Staging of multiple sclerosis (MS) lesions: Pathology of the time frame of MS

Neuropathology and Applied Neurobiology

Volumn 26, Issue 1, 2000, Pages 2-10

  Van Der Valk, P ^a,b   De Groot, C J A ^a,b  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

Immunohistochemistry; Magnetic resonance imaging; Multiple sclerosis; Pathology; Staging systems

Indexed keywords

MYELIN;

DEMYELINATION; DISEASE COURSE; GLIA CELL; HUMAN; INFLAMMATORY CELL; MULTIPLE SCLEROSIS; NERVE FIBER; NEUROIMMUNOLOGY; NOMENCLATURE; PRIORITY JOURNAL; REVIEW; SCORING SYSTEM; STAINING;

DISEASE PROGRESSION; HUMANS; MULTIPLE SCLEROSIS; TERMINOLOGY;

EID: 0034062423     PISSN: 03051846     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2990.2000.00217.x     Document Type: Review

References (42)

1. 1 Adams CWM. Gross pathology and distribution of MS lesions. In A Colour Atlas of Multiple Sclerosis and Other Myelin Disorders. London: Wolfe Medical Publications Ltd, 1989: 105-29
2. 2 Adams CWM. Histology and cellular features of multiple sclerosis. In A Colour Atlas of Multiple Sclerosis and Other Myelin Disorders. London: Wolfe Medical Publications Ltd, 1989: 130-83
3. 3 Adams CWM, Poston RN. Macrophage histology in paraffin-embedded multiple sclerosis plaques is demonstrated by the monoclonal pan-macrophage marker HAM-56: correlation with chronicity of the lesion. Acta Neuropathol (Berl) 1990; 80: 208-11
4. 4 Barnes D, Munro PMG, Youl BD, Prineas JW, McDonald WI. The longstanding MS lesion. A quantitative MRI and electron microscopic study. Brain 1991; 114: 1271-80
5. 5 Bhardwaj RS, Zotz C, Zwadlo-Klarwasser G et al. The calcium-binding proteins MRP8 and MRP14 form a membrane-associated heterodimer in a subset of monocytes/ macrophages present in acute, but absent in chronic inflammatory lesions. Eur J Immunol 1992; 22: 1891-7
6. 6 Bö L, Mörk S, Kong PA, Nyland H, Pardo CA, Trapp BD. Detection of MHC class II-antigens on macrophages and microglia, but not on astrocytes and endothelia in active multiple sclerosis lesions. J Neuroimmunol 1994; 51: 135-46
7. 7 Bonetti B, Raine CS. Multiple sclerosis: oligodendrocytes display cell death-related molecules in situ but do not undergo apoptosis. Ann Neurol 1997; 42: 74-84
8. 8 Brosnan CF, Cannella B, Battistini L, Raine CS. Cytokine localization in multiple sclerosis lesions: correlation with adhesion molecule expression and reactive nitrogen species. Neurology 1995; 45: S16-S21
9. 9 Brück W, Bitsch A, Kolenda H, Brück Y, Stiefel M, Lassmann H. Inflammatory central nervous system demyelination: correlation of magnetic resonance imaging findings with lesion pathology. Ann Neurol 1997; 42: 783-93
10. 10 Brück W, Porada P, Poser S et al. Monocyte/macrophage differentiation in early multiple sclerosis lesions. Ann Neurol 1995; 38: 788-96
11. 11 Brück W, Schmied M, Suchanek G et al. Oligodendrocytes in the early course of multiple sclerosis. Ann Neurol 1994; 35: 65-73
12. 12 Cannella B, Raine CS. The adhesion molecule and cytokine profile of multiple sclerosis lesions. Ann Neurol 1995; 37: 424-35
13. 13 Charcot M. Histologie de le sclérose en plaques. Gazette Hôpitaux, Paris 1868; 141: 554-8
14. 14 Compston DAS. The 150th anniversary of the first depiction of the lesions of multiple sclerosis. J Neurol Neurosurg Psychiatr 1988; 51: 1249-52
15. 15 Cossins J, Clements JM, Miller KM, Vos W, van der Valk P, De Groot CJA. Enhanced expression of MMP-7 and MMP-9 in demyelinating multiple sclerosis lesions. Acta Neuropathol 1998; 94: 590-8
16. 16 De Groot CJA, Montagne L, Barten AD, Sminia P, van der Valk P. Enhanced expression of transforming growth factor (TCF) -β1-β2, and -β3 isoforms and TGF-β type I and type II receptors in multiple sclerosis lesions and human adult astrocyte cultures. J Neuropathol Exp Neurol 1999; 58: 174-87
17. 17 Ferguson B, Matyszak MK, Esiri MM, Perry VH. Axonal damage in acute multiple sclerosis lesions. Brain 1997; 120: 593-9
18. 18 Hayes GM, Woodroofe MN, Cuzner ML. Microglia express MHC class II in normal and demyelinating human white matter. Ann NY Acad Sci 1988; 540: 501-3
