A synthetic 10-kD heat shock protein (hsp10) from Mycobacterium tuberculosis modulates adjuvant arthritis

Clinical and Experimental Immunology

Volumn 103, Issue 3, 1996, Pages 384-390

  Ragno, S ^a,c   Winrow, V R ^a   Mascagni, P ^b   Lucietto, P ^b   Di Pierro, F ^b   Morris, C J ^a   Blake, D R ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b Italfarmaco SpA   (Italy)

^c NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

Chaperonin 10; Early pregnancy factor; Experimental arthritis; Heat shock protein(s); Immunoregulation

Indexed keywords

CHAPERONIN; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 10; HEAT SHOCK PROTEIN 65; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTHRITIS; ARTICLE; CONTROLLED STUDY; FEMALE; IMMUNOMODULATION; INTRADERMAL DRUG ADMINISTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT;

EID: 0029937862     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2249.1996.tb08291.x     Document Type: Article

References (47)

1. Lindquist S. The heat shock response. Ann Rev Biochem 1986; 55:1151-91.
2. Young RA. Stress proteins and immunology. Ann Rev Immunol 1990; 8:401-20.
3. Strober S, Holoshitz J. Mechanisms of immune injury in rheumatoid arthritis: evidence for the involvement of T cells and heat shock protein. Immunol Rev 1990; 118:233-55.
4. McLean L, Winrow V, Blake D. Current status review. Role of immunity to mycobacterial stress proteins in rheumatoid arthritis. J Exp Pathol 1990; 71:295-303.
5. Kaufmann SHE. Heat shock proteins: a link between rheumatoid arthritis and infection? Curr Opin Rheumatol 1990; 2:430-5.
6. Kaufmann SHE. Heat shock proteins and autoimmunity: a critical appraisal. Int Arch Allergy Immunol 1994; 103:317-22.
7. Winfield J, Jarjour W. Do stress proteins play a role in arthritis and autoimmunity? Immunol Rev 1991; 21:193-220.
8. van Eden W, Holoshitz J, Nevo Z, Frenkel A, Klajman A, Cohen IR. Arthritis induced by a T-lymphocyte clone that responds to Mycobacterium tuberculosis and to cartilage proteoglycan. Proc Natl Acad Sci USA 1985; 82:5117-20.
9. Cohen IR, Holoshitz J, Van Eden W, Frenkel A. T lymphocyte clones illuminate pathogenesis and affect therapy of experimental arthritis. Arthritis Rheum 1985; 28:841-5.
10. van Eden W, Thole JER, Van der Zee R, Noordzij A, Van Embden JDA, Hensen EJ, Cohen IR. Cloning of the mycobacterial epitope recognised by T lymphocytes in adjuvant arthritis. Nature 1988; 331:171-3.
11. Baird PN, Hall LM, Coates ARM. Cloning and sequence analysis of the 10 kD antigen gene of Mycobacterium tuberculosis. J Gen Microb 1989; 135:1-9.
12. Mehra V, Bloom BR, Bajardi AC et al. A major T cell antigen of Mycobacterium leprae is a 10-kD heat-shock cognate protein. J Exp Med 1992; 175:275-84.
13. Baird PN, Hall LMC, Coates ARM. A major antigen from Mycobacterium tuberculosis which is homologous to the heat shock protein GroES from E. coli and hptA gene product of C. burnetti. Nucl Acid Res 1988; 16:9047.
14. Hartman DJ, Hoogenraad NJ, Condron R, Hoy PB. Identification of a mammalian 10-kD heat shock protein, a mitochondrial chaperonin 10 homologue essential for assisted folding of trimeric ornithine transcarbamoylase in vitro. Proc Natl Acad Sci USA 1992; 89:3394-8.
15. Monzini N, Legname G, Marcucci F, Gromo G, Modena D. Identification and cloning of human chaperonin 10 homologue. Biochim Biophys Acta 1994; 1218:478-80.
16. Hartl F-U, Hlodan R, Langer T. Molecular chaperones in protein folding: the art of avoiding sticky situations. Trends Biochem Sci 1994; 19:20-25.
17. Minden P, Houghten RA, Spear JR, Shinnick TM. A chemically synthesized peptide which elicits humoral and cellular immune responses to mycobacterial antigens. Infect Immun 1986; 53:560-4.
18. Barnes PN, Mehra V, Hirschfield GR et al. Characterisation of T cell antigens associated with the cell wall protein-peptidoglycan complex of Mycobacterium tuberculosis. J Immunol 1989; 143:2656-62.
19. Coates ARM, Pallen NMJ, Guy A, Chaparas SD, Mitchinson DA. The 45 kD molecule of Mycobacterium tuberculosis identified by immunoblotting and monoclonal antibodies as antigens in patients with tuberculosis. Br J Exp Pathol 1989; 70:215-25.
20. Verbon A, Hartskeerl RA, Kolk AHJ. Murine and human B cell epitope mapping of the Mycobacterium tuberculosis 10kDa heat shock protein using overlapping peptides. Clin Exp Immunol 1991; 86:6-12.
21. Deshpande RG, Khan MB, Navalkar RG. Immunological evaluation of a 12-kilodalton protein of Mycobacterium tuberculosis by enzyme-linked immunosorbent assay. Tubercle and Lung Disease 1993; 74:382-7.
22. Barnes PF, Mehra V, Rivoire B et al. Immunoreactivity of a 10kDa antigen of Mycobacterium tuberculosis. J Immunol 1992; 148:1835-40.
