Role of solution conformation and flexibility of short peptide ligands that bind to the p56lck SH2 domain

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 6, 2003, Pages 941-949

  Dekker, Frank J ^a   De Mol, Nico J ^a   Bultinck, Patrick ^b   Kemmink, Johan ^a   Hilbers, Hans W ^a   Liskamp, Rob M J ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b GHENT UNIVERSITY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL 4 TYROSYLALANYLALANYLISOLEUCINAMIDE; ACETYL 4 TYROSYLGLUTAMYLGLUTAMYLISOLEUCINAMIDE; ACETYL 4 TYROSYLGLYCYLGLYCYLISOLEUCINAMIDE; PEPTIDE; PROTEIN KINASE P60; PROTEIN P56; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG CONFORMATION; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG SOLUTION; ELECTRICITY; ENERGY; ENTHALPY; ENTROPY; MATHEMATICAL ANALYSIS; NUCLEAR MAGNETIC RESONANCE; PROTEIN DOMAIN; PROTEIN FAMILY; SRC HOMOLOGY DOMAIN; SURFACE PLASMON RESONANCE; TEMPERATURE; THERMODYNAMICS;

LIGANDS; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PEPTIDES; PROTEIN CONFORMATION; SOLUTIONS; SRC HOMOLOGY DOMAINS; SURFACE PLASMON RESONANCE; TEMPERATURE; THERMODYNAMICS;

EID: 0037333328     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(02)00536-9     Document Type: Article

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