Transient prevention of ethanol-induced gastric lesion by capsaicin due to release of endogenous calcitonin gene-related peptide in rats

Japanese Journal of Pharmacology

Volumn 86, Issue 3, 2001, Pages 351-354

  Hayashi, H ^a   Ohno, T ^a   Nishiyama, K ^a   Boku, K ^a   Katori, M ^a   Majima, M ^a  

^a Higashi 1 14 3   (Japan)

Author keywords

Calcitonin gene related peptide; Capsaicin; Gastric lesion

Indexed keywords

ALCOHOL; CALCITONIN GENE RELATED PEPTIDE; CALCITONIN GENE RELATED PEPTIDE[8-37]; CAPSAICIN; PEPSTATIN; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG ANTAGONISM; DRUG EFFECT; DRUG EXPOSURE; MALE; NONHUMAN; NORMAL VALUE; ORGAN PERFUSION; PEPTIDE ANALYSIS; PEPTIDE SYNTHESIS; RAT; STOMACH MUCOSA; STOMACH MUCOSA LESION;

EID: 0034903268     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.86.351     Document Type: Article

References (16)

1. Neural emergency system in the stomach
2. Stimulation of afferent nerve endings by intragastric capsaicin protects against ethanol-induced damage of gastric mucosa
3. Afferent nerve-mediated protection against deep mucosal damage in the rat stomach
4. Gastric motility changes in capsaicin-induced cytoprotection in the rat stomach
5. Role of calcitonin gene-related peptide and nitric oxide in the gastroprotective effect of capsaicin in the rat
6. Differential effect on neuropeptide release of different concentrations of hydrogen ions on afferent and intrinsic neurons of the rat stomach
7. Release of calcitonin gene-related peptide induced by capsaicin in the vascular perfused rat stomach
8. 2 generation after administration of mild hypertonic saline solution into the gastric lumen
9. Role of endogenous substance P in ethanol-induced mucosal damage in the rat stomach
10. Gastric mucosal damage by ethanol is mediated by substance P and prevented by ketotifen, a mast cell stabilizer
11. 4 in ethanol-induced mucosal injury of rat stomach
12. Mechanism of prevention by capsaicin of ethanol-induced gastric mucosal injury - A study in the rat using intravital microscopy
13. Direct observation of microcirculation of the basal region of rat gastric mucosa
14. 4 in microcirculation during ethanol-induced gastric mucosal injury in rat
15. A preventive mechanism of capsaicin in microcirculation against ethanol-induced gastric mucosal injury in rats
16. 2 is attributable to sensitization of CGRP-containing sensory nerves