Endogenous prostaglandin I2 regulates the neural emergency system through release of calcitonin gene related peptide

Gut

Volumn 52, Issue 9, 2003, Pages 1242-1249

  Arai, K ^a   Ohno, T ^a   Saeki, T ^a   Mizuguchi, S ^a   Kamata, K ^a   Hayashi, I ^a   Saigenji, K ^a   Murata, T ^b   Narumiya, S ^b   Majima, M ^a  

^a KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KYOTO UNIVERSITY FACULTY OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

6 OXOPROSTAGLANDIN F1 ALPHA; ALCOHOL; BERAPROST; CALCITONIN GENE RELATED PEPTIDE; CALCITONIN GENE RELATED PEPTIDE[8-37]; CAPSAICIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; INDOMETACIN; MESSENGER RNA; PROSTACYCLIN; PROSTACYCLIN RECEPTOR; PROSTAGLANDIN E2; SODIUM CHLORIDE; URETHAN; PROSTAGLANDIN SYNTHASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DAMAGE; CELL PROTECTION; CONTROLLED STUDY; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSORY NERVE; STOMACH MUCOSA INJURY; ANIMAL; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; METHODOLOGY; MOUSE MUTANT; PHYSIOLOGY; STOMACH MUCOSA;

6-KETOPROSTAGLANDIN F1 ALPHA; ANIMALS; CALCITONIN GENE-RELATED PEPTIDE; CAPSAICIN; CYCLOOXYGENASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; EPOPROSTENOL; ETHANOL; GASTRIC MUCOSA; INDOMETHACIN; MICE; MICE, KNOCKOUT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 0042386726     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.52.9.1242     Document Type: Article

References (50)