19. 19 Kockx MM, Muhring J, Knaapen MW, de Meyer GR. RNA synthesis and splicing interferes with DNA in situ end labeling techniques used to detect apoptosis. Am J Pathol 1998; 152: 885-8
20. 20 Lassmann H, Raine CS, Antel J, Prineas JW. Immunopathology of multiple sclerosis: report on an international meeting held at the Institute of Neurology of the University of Vienna. J Neuroimmunol 1998; 86: 21 3-17
21. 21 Lucchinetti CF, Brück W, Rodriguez M, Lassmann H. Distinct pattern of multiple sclerosis pathology indicates heterogeneity in pathogenesis. Brain Pathol 1996; 6: 259-74
22. 22 Lumsden CE. Fundamental problems in the pathology of multiple sclerosis and allied demyelinating diseases. Br Med J 1951; i: 1035-43
23. 23 Oosten BW, Barkhof F, Truyen L et al. Increased MRI activity and immune activation in two multiple sclerosis patients treated with the monoclonal anti-tumour necrosis factor antibody cA2. Neurology 1996; 47: 1531-4
24. 24 Ozawa K, Suchanek G, Breitschopf H et al. Patterns of oligodendroglia pathology in multiple sclerosis. Brain 1994; 117: 1311-22
25. 2 5 Prineas JW. Pathology of multiple sclerosis. In Handbook of Multiple Sclerosis, Ed. S Cook. New York: Marcel Dekker Inc., 1990: 187-218
26. 26 Prineas JW, Connell F. Remyelination in multiple sclerosis. Ann Neurol 1979; 5: 22-31
27. 27 Prineas JW, Kwon EE, Goldenberg PZ et al. Multiple sclerosis. Oligodendrocyte proliferation and differentiation in fresh lesions. Lab Invest 1989; 61: 489-503
28. 28 Prineas JW, McDonald WI. Demyelinating diseases. In Greenfield's Neuropathology, 6th edn, Eds DI Graham and PL Lantos. London: Edward Arnold, 1997: 813-96
29. 29 Prineas JW, Raine CS. Electron microscopy and immunoperoxidase studies of early multiple sclerosis lesions. Neurology 1976; 26 (Suppl.): 29-32
30. 30 Raine CS, Scheinberg L, Waltz JM. Multiple sclerosis: oligodendrocyte survival and proliferation in an active established lesion. Lab Invest 1981; 45: 534-46
31. 31 Selmaj K, Raine CS, Cannella B, Brosnan CF. Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions. J Clin Invest 1991; 87: 949-54
32. 32 Simpson JE, Newcombe J, Cuzner ML, Woodroofe MN. Expression of monocyte chemoattractant protein-1 and other β-chemokines by resident glia and inflammatory cells in multiple sclerosis lesions. J Neuroimmunol 1998; 84: 238-49
33. 33 Sobel RA, Mitchell ME. Fibronectin in multiple sclerosis lesions. Am J Pathol 1989; 135: 161-8
34. 34 Sobel RA, Mitchell ME, Fondren G. Intercellular adhesion molecule-1 (ICAM-1) in cellular immune reactions in the human central nervous system. Am J Pathol 1990; 136: 1309-16
35. 35 Trapp BD, Peterson J, Ransohoff RM, Rudick R, Mörk S, Bö L. Axonal transection in the lesions of multiple sclerosis. N Engl J Med 1998; 338: 278-85
36. 36 Traugott U. Multiple sclerosis; relevance of class I and class II MHC-expressing cells in lesion development. J Neuroimmunol 1987; 16: 283-303
37. 37 Traugott U. Evidence for immunopathogenesis. In Handbook of Multiple Sclerosis, Ed. S Cook. New York: Marcel Dekker Inc., 1990: 101-27
38. 38 Traugott U, Reinherz E, Raine CS. Monoclonal anti-T cell antibodies are applicable to the study of inflammatory infiltrates in the central nervous system. J Neuroimmunol 1982; 3: 365-73
39. 39 Ulvestad E, Williams K, Mörk S, Antel J, Nyland H. Phenotypic differences between human monocytes/macrophages and microglial cells studied in situ and in vitro. J Neuropathol Exp Neurol 1994; 53: 492-501
40. 40 Waesberghe JH, Kamphorst W, De Groot CJA et al. Axonal loss in MS lesions. MRI insights into substrates of disability. Ann Neurol 1999; 46: 747-54
41. 41 Walderveen MAA, Kamphorst W, Scheltens P, van Waesberghe JH, Ravid R, Valk J, Polman CH, Barkhof F. Histopathologic correlate of hypointense lesions on T1-weighted spin-echo MRI in multiple sclerosis. Neurology 1997; 50: 1282-8
42. 42 Washington R, Burton J, Todd RF III, Newman W, Dragovic L, Dore-Duffy P. Expression of immunologically relevant endothelial cell activation antigens on isolated central nervous system microvessels from patients with multiple sclerosis. Ann Neurol 1994; 35: 89-97