Prospective trial of preoperative concomitant boost radiotherapy with continuous infusion 5-fluorouracil for locally advanced rectal cancer

International Journal of Radiation Oncology Biology Physics

Volumn 47, Issue 3, 2000, Pages 713-718

  Janjan, Nora A ^a   Crane, Christopher N ^a   Feig, Barry W ^a   Cleary, Karen ^a   Dubrow, Ronelle ^a   Curley, Steven A ^a   Ellis, Lee M ^a   Vauthey, Jean Nicolas ^a   Lenzi, Renato ^a   Lynch, Patrick ^a   Wolff, Robert ^a   Brown, Thomas ^a   Pazdur, Richard ^a   Abbruzzese, James ^a   Hoff, Paulo M ^a   Allen, Pamela ^a   Brown, Barry ^a   Skibber, John ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

Chemoradiation; Rectal cancer; Sphincter preservation

Indexed keywords

FLUOROURACIL;

ADULT; ADVANCED CANCER; AGED; ANUS SPHINCTER; ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER STAGING; CLINICAL ARTICLE; CONTINUOUS INFUSION; DRUG EFFECT; FEMALE; HUMAN; MALE; MULTIMODALITY CANCER THERAPY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RADIATION DOSE FRACTIONATION; RADIATION RESPONSE; RECTUM CANCER; TUMOR LOCALIZATION;

ADULT; AGED; ANAL CANAL; ANTIMETABOLITES, ANTINEOPLASTIC; COMBINED MODALITY THERAPY; FEMALE; FLUOROURACIL; FOLLOW-UP STUDIES; HUMANS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM STAGING; PROSPECTIVE STUDIES; RADIOTHERAPY DOSAGE; RECTAL NEOPLASMS;

EID: 0034212424     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(00)00418-1     Document Type: Article

References (37)

