Transforming growth factor-β receptor-II up-regulation during wound healing in previously irradiated graft beds in vivo

Wound Repair and Regeneration

Volumn 11, Issue 4, 2003, Pages 297-305

  Schultze Mosgau, Stefan ^a,b   Wehrhan, Falk ^a   Rödel, Franz ^a   Amann, Kerstin ^a   Radespiel tröger, Martin ^a   Grabenbauer, Gerhard G ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b NONE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CYTOKINE PRODUCTION; EPITHELIZATION; FIBROSIS; GRACILIS MUSCLE; HEAD AND NECK CANCER; IMMUNOHISTOCHEMISTRY; INFLAMMATION; IRRADIATION; MALE; MYOCUTANEOUS FLAP; NONHUMAN; PREOPERATIVE CARE; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; SKIN GRAFT; WOUND HEALING;

ANIMALS; DISEASE MODELS, ANIMAL; MALE; PEPTIDE FRAGMENTS; PROTEIN PRECURSORS; RATS; RATS, WISTAR; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SKIN TRANSPLANTATION; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TRANSPLANTS; UP-REGULATION; WOUND HEALING;

EID: 0041870915     PISSN: 10671927     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1524-475X.2003.11410.x     Document Type: Article

References (43)

1. Bernstein EF, Harisiadis L, Salomon GD, Harrington F, Mitchell JB, Uitto J, Glatstein E, Russo A. Healing impairment of open wounds by skin irradiation. J Dermatol Surg Oncol 1994;20:757-60.
2. Peat BG, Bell RS, Davis A, O'Sullivan B, Mahoney J, Manktelow RT, Bowen V, Catton C, Fornasier VL, Langer F. Wound-healing complications after soft-tissue sarcoma surgery. Plast Reconstr Surg 1994;93:980-7.
3. Wei FC, Lutz BS, Chen HC, Tsai MH, Lin PY. Free transverse colon transplantation for functional reconstruction of intra-oral lining: a clinical and histologic study. Plast Reconstr Surg 1998;102:2346-51.
4. Aitasalo K, Relander M, Virolainen E. The success rate of free flaps after preoperative irradiation in head and neck reconstruction. Ann Chir Gynaecol 1997;86:311-7.
5. Wang Q, Dickson GR, Carr KE. The effect of graft-bed irradiation on the healing of rat skin grafts. J Invest Dermatol 1996;106:1053-7.
6. Grabenbauer GG, Rödel C, Brunner T, Schultze-Mosgau S, Strnad V, Müller RG, Iro H, Sauer R. Interstitial brachytherapy with Ir-192 low-dose-rate in the treatment of primary and recurrent cancer of the oral cavity and oropharyrnx. Strahlenther Onkol 2001;177:338-44.
7. Herskind C, Bamberg M, Rodemann HP. The role of cytokines in the development of normal-tissue reactions after radiotherapy. Strahlenther Onkol 1998;174 (Suppl 3):12-5.
8. Langberg CW, Hauer-Jensen M, Sung CC, Kane CJ. Expression of fibrogenic cytokines in rat small intestine after fractionated irradiation. Radiother Oncol 1994;32:29-36.
9. Amento EP, Beck LS. TGF-beta and wound healing. Ciba Found Symp 1991;157:115-23.
10. McCune BK, Patterson K, Chandra RS, Kapur S, Sporn MB, Tsokos M. Expression of transforming growth factor-beta isoforms in small round cell tumors of childhood. An immunohistochemical study. Am J Pathol 1993;142:49-58.
11. O'Kane S, Ferguson MW. Transforming growth factor betas and wound healing. Int J Biochem Cell Biol 1997;29:63-78.
12. Beck LS, Chen TL, Mikalauski P, Ammann AJ. Recombinant human transforming growth factor-beta 1 (rhTGF-beta 1) enhances healing and strength of granulation skin wounds. Growth Factors 1990;3:267-75.
13. Bullard KM, Cass DL, Banda MJ, Adzick NS. Transforming growth factor beta-1 decreases interstitial collagenase in healing human fetal skin. J Pediatr Surg 1997;32:1023-7.
14. Broekelmann TJ, Limper AH, Colby TV, McDonald JA. Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis. Proc Natl Acad Sci USA 1991;88:6642-6.
15. Adzick NS, Lorenz HP. Cells, matrix, growth factors, and the surgeon. The biology of scarless fetal wound repair. Ann Surg 1994;220:10-8.
16. Noble NA, Harper JR, Border WA. In vivo interactions of TGF-beta and extracellular matrix. Prog Growth Factor Res 1992;4:369-82.
17. Schultze-Mosgau S, Keilholz L, Rodel F, Labahn D, Neukam FW. Experimental model for transplantation of a modified free myocutaneous gracilis flap to an irradiated neck region in rats. Int J Oral Maxillofac Surg 2001;30:63-9.
18. 2) profile changes in previously irradiated free flap beds. Head Neck 2002;24:33-41.
19. Derynck R. TGF-beta-receptor-mediated signaling. Trends Biochem Sci 1994;19:548-53.
20. Lopez-Casillas F, Wrana JL, Massague J. Betaglycan presents ligand to the TGF beta signaling receptor. Cell 1993;73:1435-44.
