute weekly infusion of gemcitabine in advanced colorectal cancer: Minimal activity in colorectal cancer
    • Mani S, Kugler JW, Knost JA et al. Phase II trial of 150-minute weekly infusion of gemcitabine in advanced colorectal cancer: minimal activity in colorectal cancer. Invest. New Drugs 16, 275-278 (1998).
    • (1998) Invest. New Drugs , vol.16 , pp. 275-278
    • Mani, S.1    Kugler, J.W.2    Knost, J.A.3
  • 83
    • 0034668075 scopus 로고    scopus 로고
    • Phase I chemotherapy study of biochemical modulation of folinic acid and fluorouracil by gemcitabine in patients with solid tumor malignancies
    • Madajewicz S, Hentschel P, Burns P et al. Phase I chemotherapy study of biochemical modulation of folinic acid and fluorouracil by gemcitabine in patients with solid tumor malignancies. J. Clin. Oncol. 15, 3553-3557 (2000).
    • (2000) J. Clin. Oncol. , vol.15 , pp. 3553-3557
    • Madajewicz, S.1    Hentschel, P.2    Burns, P.3
  • 85
    • 0031868962 scopus 로고    scopus 로고
    • UFT and leucovorin: A review of its clinical development and therapeutic potential in the oral treatment of cancer
    • Hoff PM, Pazdur R, Benner SE et al. UFT and leucovorin: a review of its clinical development and therapeutic potential in the oral treatment of cancer. Anticancer Drugs 9, 479-490 (1998).
    • (1998) Anticancer Drugs , vol.9 , pp. 479-490
    • Hoff, P.M.1    Pazdur, R.2    Benner, S.E.3
  • 86
    • 0036731818 scopus 로고    scopus 로고
    • Multicenter Phase III study of uracil/tegafur and oral leucovorin versus fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer
    • Douillard JY, Hoff PM, Skillings JR et al. Multicenter Phase III study of uracil/tegafur and oral leucovorin versus fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer. J. Clin. Oncol. 20, 3605-3616 (2002).
    • (2002) J. Clin. Oncol. , vol.20 , pp. 3605-3616
    • Douillard, J.Y.1    Hoff, P.M.2    Skillings, J.R.3
  • 87
    • 0036727089 scopus 로고    scopus 로고
    • Randomized comparative study of tegafur/uracil and oral leucovorin versus parenteral fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer
    • Carmichael J, Popiela T, Radstone D et al. Randomized comparative study of tegafur/uracil and oral leucovorin versus parenteral fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer. J. Clin. Oncol. 20, 617-627 (2002).
    • (2002) J. Clin. Oncol. , vol.20 , pp. 617-627
    • Carmichael, J.1    Popiela, T.2    Radstone, D.3
  • 88
    • 0034667864 scopus 로고    scopus 로고
    • Phase I study of preoperative oral uracil and tegafur plus leucovorin and radiation therapy in rectal cancer
    • Hoff PM, Janjan N, Saad ED et al. Phase I study of preoperative oral uracil and tegafur plus leucovorin and radiation therapy in rectal cancer. J. Clin. Oncol. 18, 3529-3534 (2000).
    • (2000) J. Clin. Oncol. , vol.18 , pp. 3529-3534
    • Hoff, P.M.1    Janjan, N.2    Saad, E.D.3
  • 89
    • 0032850210 scopus 로고    scopus 로고
    • Phase II study of radiochemotherapy with UFT and low-dose oral leucovorin in patients with unresectable rectal cancer
    • De la Torre A, Ramos S, Valcarcel FJ et al. Phase II study of radiochemotherapy with UFT and low-dose oral leucovorin in patients with unresectable rectal cancer. Int. J. Radiat. Oncol. Biol. Phys. 45, 629-634 (1999).
    • (1999) Int. J. Radiat. Oncol. Biol. Phys. , vol.45 , pp. 629-634
    • De la Torre, A.1    Ramos, S.2    Valcarcel, F.J.3
  • 90
    • 0035985283 scopus 로고    scopus 로고
    • Neoadjuvant therapy of rectal carcinoma with UFT-leucovorin plus radiotherapy
    • Feliu J, Calvillo J, Escribano A et al. Neoadjuvant therapy of rectal carcinoma with UFT-leucovorin plus radiotherapy. Ann. Oncol. 13, 730-736 (2002).
