Transforming growth factor-β receptor expression on human skin fibroblasts: Dimeric complex formation of type I and type II receptors and identification of glycosyl phosphatidylinositol-anchored transforming growth factor-β binding proteins

Journal of Cellular Physiology

Volumn 176, Issue 3, 1998, Pages 553-564

  Tam, Betty Y Y ^b   Philip, Anie ^a  

^a MONTREAL GENERAL HOSPITAL   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; DIMER; DNA; GLYCOSYLPHOSPHATIDYLINOSITOL; RECEPTOR SUBTYPE; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3;

ADULT; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DNA SYNTHESIS; HUMAN; HUMAN CELL; NORMAL HUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; SKIN FIBROBLAST;

EID: 0031877381     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4652(199809)176:3<553::AID-JCP12>3.0.CO;2-0     Document Type: Article

References (43)

1. Bassing, C.H., Yingling, J.M., Howe, D.J., Wang, T., He, W.W., Gustafson, M.L., Shah, P., Donahoe, P.K., and Wang, X.-F. (1994) A transforming growth factor-β type I receptor that signals to activate gene expression. Science, 263:87-89.
2. Border, W.A., and Noble, N.A. (1994) Transforming growth factor-β in tissue fibrosis. N. Engl. J. Med., 331:1286-1292.
3. Broekelmann, T.J., Limper, A.H., Colby, T.V., and McDonald, J.A. (1991) Transforming growth factor-β is present at sites of extracellular matrix gene expression in human pulmonary fibrosis. Proc. Natl. Acad. Sci. USA, 88:6642-6646.
4. Cheifetz, S., Hernandez, H., Laiho, M., ten Dijke, P., Iwata, K., and Massague, J. (1990) Distinct transforming growth factor-β (TGF-β) receptor subsets as determinants of cellular responsiveness to three TGF-β isoforms. J. Biol. Chem., 265:20533-20538.
5. Cheifetz, S., and Massague, J. (1991) Isoform specific transforming growth factor-β binding proteins with membrane attachments sensitive to phosphatidyl-specific phospholipase C. J. Biol. Chem., 266:20767-20772.
6. Cheifetz, S., Bellon, T., Cales, C., Vera, S., Bernabeu, C., Massague, J., and Letarte, M. (1992) Endoglin is a component of the transforming growth factor-β receptor system in human endothelial cells. J. Biol. Chem., 267:19027-19030.
7. Clark, R.A.F., Nielsen, L.D., Welch, M.P., and McPherson, J.M. (1995) Collagen matrices attenuate the collagen synthetic response of cultured fibroblasts to TGF-β. J. Cell. Sci., 108:1251-1261.
8. Clark, R.A.F., McCoy, G.A., Folkvord, J.M., and McPherson, J.M. (1997) TGF-β1 stimulates cultured human fibroblasts to proliferate and produce tissue-like fibroplasia: A fibronectin matrix-dependent event. J. Cell. Physiol., 170:69-80.
9. Coffey, R.J., Goustin, A.S., Mangelsdorf Soderquist, A., Shipley, G.D., Wolfshohl, J., Carpenter, G., and Moses, H.L. (1987) Transforming growth factor α and β expression in human colon cancer lines: Implications for an autocrine model. Cancer Res., 47:4590-4594.
10. Dumont, N., O'Connor-McCourt, M., and Philip, A. (1995) Transforming growth factor-β on human endometrial cells: Identification of the type I, II and III receptors, and glycosyl-phosphatidylinositol anchored TGF-β binding proteins. Mol. Cell. Endocrinol., 111:57-66.
11. Frank, S., Madlener, M., and Werner, S. (1996) Transforming growth factors β1, β2 and β3 and their receptors are differentially regulated during normal and impaired wound healing. J. Biol. Chem., 271:10188-10193.
12. Franzen, P., ten Dijke, P., Ichijo, H., Yamashita, H., Schultz, P., Heldin, C.H., and Miyazono, K. (1993) Cloning of TGF-β type I receptor that forms a heterodimeric complex with the type II TGF-β receptor. Cell, 75:681-692.
13. Click, A.B., Danielpour, D., Morgan, D., Sporn, M.B., and Yuspa, S.H. (1990) Induction and autocrine receptor binding of TGF-β2 during terminal differentiation of primary mouse keratinocytes. Mol. Endocrinol., 4:46-52.
14. Henis, Y.I., Moustakas, A., Lin, H.Y., and Lodish, H.F. (1994) The type II and III transforming growth factor-β receptors form homooligomers. J. Cell. Biol., 726:139-154.
15. Kane, C.J.M., Knapp, A.M., Mansbridge, J.N., and Hanawalt, P.C. (1990) Transforming growth factor β1 localization in normal and psoriatic epidermal keratinocytes in situ. J. Cell. Physiol., 144:144-150.
16. Ksander, G.A., Gerhardt, C.O., and Olsen, D.R. (1993) Exogenous transforming growth factor-β2 enhances connective tissue forma-tion in transforming growth factor-β-deficient, healing-impaired dermal wounds in mice. Wound Rep. Regul., 1:137-48.
17. Laiho, M., Weis, F.M., Boyd, F.T., Ignotz, R.A., and Massague, J. (1991) Responsiveness to transforming growth factor-β (TGF-β) restored by genetic complementation between cells defective in TGF-β receptors I and II. J. Biol. Chem., 266:9108-9112.
18. Levine, J.H., Moses, H.L., Gold, L.I., and Nanney, L.B. (1993) Spatial and temporal patterns of immunoreactive patterns of immunoreactive transforming growth factor β1, β2 and β3 during excisional wound repair. Am. J. Pathol., 143:368-380.
