Herpes simplex virus type 2 virion host shutoff protein regulates alpha/beta interferon but not adaptive immune responses during primary infection in vivo

Journal of Virology

Volumn 77, Issue 17, 2003, Pages 9337-9345

  Murphy, Jenny A ^a   Duerst, Rebecca J ^a   Smith, Tracy J ^a   Morrison, Lynda A ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ALPHA INTERFERON RECEPTOR; BETA INTERFERON; BETA INTERFERON RECEPTOR; INTERFERON RECEPTOR; MUTANT PROTEIN; PROTEIN KINASE; PROTEIN KINASE R; THYMIDINE KINASE; UNCLASSIFIED DRUG; VIRION HOST SHUTOFF PROTEIN; VIRUS PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DOWN REGULATION; GENITAL SYSTEM; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 2; HINDLIMB; HOST RESISTANCE; HYPOTHESIS; IMMUNE RESPONSE; IN VIVO STUDY; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE STRAIN; MUCOSA; NERVOUS SYSTEM; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; UL41 GENE; VIRUS GENE; VIRUS IMMUNITY; VIRUS MUTANT; VIRUS REPLICATION; VIRUS VIRULENCE; WILD TYPE;

ANIMALS; FEMALE; HERPES GENITALIS; HERPESVIRUS 2, HUMAN; INTERFERON-ALPHA; INTERFERON-BETA; MEMBRANE PROTEINS; MICE; MICE, CONGENIC; MICE, INBRED BALB C; MICE, KNOCKOUT; MICE, SCID; MUTATION; RECEPTOR, INTERFERON ALPHA-BETA; RECEPTORS, INTERFERON; TIME FACTORS; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 0041888287     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.77.17.9337-9345.2003     Document Type: Article

References (57)

