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Volumn 30, Issue 9, 2003, Pages 1918-1927

Proinflammatory role of fractalkine (CX3CL1) in rheumatoid arthritis

Author keywords

Chemokines; Fractalkine; Rheumatoid arthritis; T cells

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CHEMOKINE; CHEMOKINE RECEPTOR CXCR1; CX3C CHEMOKINE; CYTOKINE; FRACTALKINE; GELATINASE A; IONOMYCIN; PHORBOL 13 ACETATE 12 MYRISTATE;

EID: 0041692874     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (100)

References (49)
  • 1
    • 0035932519 scopus 로고    scopus 로고
    • Cytokine pathways and joint inflammation in rheumatoid arthritis
    • Choy EH, Panayi GS. Cytokine pathways and joint inflammation in rheumatoid arthritis. N Eng J Med 2001;344:907-16.
    • (2001) N Eng J Med , vol.344 , pp. 907-916
    • Choy, E.H.1    Panayi, G.S.2
  • 2
    • 0034093334 scopus 로고    scopus 로고
    • Are T cells in rheumatoid synovium aggressors or bystanders?
    • Miossec P. Are T cells in rheumatoid synovium aggressors or bystanders? Curr Opin Rheumatol 2000;12:181-5.
    • (2000) Curr Opin Rheumatol , vol.12 , pp. 181-185
    • Miossec, P.1
  • 3
    • 0028052968 scopus 로고
    • Interleukin-8 and related chemotactic cytokines-CXC and CC chemokines
    • Baggiolini M, Dewald B, Moser B. Interleukin-8 and related chemotactic cytokines-CXC and CC chemokines. Adv Immunol 1994;55:97-179.
    • (1994) Adv Immunol , vol.55 , pp. 97-179
    • Baggiolini, M.1    Dewald, B.2    Moser, B.3
  • 4
    • 0030825407 scopus 로고    scopus 로고
    • Chemokines
    • Rollins BJ. Chemokines. Blood 1997;90:909-28.
    • (1997) Blood , vol.90 , pp. 909-928
    • Rollins, B.J.1
  • 5
    • 0031036347 scopus 로고    scopus 로고
    • A new class of membrane-bound chemokine with a CX3C motif
    • Bazan JF, Bacon KB, Hardiman G, et al. A new class of membrane-bound chemokine with a CX3C motif. Nature 1997;385:640-4.
    • (1997) Nature , vol.385 , pp. 640-644
    • Bazan, J.F.1    Bacon, K.B.2    Hardiman, G.3
  • 6
    • 0032547581 scopus 로고    scopus 로고
    • Fractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow
    • Fong AM, Robinson LA, Steeber DA, et al. Fractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow. J Exp Med 1998;188:1413-9.
    • (1998) J Exp Med , vol.188 , pp. 1413-1419
    • Fong, A.M.1    Robinson, L.A.2    Steeber, D.A.3
  • 7
    • 0035851124 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1)
    • Garton KJ, Gough PJ, Blobel CP, et al. Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1). J Biol Chem 2001;276:37993-8001.
    • (2001) J Biol Chem , vol.276 , pp. 37993-38001
    • Garton, K.J.1    Gough, P.J.2    Blobel, C.P.3
  • 8
    • 0033624690 scopus 로고    scopus 로고
    • NF-kappa B-dependent fractalkine induction in rat aortic endothelial cells stimulated by IL-1 beta, TNF-alpha and LPS
    • Garcia GE, Xia Y, Chen S, et al. NF-kappa B-dependent fractalkine induction in rat aortic endothelial cells stimulated by IL-1 beta, TNF-alpha and LPS. J Leukoc Biol 2000;67:577-84.
    • (2000) J Leukoc Biol , vol.67 , pp. 577-584
    • Garcia, G.E.1    Xia, Y.2    Chen, S.3
  • 9
    • 17544396739 scopus 로고    scopus 로고
    • Fractalkine-mediated endothelial cell injury by NK cells
    • Yoneda O, Imai T, Goda S, et al. Fractalkine-mediated endothelial cell injury by NK cells. J Immunol 2000;164:4055-62.
