Early pregnancy factor suppresses the infiltration of lymphocytes and macrophages in the spinal cord of rats during experimental autoimmune encephalomyelitis but has no effect on apoptosis

Journal of the Neurological Sciences

Volumn 214, Issue 1-2, 2003, Pages 27-36

  Athanasas Platsis, Stavrosia ^a   Zhang, Bing ^b   Hillyard, Narelle C ^b   Cavanagh, Alice C ^a   Csurhes, Peter A ^a   Morton, Halle ^a   McCombe, Pamela A ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b CBio Ltd   (Australia)

Author keywords

Apoptosis; Early pregnancy factor; Experimental autoimmune encephalomyelitis; Lymphocytes; Macrophages; Multiple sclerosis; Spinal cord

Indexed keywords

CD11 ANTIGEN; CD5 ANTIGEN; EARLY PREGNANCY FACTOR; IMMUNOSUPPRESSIVE AGENT; MYELIN BASIC PROTEIN; RECOMBINANT PROTEIN;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CELL PROLIFERATION; CONTROLLED STUDY; DILUTION; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG MEGADOSE; EXPERIMENTAL MODEL; INFLAMMATORY CELL; LYMPH NODE; LYMPHOCYTE COUNT; LYMPHOCYTE SUBPOPULATION; LYMPHOCYTIC INFILTRATION; MACROPHAGE; MALE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; SPINAL CORD; T LYMPHOCYTE;

EID: 0042329586     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-510X(03)00170-9     Document Type: Article

References (38)

