CTLA4 gene polymorphism contributes to the mode of onset of diabetes with antiglutamic acid decarboxylase antibody in Japanese patients: Genetic analysis of diabetic patients with antiglutamic acid decarboxylase antibody

Diabetic Medicine

Volumn 18, Issue 9, 2001, Pages 726-731

  Abe, T ^a   Yamaguchi, Y ^a   Takino, H ^a   Fujita, N ^a   Yamauchi Degawa, M ^a   Ozaki, M ^a   Yamakawa, K ^a   Sera, Y ^a   Sakamaki, H ^a   Uotani, S ^a   Kawasaki, E ^a   Awata, T ^b   Yamasaki, H ^a   Eguchi, K ^a  

^a NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b SAITAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

CTLA4; GAD Ab; INS VNTR; Mode of onset

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; ENZYME ANTIBODY; GLUTAMATE DECARBOXYLASE; GLUTAMATE DECARBOXYLASE ANTIBODY; INSULIN; UNCLASSIFIED DRUG;

ADULT; ALLELE; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DNA POLYMORPHISM; EXON; FEMALE; GENETIC ANALYSIS; GENETIC SUSCEPTIBILITY; HUMAN; INSULIN DEFICIENCY; INSULIN DEPENDENT DIABETES MELLITUS; JAPAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; ONSET AGE; PATHOGENESIS; POLYMERASE CHAIN REACTION; PROTEIN LOCALIZATION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; TANDEM REPEAT;

ADULT; ALLELES; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION; AUTOANTIBODIES; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GLUTAMATE DECARBOXYLASE; HUMANS; IMMUNOCONJUGATES; INSULIN; JAPAN; MALE; MIDDLE AGED; MINISATELLITE REPEATS; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH;

EID: 0034797762     PISSN: 07423071     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0742-3071.2001.00551.x     Document Type: Article

References (30)

1. Antibodies to glutamic acid decarboxylase reveal latent autoimmune diabetes mellitus in adults with a non-insulin-dependent onset of diabetes
2. Quantitative assay using recombinant human islet glutamic acid decarboxylase (GAD65) shows that 64K autoantibody positivity at onset predicts diabetes type
3. UKPDS 25: Autoantibodies to islet cytoplasm and glutamic acid decarboxylase for prediction of insulin requirement in type 2 diabetes
4. Clinical evaluation of non-insulin-dependent diabetes mellitus patients with autoantibodies to glutamic acid decarboxylase
5. GAD antibodies in NIDDM: Ten-year follow-up from the diagnosis
6. Latent autoimmune diabetes mellitus in adults (LADA): The role of antibodies to glutamic acid decarboxylase in diagnosis and prediction of insulin dependency
7. A genome-wide search for human type 1 diabetes susceptibility genes
8. Insulin VNTR allele-specific effect in type 1 diabetes depends on identity of untransmitted paternal allele
9. Genetic markers for insulin-dependent diabetes mellitus in Japanese
10. Evidence for association between the class I subset of the insulin gene minisatellite (IDDM2 locus) and IDDM in the Japanese population
11. Genetic analysis of type 1 diabetes using whole genome approaches
12. Panning for gold: Genome-wide scanning for linkage in type 1 diabetes
13. CTLA4 alanine-17 confers genetic susceptibility to Graves' disease and to type 1 diabetes mellitus
14. CTLA4 gene polymorphism correlates with the mode of onset and presence of ICA512 Ab in Japanese Type 1 diabetes
15. Clinical and genetic characteristics of type 2 diabetes with and without GAD antibodies
16. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation
17. Insulin gene 5′ flanking polymorphism length of class 1 alleles in number of repeat units
18. Lack of association of the insulin gene region with type 1 (insulin-dependent) diabetes mellitus in Japanese subjects
19. Autoantibodies to glutamic acid decarboxylase in patients with IDDM and autoimmune thyroid disease
20. Association of CTLA-4 polymorphism with positive anti-GAD antibody in Japanese subjects with type 1 diabetes mellitus
21. Association of CTLA-4 gene A-G polymorphism (IDDM12 locus) with acute-onset and insulin-depleted IDDM as well as autoimmune thyroid disease (Graves' disease and Hashimoto's thyroiditis) in the Japanese population
22. CTLA-4 ligation blocks CD28-dependent T cell activation
23. Regulation of T and B cell responses by modulating interactions between CD28/CTLA4 and their ligands, CD80 and CD86
24. CTLA4 mediates antigen-specific apoptosis of human T cells
25. CTLA-4, a negative regulator of T-lymphocyte activation
26. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
27. CTLA-4-B7 interaction is sufficient to costimulate T cell clonal expansion
28. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
29. CTLA4Ig prevents lymphoproliferation and fatal multiorgan tissue destruction in CTLA-4-deficient mice
30. Cytotoxic T cells specific for glutamic acid decarboxylase in autoimmune diabetes