    • (2002) Ann. Oncol. , vol.13 , pp. 730-736
    • Feliu, J.1    Calvillo, J.2    Escribano, A.3
  • 91
    • 0036787579 scopus 로고    scopus 로고
    • Phase I trial evaluating the concurrent combination of radiotherapy and capecitabine in rectal cancer
    • Dunst J, Reese T, Sutter T et al Phase I trial evaluating the concurrent combination of radiotherapy and capecitabine in rectal cancer. J. Clin. Oncol. 20, 3983-3991 (2002).
    • (2002) J. Clin. Oncol. , vol.20 , pp. 3983-3991
    • Dunst, J.1    Reese, T.2    Sutter, T.3
  • 92
    • 0043177757 scopus 로고    scopus 로고
    • Capecitabine combined with radiotherapy as neoadjuvant treatment of locally advanced rectal cancer
    • (Abstract 1113)
    • Dunst J, Reese T, Hoelscher V et al. Capecitabine combined with radiotherapy as neoadjuvant treatment of locally advanced rectal cancer. Proc. Am. Soc. Clin. Oncol. (2003) (Abstract 1113).
    • (2003) Proc. Am. Soc. Clin. Oncol.
    • Dunst, J.1    Reese, T.2    Hoelscher, V.3
  • 93
    • 0036804343 scopus 로고    scopus 로고
    • Preoperative chemoradiation using oral capecitabine in locally advanced rectal cancer
    • Kim J-S, Kim J-S, Cho M-J et al. Preoperative chemoradiation using oral capecitabine in locally advanced rectal cancer. Int. J. Radiat. Oncol. Biol. Phys. 54, 3-8 (2002).
    • (2002) Int. J. Radiat. Oncol. Biol. Phys. , vol.54 , pp. 3-8
    • Kim, J.-S.1    Kim, J.-S.2    Cho, M.-J.3
  • 94
    • 0033199927 scopus 로고    scopus 로고
    • Enhancement of tumor response to γ-radiation by an inhibitor of cyclooxygenase-2 enzyme
    • Milas L, Kishi K, Hunter N et al. Enhancement of tumor response to γ-radiation by an inhibitor of cyclooxygenase-2 enzyme. J. Natl Cancer Inst 91, 1501-1504 (1999).
    • (1999) J. Natl. Cancer Inst. , vol.91 , pp. 1501-1504
    • Milas, L.1    Kishi, K.2    Hunter, N.3
  • 95
    • 0037010076 scopus 로고    scopus 로고
    • Overview of epidermal growth factor receptor biology and its role as a therapeutic target in human neoplasia
    • Arteaga CL. Overview of epidermal growth factor receptor biology and its role as a therapeutic target in human neoplasia. Semin. Oncol 29(Suppl. 14), 3-9 (2002).
    • (2002) Semin. Oncol. , vol.29 , Issue.SUPPL. 14 , pp. 3-9
    • Arteaga, C.L.1
  • 96
    • 0036934482 scopus 로고    scopus 로고
    • Expression of cyclooxygenase-2 protein in colorectal carcinomas
    • Joo YE, Kim HS, Min SW et al. Expression of cyclooxygenase-2 protein in colorectal carcinomas. Int. J. Gastrointest. Cancer 31, 147-154 (2002).
    • (2002) Int. J. Gastrointest. Cancer , vol.31 , pp. 147-154
    • Joo, Y.E.1    Kim, H.S.2    Min, S.W.3
  • 97
    • 0036891110 scopus 로고    scopus 로고
    • Epidermal growth factor receptor is a predictor of tumor response in locally advanced rectal cancer patients treated with preoperative radiotherapy
    • Giralt J, Eraso A, Armengol M et al. Epidermal growth factor receptor is a predictor of tumor response in locally advanced rectal cancer patients treated with preoperative radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 54, 1460-1465 (2002).