1. Bolovan, C. A., N. M. Sawtell, and R. L. Thompson. 1994, ICP34.5 mutants of herpes simplex virus type 1 strain 17syn+ are attenuated for neurovirulence in mice and for replication in confluent primary mouse embryo cell cultures. J. Virol. 68:48-55.
2. Cai, W., T. L. Astor, L. M. Liptak, C. Cho, D. M. Coen, and P. A. Schaffer. 1993. The herpes simplex virus type 1 regulatory protein ICP0 enhances virus replication during acute infection and reactivation from latency. J. Virol. 67:7501-7512.
3. 134.5 gene if present before activation of protein kinase R by precluding its phosphorylation and that of the α subunit of eukaryotic translation initiation factor 2. J. Virol. 72:8620-8626.
4. r 90, 000 phosphoprotein with protein kinase PKR in cells exhibiting enhanced phosphorylation of translation initiation factor eIF-2 alpha and premature shutoff of protein synthesis after infection with γ134.5-mutants of herpes simplex virus 1. Proc. Natl. Acad. Sci. USA 92:10516-10520.
5. Clements, G. B., and N. A. Stow. 1989. A herpes simplex virus type 1 mutant containing a deletion within immediate early gene 1 is latency-competent in mice. J. Gen. Virol. 70:2501-2506.
6. Colonna, M., A. Krug, and M. Cella. 2002. Interferon-producing cells: on the front line in immune responses against pathogens. Curr. Opin. Immunol. 14:373-379.
7. Efstathiou, S., S. Kemp, G. Darby, and A. C. Minson. 1989. The role of herpes simplex virus type 1 thymidine kinase in pathogenesis. J. Gen. Virol. 70:869-879.
8. Elgadi, M. M., and J. R. Smiley. 1999. Picornavirus internal ribosome entry site elements target RNA cleavage events induced by the herpes simplex virus virion host shutoff protein. J. Virol. 73:9222-9231.
9. Elgadi, M. M., C. E. Hayes, and J. R. Smiley. 1999. The herpes simplex virus vhs protein induces endoribonucleolytic cleavage of target RNAs in cell extracts. J. Virol. 73:7153-7164.
10. Everly, D. N., and G. S. Read. 1997. Mutational analysis of the virion host shutoff gene (UL41) of herpes simplex virus (HSV): characterization of HSV type 1 (HSV-1)/HSV-2 chimeras. J. Virol. 71:7157-7166.
11. Everly, D. N., and G. S. Read. 1999. Site-directed mutagenesis of the virion host shutoff gene (UL41) of herpes simplex virus (HSV): analysis of functional differences between HSV type 1 (HSV-1) and HSV-2 alleles. J. Virol. 73:9117-9129.
12. Fenwick, M. L., and R. D. Everett. 1990. Transfer of UL41, the gene controlling virion-associated host cell shutoff, between different strains of herpes simplex virus. J. Gen. Virol. 71:411-418.
13. Field, H. J., and P. Wildy. 1978. The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice. J. Hyg. 81:267-277.
14. Gale, M., Jr., and M. G. Katze. 1998. Molecular mechanisms of interferon resistance mediated by viral-directed inhibition of PKR, the interferon-induced protein kinase. Pharmacol. Ther. 78:29-46.
15. Gordon, Y. J., D. M. Gilden, and Y. Becker. 1983. HSV-1 thymidine kinase promotes virulence and latency in the mouse. Investig. Ophthalmol. Vis. Sci. 24:599-602.
16. Harle, P., B. Sainz, Jr., D. J. Carr, and W. P. Halford. 2002. The immediate-early protein, ICP0, is essential for the resistance of herpes simplex virus to alpha/beta interferon. Virology 293:295-304.
17. 134.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1 alpha to dephosphorylate the alpha subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-activated protein kinase. Proc. Natl. Acad. Sci. USA 94:843-848.
18. Hill, A. B., B. C. Barnett, A. J. McMichael, and D. J. McGeoch. 1994. HLA class I molecules are not transported to the cell surface in cells infected with herpes simplex virus types 1 and 2. J. Immunol. 152:2736-2741.
19. Hill, T., R. Sinden, and J. Sadler. 1983. Herpes simplex virus types 1 and 2 induce shutoff of host protein synthesis by different mechanisms in Friend erythroleukemia cells. J. Virol. 45:241-250.
20. Jamieson, A. T., G. A. Gentry, and J. H. Subak-Sharpe. 1974. Induction of both thymidine and deoxycytidine kinase activity by herpes viruses. J. Gen. Virol. 24:465-480.
21. Knipe, D. M., and A. E. Spang. 1982. Definition of a series of stages in the association of two herpesviral proteins with the cell nucleus. J. Virol. 43:314-324.
22. Kwong, A. D., and N. Frenkel. 1987. Herpes simplex virus-infected cells contain a function(s) that destabilizes both host and viral mRNAs. Proc. Natl. Acad. Sci. USA 84:1926-1930.
23. Kwong, A. D., and N. Frenkel. 1989. The herpes simplex virus virion host shutoff function. J. Virol. 63:4834-4839.
24. Lausch, R. N., Y. H. Su, M. Ritchie, and J. E. Oakes. 1991. Evidence endogenous interferon production contributed to the lack of ocular virulence of an HSV intertypic recombinant. Curr. Eye Res. 10:39-45.
25. Leib, D. A., T. E. Harrison, K. M. Laslo, M. A. Machalek, N. J. Moorman, and H. W. Virgin. 1999. Interferons regulate the phenotype of wild-type and mutant herpes simplex viruses in vivo. J. Exp. Med. 189:663-672.
26. Leib, D. A., M. A. Machalek, B. R. Williams, R. H. Silverman, and H. W. Virgin. 2000. Specific phenotypic restoration of an attenuated virus by knockout of a host resistance gene. Proc. Natl. Acad. Sci. USA 97:6097-6101.
27. McDermott, M. R., J. R. Smiley, P. Leslie, J. Brais, H. E. Rudzroga, and J. Bienenstock. 1984. Immunity in the female genital tract after intravaginal vaccination of mice with an attenuated strain of herpes simplex virus type 2. J. Virol. 51:747-753.
28. Mittnacht, S., P. Straub, H. Kirchner, and H. Jacobsen. 1988. Interferon treatment inhibits onset of herpes simplex virus immediate-early transcription. Virology 164:201-210.
