Altered expression of 3α-hydroxysteroid dehydrogenases in human glaucomatous optic nerve head astrocytes

Neurobiology of Disease

Volumn 14, Issue 1, 2003, Pages 63-73

  Agapova, O A ^a   Yang, P ^a   Wang, W H ^b   Lane, D A ^b   Clark, A F ^b   Weinstein, B I ^c   Hernandez, M R ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ALCON RESEARCH LTD   (United States)

^c NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

3 HSD; AKR1C1; AKR1C2; AKR1C3; Glaucoma; Human; Immunohistochemistry; In situ hybridization; Monkey; Neurosteroid; Optic nerve head astrocytes; Optic nerve transection; Real time RT PCR

Indexed keywords

3ALPHA HYDROXYSTEROID DEHYDROGENASE; ANDROSTANEDIOL; ISOPROTEIN; MESSENGER RNA; NEUROSTEROID;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; EXPERIMENTAL MODEL; FEMALE; GLAUCOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROSTATIC PRESSURE; IN VITRO STUDY; INTRAOCULAR PRESSURE; MALE; MONKEY; NERVE TRANSECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN ANGLE GLAUCOMA; OPTIC NERVE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS;

EID: 0041833412     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-9961(03)00101-3     Document Type: Article

References (50)

1. Agapova O.A., Kaufman P.L., Lucarelli M.J., Gabelt B.T., Hernandez M.R. Differential expression of matrix metalloproteinases in monkey eyes with experimental glaucoma or optic nerve transection. Brain Res. 967:2003;132-143.
2. Agapova O.A., Ricard C.S., Salvador-Silva M., Hernandez M.R. Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human optic nrve head astrocytes. Glia. 33:2001;205-216.
3. Alward W.L., Fingert J.H., Coote M.A., Johnson A.T., Lerner S.F., Junqua D., Durcan F.J., McCartney P.J., Mackey D.A., Sheffield V.C., Stone E.M. Clinical features associated with mutations in the chromosome 1 open-angle glaucoma gene (GLCIA). N. Engl. J. Med. 338:1998;1022-1027.
4. Armaly M.F., Becker B. Intraocular pressure response to topical corticosteroids. Fed. Proc. 24:1965;1274-1278.
5. Baulieu E.E., Robel P., Schumacher M. Neurosteroids beginning of the story . Int. Rev. Neurobiol. 46:2001;1-32.
6. Burczynski M.E., Lin H.K., Penning T.M. Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase . Cancer Res. 59:1999;607-614.
7. Burczynski M.E., Sridhar G.R., Palackal N.T., Penning T.M. The reactive oxygen species - and Michael acceptor-inducible human aldo-keto reductase AKR1C1 reduces the alpha, beta-unsaturated aldehyde4-hydroxy-2-nonenal to 1,4-dihydroxy-2-nonene. J. Biol. Chem. 276:2001;2890-2897.
8. Covey D.F., Evers A.S., Mennerick S., Zorumski C.F., Purdy R.H. Recent developments in structure-activity relationships for steroid modulators of GABA(A) receptors. Brain Res. Brain Res. Rev. 37:2001;91-97.
9. Del Cerro S., Garcia-Estrada J., Garcia-Segura L.M. Neuroactive steroids regulate astroglia morphology in hippocampal cultures from adult rats. Glia. 14:1995;65-71.
10. di Michele F., Lekieffre D., Pasini A., Bernardi G., Benavides J., Romeo E. Increased neurosteroids synthesis after brain and spinal cord injury in rats. Neurosci. Lett. 284:2000;65-68.
11. Empson R.M., Sheardown M.J., Newberry N.R. Modulation of gamma-aminobutyric acid responses in the rat optic nerve. Eur. J. Pharmacol. 401:2000;339-342.
12. Falkenstein E., Tillmann H.C., Christ M., Feuring M., Wehling M. Multiple actions of steroid hormones - a focus on rapid, nongenomic effects. Pharmacol. Rev. 52:2000;513-556.
13. Fern R., Waxman S.G., Ransom B.R. Endogenous GABA attenuates CNS white matter dysfunction following anoxia. J. Neurosci. 15:1995;699-708.