1. Cavanagh A.C., Morton H. The purification of early pregnancy factor to homogeneity from human platelets and identification as chaperonin 10. Eur. J. Biochem. 222:1994;551-560.
2. Linquist S., Craig E.A. The heat shock proteins. Annu. Rev. Genet. 22:1988;631-677.
3. Morton H., Hegh V., Clunie G.J.A. Immunosuppression detected in pregnant mice by the rosette inhibition test. Nature. 249:1974;459-460.
4. Morton H. Early pregnancy factor: an extracellular chaperonin 10 homologue. Immunol. Cell Biol. 76:1998;483-496.
5. Noonan F.P., Halliday W.J., Morton H., Clunie G.J.A. Early pregnancy factor is immunosuppressive. Nature. 278:1979;649-651.
6. Athanasas-Platsis S., Morton H., Dunglison G.F., Kaye P.L. Antibodies to early pregnancy factor retard embryonic development in mice in vivo. J. Reprod. Fertil. 92:1991;443-451.
7. Athanasas-Platsis S., Corcoran C.M., Kaye P.L., Cavanagh A.C., Morton H. Early pregnancy factor is required at two important stages of development in the mouse. Am. J. Reprod. Immunol. 43:2000;223-233.
8. Quinn K.A., Athanasas-Platsis S., Wong T.-Y., Rolfe B.E., Cavanagh A.C., Morton H. Monoclonal antibodies to early pregnancy factor perturb tumour cell growth. Clin. Exp. Immunol. 80:1990;100-108.
9. Quinn K.A., Cavanagh A.C., Hillyard N.C., McKay D.A., Morton H. Early pregnancy factor in liver regeneration after partial hepatectomy in rats: relationship with chaperonin 10. Hepatology. 20:1994;1294-1302.
10. Zhang B., Harness J., Somodevilla-Torres M.et al. Early pregnancy factor suppresses experimental autoimmune encephalomyelitis induced in Lewis rats with myelin basic protein and in SJL/J mice with myelin proteolipid protein peptide 139-151. J. Neurol. Sci. 182:2000;5-15.
11. Pettinelli C.B., McFarlin D.E. Adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice after in vitro activation of lymph node cells by myelin basic protein: requirement for Lyt1+2-T lymphocytes. J. Immunol. 127:1981;1420-1423.
12. Pender M.P. Experimental autoimmune encephalomyelitis. Pender M.P., McCombe P.A. Autoimmune neurological disease. 1995;26-88 Cambridge Univ. Press, Cambridge.
13. Davidson A., Diamond B. Autoimmune diseases. N. Engl. J. Med. 345:2001;340-350.
14. McCombe P.A., Fordyce B.W., de Jersey J., Yoong G., Pender M.P. Expression of CD45RC and Ia antigen in the spinal cord in acute experimental allergic encephalomyelitis: an immunocytochemical and flow cytometric study. J. Neurol. Sci. 113:1992;177-186.
15. van der Valk P., De Groot C.J.A. Staging of multiple sclerosis (MS) lesions: pathology of the time frame of MS. Neuropathol. Appl. Neurobiol. 26:2000;2-10.
16. Offner H., Buenafe A.C., Vainiene M., Celnik B., Weinberg A.D., Gold D.P.et al. Where, when and how to detect biased expression of disease-relevant V beta genes in rats with experimental autoimmune encephalomyelitis. J. Immunol. 151:1993;506-517.
17. + cells. J. Neuroimmunol. 70:1996;93-101.
18. McCombe P.A., Harness J., Pender M.P. Effects of cyclosporin A treatment on clinical course and inflammatory cell apoptosis in experimental autoimmune encephalomyelitis induced in Lewis rats by inoculation with myelin basic protein. J. Neuroimmunol. 97:1999;60-69.
19. Deibler G.E., Martenson R.E., Kies M.W. Large scale preparation of myelin basic protein from central nervous tissue of several mammalian species. Prep. Biochem. 2:1972;139-165.
20. Pender M.P. Ascending impairment of nociception in rats with experimental allergic encephalomyelitis. J. Neurol. Sci. 75:1986;317-328.
21. + encephalitogenic T-cells. Eur. J. Immunol. 24:1994;2609-2617.
22. Telford W.G., King L.E., Fraker P.J. Evaluation of glucocorticoid-induced DNA fragmentation in mouse thymocytes by flow cytometry. Cell Prolif. 24:1991;447-459.
23. Tabi Z., McCombe P.A., Pender M.P. Antigen-specific downregulation of myelin basic protein-reactive T-cells during spontaneous recovery from experimental autoimmune encephalomyelitis: further evidence of apoptotic deletion of autoreactive T-cells in the central nervous system. Int. Immunol. 7:1995;967-973.
24. Fazekas de St. Groth S. The evaluation of limiting dilution assays. J. Immunol. Methods. 49:1982;R11.
25. Ragno S., Winrow V.R., Mascagni P.et al. A synthetic 10-kD heat shock protein (hsp 10) from Mycobacterium tuberculosis modulates adjuvant arthritis. Clin. Exp. Immunol. 103:1996;384-390.
26. Ben-Nun A., Mendel I., Sappler G., Kerlero de Rosbo N.A. 12-kDa protein of Mycobacterium tuberculosis protects mice against experimental autoimmune encephalomyelitis. Protection in the absence of shared T cell epitopes with encephalitogenic proteins. J. Immunol. 54:1995;2939-2948.
27. Ferrero R.L., Thiberge J.-M., Kansau I., Wusher N., Huerre M., Labigne A. The Gro-ES of Helicobacter pylon confers protective immunity against mucosal infection in mice. Proc. Natl. Acad. Sci. U. S. A. 92:1995;6499-6503.
28. van Eden W., van der Zee R., Paul A.G.A.et al. Do heat shock proteins control the balance of T-cell regulation in inflammatory disease? Immunol. Today. 19:1998;303-307.
29. White C.A., Nguyen K.B., Pender M.P. B cell apoptosis in the central nervous system in experimental autoimmune encephalomyelitis: roles of B cell CD95, CD95L and Bcl-2 expression. J. Autoimmun. 14:2000;195-204.
30. Tran E.H., Hoekstra K., van Rooijen N., Dijkstra C.D., Owens T. Immune invasion of the central nervous system parenchyma and experimental allergic encephalomyelitis, but not leukocyte extravasation from blood, are prevented in macrophage-depleted mice. J. Immunol. 161:1998;3767-3775.
31. Noseworthy Jh., Lucchinetti C., Rodriguez M., Weinshenker B.G. Multiple sclerosis. N. Engl. J. Med. 343:2000;938-952.
32. Schmidt J., Stürzebecher S., Toyka K.V., Gold R. Interferon-β treatment of experimental autoimmune encephalomyelitis leads to rapid nonapoptotic termination of T cell infiltration. J. Neurosci. Res. 65:2001;59-67.
33. Zhang B., Walsh M.D., Nguyen K.B., Hillyard N.C., Cavanagh A.C., McCombe P.A.et al. Early pregnancy factor treatment suppresses the inflammatory response and adhesion molecule expression in the spinal cord of SJL/J mice with experimental autoimmune encephalomyelitis and the delayed-type hypersensitivity reaction to trinitrochlorobenzene in normal BALB/c mice. J. Neurol. Sci. 212:2003;37-46.
34. Boring L., Gosling J., Chensue S.W.et al. Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice. J. Clin. Invest. 100:1997;2552-2561.
35. Izikson L., Klein R.S., Charo I.F., Weiner H.L., Luster A.D. Resistance to experimental autoimmune encephalomyelitis in mice lacking the CC chemokine receptor (CCR) 2. J. Exp. Med. 192:2000;1075-1080.
36. Huang D.R., Wang J., Kivisakk P., Rollins B.J., Ransohoff R.M. Absence of monocyte chemoattractant protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis. J. Exp. Med. 193:2001;713-726.
37. Kuziel W.A., Morgan S.J., Dawson T.C.et al. Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2. Proc. Natl. Acad. Sci. U. S. A. 94:1997;12053-12058.
38. Phillips M.J., Weller R.O., Kida S., Iannotti F. Focal brain damage enhances experimental autoimmune encephalomyelitis in brain and spinal cord. Neuropathol. Appl. Neurobiol. 21:1995;189-200.