Sensorimotor deficits and increased brain nicotinic acetylcholine receptors following exposure to chlorpyrifos and/or nicotine in rats

Archives of Toxicology

Volumn 77, Issue 8, 2003, Pages 452-458

  Abou Donia, Mohamed B ^a   Abdel Rahman, Ali ^a   Goldstein, Larry B ^b   Dechkovskaia, Anjelika M ^a   Shah, Deepti U ^a   Bullman, Sarah L ^b   Khan, Wasiuddin A ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b DURHAM VA MEDICAL CENTER   (United States)

Author keywords

Acetylcholinesterase; Central nervous system; Chlorpyrifos; Combined exposure; Muscarinic acetylcholine receptor; Neurotoxicity; Nicotine; Nicotinic acetylcholine receptor; Organophosphorus Insecticides; Sensorimotor; Smoking

Indexed keywords

ACETYLCHOLINESTERASE; CHEMICAL COMPOUND; CHLORPYRIFOS; MUSCARINIC RECEPTOR; NICOTINE; NICOTINIC RECEPTOR;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; BRAIN; BRAIN CORTEX; BRAIN STEM; CENTRAL NERVOUS SYSTEM; CEREBELLUM; CHEMICAL ANALYSIS; CHOLINERGIC SYSTEM; COGNITION; CONTROLLED STUDY; DATA ANALYSIS; ENZYME ACTIVITY; EVALUATION; EXPOSURE; LIGAND BINDING; LOW DRUG DOSE; MALE; MESENCEPHALON; MOTOR DYSFUNCTION; MOTOR PERFORMANCE; NONHUMAN; PRIORITY JOURNAL; RAT; SCORING SYSTEM; SENSORY DYSFUNCTION; STATISTICAL SIGNIFICANCE; TASK PERFORMANCE;

ACETYLCHOLINE; ANIMALS; BEHAVIOR, ANIMAL; BRAIN; CENTRAL NERVOUS SYSTEM AGENTS; CHLORPYRIFOS; CHOLINESTERASES; DRUG INTERACTIONS; INSECTICIDES; LIGANDS; MALE; MOTOR ACTIVITY; NICOTINE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, MUSCARINIC M2; RECEPTORS, NICOTINIC;

ANIMALIA; NICOTIANA TABACUM;

EID: 0041909619     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-003-0463-x     Document Type: Article

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