    • (2000) J Immunol , vol.164 , pp. 4055-4062
    • Yoneda, O.1    Imai, T.2    Goda, S.3
  • 10
    • 0031730067 scopus 로고    scopus 로고
    • Neuronal expression of fractalkine in the presence and absence of inflammation
    • Schwaeble WJ, Stover CM, Schall TJ, et al. Neuronal expression of fractalkine in the presence and absence of inflammation. FEBS Lett 1998;439:203-7.
    • (1998) FEBS Lett , vol.439 , pp. 203-207
    • Schwaeble, W.J.1    Stover, C.M.2    Schall, T.J.3
  • 11
    • 0032510831 scopus 로고    scopus 로고
    • Localization of fractalkine and CX3CR1 mRNAs in rat brain: Does fractalkine play a role in signaling from neuron to microglia?
    • Nishiyori A, Minami M, Ohtani Y, et al. Localization of fractalkine and CX3CR1 mRNAs in rat brain: does fractalkine play a role in signaling from neuron to microglia? FEBS Lett 1998;429:167-72.
    • (1998) FEBS Lett , vol.429 , pp. 167-172
    • Nishiyori, A.1    Minami, M.2    Ohtani, Y.3
  • 12
    • 13144279282 scopus 로고    scopus 로고
    • Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia
    • Harrison JK, Jiang Y, Chen S, et al. Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia. Proc Natl Acad Sci USA 1998;95:10896-901.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 10896-10901
    • Harrison, J.K.1    Jiang, Y.2    Chen, S.3
  • 13
    • 0035805392 scopus 로고    scopus 로고
    • Synergistic stimulation, by tumor necrosis factor-alpha and interferon-gamma, of fractalkine expression in human astrocytes
    • Yoshida H, Imaizumi T, Fujimoto K, et al. Synergistic stimulation, by tumor necrosis factor-alpha and interferon-gamma, of fractalkine expression in human astrocytes. Neurosci Lett 2001;303:132-6.
    • (2001) Neurosci Lett , vol.303 , pp. 132-136
    • Yoshida, H.1    Imaizumi, T.2    Fujimoto, K.3
  • 14
    • 0034937630 scopus 로고    scopus 로고
    • Fractalkine, a novel chemokine in rheumatoid arthritis and in rat adjuvant-induced arthritis
    • Ruth JH, Volin MV, Haines GK 3rd, et al. Fractalkine, a novel chemokine in rheumatoid arthritis and in rat adjuvant-induced arthritis. Arthritis Rheum 2001;44:1568-81.
    • (2001) Arthritis Rheum , vol.44 , pp. 1568-1581
    • Ruth, J.H.1    Volin, M.V.2    Haines G.K. III3
  • 15
    • 0034654535 scopus 로고    scopus 로고
    • Fractalkine is an epithelial and endothelial cell-derived chemoattractant for intraepithelial lymphocytes in the small intestinal mucosa
    • Muehlhoefer A, Saubermann LJ, Gu X, et al. Fractalkine is an epithelial and endothelial cell-derived chemoattractant for intraepithelial lymphocytes in the small intestinal mucosa. J Immunol 2000;164:3368-76.
    • (2000) J Immunol , vol.164 , pp. 3368-3376
    • Muehlhoefer, A.1    Saubermann, L.J.2    Gu, X.3
  • 16
    • 0035104518 scopus 로고    scopus 로고
    • The transmembrane form of the CX3CL1 chemokine fractalkine is expressed predominantly by epithelial cells in vivo
    • Lucas AD, Chadwick N, Warren BF, et al. The transmembrane form of the CX3CL1 chemokine fractalkine is expressed predominantly by epithelial cells in vivo. Am J Pathol 2001;158:855-66.