1. Holzer P. Neural emergency system in the stomach. Gastroenterology 1998;114:823-39.
2. Green T, Dockray GJ. Calcitonin gene-related peptide and substance P in afferents to the upper gastrointestinal tract in the rat. Neurosci Lett 1987;76:151-6.
3. Sharkey KA, Williams RG, Dockray GJ. Sensory substance P innervation of the stomach and pancreas. Demonstration of capsaicin-sensitive sensory neurons in the rat by combined immunohistochemistry and retrograde tracing. Gastroenterology 1984;87:914-21.
4. Gono Y, Ichikawa T, Hotta K, et al. Topographical distribution of neuropeptide- containing nerve fibers in the rat stomach: A quantitative analysis using antibodies against protein gene product 9.5 and gastric mucins. Biomed Res 1998;19:357-68.
5. Jakab G, Webster H, Salamon I, et al. Neural and non-neural origin of calcitonin gene-related peptide in the gastric mucosa. Neuropeptides 1993;24:117-22.
6. Holzer P, Sametz W. Gastric mucosal protection against ulcerogenic factors in the rat mediated by capsaicin-sensitive afferent neurons. Gastroenterology 1986;91:975-81.
7. Holzer P, Sametz W. Capsaicin-sensitive afferent neurons involved in gastric mucosal protection. Br J Pharmacol 1986;89:562.
8. Holzer P, Lippe IT. Stimulation of afferent nerve endings by intragastric capsaicin protects against ethanol-induced damage of gastric mucosa. Neuroscience 1988;27:981-7.
9. Holzer P, Pabst MA, Lippe IT. Intragastric capsaicin protects against aspirin-induced lesion formation and bleeding in the rat gastric mucosa. Gastroenterology 1989;96:1425-33.
10. Holzer P, Pabst MA, Lippe IT, et al. Afferent nerve-mediated protection against deep mucosal damage in the rat stomach. Gastroenterology 1990;98:838-48.
11. Hayashi H, Ohno T, Nishiyama K, et al., Transient prevention of ethanol-induced gastric lesion by capsaicin due to release of endogenous calcitonin gene-related peptide in rats. Jpn J Pharmacol 2001;86:351-4.
12. Katori M, Ohno T, Nishiyama K. Interaction of substance P and leukotriene C4 in ethanol-induced mucosal injury of rat stomach. Regul Pept 1993;46:241-3.
13. Katori M, Nishiyama K, Ueno A, et al. An important role of leukotriene C4 in microcirculation during ethanol-induced gastric mucosal injury in rat. Adv Prostaglandin Thromboxane Leukot Res 1990;21:771-6.
14. Ohno T, Katori M, Nishiyama K, et al. A role of leukotriene C4 in ethanol-induced gastric mucosal injury in rat. Microcirculation Ann 1992;8:51-2.
15. Saeki T, Ohno T, Boku K, et al. Capsaicin prevents ethanol-induced gastric lesion by suppression of constriction of collecting venules in rats: A study using intravital microscopy. Gastroenterology 1998;114:303.
16. Nishiyama K, Katori M, Ueno A, et al. Suppression of myoelectrical activity of gastric smooth muscle by endogenous gastric prostaglandin E2. Dig Dis Sci 1992;37:1002-8.
17. Ferreira SH. Peripheral analgesic sites of action of anti-inflammatory drugs. Int J Clin Pract Suppl 2002;128:2-10.
18. Holzer P, Pabst MA, Lippe IT, et al. Afferent nerve-mediated protection against deep mucosal damage in the rat stomach. Gastroenterology 1990;98:838-48.
19. Lambrecht N, Burchert M, Respondek M, et al. Role of calcitonin gene-related peptide and nitric oxide in the gastroprotective effect of capsaicin in the rat. Gastroenterology 1993;104:1371-80.
20. Brzozowski T, Drozdowicz D, Szlachcic A, et al. Role of nitric oxide and prostaglandins in gastroprotection induced by capsaicin and papaverine. Digestion 1993;54:24-31.
21. Takeuchi K, Niida H, Matsumoto J, et al. Gastric motility changes in capsaicin, induced cytoprotection in the rat stomach. Jpn J Pharmacol 1991;55:147-55.
22. Hatakeyama Y, Matsuo M, Tomoi M, et al. Luminal dilution caused by certain mild irritants and capsaicin contributes to their gastric mucosal protection. Am J Physiol 1995;268:G200-6.
23. Mercer DW, Ritchie WP Jr, Dempsey DT. Sensory neuron-mediated gastric mucosal protection is blockedby cyclooxygenase inhibition. Surgery 1994;115:156-63.
24. Narumiya S, Sugimoto Y, Ushikubi F. Prostanoid receptors: structures, properties, and function. Physiol Rev 1999;79:1193-1226.
25. Murata T, Ushikubi F, Matsuoka T, et al. Altered pain perception and inflammatory response in mice lacking prostacycline receptor. Nature 1997;388:678-82.
26. Sugimoto Y, Yamasaki A, Segi E, et al. Failure of parturition in mice lacking the prostaglandin F receptor. Science 1997;277:681-3.
27. Segi E, Sugimoto Y, Yamasaki A, et al. Patent ductus arteriosus and neonatal death in prostaglandin receptor EP4-deficient mice. Biochem. Biophys. Res Commun 1998;246:7-12.
28. Ushikubi F, Segi E, Sugimoto Y, et al. Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3. Nature 1998;395:281-4.
29. 2. Proc. Natl Acad Sci U S A 1999;96:10501-6.
30. 2 as a mediator of allergic asthma. Science 2000;287:2013-17.
31. Purcell WM, Atterwill CK. Mast cells in neuroimmune function: neurotoxicological and neuropharmacological perspectives. Neurochem Res 1995;20:521-32.
32. Suzuki Y, Ueno A, Nishiyama K, et al. Prostaglandin levels in the rat resting gastric wall and enhancement of prostaglandin E2 generation after administration of mild hyperosmotic saline solution into gastric lumen. Eicosanoids 1990;3:23-7.
33. Saeki T, Ohno T, Boku K, et al. Mechanism of prevention by capsaicin of ethanol- induced gastric mucosal injury: A study using intravital microscopy. Alim Pharmacol Ther 2000;14:135-44.
34. Maggi CA, Chiba T, Giuliani S. Human alpha-calcitonin gene-related peptide-(8-37) as an antagonist of exogenous and endogenous calcitonin gene-related peptide. Eur J Pharmacol 1991;192:85-8.
35. Gardiner SM, Compton AM, Kemp PA, et al. Antagonistic effect of human alpha- CGRP [8-37] on the in vivo regional haemodynamic action of human alpha-CGRP. Biochem Biophys Res Commun 1990;171:938-43.
36. Donoso MV, Fournier A, St-Pierre S, et al. Pharmacological characterization of CGRP1 receptor subtype in vascular system of the rat: Studies with hCGRP fragments and analogs. Peptide 1990;11:885-9.
37. Hughes SR, Brain SD. A calcitonin gene-related peptide (CGRP) antagonist (CGRP8-37) inhibits microvascular responses induced by CGRP and capsaicin in skin. Br J Pharmacol 1991;104:738-42.
38. Drossman DA, Richter JE, Talley NJ, et al. The Functional Gastrointestinal Disorders. Boston: Little Brown, 1994.
39. Mayer EA, Raybould HE. Role of visceral afferent mechanisms in functional bowel disorders. Gastroenterology 1990;99:1688-704.
40. 2 is attributable to sensitization of CGRP-containing sensory nrerves. Gastroenterology 2001;120:134-43.
41. 2. Gastroenterology 1983;84:498-505.
42. Hori Y, Katori M, Uchida Y, et al. Potentiation of bradykinin-induced nociceptive response by arachidonate metabolites in dogs. Eur J Pharmacol 1986;132:47-52.
43. Schmassmann A, Peskar BM, Stettler C, et al. Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastro-intestinal ulcer models in rats. Br J Pharmacol 1998;123:795-804.
44. Iseki S. Immunocytochemical localization of cyclooxygenase-1 and cylooxygenase-2 in the rat stomach. Histochem J 1995;27:323-8.
45. Tone Y, Inoue H, Hara S, et al. The regional distribution and cellular localization of mRNA encoding rat prostacyclin synthase. Eur J Cell Biol 1997;72:268-77.
46. Oida H, Namba T, Sugimoto Y, et al. In situ hybridization studies of prostaglandin receptor mRNA expression in various mouse organs. Br J Pharmacol 1995;116:2828-37.
47. Inaba N, Shibata M, Onodera S, et al. Capsaicin-induced calcitonin gene-related peptide release from isolated rat stomach measured with a new chemiluminescent enzyme immunoassay. Jpn J Pharmacol 1996;72:223-9.
48. Nozawa Y, Nishihara K, Yamamoto A, et al. Distribution and characterization of vanilloid receptors in the rat stomach. Neurosci Lett 2001;309:33-6.
49. Birder LA, Nakamura Y, Kiss S, et al. Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1. Nat Neurosci 2002;5:856-60.
50. Kumazawa T, Mizumura K, Koda H, et al. EP receptor subtypes implicated in the PGE2-induced sensitization of polymodal receptors in response to bradykinin and heat. J Neurophysiol 1996;75:2361-8.