Enhanced expression of transforming growth factor-β type I and type II receptors in wound granulation tissue and hypertrophic scar

American Journal of Pathology

Volumn 152, Issue 2, 1998, Pages 485-493

  Schmid, Peter ^a,d   Itin, Peter ^a   Cherry, George ^b   Bi, Chen ^c   Cox, David A ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b CHURCHILL HOSPITAL   (United Kingdom)

^c FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^d NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2;

ADOLESCENT; ADULT; ARTICLE; BURN; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; EPIDERMIS; FEMALE; GRANULATION TISSUE; HUMAN; HUMAN TISSUE; HYPERTROPHIC SCAR; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN FIBROBLAST; WOUND HEALING;

ACTINS; ADOLESCENT; ADULT; CHILD; CHILD, PRESCHOOL; CICATRIX, HYPERTROPHIC; FEMALE; GRANULATION TISSUE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MUSCLE, SMOOTH; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; REFERENCE VALUES; RNA, MESSENGER; WOUND HEALING;

EID: 0031931615     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Roberts AB, Sporn MB: Physiological actions and clinical application of transforming growth factor-β (TGF-β). Growth Factors 1993, 8:1-9
2. Wrana JL, Attisano L, Wieser R, Ventura F, Massague J: Mechanism of activation of the TGF-β receptor. Nature 1994, 370:341-347
3. Wieser R, Wrana JL, Massague J: GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex. EMBO J 1995, 14:2199-2208
4. Attisano L, Wrana JL, Montalvo E, Massague J: Activation of signaling by the activin receptor complex. Mol Cell Biol 1996, 16:1066-1073
5. Massague J: TGF-β signaling: receptors, transducers, and Mad proteins. Cell 1996, 85:947-950
6. Wrana JL, Attisano L: Mad-related proteins in TGF-β signaling. Trends Genet 1996, 12:493-496
7. Wahl SM, Hunt DA, Wakefield LM, McCartney-Francis N, Wahl LM, Roberts AB, Sporn MB: Transforming growth factor type β induces monocyte chemotaxis and growth factor production. Proc Natl Acad Sci USA 1987, 84:5788-5792
8. Postlethwaite AE, Keski-Oja J, Moses HL, Kang AH: Stimulation of the chemotactic migration of human fibroblasts by transforming growth factor-β. J Exp Med 1987, 165:251-256
9. Wahl SM, McCartney-Francis N, Allen JB, Dougherty EB, Dougherty SF: Macrophage production of TGF-β and regulation by TGF-β. Ann NY Acad Sci 1990, 593:188-196
10. Van-Obberghen-Schilling E, Roche NS, Flanders KC, Sporn MB, Roberts AB: Transforming growth factor beta 1 positively regulates its own expression in normal and transformed cells. J Biol Chem 1988, 263:7741-7746
11. Roberts AB: Transforming growth factor-β: activity and efficacy in animal models of wound healing. Wound Rep Reg 1995, 3:408-418
12. Frank S, Madlener M, Werner S: Transforming growth factors β1, β2, and β3 and their receptors are differentially regulated during normal and impaired wound healing. J Biol Chem 1996, 271:10188-10193
13. Border WA, Noble NA: Transforming growth factor β in tissue fibrosis. N Engl J Med 1994, 10:1286-1292
14. Peltonen J, Kahari L, Jaakkola S, Kahari VM, Varga J, Uitto J, Jimenez SA: Evaluation of transforming growth factor β and type I procollagen gene expression in fibrotic skin diseases by in situ hybridisation. J Invest Dermatol 1990, 94:365-367
15. Ghahary A, Shen YJ, Scott PG, Gong Y, Tredget EE: Enhanced expression of mRNA for transforming growth factor-β, type I and type III procollagen in human post-burn hypertrophic scar tissues. J Lab Clin Med 1993, 122:465-473
16. Scott PG, Dodd CM, Tredget EE, Ghahary A, Raehemtulla F: Immunohistochemical localization of the proteoglycans decorin, biglycan and versican and transforming growth factor-β in human post-burn hypertrophic and mature scars. Histopathology 1995, 6:423-431
17. Zhang K, Warren G, Cohen, Rodrigues J, Phan S: Increased types I and II collagen and transforming growth factor-β1 mRNA and protein in hypertrophic burn scar. J Invest Dermatol 1995, 104:750-754
18. Peltonen J, Hsiao LL, Jaakkola S, Kähäri VM, Varga J, Uitto J, Jimenez SA: Activation of collagen gene expression in keloids: co-localization of type I and VI collagen and transforming growth factor-beta 1. J Invest Dermatol 1991, 97:240-248