14. Frye C.A., McCormick C.M. The neurosteroid, 3alpha-androstanediol, prevents inhibitory avoidance deficits and pyknotic cells in the granule layer of the dentate gyrus induced by adrenalectomy in rats. Brain Res. 855:2000;166-170.
15. Gibbs, T.T., Farb, D.H., 2000. Dueling enigmas: neurosteroids and sigma receptors in the limelight. Sci. STKE 2000, E1.
16. Hernandez M.R. The optic nerve head in glaucoma role of astrocytes in tissue remodeling . Prog. Retin Eye Res. 19:2000;297-321.
17. Hernandez M.R., Agapova O.A., Yang P., Salvador-Silva M., Ricard C.S., Aoi S. Differential gene expression in astrocytes from human normal and glaucomatous optic nerve head analyzed by cDNA microarray. Glia. 38:2002;45-64.
18. Hernandez M.R., Pena J.D. The optic nerve head in glaucomatous optic neuropathy. Arch. Ophthalmol. 115:1997;389-395.
19. Hernandez M.R., Pena J.D., Selvidge J.A., Salvador-Silva M., Yang P. Hydrostatic pressure stimulates synthesis of elastin in cultured optic nerve head astrocytes. Glia. 32:2000;122-136.
20. Kaarniranta K., Elo M., Sironen R., Lammi M.J., Goldring M.B., Eriksson J.E., Sistonen L., Helminen H.J. Hsp70 accumulation in chondrocytic cells exposed to high continuous hydrostatic pressure coincides with mRNA stabilization rather than transcriptional activation. Proc. Natl. Acad. Sci. USA. 95:1998;2319-2324.
21. Kass M.A., Heuer D.K., Higginbotham E.J., Johnson C.A., Keltner J.L., Miller J.P., Parrish R.K., Wilson M.R., Gordon M.O. The Ocular Hypertension Treatment Study a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma . Arch. Ophthalmol. 120:2002;701-713.
22. Leske M.C. The epidemiology of open-angle glaucoma. Am. J. Epidemiol. 118:1983;166-191.
23. Makara G.B., Haller J. Non-genomic effects of glucocorticoids in the neural system. Evidence, mechanisms and implications. Prog. Neurobiol. 65:2001;367-390.
24. Martini L., Celotti F., Melcangi R.C. Testosterone and progesterone metabolism in the CNS cellular localization and mechanism of control of the enzymes involved . Cell. Mol. Neurobiol. 16:1996;271-282.
25. Melcangi R.C., Celotti F., Martini L. Progesterone 5-alpha-reduction in neuronal and in different types of glial cell cultures type 1 and 2 astrocytes and oligodendrocytes . Brain Res. 639:1994;202-206.
26. Neufeld A.H. Nitric oxide a potential mediator of retinal ganglion cell damage in glaucoma . Surv. Ophthalmol. 43:(Suppl. 1):1999;S129-S135.
27. Neufeld A.H., Hernandez M.R., Gonzalez M. Nitric oxide synthase in the human glaucomatous optic nerve head. Arch. Ophthalmol. 115:1997;497-503.
28. Nguyen T.D., Chen P., Huang W.D., Chen H., Johnson D., Polansky J.R. Gene structure and properties of TIGR, an olfactomedin-related glycoprotein cloned from glucocorticoid-induced trabecular meshwork cells. J. Biol. Chem. 273:1998;6341-6350.
29. Pena J.D., Agapova O., Gabelt B.T., Levin L.A., Lucarelli M.J., Kaufman P.L., Hernandez M.R. Increased elastin expression in astrocytes of the lamina cribrosa in response to elevated intraocular pressure. Invest. Ophthalmol. Vis. Sci. 42:2001;2303-2314.
30. Pena J.D., Netland P.A., Vidal I., Dorr D.A., Rasky A., Hernandez M.R. Elastosis of the lamina cribrosa in glaucomatous optic neuropathy. Exp. Eye Res. 67:1998;517-524.
31. Penning T.M., Burczynski M.E., Jez J.M., Hung C.F., Lin H.K., Ma H., Moore M., Palackal N., Ratnam K. Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones . Biochem. J. 351:2000;67-77.
32. Pfaffl M.W. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29:2001;E45.