    • (2001) Am J Pathol , vol.158 , pp. 855-866
    • Lucas, A.D.1    Chadwick, N.2    Warren, B.F.3
  • 17
    • 0037080042 scopus 로고    scopus 로고
    • Fractalkine is expressed by smooth muscle cells in response to IFN-gamma and TNF-alpha and is modulated by metalloproteinase activity
    • Ludwig A, Berkhout T, Moores K, Groot P, Chapman G. Fractalkine is expressed by smooth muscle cells in response to IFN-gamma and TNF-alpha and is modulated by metalloproteinase activity. J Immunol 2002;168:604-12.
    • (2002) J Immunol , vol.168 , pp. 604-612
    • Ludwig, A.1    Berkhout, T.2    Moores, K.3    Groot, P.4    Chapman, G.5
  • 18
    • 0030723388 scopus 로고    scopus 로고
    • Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion
    • Imai T, Hieshima K, Haskell C, et al. Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. Cell 1997;91:521-30.
    • (1997) Cell , vol.91 , pp. 521-530
    • Imai, T.1    Hieshima, K.2    Haskell, C.3
  • 19
    • 0031593822 scopus 로고    scopus 로고
    • MIP-3 alpha, MIP-3 beta and fractalkine induce the locomotion and the mobilization of intracellular calcium, and activate the heterotrimeric G proteins in human natural killer cells
    • Al-Aoukaty A, Rolstad B, Giald A, Maghazachi AA. MIP-3 alpha, MIP-3 beta and fractalkine induce the locomotion and the mobilization of intracellular calcium, and activate the heterotrimeric G proteins in human natural killer cells. Immunology 1998;95:618-24.
    • (1998) Immunology , vol.95 , pp. 618-624
    • Al-Aoukaty, A.1    Rolstad, B.2    Giald, A.3    Maghazachi, A.A.4
  • 20
    • 0033987137 scopus 로고    scopus 로고
    • Fractalkine receptor expression by T lymphocyte subpopulations and in vivo production of fractalkine in human
    • Foussat A. Coulomb-L'Hermine A, Gosling J, et al. Fractalkine receptor expression by T lymphocyte subpopulations and in vivo production of fractalkine in human. Eur J Immunol 2000;30:87-97.
    • (2000) Eur J Immunol , vol.30 , pp. 87-97
    • Foussat, A.1    Coulomb-L'Hermine, A.2    Gosling, J.3
  • 21
    • 0033847005 scopus 로고    scopus 로고
    • Mast cells migrate, but do not degranulate, in response to fractalkine, a membrane-bound chemokine expressed constitutively in diverse cells of the skin
    • Papadopoulos EJ, Fitzhugh DJ, Tkaczyk C, et al. Mast cells migrate, but do not degranulate, in response to fractalkine, a membrane-bound chemokine expressed constitutively in diverse cells of the skin. Eur J Immunol 2000;30:2355-61.
    • (2000) Eur J Immunol , vol.30 , pp. 2355-2361
    • Papadopoulos, E.J.1    Fitzhugh, D.J.2    Tkaczyk, C.3
  • 23
    • 0033485550 scopus 로고    scopus 로고
    • Chemokine modulation of matrix metalloproteinase and TIMP production in adult rat brain microglia and a human microglial cell line in vitro
    • Cross AK, Woodroofe MN. Chemokine modulation of matrix metalloproteinase and TIMP production in adult rat brain microglia and a human microglial cell line in vitro. Glia 1999;28:183-9.
    • (1999) Glia , vol.28 , pp. 183-189
    • Cross, A.K.1    Woodroofe, M.N.2
  • 24
    • 0023945481 scopus 로고
    • The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis
    • Arnett FC, Edworthy SM, Bloch DA, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
    • (1988) Arthritis Rheum , vol.31 , pp. 315-324
    • Arnett, F.C.1    Edworthy, S.M.2    Bloch, D.A.3
  • 25
    • 0025086688 scopus 로고
    • Judging disease activity in clinical practice in rheumatoid arthritis: First step in the development of a disease activity score
    • van der Heijde DM, van't Hof MA, van Riel PL, et al. Judging disease activity in clinical practice in rheumatoid arthritis: first step in the development of a disease activity score. Ann Rheum Dis 1990;49:916-20.
