Hydroxymethylglutaryl coenzyme A reductase inhibition reduces Chlamydia pneumoniae-induced cell interaction and activation

Circulation

Volumn 108, Issue 3, 2003, Pages 261-265

  Dechend, Ralf ^a   Gieffers, Jens ^c   Dietz, Rainer ^a   Joerres, Achim ^b   Rupp, Jan ^c   Luft, Friedrich C ^a   Maass, Matthias ^c  

^a FRANZ VOLHARD CLINIC   (Germany)

^b HUMBOLDT UNIVERSITY   (Germany)

^c Franz Volhard Clinic ^*

Author keywords

Atherosclerosis; Chlamydia pneumoniae; Immunology; Infection; Statins

Indexed keywords

CERIVASTATIN; CYTOCHROME C; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; MEVALONIC ACID; MONOCYTE CHEMOTACTIC PROTEIN 1; RAC1 PROTEIN; RANTES; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CELL ACTIVATION; CELL INTERACTION; CHLAMYDOPHILA PNEUMONIAE; COCULTURE; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; INFECTION; PRENYLATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING;

ANIMALS; ARTERIOSCLEROSIS; CELL COMMUNICATION; CELL MEMBRANE; CELLS, CULTURED; CHEMOKINES; CHLAMYDOPHILA INFECTIONS; CHLAMYDOPHILA PNEUMONIAE; COCULTURE TECHNIQUES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; HEPTANOIC ACIDS; HUMANS; HYDROXYMETHYLGLUTARYL COA REDUCTASES; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MACROPHAGES; MICE; MICE, KNOCKOUT; MUSCLE, SMOOTH, VASCULAR; NF-KAPPA B; PROTEIN ISOPRENYLATION; PYRIDINES; PYRROLES; RAC1 GTP-BINDING PROTEIN; REACTIVE OXYGEN SPECIES; RHOA GTP-BINDING PROTEIN; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 0041807643     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000083367.93022.78     Document Type: Article

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