Suppressive effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the high-affinity antibody response in C57BL/6 mice

Toxicological Sciences

Volumn 74, Issue 2, 2003, Pages 315-324

  Inouye, Kaoru ^a,b   Ito, Tomohiro ^a,c   Fujimaki, Hidekazu ^a   Takahashi, Yoshimasa ^d   Takemori, Toshitada ^d   Pan, Xiaoqing ^a,c   Tohyama, Chiharu ^a,c   Nohara, Keiko ^a,c  

^a NATIONAL INSTITUTE FOR ENVIRONMENTAL STUDIES   (Japan)

^b JAPAN SOCIETY FOR THE PROMOTION OF SCIENCE   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

Author keywords

Germinal center; High affinity antibody; High affinity antibody forming cell; Humoral immunity; Immune suppression; TCDD

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; ACETIC ACID DERIVATIVE; ANTIGEN; IMMUNOGLOBULIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; OVALBUMIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY AFFINITY; ANTIBODY BLOOD LEVEL; ANTIBODY PRODUCING CELL; ANTIBODY RESPONSE; APOPTOSIS; ARTICLE; B LYMPHOCYTE DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; EXPOSURE; FEMALE; GERMINAL CENTER; HUMORAL IMMUNITY; IMMUNIZATION; IMMUNOGLOBULIN PRODUCTION; IMMUNOTOXICITY; MOUSE; MOUSE STRAIN; NONHUMAN; SPLEEN;

ADMINISTRATION, ORAL; ANIMALS; ANTIBODY AFFINITY; ANTIBODY FORMATION; ANTIBODY-PRODUCING CELLS; ENVIRONMENTAL POLLUTANTS; FEMALE; FLOW CYTOMETRY; GERMINAL CENTER; IMMUNOGLOBULIN G; IMMUNOSUPPRESSIVE AGENTS; MICE; MICE, INBRED C57BL; OVALBUMIN; SPLEEN; TETRACHLORODIBENZODIOXIN;

ANIMALIA; GALLUS GALLUS;

EID: 0042090359     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfg132     Document Type: Article

References (41)