19. Garner WL, Karmiol S, Rodriguez JL, Smith DJ, Phan SH: Phenotypic differences in cytokine responsiveness of hypertrophic scar versus normal dermal fibroblasts. J Invest Dermatol 1993, 101:875-879
20. Schmid P, Itin P, Rufli T: In situ analysis of transforming growth factors (TGF-β1, TGF-β2, TGF-β3), and TGF-β type II receptor expression in malignant melanoma. Carcinogenesis 1995, 7:1499-1503
21. Blackburn WR, Cosman C: Histologic basis of keloid and hypertrophic scar differentiation. Arch Pathol 1996, 82:65-71
22. Linares HA, Kischer CW, Dobrowsky M, Larson DL: The histotypic organization of the hypertrophic scar in humans. J Invest Dermatol 1972, 59:323-331
23. Sempowski GD, Borrello MA, Blieden TM, Barth RK, Phipps RP: Fibroblast heterogeneity in the healing wound. Wound Rep Reg 1995, 3:120-131
24. Goldring SR, Stephenson ML, Downie E, Krane SM, Korn JH: Heterogeneity in hormone responses and pattern of collagen synthesis in cloned dermal fibroblasts. J Clin Invest 1990, 85:798-803
25. Kim SJ, Angel P, Lafyatis R, Hattori K, Kim KY, Sporn MB, Karin M, Roberts AB: Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex. Mol Cell Biol 1990, 10:1492-1497
26. Quaglino D, Nanney LB, Kennedy R, Davidson JM: Transforming growth factor-β stimulates wound healing and modulates extracellular matrix gene expression in pig skin. I. Excisional wound model. Lab Invest 1990, 63:307-319
27. Quaglino D, Nanney LB, Dietesheim JA, Davidson JM: Transforming growth factor-β stimulates wound healing and modulates extracellular matrix gene expression in pig skin. II. Incisional wound model. J Invest Dermatol 1991, 97:34-42
28. Schmid P, Kunz S, Cerletti N, McMaster G, Cox D: Injury induced expression of TGF-β1 mRNA is enhanced by exogenously applied TGF-βs. Biochem Biophys Res Commun 1993, 194:399-406
29. Bloom BB, Humphries DE, Kuang PP, Fine A, Goldstein RH: Structure and expression of the promotor for the RI human type I transforming growth factor-β receptor: regulation by TGF-β. Biochim Biophys Acta 1996, 1312:243-248
30. McWhirter A, Colosetti P, Rubin K, Miyazono K, Black C: Collagen type I is not under autocrine control by transforming growth factor-beta 1 in normal and scleroderma fibroblasts. Lab Invest 1994, 71:885-894
31. Gold LI, Sung JJ, Siebert JW, Longaker MT: Type I (RI) and type II (RII) receptors for transforming growth factor-β isoforms are expressed subsequently to transforming growth factor-β ligands during excisional wound repair. Am J Pathol 1997, 150:209-222
32. Häkkinen L, Westermarck J, Kähäri V-M, Larjava H: Human granulation-tissue fibroblasts show enhanced proteoglycan gene expression and altered response to TGF-β1. J Dent Res 1996, 75:1767-1778
33. Whitby DJ, Ferguson MWJ: The extracellular matrix of lip wounds in fetal, neonatal and adult mice. Development 1991, 112:651-668
34. Whitby DJ, Ferguson MWJ: Immunohistochemical localization of growth factors in fetal wound healing. Dev Biol 1991, 147:207-215
35. Shah M, Foreman DM, Ferguson MWJ: Control of scarring in adult wounds by neutralising antibody to transforming growth factor β. Lancet 1992, 339:213-214
36. Darby I, Skalli O, Gabbiani G: α-Smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing. Lab Invest 1990, 63:21-29
37. Ehrlich HP, Desmouliere A, Diegelmann RF, Cohen IK, Compton CC, Garner WL, Kapanci Y, Gabbiani G: Morphological and immunochemical differences between keloid and hypertrophic scar. Am J Pathol 1994, 145:105-113
38. Sundberg C, Ivarsson M, Gerdi B, Rubin K: Pericytes as collagen-producing cells in excessive dermal scarring. Lab Invest 1996, 74: 452-466
39. Ivarsson M, Sundberg C, Farrokhnia N, Pertoft H, Rubin K, Gerdin B: Recruitment of type I collagen producing cells from the microvasculature in vitro. Exp Cell Res 1996, 229:336-349
40. Desmouliere A, Geinoz A, Gabbiani F, Gabbiani G: Transforming growth factor-β1 induces α-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J Cell Biol 1993, 122:103-111
41. Desmouliere A, Redard M, Darby I, Gabbiani G: Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar. Am J Pathol 1995, 146:56-66