Preoperative chemoradiation in fixed distal rectal cancer: Dose time factors for pathological complete response

International Journal of Radiation Oncology Biology Physics

Volumn 46, Issue 4, 2000, Pages 883-888

  Mohiuddin, Mohammed ^a   Regine, William F ^a   John, William J ^b   Hagihara, Patrick F ^c   McGrath, Patrick C ^c   Kenady, Daniel E ^c   Marks, Gerald ^d  

^a Department of Radiation Medicine ^*  (United States)

^b Division of Hematology/Oncology   (United States)

^c UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

^d LANKENAU HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROURACIL;

ADULT; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTINUOUS INFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYSTITIS; DIARRHEA; DOSE TIME EFFECT RELATION; ENTERITIS; FEMALE; HUMAN; MALE; MUCOSA INFLAMMATION; MULTIMODALITY CANCER THERAPY; PREOPERATIVE RADIOTHERAPY; PRIORITY JOURNAL; RECTUM CANCER;

ADULT; AGED; AGED, 80 AND OVER; ANTIMETABOLITES, ANTINEOPLASTIC; COMBINED MODALITY THERAPY; DIARRHEA; FEMALE; FLUOROURACIL; HUMANS; MALE; MIDDLE AGED; NEOPLASM STAGING; NEOPLASM, RESIDUAL; PELVIC PAIN; PREOPERATIVE CARE; RADIOTHERAPY DOSAGE; RECTAL NEOPLASMS; SURVIVAL ANALYSIS; TIME FACTORS;

EID: 0034000894     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(99)00486-1     Document Type: Article

References (30)