1. Ahmed, R., and Gray, D. (1996). Immunological memory and protective immunity: Understanding their relation. Science 272, 54-60.
2. Camacho, I. A., Nagarkatti, M., and Nagarkatti, P. S. (2002). 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces Fas-dependent activation-induced cell death in superantigen-primed T cells. Arch. Toxicol. 76, 570-580.
3. Fujimaki, H., Nohara, K., Kobayashi, T., Suzuki, K., Eguchi-Kasai, K., Tsukumo, S., Kijima, M., and Tohyama, C. (2002). Effect of a single oral dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin on immune function in male NC/Nga mice. Toxicol. Sci. 66, 117-124.
4. Garside, P., Elizabeth, I., Merica, R. R., Johnson, J. G., Noelle, R. J., and Jenkins, M. K. (1998). Visualization of specific B and T lymphocyte interactions in the lymph node. Science 281, 96-99.
5. Gehrs, B. C., and Smialowicz, R. J. (1999). Persistent suppression of delayed-type hypersensitivity in adult F344 rats after perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicology 134, 79-88.
6. Han, S., Hathcock, K., Zheng, B., Kepler, T. B., Hodes, R., and Kelsoe, G. (1995). Cellular interaction in germinal centers; Roles of CD40 ligand and B7-2 in established germinal centers. J. Immunol. 155, 556-567.
7. Harper, N., Connor, K., Steinberg, M., and Safe, S. (1994). An enzyme-linked immunosorbent assay (ELISA) specific for antibodies to TNP-LPS detects alterations in serum immunoglobulins and isotype switching in C57BL/6 and DBA/2 mice exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds. Toxicology 92, 155-167.
8. Holsapple, M. P., Snyder, N. K., Wood, S. C., and Morris, D. L. (1991). A review of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced changes in immunocompetence: 1991 update. Toxicology 69, 219-255.
9. Ito, T., Inouye, K., Fujimaki, H., Tohyama, C., and Nohara, K. (2002). Mechanism of TCDD-induced suppression of antibody production: Effect on T cell-derived cytokine production in the primary immune reaction of mice. Toxicol. Sci. 70, 46-54.
10. Kamath, A. B., Xu, H., Nagarkatti, P. S., and Nagarkatti, M. (1997). Evidence for the induction of apoptosis in thymocytes by 2,3,7,8-tetrachlorodibenzo-p-dioxin in vivo. Toxicol. Appl. Pharmacol. 142, 367-377.
11. Kelsoe, G. (2000). Studies of the humoral immune response. Immunol. Res. 22, 199-210.
12. Kerkvliet, N. I. (2002). Recent advances in understanding the mechanisms of TCDD immunotoxicity. Int. Immunopharmacol. 2, 277-291.
13. Kerkvliet, N. I., Baecher-Steppan, L., Shepherd, D. M., Oughton, J. A., Vorderstrasse, B. A., and DeKrey, G. K. (1996). Inhibition of TC-1 cytokine production, effector cytotoxic T lymphocyte development and alloantibody production by 2,3,7,8-tetrachlorodibenzo-p-dioxin. J. Immunol. 157, 2310-2319.
14. Kerkvliet, N. I., and Brauner, J. A. (1987). Mechanisms of 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin(HpCDD)-induced humoral immune suppression: Evidence of primary defect in T cell regulation. Toxicol. Appl. Pharmacol. 87, 18-31.
15. Kerkvliet, N. I., Steppan, L. B., Brauner, J. A., Deyo, J. A., Henderson, M. C., Tomar, R. S., and Buhler, D. R. (1990). Influence of the Ah locus on the humoral immunotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin: Evidence for Ah-receptor-dependent and Ah-receptor-independent mechanisms of immunosuppression. Toxicol. Appl. Pharmacol. 105, 26-36.
16. Kolluri, S. K., Weiss, C., Koff, A., and Gottlicher, M. (1999). P27(Kip1) induction and inhibition of proliferation by the intracellular Ah receptor in developing thymus and hepatoma cells. Genes Dev. 13, 1742-1753.
17. Lundberg, K., Dencker, L., and Grinvik, K. O. (1992). 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) inhibits the activation of antigen-specific T cells in mice. Int. J. Immunopharmacol. 14, 699-705.
18. Lundberg, K., Gronvik, K. O., and Dencker, L. (1991). 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induced suppression of the local immune response. Int. J. Immunopharmacol. 13, 357-368.
19. Luster, M. I., Germolec, D. R., Clark, G., Wiegand, G., and Rosenthal, G. J. (1988). Selective effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and corticosteroid on in vitro lymphocyte maturation. J. Immunol. 140, 928-935.
20. MacLennan, I. C. (1994). Germinal centers. Annu. Rev. Immunol. 12, 117-139.
21. Nohara, K., Fujimaki, H., Tsukumo, S., Inouye, K., Sone, H., and Tohyama, C. (2002). Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on T cell-derived cytokine production in ovalbumin (OVA)-immunized C57B1/6 mice. Toxicology 172, 49-58.
