Association of the CTLA-4 gene 49 A/G polymorphism with type 1 diabetes and autoimmune thyroid disease in Japanese children

Diabetes Care

Volumn 26, Issue 3, 2003, Pages 843-847

  Mochizuki, Mie ^a   Amemiya, Shin ^a   Kobayashi, Kisho ^a   Kobayashi, Koji ^a   Shimura, Yoshie ^a   Ishihara, Toshihide ^a   Nakagomi, Yoshiko ^a   Onigata, Kazumichi ^b   Tamai, Shinya ^c   Kasuga, Akira ^d   Nanazawa, Shinpei ^a  

^a UNIVERSITY OF YAMANASHI   (Japan)

^b GUNMA UNIVERSITY   (Japan)

^c Yamato City Hospital   (Japan)

^d Tokyo Denryoku Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GLUTAMATE DECARBOXYLASE ANTIBODY; HLA DR ANTIGEN;

ALLELE; ARTICLE; CELL FUNCTION; COHORT ANALYSIS; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENOTYPE; GRAVES DISEASE; HASHIMOTO DISEASE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; JAPAN; MAJOR CLINICAL STUDY; MALE; PANCREAS ISLET BETA CELL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

ADOLESCENT; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION; AUTOANTIBODIES; CHILD; DIABETES MELLITUS, TYPE 1; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GRAVES DISEASE; HLA-DR ANTIGENS; HUMANS; ISLETS OF LANGERHANS; JAPAN; MALE; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH;

EID: 0041989837     PISSN: 01495992     EISSN: None     Source Type: Journal    
DOI: 10.2337/diacare.26.3.843     Document Type: Article

References (34)