1. Moertel C., Childs D., O'Fallon J. Combined 5-FU and radiation therapy as a surgical adjuvant for poor prognosis gastric carcinoma. J Clin Oncol. 2:1984;1249-1254.
2. John M., Pajak T., Flam M., et al. Dose acceleration in chemoradiation for anal cancer Preliminary results of RTOG 9208 . Cancer J Sci Am. 2:1996;205.
3. O'Connell M.J., Martenson J.A., Weiand H.S., et al. Improving adjuvant therapy for rectal cancer by combining protracted infusion fluorouracil with radiation therapy after curative surgery. N Engl J Med. 331:1994;502-507.
4. Fortier G.A., Constable W.C., Meyers H., Wanebo H.J. Preoperative radiation therapy for rectal cancer. Arch Surg. 121:1986;1380-1384.
5. Wong R., Thomas G., Cummings B., Froud P., Shelley W., Withers R., Williams J. In search of a dose-response relationship with radiotherapy in the management of recurrent rectal carcinoma in the pelvis A systematic review . Int J Radiat Oncol Phys. 40:1998;437-446.
6. Overgaard M., Overgaard J., Sell A. Dose-response relationship for radiation therapy of recurrent, residual, and primarily inoperable rectal cancer. Radiother Oncol. 1:1984;217-225.
7. Kaplan E.L., Meier P. Nonparametric estimations from incomplete observation. J Am Stat Assoc. 53:1958;457-463.
8. McDermott F.T., Hughes E.S.R., Pihl E., Johnson W.R., Price A.B. Local recurrence after potentially curative resection for rectal cancer in a series of 1008 patients. Br J Surg. 72:1985;34-37.
9. Pearlman N.W., Stiegmann G.V., Donohue R.E. Extended resection of fixed rectal cancer. Cancer. 63:1989;2438-2441.
10. Phillips R.K.S., Hittinger R., Blesovsky L., Fry J.S., Fielding L.P. Local recurrence following curative surgery for large bowel cancer II. The rectum and rectosigmoid . Br J Surg. 71:1984;17-20.
11. James R.D., Schofield P.F. Resection of 'inoperable' rectal cancer following radiotherapy. Br J Surg. 72:1985;279-281.
12. Tobin R.L., Mohiuddin M., Marks G. Preoperative irradiation for cancer of the rectum with extrarectal fixation. Int J Radiat Oncol Biol Phys. 21:1991;1127-1132.
13. Willett C.G., Shellito P.C., Rodkey G.V., Wood W.C. Preoperative irradiation for tethered rectal carcinoma. Radiother Oncol. 21:1991;141-142.
14. Dosoretz D.E., Gunderson L.L., Hedberg S., Hoskins B., Blitzer P.H., Shippley W., Cohen A. Preoperative irradiation for unresectable rectal and rectosigmoid carcinomas. Cancer. 52:1983;814-818.
15. Byfield J.E., Calabro-Jones P., Klisak I., Kulhanian F. Pharmacologic requirements for obtaining sensitization of human tumor cells in vitro to combine 5-fluorouracil or ftorafur and x-rays. Int J Radiat Oncol Biol Phys. 8:1982;1923-1933.
16. Byfield J.E., Chan P.Y.M., Seagren S. Radiosensitization by 5-fluorouracil (5-FU) Molecular and clinical scheduling implications . Proc Am Assoc Cancer Res. 18:1977;74.
17. Survival after postoperative combination treatment of rectal cancer. N Engl J Med. 315:1986;1294-1295.
18. Krook J.E., Moertel C.G., Gunderson L., et al. Effective surgical adjuvant therapy for high-risk rectal carcinoma. N Engl J Med. 324:1991;710-715.
19. Chen E.T., Mohiuddin M., Brodovsky H., Fishbein G., Marks G. Downstaging of advanced rectal cancer following combined preoperative chemotherapy and high dose radiation. Int J Radiat Oncol Biol Phys. 30:1994;169-175.
20. Landry J.C., Koretz M.J., Wood W.C., Bahn S., Smith R.G., Costa M., Daneker G.W., York M.R., Sarma P.R., Lynn M., Ward A.A., McGinley P., Davis L.W. Preoperative irradiation and fluorouracil chemotherapy for locally advanced rectosigmoid carcinoma Phase I-II study . Radiology. 188:1993;423-426.
21. Minsky B.D., Cohen A.M., Kemeny N., Enker W.E., Kelsen D.P., Reichman B., Saltz L., Sigurdson E.R., Frankel J. Enhancement of radiation-induced downstaging of rectal cancer by fluorouracil and high-dose leucovorin chemotherapy. J Clin Oncol. 10:1992;79-84.
22. Chan A., Wong A., Langevin J., Khoo R. Preoperative concurrent 5-fluorouracil infusion, mitomycin-c and pelvic radiation therapy in tethered and fixed rectal carcinoma. Int J Radiat Oncol Biol Phys. 25:1993;791-799.
23. Chari R.S., Tyler D.S., Anscher M.S., Russell L., Clary B.M., Hathorn J., Seigler H.F. Preoperative radiation and chemotherapy in the treatment of adenocarcinoma of the rectum. Ann Surg. 221:1995;778-787.
24. Grann A., Minsky B.D., Cohen A.M., et al. Preliminary results of preoperative 5-FU, low dose leucovorin, and concurrent radiation therapy for resectable T3 rectal cancer. (abstr) Int J Radiat Oncol Biol Phys. 36:1996;260.
25. Minsky B.D., Kemeny N., Cohen A.M., et al. Preoperative high-dose leucovorin/5-fluorouracil and radiation therapy for unresectable rectal cancer. Cancer. 67:1991;2859-2866.
26. Rich T.A., Skibber J.M., Ajani J.A., et al. Preoperative infusional chemoradiation therapy for stage T# rectal cancer. Int J Radiat Oncol Biol Phys. 32:1995;1025-1029.
27. Ahmad N.R., Marks G., Mohiuddin M. High-dose preoperative radiation for cancer of the rectum Impact of radiation dose on patterns of failure and survival . Int J Radiat Oncol Biol Phys. 27:1993;773-778.
28. Ahmad N.R., Nagle D.A., Topham A. Pathologic complete response predicts long-term survival following preoperative radiation therapy for rectal cancer. Int J Radiat Oncol Biol Phys. 39:(Suppl.):1997;284.
29. Suwinski R., Taylor J.M.G., Withers H.R. Rapid growth of microscopic rectal cancer as a determinant of response to preoperative radiation therapy. Int J Radiat Oncol Biol Phys. 42:1998;943-951.
30. Valentini V., Coco C., Cellini N., Picciocchi A., Genovesi D., Mantint G., Barbaro B., Cogliandolo S., Mattana C., Ambesi-Impiombato F., Tedesco M., Cosimelli M. Preoperative chemoradiation for extraperitoneal T3 rectal cancer Acute toxicity, tumor response, and sphincter preservation . Int J Radiat Oncol Biol Phys. 40:1998;1067-1075.