    • (2002) Int. J. Radiat. Oncol. Biol. Phys. , vol.54 , pp. 1460-1465
    • Giralt, J.1    Eraso, A.2    Armengol, M.3
  • 98
    • 0036842170 scopus 로고    scopus 로고
    • Phase I safety, pharmacokinetic and pharmacodynamic trial of ZD1839, a selective oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with five selected solid tumor types
    • Baselga J, Rischin D, Ranson M et al. Phase I safety, pharmacokinetic and pharmacodynamic trial of ZD1839, a selective oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with five selected solid tumor types. J. Clin. Oncol. 20, 4292-4302 (2002).
    • (2002) J. Clin. Oncol. , vol.20 , pp. 4292-4302
    • Baselga, J.1    Rischin, D.2    Ranson, M.3
  • 99
    • 0036569870 scopus 로고    scopus 로고
    • ZD1839, a selective oral epidermal growth factor receptor-tyrosine kinase inhibitor, is well-tolerated and active in patients with solid, malignant tumors: Results of a Phase I trial
    • Ranson M, Hammond LA, Ferry D et al. ZD1839, a selective oral epidermal growth factor receptor-tyrosine kinase inhibitor, is well-tolerated and active in patients with solid, malignant tumors: results of a Phase I trial. J. Clin. Oncol. 20, 22-2250 (2002).
    • (2002) J. Clin. Oncol. , vol.20 , pp. 22-2250
    • Ranson, M.1    Hammond, L.A.2    Ferry, D.3
  • 100
    • 0037106377 scopus 로고    scopus 로고
    • Selective oral epidermal growth factor receptor tyrosine kinase inhibitor ZD 1839 is generally well-tolerated and has activity in non-small cell lung cancer and other solid tumors: Results of a Phase I study
    • Herbst RS, Maddox AM, Rothenberg ML et al. Selective oral epidermal growth factor receptor tyrosine kinase inhibitor ZD 1839 is generally well-tolerated and has activity in non-small cell lung cancer and other solid tumors: results of a Phase I study. J. Clin. Oncol. 20, 3815-3825 (2002).
    • (2002) J. Clin. Oncol. , vol.20 , pp. 3815-3825
    • Herbst, R.S.1    Maddox, A.M.2    Rothenberg, M.L.3
  • 101
    • 0036984738 scopus 로고    scopus 로고
    • Tumor angiogenesis and accessibility: Role of vascular endothelial growth factor
    • Jain RK. Tumor angiogenesis and accessibility: role of vascular endothelial growth factor. Semin. Oncol. 29(Suppl. 16), 3-9 (2002).
    • (2002) Semin. Oncol. , vol.29 , Issue.SUPPL. 16 , pp. 3-9
    • Jain, R.K.1
  • 102
    • 0036985699 scopus 로고    scopus 로고
    • Role of vascular endothelial growth factor in physiologic and pathologic angiogenesis: Therapeutic implications
    • Ferrara N. Role of vascular endothelial growth factor in physiologic and pathologic angiogenesis: therapeutic implications. Semin. Oncol. 29(Suppl. 16), 10-14 (2002).
    • (2002) Semin. Oncol. , vol.29 , Issue.SUPPL. 16 , pp. 10-14
    • Ferrara, N.1
  • 103
    • 0037636709 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor D is associated with lymph node metastasis in human colorectal carcinoma
    • Funaki H, Nishimura G, Harada S et al. Expression of vascular endothelial growth factor D is associated with lymph node metastasis in human colorectal carcinoma. Oncology 64, 416-422 (2003).
    • (2003) Oncology , vol.64 , pp. 416-422
    • Funaki, H.1    Nishimura, G.2    Harada, S.3
  • 104
    • 18344388638 scopus 로고    scopus 로고
    • An analysis of p53, Bax and vascular endothelial growth factor expression in node-positive rectal cancer. Relationships with tumour recurrence and event-free survival of patients treated with adjuvant chemoradiation
    • Cascinu S, Graziano F, Catalano V et al. An analysis of p53, Bax and vascular endothelial growth factor expression in node-positive rectal cancer. Relationships with tumour recurrence and event-free survival of patients treated with adjuvant chemoradiation. Br. J. Cancer 86, 744-749 (2002).