    • (1990) Ann Rheum Dis , vol.49 , pp. 916-920
    • Van der Heijde, D.M.1    Van't Hof, M.A.2    Van Riel, P.L.3
  • 26
    • 0029855587 scopus 로고    scopus 로고
    • Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice
    • Muller-Ladner U, Kriegsmann J, Franklin BN, et al. Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice. Am J Pathol 1996;149:1607-15.
    • (1996) Am J Pathol , vol.149 , pp. 1607-1615
    • Muller-Ladner, U.1    Kriegsmann, J.2    Franklin, B.N.3
  • 27
    • 0342264480 scopus 로고    scopus 로고
    • Analysis of Th1 and Th2 cytokines expressing CD4+ and CD8+ T cells in rheumatoid arthritis by flow cytometry
    • Berner B, Akca D, Jung T, Muller GA, Reuss-Borst MA. Analysis of Th1 and Th2 cytokines expressing CD4+ and CD8+ T cells in rheumatoid arthritis by flow cytometry. J Rheumatol 2000;27:1128-35.
    • (2000) J Rheumatol , vol.27 , pp. 1128-1135
    • Berner, B.1    Akca, D.2    Jung, T.3    Muller, G.A.4    Reuss-Borst, M.A.5
  • 28
    • 0035153586 scopus 로고    scopus 로고
    • Expression of the T-cell chemoattractant chemokine lymphotactin in Crohn's disease
    • Middel P, Thelen P, Blaschke S, et al. Expression of the T-cell chemoattractant chemokine lymphotactin in Crohn's disease. Am J Pathol 2001;159:1751-61.
    • (2001) Am J Pathol , vol.159 , pp. 1751-1761
    • Middel, P.1    Thelen, P.2    Blaschke, S.3
  • 30
    • 0034112481 scopus 로고    scopus 로고
    • Basic fibroblast growth factor expression is increased in human renal fibrogenesis and may mediate autocrine fibroblast proliferation
    • Strutz F, Zeisberg M, Hemmerlein B, et al. Basic fibroblast growth factor expression is increased in human renal fibrogenesis and may mediate autocrine fibroblast proliferation. Kidney Int 2000;57:1521-38.
    • (2000) Kidney Int , vol.57 , pp. 1521-1538
    • Strutz, F.1    Zeisberg, M.2    Hemmerlein, B.3
  • 31
    • 0036233040 scopus 로고    scopus 로고
    • Role of the fibroblast growth factor-2 in epithelial-mesenchymal transformation
    • Strutz F, Zeisberg M, Ziyadeh FN, et al. Role of the fibroblast growth factor-2 in epithelial-mesenchymal transformation. Kidney Int 2002;61:1714-28.
    • (2002) Kidney Int , vol.61 , pp. 1714-1728
    • Strutz, F.1    Zeisberg, M.2    Ziyadeh, F.N.3
  • 32
    • 0034737714 scopus 로고    scopus 로고
    • The role of fractalkine in the recruitment of monocytes to the endothelium
    • Chapman GA, Moores KE, Gohil J, et al. The role of fractalkine in the recruitment of monocytes to the endothelium. Eur J Pharmacol 2000;392:189-95.
    • (2000) Eur J Pharmacol , vol.392 , pp. 189-195
    • Chapman, G.A.1    Moores, K.E.2    Gohil, J.3
  • 33
    • 0035012168 scopus 로고    scopus 로고
    • Fractalkine (CX3CL1) as an amplification circuit of polarized Th1 responses
    • Fraticelli P, Sironie M, Bianchi G, et al. Fractalkine (CX3CL1) as an amplification circuit of polarized Th1 responses. J Clin Invest 2001;107:1173-81.