33. Quigley H.A. Neuronal death in glaucoma. Prog. Retin Eye Res. 18:1999;39-57.
34. Raghavendra R., Dogan A., Bowen K.K., Dempsey R.J. Traumatic brain injury leads to increased expression of peripheral-type benzodiazepine receptors, neuronal death, and activation of astrocytes and microglia in rat thalamus. Exp. Neurol. 161:2000;102-114.
35. Ricard C.S., Kobayashi S., Pena J.D., Salvador-Silva M., Agapova O., Hernandez M.R. Selective expression of neural cell adhesion molecule (NCAM) 180 in optic nerve head astrocytes exposed to elevated hydrostatic pressure in vitro. Brain Res. Mol. Brain Res. 81:2000;62-79.
36. Ricard C.S., Pena J.D., Hernandez M.R. Differential expression of neural cell adhesion molecule isoforms in normal and glaucomatous human optic nerve heads. Brain Res. Mol. Brain Res. 74:1999;69-82.
37. Ridet J.L., Malhotra S.K., Privat A., Gage F.H. Reactive astrocytes cellular and molecular cues to biological function . Trends Neurosci. 20:1997;570-577.
38. Rosellini R.A., Svare B.B., Rhodes M.E., Frye C.A. The testosterone metabolite and neurosteroid 3alpha-androstanediol may mediate the effects of testosterone on conditioned place preference. Brain Res. Brain Res. Rev. 37:2001;162-171.
39. Rozsival P., Hampl R., Obenberger J., Starka L., Rehak S. Aqueous humour and plasma cortisol levels in glaucoma and cataract patients. Curr. Eye Res. 1:1981;391-396.
40. Salvador-Silva M., Ricard C.S., Agapova O.A., Yang P., Hernandez M.R. Expression of small heat shock proteins and intermediate filaments in the human optic nerve head astrocytes exposed to elevated hydrostatic pressure in vitro. J. Neurosci. Res. 66:2001;59-73.
41. Sandell J.H. GABA as a developmental signal in the inner retina and optic nerve. Perspect. Dev. Neurobiol. 5:1998;269-278.
42. Schwartz B., McCarty G., Rosner B. Increased plasma free cortisol in ocular hypertension and open angle glaucoma. Arch. Ophthalmol. 105:1987;1060-1065.
43. Southren A.L., Gordon G.G., Munnangi P.R., Vittek J., Schwartz J., Monder C., Dunn M.W., Weinstein B.I. Altered cortisol metabolism in cells cultured from trabecular meshwork specimens obtained from patients with primary open-angle glaucoma. Invest. Ophthalmol. Vis. Sci. 24:1983;1413-1417.
44. Stone E.M., Fingert J.H., Alward W.L., Nguyen T.D., Polansky J.R., Sunden S.L., Nishimura D., Clark A.F., Nystuen A., Nichols B.E., Mackey D.A., Ritch R., Kalenak J.W., Craven E.R., Sheffield V.C. Identification of a gene that causes primary open angle glaucoma. Science. 275:1997;668-670.
45. Sun B.B., Chiu S.Y. N-type calcium channels and their regulation by GABAB receptors in axons of neonatal rat optic nerve. J. Neurosci. 19:1999;5185-5194.
46. Theodosis D.T., Poulain D.A. Contribution of astrocytes to activity-dependent structural plasticity in the adult brain. Adv. Exp. Med. Biol. 468:1999;175-182.
47. Weinstein B.I., Munnangi P., Gordon G.G., Southern A.L. Defects in cortisol-metabolizing enzymes in primary open-angle glaucoma. Invest. Ophthalmol. Vis. Sci. 26:1985;890-893.
48. Wordinger R.J., Clark A.F. Effects of glucocorticoids on the trabecular meshwork towards a better understanding of glaucoma . Prog. Retin Eye Res. 18:1999;629-667.
49. Yucel Y.H., Zhang Q., Gupta N., Kaufman P.L., Weinreb R.N. Loss of neurons in magnocellular and parvocellular layers of the lateral geniculate nucleus in glaucoma. Arch. Ophthalmol. 118:2000;378-384.
50. Zhang Y., Dufort I., Rheault P., Luu-The V. Characterization of a human 20alpha-hydroxysteroid dehydrogenase. J. Mol. Endocrinol. 25:2000;221-228.