19. Lin, H.Y., Wang, X.-F., Ng-Eaton, E., Wainberg, R.A., and Lodish, H.F. (1992) Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase. Cell, 68:775-785.
20. Lopez-Casillas, F., Chieftez, S., Doody, J., Andres, J., Lane, W.S., and Massague, J. (1991) Structure and expression of the membrane proteoglycan betaglycan, a component of the TGF-β receptor system Cell, 67:785-795.
21. Lopez-Casillas, F., Wrana, J.L., and Massague, J. (1993) Betaglycan presents ligand to the TGF-β signalling receptor. Cell, 73:1435-1444.
22. Luo, K., and Lodish, H. (1996) Signaling by chimeric erythropoietin-TGF-β receptors: Homodimerization of the cytoplasmic domain of the type I TGF-β receptor and heterodimerization with the type II receptor are both required for intracellular signal transduction. EMBO J., 15:4485-4496.
23. MacKay, K., and Danielpour, D. (1991) Novel 150 and 180 kDa glycoproteins that bind TGF-β1, but not TGF-β2 are present in several cell lines. J. Biol. Chem., 206:9907-9911.
24. MacKay, K., Robbins, A.R., Bruce, M.D., and Danielpour, D. (1990) Identification of disulfide linked transforming growth factor-β1-specific binding proteins in rat glomeruli. J. Biol. Chem., 265:9351-9356.
25. Massague, J. (1990) The transforming growth factor-β family. Annu. Rev. Cell Biol., 6:597-641.
26. Moustakas, A., Lin, H.Y., Henis, Y.I., Plamondon, J., O'Conner-McCourt, M.D., and Lodish, H.F. (1993) The TGF-β receptors types I, II and III form hetero-oligomeric complexes in the presence of ligand. J. Biol. Chem., 268:22215-22218.
27. Nagy, P., Schaff, Z., and Lapis, K. (1991) Immunohistochemical detection of transforming growth factor-β1 in fibrotic liver diseases. Hepatology, 74:269-273.
28. O'Kane, S., and Ferguson, M.W.J. (1997) Transforming growth factor βs and wound healing. Int. J. Biochem. Cell Biol., 29:63-78.
29. Peltonen, J., Hsiao, L.L., Jaakkola, S., Sollberg, S., Aumailley, M., Timpl, R., Chu, M.L., and Uitto, J. (1991) Activation of collagen gene expression in keloids: Co-localization of type I and type IV collagen and transforming growth factor-β1 mRNA. J. Invest. Dermatol., 97:240-248.
30. 2-macroglobulin: Role in transforming growth factor-β1 clearance. J. Biol. Chem., 266:22290-22296.
31. Quaglino, D., Nanney, L.B., Ditesheim, J.A., and Davidson, J.M. (1987) Transforming growth factor-β stimulates wound healing and modulates extracellular matrix gene expression in pig skin incisional wound model. J. Invest. Dermatol., 97:34-42.
32. Roberts, A.B., and Sporn, M.B. (1990) The transforming growth factor-βs. In: Peptide Growth Factors and Their Receptors I. M.B. Sporn and A.B. Roberts, eds., Springer-Verlag, New York, pp. 419-472.
33. Schmid, P., Cox, D., Bilbe, G., McMaster, G., Morrison, C., Stahelin, H., Luscher, N., and Seiler, W. (1993) Transforming growth factor-βs and transforming growth factor-β type II receptor in human epidermis: Differential expression in acute and chronic skin wounds. J. Pathol., 171:191-197.
34. Segarini, P., Rosen, D.M., and Seyedin, S.M. (1989) Binding of transforming growth factor-β to cell surface proteins varies with cell type. Mol. Endocrinol., 3:261-272.
35. Shah, M., Foreman, D.M., and Ferguson, M.W.J. (1995) Neutralization of TGF-β1 and TGF-β2 on exogenous addition of TGF-β3 to cutaneous rat wounds reduces scarring. J. Cell Sci., 108:985-1002.
36. Soma, Y., and Grotentdorst, G.R. (1989) TGF-β stimulates primary human skin fibroblast DNA synthesis via an autocrine production of PDGF-related peptides. J. Cell. Physiol., 140:246-253.
37. Stefanova, I., Corcoran, M.L., Horak, E.M., Wahl, L.M., Bolen, J.B., and Horak, I.D. (1993) Lipopolysaccharide induces activation of CD14-associated protein tyrosine kinase P53/561yn. J. Biol. Chem., 268:20725-20728.
38. Wakefield, L.M., Smith, D.M., Masui, T., Harris, C.C., and Sporn, M.B. (1987) Distribution and modulation of the cellular receptors for transforming growth factor-β. J. Cell Biol., 105:965-75.
39. Wang, X.F., Lin. H.F., Ng-Eaton, E., Downward, J., Lodish, H.F., and Weinberg, R.A. (1992) Expression cloning and characterization of the TGF-β type III receptor. Cell, 67:797-805.
40. Wrana, J.L., Attisano, L., Carcamo, J., Zentella, A., Doody, J., Laiho, M., Wang, X.-F., and Massague, J. (1992) TGF-β signals through a heterodimeric protein kinase receptor complex. Cell, 71:1003-1014.
41. Wu, L., and Mustoe, T.A. (1995) Effect of ischemia on growth factor enhancement of incisional wound healing. Surgery, 177:570-576.
42. Yamamoto, T., Noble, N.A., Miller, D.E., and Border, W.A. (1994) Sustained expression of TGF-β1 underlies development of progressive kidney fibrosis. Kidney Int., 45:916-927.
43. Yamashita, H., ten Dijke, P., Franzen, P., Miyazono, K., and Heldin, C. (1994) Formation of heterooligomeric complexes of type I, type II receptors for transforming growth factor-β. J. Biol. Chem., 269:20172-20178.