    • (2001) J Clin Invest , vol.107 , pp. 1173-1181
    • Fraticelli, P.1    Sironie, M.2    Bianchi, G.3
  • 34
    • 0036845154 scopus 로고    scopus 로고
    • Migration of CX3CR1-positive T cells producing type 1 cytokines and cytotoxic molecules into the synovium of patients with rheumatoid arthritis
    • Nanki T, Imai T, Nagasaka K, et al. Migration of CX3CR1-positive T cells producing type 1 cytokines and cytotoxic molecules into the synovium of patients with rheumatoid arthritis. Arthritis Rheum 2002;46:2878-83.
    • (2002) Arthritis Rheum , vol.46 , pp. 2878-2883
    • Nanki, T.1    Imai, T.2    Nagasaka, K.3
  • 35
    • 0030459439 scopus 로고    scopus 로고
    • Shift toward T lymphocytes with a T helper 1 cytokine-secretion profile in the joints of patients with rheumatoid arthritis
    • Dolhain RJ, van der Heiden AN, ter Haar NT, Breedveld FC, Miltenburg AM. Shift toward T lymphocytes with a T helper 1 cytokine-secretion profile in the joints of patients with rheumatoid arthritis. Arthritis Rheum 1996;39:1961-9.
    • (1996) Arthritis Rheum , vol.39 , pp. 1961-1969
    • Dolhain, R.J.1    Van der Heiden, A.N.2    Ter Haar, N.T.3    Breedveld, F.C.4    Miltenburg, A.M.5
  • 36
    • 0034544543 scopus 로고    scopus 로고
    • A role for fractalkine and its receptor (CX3CR1) in cardiac allograft rejection
    • Robinson LA, Nataraj C, Thomas DW, et al. A role for fractalkine and its receptor (CX3CR1) in cardiac allograft rejection. J Immunol 2000;165:6067-72.
    • (2000) J Immunol , vol.165 , pp. 6067-6072
    • Robinson, L.A.1    Nataraj, C.2    Thomas, D.W.3
  • 37
    • 0035725605 scopus 로고    scopus 로고
    • Cellular localization of fractalkine at sites of inflammation: Antigen-presenting cells in psoriasis express high levels of fractalkine
    • Raychaudhuri SP, Jiang WY, Farber EM. Cellular localization of fractalkine at sites of inflammation: antigen-presenting cells in psoriasis express high levels of fractalkine. Br J Dermatol 2001;144:1105-13.
    • (2001) Br J Dermatol , vol.144 , pp. 1105-1113
    • Raychaudhuri, S.P.1    Jiang, W.Y.2    Farber, E.M.3
  • 38
    • 0008741084 scopus 로고    scopus 로고
    • Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids from patients with rheumatoid arthritis or osteoarthritis
    • Yoshihara Y, Nakamura H, Obata K, et al. Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids from patients with rheumatoid arthritis or osteoarthritis. Ann Rheum Dis 2000;59:455-61.
    • (2000) Ann Rheum Dis , vol.59 , pp. 455-461
    • Yoshihara, Y.1    Nakamura, H.2    Obata, K.3
  • 39
    • 0025616093 scopus 로고
    • Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts. Purification and activation of the precursor and enzymic properties
    • Okada Y, Morodomi T, Enghild JJ, et al. Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts. Purification and activation of the precursor and enzymic properties. Eur J Biochem 1990;194:721-30.
    • (1990) Eur J Biochem , vol.194 , pp. 721-730
    • Okada, Y.1    Morodomi, T.2    Enghild, J.J.3
  • 40
    • 0029963757 scopus 로고    scopus 로고
    • TNF-alpha-mediated expression of membrane-type matrix metalloproteinase in rheumatoid synovial fibroblasts
    • Migita K, Eguchi K, Kawabe Y, et al. TNF-alpha-mediated expression of membrane-type matrix metalloproteinase in rheumatoid synovial fibroblasts. Immunology 1996;89:553-7.
    • (1996) Immunology , vol.89 , pp. 553-557
    • Migita, K.1    Eguchi, K.2    Kawabe, Y.3
  • 41
    • 0025348745 scopus 로고
    • How important are T cells in chronic rheumatoid synovitis?
    • Firestein GS, Zvaifler NJ. How important are T cells in chronic rheumatoid synovitis? Arthritis Rheum 1990;33:768-73.