23. Noonan FP, Halliday WJ, Morton H, Clunie GJA. Early pregnancy factor is immunosuppressive. Nature 1979; 278:649-50.
24. Rolfe BR, Cavanagh AC, Quinn KA, Morton H. Identification of two suppressor factors induced by early pregnancy factor. Clin Exp Immunol 1988; 73:219-25.
25. Rolfe B, Quinn K, Athanasas S, Cavanagh A, Morton H. Genetically restricted effector molecules released by human lymphocytes in response to early pregnancy factor. Immunol Cell Biol 1989; 67:205-8.
26. Cavanagh AC, Morton H. The purification of early pregnancy factor to homogeneity from human platelets and identification as chaperonin 10. Eur J Biochem 1994; 222:551-60.
27. Winrow VR, Mojdehi G, Mapp PI, Rampton DS, Blake DR. Immunohistological localisation of stress proteins in inflammatory tissue. In: Burdon R, Rice-Evans C, Blake D, Winrow V, eds. Stress proteins in inflammation. London: Richelieu Press, 1990: 237-51.
28. Lamb FI, Kingston AE, Estrada-GI, Colslon MJ. Heterologous expression of the 65-kiloDalton antigen of Mycobacterium leprae and murine T-cell responses to the gene product. Infect Immun 1988; 56:1237-41.
29. Mascagni P, Sia DY, Coates ARM, Gibbons WA. Protein engineering HIV viral proteins by total chemical synthesis. The C-terminal 104 residue peptide from GAG-P24. Tetrahedron Letters 1990; 31:4637-40.
30. Mascagni P, Tonolo M, Ball H, Lim M, Ellis RJ, Coates A. Chemical synthesis of 10 kDa chaperonin. Biological activity suggests chaperonins do not require other molecular chaperones. FEBS Lett 1991; 286:201-3.
31. Andrews FJ, Morris CJ, Kondratowicz G, Blake DR. Effect of iron chelation on inflammatory joint disease. Ann Rheum Dis 1987; 46:327-33.
32. Currey HLF, Ziff M. Suppression of adjuvant disease in the rat by heterologous antilymphocyte globulin. J Exp Med 1968; 127:185-203.
33. Winrow VR, Ragno S, Morris CJ et al. Arthritogenic potential of the 65 kDa stress protein - an experimental model. Ann Rheum Dis 1993; 53:197-201.
34. Billingham MEJ, Hicks C, Carney S. Monoclonal antibodies and arthritis. Agents Actions 1990; 29:77-87.
35. Elliott MJ, Maini RN. New directions for biological therapy in rheumatoid arthritis. Int Arch Allergy Immunol 1994; 104:112-25.
36. Billingham MEJ, Carney S, Butler R, Colston MJ. A mycobacterial 65-kD heat shock protein induces antigen-specific suppression of adjuvant arthritis, but is not itself arthritogenic. J Exp Med 1990; 171:339-44.
37. Hogervorst EJM, Schouls L, Wagenaar JPA, Boog CJP, Spaan WJM, van Embden JDA, van Eden W. Modulation of experimental autoimmunity: treatment of adjuvant arthritis by immunisation with a recombinant vaccinia virus. Infect Immun 1991; 59:2029-35.
38. Sternberg EM, Hill JM, Chrousos GP, Kamilaris T, Listwak SJ, Gold PW, Wilder RL. Inflammatory mediator-induced hypothalamic pituitary adrenal axis activation is defective in streptococcal cell wall arthritis-susceptible Lewis rats. Proc Natl Acad Sci USA 1989; 86:2374-8.
39. Chikanza IC, Petrou P, Kingsley G, Chrousos G, Panayi GS. Defective hypothalamic response to immune and inflammatory stimuli in patients with rheumatoid arthritis. Arthritis Rheum 1992; 35:1281-8.
40. Persellin RH. The effect of pregnancy on rheumatoid arthritis. Bull Rheum Dis 1977; 27:922-6.
41. Anderton SM, van der Zee R, Prakken B, Noordzij A, van Eden W. Activation of T cells recognizing self 60-kD heat shock protein can protect against experimental arthritis. J Exp Med 1995; 181:943-52.
42. Elson CJ, Barker RN, Thompson SJ, Williams NA. Immunologically ignorant autoreactive T cells, epitope spreading and repertoire limitation. Immunol Today 1995; 16:71-76.
43. Barrios C, Tougne C, Polla BS, Lambert P-H, Del Guidice G. Specificity of antibodies induced after immunization of mice with the mycobacterial heat shock protein of 65 kDa. Clin Exp Immunol 1994; 98:224-8.
44. Gupta RS. Identification of a GroES (Cpn10)-related sequence motif in the GroEL (Cpn60) chaperonins. Biochem Mol Biol Int 1994; 33:591 5.
45. Ramos-Ruiz R, Lopez-Bote JP, Pelayo F, Larraga V, Van der Zee R, Bernabeu C. Cellular and humoral reactivity pattern to the mycobacterial heat shock protein hsp65 in adjuvant arthritis susceptible and resistant Wistar rats. Autoimmunity 1991; 9:1-5.
46. Ben-Nun A, Mendel I, Sappler G, Kerlero de Rosbo N. A 12-kDa protein of Mycobacterium tuberculosis protects mice against experimental autoimmune encephalomyelitis. Protection in the absence of shared T cell epitopes with encephalitogenic proteins. J Immunol 1995; 154:2939-48.
47. Ferrero RL, Thiberge J-M, Kansau I, Wuscher N, Huerre M, Labigne A. The GroES of Helicobacter pylori confers protective immunity against mucosal infection in mice. Proc Natl Acad Sci USA 1995; 92:6499-503.