1. Todd JA, Farrall M: Panning for gold: genome-wide scanning for linkage in type 1 diabetes (Review Article). Hum Mol Genet 5:1443-1448, 1996
2. Davies JL, Kawaguchi Y, Bennett ST, Copeman JB, Cordell HJ, Pritchard LE, Reed PW, Gough SC, Jenkins SC, Palmer SM, Balfour KM, Rowe BR, Farrall M, Barnett AH, Bain SC, Todd JA: Genome-wide search for human type 1 diabetes susceptibility genes. Nature 371:130-136, 1994
3. Concannon P, Gogolin-Ewens KJ, Hinds DA, Wapelhorst B, Morrison VA, Stirling B, Mitra M, Farmer J, Williams SR, Cox NJ, Bell GI, Risch N, Spielman RS: A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes. Nat Genet 19:292-296, 1998
4. Walunas TL, Lenschow DJ, Bakker CY, Linsley PS, Freeman GJ, Green JM, Thompson CB, Bluestone JA: CTLA-4 can function as a negative regulator of T cell activation. Immunity 1:405-413, 1994
5. Krummel MF, Allison JP: CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J Exp Med 182:459-465, 1995
6. Walunas TL, Bakker CY, Bluestone JA: CTLA-4 ligation blocks CD28-dependent T cell activation. J Exp Med 183:2541-2550, 1996
7. Yanagawa T, Taniyama M, Enomoto S, Gomi K, Maruyama H, Ban Y, Saruta T: CTLA4 gene polymorphism confers susceptibility to Graves' disease in Japanese. Thyroid 7:843-846, 1997
8. Yanagawa T, Hidaka Y, Guimaraes V, Soliman M, DeGroot LJ: CTLA4 gene polymorphism associated with Graves' disease in Caucasian popilation. J Clin Endocrinol Matab 80:41-45, 1995
9. Awata T, Kurihara S, Iitaka M, Takei S, Inoue I, Ishii C, Negishi K, Izumida T, Yoshida Y, Hagura R, Kuzuya N, Kanazawa Y, Katayama S: Association of CTLA-4 gene A-G polymorphism (IDDM12 locus) with acute-onset and insulin-depleted IDDM as well as autoimmune thyroid disease (Graves' disease and Hashimoto's thyroiditis) in the Japanese population. Diabetes 47:128-129, 1998
10. Donner H, Rau H, Walfish PG, Braun J, Siegmund T, Finke R, Herwig J, Usadel KH, Badenhoop K: CTLA4 alanine-17 confers genetic susceptibility to Graves' disease and to type 1 diabetes mellitus. J Clin Endocrinol Matab 82:143-146, 1997
11. Saiah ID, Larger E, Hammoud EH, Timsit J, Clerc J, Bertin E, Assan R, Boitard C, Bach JFR, Zucman SC: No major role for the CTLA-4 gene in the assciation of autoimmune thyroid disease with IDDM. Diabetes 47:125-127, 1998
12. Marron MP, Raffel LJ, Garchon HJ, Jacob CO, Serrano-Rios M, Larrad MTM, Teng WP, Park Y, Zhang ZX, Goldstein DR, Tao YW, Beaurain G, Bach JF, Huang HS, Luo DF, Zeidler A, Rotter JI, Yang M, Modilevsky T, Zeiler A: Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA-4 polymorphisms in multiple ethnic group. Hum Mol Genet 6:1275-1282, 1997
13. Van der Auwera BJ, Vandewalle CL, Schuit FC, Winnock F, De Leeuw IH, Van Imschoot S, Lamberigts G, Gorus FK: CTLA-4 gene polymorphism confers susceptibility to insulin-dependent diabetes mellitus (IDDM) independently from age and from other genetic or immune disease markers. The Belgian Diabetes Registry. Clin Exp Immunology 110:98-103, 1997
14. Lee YJ, Huang FH, Lo FS, Wang WC, Hsu CH, Kao HA, Yang TY, Chang JG: Assciation of CTLA-4 gene A→G polymorphism with type 1 diabetes in Chinese children. Clin Endocrinol 52:153-157, 2000
15. Yanagawa T, Maruyama T, Gomi K, Taniyama M, Kasuga A, Ozawa Y, Trauchi M, Hiroshi H, Maruyama H, Sruta T: Lack of association between CTLA-4 gene polymorphism and IDDM in Japanese subjects. Autoimmunity 53-56, 1999
16. Takara M, Komiya I, Kinjo Y, Tomoyose T, Yamashiro S, Akamine H, Masuda M, Takasu N: Association of CTLA-4 gene A/G polymorphism in Japanese type 1 diabetic patients with younger age of onset and autoimmune thyroid disease. Diabetes Care 23:975-978, 2000
17. Abe T, Yamaguchi Y, Takino H, Fujita N, Yamaguchi-Degawa M, Ozaki M, Yamakawa K, Sera Y, Sakamachi H, Uotani S, Kawasaki E, Awata T, Yamasaki H, Eguchi K: CTLA-4 gene polymorphism contributes to the mode of onset of diabetes with antiglutamic acid decalboxylase antibody in Japanese patients: genetic analysis of diabetic patients with antiglutamic acid decarboxylase antibody. Diabet Med 18:726-731, 2001
18. Chikuba N, Akazawa S, Yamaguchi Y, Kawasaki E, Takino H, Takao Y, Maeda Y, Okuno S, Yamamoto H, Yokota A, Yoshimoto M, Nagataki S: Type 1 (insulin-dependent) diabetes mellitus with coexisting autoimmune thyroid disease in Japan. Internal Medicine 31:1076-1080, 1992
19. Radetti G, Paganini C, Gentili L, Bernasconi S, Betterle C, Borkenstein M, Cvijovic K, Kadrnka-Lovrencic M, Krzisnik C, Battelino T, Lorini R, Marinoni S, Rigon F, Tato L, Pinelli L, Tonini G: Frequency of Hashimoto's thyroiditis in children with type 1 diabetes mellitus. Acta Diabetologica 32:121-124, 1995
20. Roldan MB, Alonso M, Barrio R: Thyroid autoimmunity in children and adolescents with type 1 diabetes mellitus. Diabetes Nutr Metab 12:27-31, 1999
21. Kawasaki E, Abiru N, Yano M, Uotani S, Matsumoto K, Matsuo H, Yamasaki H, Yamamoto H, Yamaguchi Y, Akazawa S, Nagataki S: Autoantibodies to glutamic acid decarboxylase in patients with autoimmune thyroid disease: relation to competitive insulin autoantibodies. J Autoimmun 8:633-643, 1995
22. Kawasaki E, Takino H, Yano M, Uotani S, Matsumoto K, Takao Y, Yamaguchi Y, Akazawa S, Nagataki S: Autoantibodies to glutamic acid decarboxylase in patients with IDDM and autoimmune thyroid disease. Diabetes 43:80-86, 1994
23. The Committee of Japan Diabetes Society for the Diagnostic Criteria of Diabetes Mellitus: Report of the Committee of Japan Diabetes Society on the Classification and Diagnostic Criteria of Diabetes Mellitus. J Japan Diab Soc 42:385-404, 1999
24. The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus: Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 22 (Suppl. 1):5-19, 1999
25. Akaza T, Imanishi T, Fujiwara K, Tokunaga T, Yashiki S, Fujiyoshi T, Sonoda S, Juji: HLA alleles and haplotypes of Japanese population. MHC & IRS 1 (Suppl): 219-226, 1994
26. Sugihara S, Sakamjak Ti, Konda S, Murata A, Wataki K, Kobayashi Y, Minamitani K, Miyamoto S, Sasaki N, Niimi H: Association of HLA-DR, DQ genotype with different β-cell functions at IDDM diagnosis in Japanese children. Diabetes 46:1893-1897, 1997
27. Kasuga K, Maruyama T, Ozawa O, Takei I, Lernmark A, Saruta T: Antibody to the M(r) 65,000 isoform of glutamic acid decarboxylase are detected in non-insulin-dependent diabetes in Japanese. J Autoimmun 9:105-111, 1996
28. Kasuga A, Ozawa Y, Maryyama T, Ishihara T, Amemiya S, Sruta S: Autoantibody against IA-2 improves the test sensitivity for insulin-dependent diabetes mellitus in Japanese patients of child onset. Endocr J 44:485-491, 1997
29. Urakami T, Miyamoto Y, Fujita H, Kitagawa T: Type 1 (insulin-dependent) diabetes in Japanese children is not a uniform disease. Diabetologia 32:312-315, 1989
30. Kobayashi T, Maruyama T, Shimada A, Kasuga A, Kanatsuka A, Takei I, Takano S, Junichi Y: Insulin intervention to preserve beta cells in slowly progressive insulin-dependent (type 1) diabetes mellitus. Ann N Y Acad Sci 958:117-130, 2002
31. Mochizuki M, Amemiya S, Kobayashi K, Kobayashi K, Ishihara T, Aya M, Kato K, Kasuga A, Nakazawa S: The association of Ala45Thr polymorphism in NeuroD with child-onset type 1a diabetes in Japanese. Diabetes Res Clin Pract 55:11-17, 2002
32. Suzuki H: Chronic thyroiditis (Japanese). Nippon Rinsho 51 (Suppl.):69-76, 1993
33. Iitaka M, Ishii J, Momotani N, Ito K: Graves' disease (Japanese). Nippon Rinsho 51 (Suppl.):53-58, 1993
34. Guo J, Rapoport B, McLachlan SM: Balance of Th1/Th2 cytokines in thyroid autoantibody synthesis in vitro. Autoimmunity 30:1-9, 1999