    • (2002) Br. J. Cancer , vol.86 , pp. 744-749
    • Cascinu, S.1    Graziano, F.2    Catalano, V.3
  • 105
    • 0034255151 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is an in vitro survival factor for tumor endothlium in a murine model of colorectal carcinoma liver metastases
    • Bruns CJ, Liu W, Davis DW et al. Vascular endothelial growth factor is an in vitro survival factor for tumor endothlium in a murine model of colorectal carcinoma liver metastases. Cancer 89, 488-499 (2000).
    • (2000) Cancer , vol.89 , pp. 488-499
    • Bruns, C.J.1    Liu, W.2    Davis, D.W.3
  • 106
    • 0043177668 scopus 로고    scopus 로고
    • Bevacizumab (Avastin, a monoclonal antibody to vascular endothelial growth factor) prolongs survival in first-line colorectal cancer (CRC): Results of a Phase III trial of bevacizumab in combination with bolus IFL (irinotecan, 5-fluorouracil, leucovorin) as first-line therapy in subjects with metastatic CRC
    • Hurwitz H, Fehrenbacher L, Cartwright T et al. Bevacizumab (Avastin, a monoclonal antibody to vascular endothelial growth factor) prolongs survival in first-line colorectal cancer (CRC): results of a Phase III trial of bevacizumab in combination with bolus IFL (irinotecan, 5-fluorouracil, leucovorin) as first-line therapy in subjects with metastatic CRC. Proc. Am. Soc. Clin. Oncol. 22, 2107 (2003).
    • (2003) Proc. Am. Soc. Clin. Oncol. , vol.22 , pp. 2107
    • Hurwitz, H.1    Fehrenbacher, L.2    Cartwright, T.3
  • 107
    • 0035045195 scopus 로고    scopus 로고
    • Improved overall survival among responders to preoperativc chemoradiation for locally advanced rectal cancer
    • Janjan NA, Crane C, Feig BW et al. Improved overall survival among responders to preoperativc chemoradiation for locally advanced rectal cancer. Am. J. Clin. Oncol. 24, 107-112 (2001).
    • (2001) Am. J. Clin. Oncol. , vol.24 , pp. 107-112
    • Janjan, N.A.1    Crane, C.2    Feig, B.W.3
  • 108
    • 0034333264 scopus 로고    scopus 로고
    • Prognostic significance of postchemoradiation stage following preoperative chemotherapy and radiation for advanced/recurrent rectal cancers
    • Mohiuddin M, Hayne M, Regine WF et al. Prognostic significance of postchemoradiation stage following preoperative chemotherapy and radiation for advanced/recurrent rectal cancers. Int. J. Radiat. Oncol. Biol. Phys. 48, 1075-1080 (2000).
    • (2000) Int. J. Radiat. Oncol. Biol. Phys. , vol.48 , pp. 1075-1080
    • Mohiuddin, M.1    Hayne, M.2    Regine, W.F.3
  • 109
    • 0029016835 scopus 로고
    • Tumor proliferation in rectal cancer following preoperative irradiation
    • Willett CG, Warland G, Hagan MP et al. Tumor proliferation in rectal cancer following preoperative irradiation. J. Clin. Oncol. 13, 1417-1424 (1995).
    • (1995) J. Clin. Oncol. , vol.13 , pp. 1417-1424
    • Willett, C.G.1    Warland, G.2    Hagan, M.P.3
  • 110
    • 0033887695 scopus 로고    scopus 로고
    • Alteration of DNA ploidy status and cell proliferation induced by preoperative radiotherapy is a prognostic factor in rectal cancer
    • Lammering G, Taher MM, Gruenagel H et al. Alteration of DNA ploidy status and cell proliferation induced by preoperative radiotherapy is a prognostic factor in rectal cancer. Clin. Cancer Res. 6, 3215-3222 (2000).