    • (1990) Arthritis Rheum , vol.33 , pp. 768-773
    • Firestein, G.S.1    Zvaifler, N.J.2
  • 43
    • 0031571717 scopus 로고    scopus 로고
    • Defective TCR-mediated signaling in synovial T cells in rheumatoid arthritis
    • Maurice MM, Lankester AC, Bezemer AC, et al. Defective TCR-mediated signaling in synovial T cells in rheumatoid arthritis. J Immunol 1997;159:2973-78.
    • (1997) J Immunol , vol.159 , pp. 2973-2978
    • Maurice, M.M.1    Lankester, A.C.2    Bezemer, A.C.3
  • 44
    • 0025274640 scopus 로고
    • Cytokines and cytokine inhibitors or antagonists in rheumatoid arthritis
    • Arend WP, Dayer JM. Cytokines and cytokine inhibitors or antagonists in rheumatoid arthritis. Arthritis Rheum 1990;33:305-15.
    • (1990) Arthritis Rheum , vol.33 , pp. 305-315
    • Arend, W.P.1    Dayer, J.M.2
  • 45
    • 0028882681 scopus 로고
    • Double-blind, placebo-controlled multicenter trial using chimeric monoclonal anti-CD4 antibodies, cM-T412, in rheumatoid arthritis patients receiving concomitant methotrexate
    • Moreland LW, Pratt PW, Mayes MD, et al. Double-blind, placebo-controlled multicenter trial using chimeric monoclonal anti-CD4 antibodies, cM-T412, in rheumatoid arthritis patients receiving concomitant methotrexate. Arthritis Rheum 1995;38:1581-8.
    • (1995) Arthritis Rheum , vol.38 , pp. 1581-1588
    • Moreland, L.W.1    Pratt, P.W.2    Mayes, M.D.3
  • 46
    • 0025764433 scopus 로고
    • Association of HLA-DR4 with a more progressive disease course in patients with rheumatoid arthritis. Results of a follow-up study
    • van Zeben D, Hazes JM, Zwinderman AH, et al. Association of HLA-DR4 with a more progressive disease course in patients with rheumatoid arthritis. Results of a follow-up study. Arthritis Rheum 1991;34:822-30.
    • (1991) Arthritis Rheum , vol.34 , pp. 822-830
    • Van Zeben, D.1    Hazes, J.M.2    Zwinderman, A.H.3
  • 47
    • 0026752620 scopus 로고
    • The importance of the T cell in initiating and maintaining the chronic synovitis of rheumatoid arthritis
    • Panayi GS, Lanchbury JS, Kingsley GH. The importance of the T cell in initiating and maintaining the chronic synovitis of rheumatoid arthritis. Arthritis Rheum 1992;35:729-35.
    • (1992) Arthritis Rheum , vol.35 , pp. 729-735
    • Panayi, G.S.1    Lanchbury, J.S.2    Kingsley, G.H.3
  • 48
    • 0032939156 scopus 로고    scopus 로고
    • Human interleukin-17: A T-cell derived proinflammatory cytokine produced by the rheumatoid synovium
    • Chabaud M, Durand JM, Buchs N, et al. Human interleukin-17: A T-cell derived proinflammatory cytokine produced by the rheumatoid synovium. Arthritis Rheum 1999;42:963-70.
    • (1999) Arthritis Rheum , vol.42 , pp. 963-970
    • Chabaud, M.1    Durand, J.M.2    Buchs, N.3
  • 49
    • 0033083111 scopus 로고    scopus 로고
    • IL-17 is produced by some proinflammatory Th1/Th0 cells but not by Th2 cells
    • Aarvak T, Chabaud M, Miossec P, Natvig JB. IL-17 is produced by some proinflammatory Th1/Th0 cells but not by Th2 cells. J Immunol 1999;162:1246-51.
    • (1999) J Immunol , vol.162 , pp. 1246-1251
    • Aarvak, T.1    Chabaud, M.2    Miossec, P.3    Natvig, J.B.4


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