21. Massague J, Cheifetz S, Boyd FT, Andres JL. TGF-beta receptors and TGF-beta binding proteoglycans: recent progress in identifying their functional properties. Ann NY Acad Sci 1990;593:59-72.
22. Massague J, Andres J, Attisano L, Cheifetz S, Lopez-Casillas F, Ohtsuki M, Wrana JL. TGF-beta receptors. Mol Reprod Dev 1992;32:99-104.
23. Wrana JL, Attisano L, Wieser R, Ventura F, Massague J. Mechanism of activation of the TGF-beta receptor. Nature 1994;370:341-7.
24. Attisano L, Carcamo J, Ventura F, Weis FM, Massague J, Wrana JL. Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors. Cell 1993;75:671-80.
25. Chen YG, Massague J. Smad1 recognition and activation by the ALK1 group of transforming growth factor-beta family receptors. J Biol Chem 1999;274:3672-7.
26. Choy L, Skillington J, Derynck R. Roles of autocrine TGF-beta receptor and Smad signaling in adipocyte differentiation. J Cell Biol 2000;149:667-82.
27. Massague J. TGF-beta signal transduction. Annu Rev Biochem 1998;67:753-91.
28. Derynck R, Feng XH. TGF-beta receptor signaling. Biochim Biophys Acta 1997;24:1333:F105-50.
29. Gold LI, Sung JJ, Siebert JW, Longaker MT. Type I (RI) and type II (RII) receptors for transforming growth factor-beta isoforms are expressed subsequent to transforming growth factor-beta ligands during excisional wound repair. Am J Pathol 1997;150:209-22.
30. Tam BY, Philip A. Transforming growth factor-beta receptor expression on human skin fibroblasts: dimeric complex formation of type I and type II receptors and identification of glycosyl phosphatidylinositol-anchored transfoming growth factor-beta binding proteins. J Cell Physiol 1998;176:553-64.
31. Schultze-Mosgau S, Rödel F, Radespiel-Tröger M, Wörl J, Grabenbauer GG, Neukam FW. Vascularisation of the area between free grafts and irradiated graft beds in the neck in rats. Br J Oral Maxillofac Surg 2002;40:37-44.
32. Weibel ER. Measuring through the microscope: development and evolution of stereological methods. J Microsc 1989;155:393-403.
33. Ravitz MJ, Wenner CE. Cyclin-dependent kinase regulation during G1 phase and cell cycle regulation by TGF-beta. Adv Cancer Res 1997;71:165-207.
34. Matsuura H, Myokai F, Arata J, Noji S, Taniguchi S. Expression of type II transforming growth factor-beta receptor mRNA in human skin, as revealed by in situ hybridization. J Dermatol Sci 1994;8:25-32.
35. Schultze-Mosgau S, Rödel F, Wehrhan F, Grabenbauer GG, Amann K, Radespiel-Tröger M, Neukam FW. Differences in expression profiles of TGFβ1 and TGFβ2 according to wound healing disorders of free vascular grafts in irradiated graft beds. Eur J Med Res 2001;6:457-8.
36. Schmid P, Itin P, Cherry G, Bi C, Cox DA. Enhanced expression of transforming growth factor-beta type I and type II receptors in wound granulation tissue and hypertrophic scar. Am J Pathol 1998;152:485-93.
37. Chin GS, Liu W, Peled Z, Lee TY, Steinbrech DS, Hsu M, Longaker MT. Differential expression of transforming growth factor-beta receptors I and II and activation of Smad 3 in keloid fibroblasts. Plast Reconstr Surg 2001;108:423-9.
38. Pu LL, Smith PD, Payne WG, Kuhn MA, Wang X, Ko F, Robson MC. Overexpression of transforming growth factor beta-2 and its receptor in rhinophyma: an alternative mechanism of pathobiology. Ann Plast Surg 2000;45:515-9.
39. Hsu M, Peled ZM, Chin GS, Liu W, Longaker MT. Ontogeny of expression of transforming growth factor-beta 1 (TGF-beta 1), TGF-beta 3, and TGF-beta receptors I and II in fetal rat fibroblasts and skin. Plast Reconstr Surg 2001;107:1787-94.
40. Cowin AJ, Holmes TM, Brosnan P, Ferguson MW. Expression of TGF-beta and its receptors in murine fetal and adult dermal wounds. Eur J Dermatol 2001;11:424-31.
41. Zheng H, Wang J, Koteliansky VE, Gotwals PJ, Hauer-Jensen M. Recombinant soluble transforming growth factor beta type II receptor ameliorates radiation enteropathy in mice. Gastroenterology 2000;119:1286-96.
42. Isaka Y, Akagi Y, Ando Y, Tsujie M, Sudo T, Ohno N, Border WA, Noble NA, Kaneda Y, Hori M, Imai E. Gene therapy by transforming growth factor-beta receptor-IgG Fc chimera suppressed extracellular matrix accumulation in experimental glomerulonephritis. Kidney Int 1999;55:465-75.
43. Mori Y, Hatamochi A, Arakawa M, Ueki H. Reduced expression of mRNA for transforming growth factor beta (TGF beta) and TGF beta receptors I and II and decreased TGF beta binding to the receptors in in vitro-aged fibroblasts. Arch Dermatol Res 1998;290:158-62.