    • (2000) Clin. Cancer Res. , vol.6 , pp. 3215-3222
    • Lammering, G.1    Taher, M.M.2    Gruenagel, H.3
  • 111
    • 0031963120 scopus 로고    scopus 로고
    • Role of p53 and p21 /WAF1 detection in patient selection for preoperative radiotherapy in rectal cancer patients
    • Fu CG, Tominaga O, Nagawa H et al. Role of p53 and p21 /WAF1 detection in patient selection for preoperative radiotherapy in rectal cancer patients. Dis. Colon Rectum 41, 68-74 (1998).
    • (1998) Dis. Colon Rectum , vol.41 , pp. 68-74
    • Fu, C.G.1    Tominaga, O.2    Nagawa, H.3
  • 112
    • 0344701057 scopus 로고    scopus 로고
    • Apoptosis, proliferation, bax, bcl-2 and p53 status prior to and after preoperative radiochemotherapy for locally advanced rectal cancer
    • Tannapfel A, Nublein S, Fietkau R et al. Apoptosis, proliferation, bax, bcl-2 and p53 status prior to and after preoperative radiochemotherapy for locally advanced rectal cancer. Int. J. Radiat. Oncol. Biol. Phys. 41, 585-591 (1998).
    • (1998) Int. J. Radiat. Oncol. Biol. Phys. , vol.41 , pp. 585-591
    • Tannapfel, A.1    Nublein, S.2    Fietkau, R.3
  • 113
    • 0034254821 scopus 로고    scopus 로고
    • Can p53 alterations be used to predict tumour response to pre-operative chemotherapy in locally advanced rectal cancer?
    • Elsaleh H, Robbins P, Joseph D et al. Can p53 alterations be used to predict tumour response to pre-operative chemotherapy in locally advanced rectal cancer? Radiother. Oncol. 56, 239-244 (2000).
    • (2000) Radiother. Oncol. , vol.56 , pp. 239-244
    • Elsaleh, H.1    Robbins, P.2    Joseph, D.3
  • 114
    • 0012086347 scopus 로고    scopus 로고
    • Epidermal growth factor is a predictor of tumor response in locally advanced rectal cancer patients treated with preoperatice radiotherapy
    • Giralt J, Eraso A, de Torres I et al. Epidermal growth factor is a predictor of tumor response in locally advanced rectal cancer patients treated with preoperatice radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 51, 10 (2001).
    • (2001) Int. J. Radiat. Oncol. Biol. Phys. , vol.51 , pp. 10
    • Giralt, J.1    Eraso, A.2    de Torres, I.3
  • 115
    • 0033994163 scopus 로고    scopus 로고
    • Molecular prognostic factors in rectal cancer treated by radiation and surgery
    • Qiu H, Sirivongs P, Rothenberger M et al. Molecular prognostic factors in rectal cancer treated by radiation and surgery. Dis. Colon Rectum 43, 451-459 (2000).
    • (2000) Dis. Colon Rectum , vol.43 , pp. 451-459
    • Qiu, H.1    Sirivongs, P.2    Rothenberger, M.3
  • 116
    • 0034087575 scopus 로고    scopus 로고
    • Thymidylate synthase expression: An independent prognostic factor for local recurrence, distant metastasis, disease-free and overall survival in rectal cancer
    • Edler D, Hallatrom M, Johnson PG et al. Thymidylate synthase expression: an independent prognostic factor for local recurrence, distant metastasis, disease-free and overall survival in rectal cancer. Clin. Cancer Res. 6, 1378-1384 (2000).
    • (2000) Clin. Cancer Res. , vol.6 , pp. 1378-1384
    • Edler, D.1    Hallatrom, M.2    Johnson, P.G.3
  • 117
    • 0030883708 scopus 로고    scopus 로고
    • Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin
    • Leichman CG, Lenz H, Leichman L et al. Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin. J. Clin. Oncol 15, 3223-3229 (1997).
    • (1997) J. Clin. Oncol , vol.15 , pp. 3223-3229
    • Leichman, C.G.1    Lenz, H.2    Leichman, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.