The association of Ala45Thr polymorphism in NeuroD with child-onset Type 1a diabetes in Japanese

Diabetes Research and Clinical Practice

Volumn 55, Issue 1, 2002, Pages 11-17

  Mochizuki, Mie ^a   Amemiya, Shin ^a   Kobayashi, Kisho ^a   Kobayashi, Koji ^a   Ishihara, Toshihide ^a   Aya, Misaki ^b   Kato, Kazuaki ^c   Kasuga, Akira ^d   Nakazawa, Shinpei ^a  

^a UNIVERSITY OF YAMANASHI   (Japan)

^b Department of Pediatrics   (Japan)

^c Imperial Foundation Saiseikai Utsunomiya Hospital   (Japan)

^d KEIO UNIVERSITY   (Japan)

Author keywords

HLA; IDDM7; NeuroD; Residual beta cell function; Type 1 diabetes

Indexed keywords

ALANINE; GLUTAMATE DECARBOXYLASE; THREONINE;

ADOLESCENT; ALLELE; ARTICLE; B LYMPHOCYTE; CELL FUNCTION; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; EXON; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HETEROZYGOTE; HIGH RISK POPULATION; HLA SYSTEM; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; JAPAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; ONSET AGE; POLYMERASE CHAIN REACTION; PROTEIN VARIANT; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SCHOOL CHILD; TRANSCRIPTION REGULATION;

ADOLESCENT; AGE OF ONSET; ALANINE; ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CHILD; DIABETES MELLITUS, TYPE 1; GENETIC PREDISPOSITION TO DISEASE; HELIX-LOOP-HELIX MOTIFS; HETEROZYGOTE DETECTION; HLA-DR ANTIGENS; HOMOZYGOTE; HUMANS; JAPAN; NERVE TISSUE PROTEINS; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; REFERENCE VALUES; THREONINE; TIME FACTORS; VARIATION (GENETICS);

EID: 0036140222     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8227(01)00242-X     Document Type: Article

References (27)

1. Panning for gold genome-wide scanning for linkage in Type 1 diabetes
2. Linkage disequilibrium mapping of a Type 1 diabetes susceptibility gene (IDDM7) to chromosome 2q31-q33
3. The NEUROD gene maps to human chromosome 2q32 and mouse chromosome 2
4. Analysis of candidate genes for susceptibility to Type 1 diabetes. A case-control and family-association study of genes on chromosome 2q31-35
5. Association of polymorphism in the NeuroD/BETA2 gene with Type 1 diabetes in the Japanese
6. Diabetes detective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/NeuroD-deficient mice, diabetes detective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/NeuroD-deficient mice
7. Mutations in NEUROD1 are associated with the development of Type 2 diabetes mellitus
8. A newly discovered role of transcription factors involved in pancreas development and the pathigenesis of diabetes mellitus
9. Beta-cell transcription factors and diabetes: Mutations in the coding region of the BETA2/NeuroD (NEUROD1) and Nkx2.2 (NKX2B) genes are not associated with maturity-onset diabetes of the young in Japanese
10. No evidence of linkage or diabetes-associated mutations in the transcription factors BETA2/NEUROD1 and PAX4 in Type 2 diabetes in France
11. NeuroD/BETA2 gene variability and diabetes: No associations to late-onset Type 2 diabetes but an A45 allele may represent a susceptibility marker for Type 1 diabetes among Danes
12. Report of The Committee of Japan Diabetes Society on the Classification and Diagnostic Criteria of Diabetes Mellitus
13. The expert committee on the diagnosis and classification of diabetes mellitus. Report of the expert committee on the diagnosis and classification of diabetes mellitus
14. HLA allele and haplotypes of Japanese population
15. Association of HLA-DR, DQ genotype with different β-Cell functions at IDDM diagnosis in Japanese children
16. Antibody to the M(r) 65 000 isoform of glutamic acid decarboxylase are detected in non-insulin-dependent diabetes in Japanese
17. Autoantibody against IA-2 improves the test sensitivity for insulin-dependent diabetes mellitus in Japanese patients of child onset
18. Type 1 (insulin-dependent) diabetes in Japanese children is not a uniform disease
19. The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cells
20. The search for IDDM susceptibility genes: The next generation
21. Age- and HLA-dependent heterogeneity in the association of a marker on chromosome 2q with insulin-dependent diabetes mellitus
22. A genome-wide search for human Type 1 diabetes susceptibility genes
23. Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome 11q
24. A locus on chromosome 15q26 (IDDM3) produces susceptibility to insulin-dependent diabetes mellitus
25. Genetic markers for insulin-dependent diabetes mellitus in Japanese
26. Analysis by polymerase chain reaction of histocompatibility leucocyte antigen-DR9-linled susceptibility to insulin-dependent diabetes mellitus
27. Cross-ethnic group comparisons of HLA class II alleles and insulin dependent diabetes mellitus