1. Willett C.G. The role of radiation therapy and 5-fluorouracil in colon and rectal cancer. Semin Radiat Oncol. 7:1997;300-305.
2. Grann A., Minsky B.D., Cohen A.M., et al. Preliminary results of pre-operative 5-fluorouracil (5-FU), low dose leucovorin, and concurrent radiation therapy for resectable T3 rectal cancer. Dis Colon Rectum. 40:1999;515-522.
3. Minsky B.D., Cohen A.M., Enker W.E., et al. Preoperative 5-FU, low-dose leucovorin, and radiation therapy for locally advanced and unresectable rectal cancer. Int J Radiat Oncol Biol Phys. 37:1997;289-295.
4. Janjan N.A., Khoo V.S., Abbruzzese J., et al. Tumor down-staging and sphincter preservation with preoperative chemoradiation in locally advanced rectal cancer The M. D. Anderson Cancer Center Experience . Int J Radiat Oncol Biol Phys. 44:1999;1027-1038.
5. Valentini V., Coco C., Cellini N., et al. Preoperative chemoradiation for extraperitoneal T3 rectal cancer Acute toxicity, tumor response, and sphincter preservation . Int J Radiat Oncol Biol Phys. 40:1998;1067-1075.
6. Janjan N.A., Khoo V.S., Rich T.A., et al. Locally advanced rectal cancer Surgical complications after infusional chemotherapy and radiation therapy . Radiology. 206:1998;131-136.
7. Acker J.C., Marks L.B. The lack of impact of pelvic irradiation on small bowel mobility Implications for radiotherapy treatment planning . Int J Radiat Oncol Biol Phys. 32:1995;1473-1475.
8. Das I.J., Lanciano R.M., Movsas B., Kagawa K., Barnes S.J. Efficacy of a belly board device with CT-simulation in reducing small bowel volume within pelvic irradiation fields. Int J Radiat Oncol Biol Phys. 39:1997;67-76.
9. Letschert J.G.J., Lebesque J.V., Aleman B.M.P., et al. The volume effect in radiation-related late small bowel complications Results of a clinical study of the EORTC Radiotherapy Cooperative Group in patients treated for rectal carcinoma . Radiother Oncol. 32:1994;116-123.
10. Minsky B.D., Conti J.A., Huang Y., Knopf K. Relationship of acute gastrointestinal toxicity and the volume of irradiated small bowel in patients receiving combined modality therapy for rectal cancer. J Clin Oncol. 13:1995;1409-1416.
11. Koutcher J.A., Alfieri A.A., Thaler H., Matel C., Martin D.S. Radiation enhancement by biochemical modulation and 5-fluorouracil. Int J Radiat Oncol Biol Phys. 39:1997;1145-1152.
12. Lawrence T.S., Tepper J.E., Blackstock A.W. Fluoropyrimidine-radiation interactions in cells and tumors. Semin Radiat Oncol. 7:1997;260-266.
13. Rich T.A. Irradiation plus 5-fluorouracil Cellular mechanisms of action and treatment schedules . Semin Radiat Oncol. 7:1997;267-273.
14. Glimelius B., Isacsson U., Jung B., Pahlman L. Radiotherapy in addition to radical surgery in rectal cancer Evidence for a dose-response effect favoring preoperative treatment . Int J Radiat Oncol Biol Phys. 37:1997;281-287.
15. Bannon J.P., Marks G.J., Mohiuddin M., Rakinic J., Nong-Zhou J., Nagle D. Radical and local excisional methods of sphincter-sparing surgery after high-dose radiation for cancer of the distal 3 cm of the rectum. Ann Surg Oncol. 2:1995;221-227.
16. Marks G., Mohiuddin M., Masoni L., Montori. High-dose preoperative radiation therapy as the key to extending sphincter-preservation surgery for cancer of the distal rectum. Surg Oncol Clin North Am. 1:(1):1992;71-86.
17. Mendenhall W.M., Bland K.I., Souba W.W., Sombeck M.D., Copeland E.M., Million R.R. Preoperative irradiation for clinically resectable rectal adenocarcinoma. Semin Radiat Oncol. 3:1993;48-54.
18. Wong R., Thomas G., Cummings B., et al. In search of a dose-response relationship with radiotherapy in the management of recurrent rectal carcinoma in the pelvis A systematic review . Int J Radiat Oncol Biol Phys. 40:1998;437-446.
19. Movsas B., Hanlon A.L., Lanciano R., et al. Phase I dose escalating trial of hyperfractionated pre-operative chemoradiation for locally advanced rectal cancer. Int J Radiat Oncol Biol Phys. 42:1998;43-50.
20. Bozzetti F., Baratti D., Andreola S., et al. Preoperative radiation therapy for patients with T2-T3 carcinoma of the middle-to-lower rectum. Cancer. 86:1999;398-404.
21. Coucke P.A., Sartorelli B., Cuttat J.F., Jeanneret W., Gillet M., Mirimanoff R.O. The rationale to switch from postoperative hyperfractionated accelerated radiotherapy to preoperative hyperfractionated accelerated radiotherapy in rectal cancer. Int J Radiat Oncol Biol Phys. 32:1995;181-188.
22. Gwozdz J.T., Morrison W.H., Garden A.S., Weber R.S., Peters L.J., Ang K.K. Concomitant boost radiotherapy for squamous carcinoma of the tonsillar area. Int J Radiat Oncol Biol Phys. 39:1997;127-135.
23. Mak A.C., Morrison W.H., Garden A.S., Ang K.K., Goepfert H., Peters L.J. Base-of-tongue carcinoma Treatment results using concomitant boost radiotherapy . Int J Radiat Oncol Biol Phys. 33:1995;289-296.
24. Allal A.S., Bieri S., Miralbell R., Marchal F., Lehmann W., Kurtz J.M. Feasibility and outcome of a progressively accelerated concomitant boost radiotherapy schedule for head and neck carcinomas. Int J Radiat Oncol Biol Phys. 38:1997;685-689.
25. Garden A.S., Glisson B.S., Ang K.K., et al. Phase I/II trial of radiation with chemotherapy "boost" for advanced squamous cell carcinomas of the head and neck Toxicities and responses . J Clin Oncol. 17:1999;2390-2395.
26. Withers R.H., Taylor J., Maciejewski B. The hazard of accelerated tumor clonogen repopulation during radiotherapy. Acta Oncol. 27:1988;131-146.
27. Ang K.K., Peters L.J., Weber R.S., et al. Concomitant radiotherapy schedules in the treatment of carcinoma of the oropharynx and nasopharynx. Int J Radiat Oncol Biol Phys. 19:1990;1339-1345.
28. Kaanders J.H.A.M., van der Kogel A.J., Ang K.K. Altered fractionation Limited by mucosal reactions? Radiother Oncol. 50:1998;247-260.
29. Hendry J.H., MacKay R.I., Roberts S.A., Slevin N.J. Outstanding issues in radiation dose-fractionation studies. Int J Radiat Biol Phys. 73:1998;383-394.
30. Berger C., de Muret A., Garaud P., et al. Preoperative radiotherapy [RT] for rectal cancer Predictive factors of tumor downstaging and residual tumor cell density [RTCD]: Prognostic implications . Int J Radiat Oncology Biol Phys. 37:1997;619-627.
31. Francois Y., Nemoz C.J., Baulieux J., et al. Influence of the interval between preoperative radiation therapy and surgery on downstaging and on the rate of sphincter sparing surgery for rectal cancer The Lyon R90-01 randomized trial . J Clin Oncol. 17:1999;2396-2402.
32. Graf W., Dahlberg M., Osman M.M., Holmberg L., Pahlman L., Glimelius B. Short-term preoperative radiotherapy results in down-staging of rectal cancer A study of 1316 patients . Radiother Oncol. 43:1997;133-137.
33. Wagman R., Minsky B.D., Cohen A.M., Guillem J.G., Paty P.P. Sphincter preservation in rectal cancer with preoperative radiation therapy and coloanal anastomosis Long term follow-up . Int J Radiat Oncol Biol Phys. 42:1998;51-57.
34. Videtic G.M.M., Fisher B.J., Perera F.E., et al. Preoperative radiation with concurrent 5-fluorouracil continuous infusion for locally advanced unresectable rectal cancer. Int J Radiat Oncol Biol Phys. 42:1998;319-324.
35. Efficacy of intravenous continuos infusion of fluorouracil compared with bolus administration in advanced colorectal cancer. J Clin Oncol. 16:1998;301-308.
36. O'Connell M.J., Martenson J.A., Wieand H.S., et al. Improving adjuvant therapy for rectal cancer by combining protracted infusion fluorouracil and radiation therapy after curative surgery. N Engl J Med. 331:1994;502-507.
37. Machover D. A comprehensive review of 5-fluorouracil and leucovorin in patients with metastatic colorectal carcinoma. Cancer. 80:1997;1179-1187.