29. Mohr, I., and Y. Gluzman. 1996. A herpesvirus genetic element which affects translation in the absence of the viral GADD34 function. EMBO J. 15:4759-4766.
30. Montoya, M., G. Schiavoni, F, Mattei, I. Gresser, F. Belardelli, P. Borrow, and D. F. Tough. 2002. Type I interferons produced by dendritic cells promote their phenotypic and functional activation. Blood 99:3263-3271.
31. Morrison, L. A., and D. M. Knipe. 1996. Mechanisms of immunization with a replication-defective mutant of herpes simplex virus 1. Virology 320:402-413.
32. Mossman, K. L., H. A. Saffran, and J. R. Smiley. 2000. Herpes simplex virus ICP0 mutants are hypersensitive to interferon. J. Virol. 74:2052-2056.
33. Mossman, K. L., and J. R. Smiley. 2002. Herpes simplex virus ICP0 and ICP34.5 counteract distinct interferon-induced barriers to virus replication. J. Virol. 76:1995-1998.
34. Muller, U., U. Steinhoff, L. F. Reis, S. Hemmi, J. Pavlovic, R. M. Zinkernagel, and M. Aguet. 1994. Functional role of type I and type II interferons in antiviral defense. Science 264:1918-1921.
35. Narita, M., Y. Ando, S. Soushi, T. Kurata, and Y. Arao. 1998. The Bg/ II-N fragment of herpes simplex virus type 2 contains a region responsible for resistance to antiviral effects of interferon. J. Gen. Virol. 79:565-572.
36. Ng, T. I., E. Y. Chang, and B. Roizman. 1997. Infected cell protein 22 of herpes simplex virus 1 regulates the expression of virion host shutoff gene UL41. Virology 234:226-234.
37. Nicholl, M. J., L. H. Robinson, and C. M. Preston. 2000. Activation of cellular interferon-responsive genes after infection of human cells with herpes simplex virus type 1. J. Gen. Virol. 81:2215-2218.
38. Oberman, F., and A. Panel. 1988. Inhibition of transcription of herpes simplex virus immediate early genes in interferon-treated human cells. J. Gen. Virol. 69:1167-1177.
39. Oroskar, A. A., and G. S. Read. 1989. Control of mRNA stability by the virion host shutoff function of herpes simplex virus. J. Virol. 63:1897-1906.
40. Overton, H. A., D. J. McMillan, L. S. Klavinskis, L. Hope, A. J. Ritchie, and P. Wong-Kai-In. 1992. Herpes simplex virus type 1 gene UL13 encodes a phosphoprotein that is a component of the virion. Virology 190:184-192.
41. Overton, H., D. McMillan, L. Hope, and P. Wong-Kai-In. 1994. Production of host shutoff-defective mutants of herpes simplex virus type 1 by inactivation of the UL13 gene. Virology 202:97-106.
42. Preston, C. M., A. N. Harman, and M. J. Nicholl. 2001. Activation of interferon response factor-3 in human cells infected with herpes simplex virus type 1 or human cytomegalovirus. J. Virol. 75:8909-8916.
43. Read, G. S., and N. Frenkel. 1983. Herpes simplex virus mutants defective in the virion-associated shutoff of host polypeptide synthesis and exhibiting abnormal synthesis of (immediate early) viral polypeptides. J. Virol. 46:498-512.
44. Reich, N. C. 2002. Nuclear/cytoplasmic localization of IRFs in response to viral infection or interferon stimulation. J. Interferon Cytokine Res. 22:103-109.
45. Sherry, B., J. Torres, and M. A. Blum. 1998. Reovirus induction of and sensitivity to beta interferon in cardiac myocyte cultures correlate with induction of myocarditis and are determined by viral core proteins. J. Virol. 72:1314-1323.
46. Shibaki, T., T. Suzutani, I. Yoshida, M. Ogasawara, and M. Azuma. 2001. Participation of type I interferon in the decreased virulence of the UL13 gene-deleted mutant of herpes simplex virus type I. J. Interferon Cytokine Res. 21:279-285.
47. Smith, T. J., L. A. Morrison, and D. A. Leib. 2001. Pathogenesis of herpes simplex virus type 2 virion host shutoff (vhs) mutants. J. Virol. 76:2054-2061.
48. Smith, T. J., C. E. Ackland-Berglund, and D. A. Leib. 2000. Herpes simplex virus virion host shutoff (vhs) activity alters periocular disease in mice. J. Virol. 74:3598-3604.
49. Strelow, L. I., and D. A. Leib. 1995. Role of the virion host shutoff (vhs) of herpes simplex virus type 1 in latency and pathogenesis. J. Virol. 69:6779-6786.
50. Strelow, L. I., T. Smith, and D. A. Leib. 1997. The virion host shutoff function of herpes simplex virus type 1 plays a role in corneal invasion and functions independently of the cell cycle. Virology 231:28-34.
51. Su, Y. H., J. E. Oakes, and R. N. Lausch. 1993. Mapping the genetic region coding for herpes simplex virus resistance to mouse interferon alpha/beta. J. Gen. Virol. 74:2325-2332.
52. Suzutani, T., M. Nagamine, T. Shibaki, M. Ogasawara, I. Yoshida, T. Daikoku, Y. Nishiyama, and M. Azuma. 2000. The role of the UL41 gene of herpes simplex virus type 1 in evasion of non-specific host defense mechanisms during primary infection. J. Gen. Virol. 81:1763-1771.
53. Taniguchi, T., and A. Takaoka. 2002. The interferon-alpha/beta system in antiviral responses: a multimodal machinery of gene regulation by the IRF family of transcription factors. Curr. Opin. Immunol. 14:111-116.
54. + CTL clones recognize HSV-2 infected fibroblasts after treatment with IFN-γ or when virion host shutoff functions are disabled. J. Immunol. 156:3901-3910.
55. L41 genes of herpes simplex virus 1. J. Virol. 76:6974-6986.
56. Yang, Y. L., L. F. Reis, J. Pavlovic, A. Aguzzi, R. Schafer, A. Kumar, B. R. Williams, M. Aguet, and C. Weissmann. 1995. Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase. EMBO J. 14:6095-6106.
57. Zelus, B. D., R. S. Stewart, and J. Ross. 1996. The virion host shutoff protein of herpes simplex virus type 1: messenger ribonucleolytic activity in vitro. J. Virol. 70:2411-2419.