22. Nohara, K., Fujimaki, H., Tsukumo, S., Ushio, H., Miyabara, Y., Kijima, M., Tohyama, C., and Yonemoto, J. (2000). The effects of perinatal exposure to low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin on immune organs in rats. Toxicology 145, 227-235.
23. Perez-Melgosa, M., Hollenbaugh, D., and Wilson, C. B. (1999). Cutting edge: CD40 ligand is a limiting factor in the humoral immune response to T cell-dependent antigens. J. Immunol. 163, 1123-1127.
24. Puga, A., Barnes, S. J., Dalton, T. P., Chang, C., Knudsen, E. S., Maier, M. A. (2000). Aromatic hydrocarbon receptor interaction with the retinoblastoma protein potentiates repression of E2F-dependent transcription and cell cycle arrest. J. Biol. Chem. 275, 2943-2950.
25. Schmidt, J. V., and Bradfield, C. A. (1996). Ah receptors signaling pathways. Annu. Rev. Cell. Dev. Biol. 12, 55-89.
26. Shepherd, D. M., Dearstyne, E., and Kerkvliet, N. I. (2000). The effects of TCDD on the activation of ovalbumin (OVA)-specific DO11. 10 transgenic CD4(+) T cells in adoptively transferred mice. Toxicol. Sci. 56, 340-350.
27. Shinall, S. M., Gonzalez-Fernandez, M., Noelle, R. J., and Waldschmidt, T. J. (2000). Identification of murine germinal center B cell subsets defined by the expression of surface isotypes and differentiation antigens. J. Immunol. 164, 5729-5738.
28. Smialowicz, R. J., Williams, W. C., and Riddle, M. M. (1996). Comparison of the T cell-independent antibody response of mice and rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Fundam. Appl. Toxicol. 32, 293-297.
29. Smith, K. G. C., Light, A., Nossal, G. J. V., and Tarlinton, D. M. (1997). The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response. EMBO J. 16, 2996-3006.
30. Staple, J. E., Murante, F. G., Fiore, N. C., Gasiewicz, T. A., and Silverstone, A. E. (1998). Thymic alterations induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin are strictly dependent on aryl hydrocarbon receptor activation in hemopoietic cells. J. Immunol. 160, 3844-3854.
31. Sulentic, C. E. W., Holsapple, M. P., and Kaminski, N. E. (2000). Putative Link between transcriptional regulation of IgM expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin and the aryl hydrocarbon receptor/dioxin-responsive enhancer signaling pathway. J. Pharmacol. Exp. Ther. 295, 705-716.
32. Takahashi, Y., Dutta, P. R., Cerasoli, D. M., and Kelsoe, G. (1998). In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. V. Affinity maturation develops in two stages of clonal selection. J. Exp. Med. 187, 885-895.
33. Takahashi, Y., Ohta, H., and Takemori, T. (2001). Fas is required for clonal selection in germinal centers and the subsequent establishment of the memory B cell repertoire. Immunity 14, 181-192.
34. Tohyama, C. (2002). Low-dose exposure to dioxin, its toxicities and health risk assessment. Environ. Sci. 9, 37-50.
35. Tomar, R. S., and Kerkvliet, N. I. (1991). Reduced T-helper cell function in mice exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Toxicol. Lett. 57, 55-64.
36. Van den Berg, M., Birnbaum, L., Bosveld, A. T. C., Brunstrom, B., Cook, P., Feeley, M., Giesy, J. P., Hanberg, A., Hasegawa, R., Kennedy, S. W., et al. (1998). Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife. Environ. Health Perspect. 106, 775-792.
37. Vorderstrasse, B. A., Steppan, L. B., Silverstone, A. E., and Kerkvliet, N. I. (2001). Aryl hydrocarbon receptor-deficient mice generate normal immune response to model antigens and are resistant to TCDD-induced immune suppression. Toxicol. Appl. Pharmacol. 191, 157-164.
38. Vos, J. G., De Heer, C., and Van Loveren, H. (1997-98). Immunotoxic effects of TCDD and toxic equivalency factors. Teratog. Carcinog. Mutagen. 17, 275-284.
39. Warren, T. K., Mitchell, K. A., and Lawrence, B. P. (2000). Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) suppresses the humoral and cell-mediated immune responses to influenza A virus without affecting cytolytic activity in the lung. Toxicol. Sci. 56, 114-123.
40. Weihua, Z., Saji, S., Makinen, S., Cheng, G., Jensen, E. V., Warner, M., and Gustafsson, J. A. (2000). Estrogen receptor (ER), a modulator of ER in the uterus. Proc. Natl. Acad. Sci. U.S.A. 97, 5936-5941.
41. Wood, S. C., and Holsapple, M. P. (1993). Direct suppression of superantigen-induced IgM secretion in human lymphocytes by 2,3,7,8-TCDD. Toxicol. Appl. Pharmacol. 122, 308-313.