Role for Id-1 in immunobiology of normal keratinocytes and in basal cell carcinoma

Experimental Dermatology

Volumn 12, Issue 3, 2003, Pages 255-260

  Chaturvedi, Vijaya ^a   Bonish, Brian ^a   Bacon, Patricia ^a   Qin, Jian Zhong ^a   Denning, Mitchell F ^a   Foreman, Kimberly ^a   Diaz, Manuel O ^a   Robinson, June ^a   Nickoloff, Brian J ^a  

^a LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Adhesion molecules; Differentiation; Id 1; Immubiology; Skin cancer

Indexed keywords

ANTINEOPLASTIC AGENT; FAS ANTIGEN; GAMMA INTERFERON; HELIX LOOP HELIX PROTEIN; HLA DR ANTIGEN; INHIBITOR OF DIFFERENTIATION 1; INHIBITOR OF DIFFERENTIATION, HELIX LOOP HELIX PROTEIN; INHIBITOR OF DIFFERENTIATION, HELIX-LOOP-HELIX PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INVOLUCRIN; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 3; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MARKER; RECOMBINANT GAMMA INTERFERON; RETROVIRUS VECTOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; ARTICLE; BASAL CELL CARCINOMA; CELL AGING; CELL CULTURE; CELL DIFFERENTIATION; CELL STIMULATION; CONTROLLED STUDY; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETIC TRANSDUCTION; GENETIC TRANSFECTION; GENETICS; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOBIOLOGY; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; IMMUNOSURVEILLANCE; KERATINOCYTE; PROTEIN EXPRESSION; SENESCENCE; SKIN TUMOR; TUMOR CELL; TUMOR ESCAPE; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; CARCINOMA, BASAL CELL; CELL DIFFERENTIATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HLA-DR ANTIGENS; HUMANS; INHIBITOR OF DIFFERENTIATION PROTEIN 1; INTERCELLULAR ADHESION MOLECULE-1; INTERFERON TYPE II; KERATINOCYTES; REPRESSOR PROTEINS; SKIN NEOPLASMS; TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0041672232     PISSN: 09066705     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0625.2003.00066.x     Document Type: Article

References (37)

1. Norton J D, Deed R W, Craggs G, Sabilitzky F. Id helix-loop-helix proteins in cell growth and differentiation. Trends Cell Biol 1998: 8: 58-65.
2. Barone M, Pepperkok R, Pevareli F A, Philipson L. Id proteins control growth induction in mammalian cells. Proc Natl Acad Sci USA 1994: 91: 4485-4988.
3. Desprez P-Y, Hara E, Bissel M J, Campisi J. Suppression of mammary epithelial cell differentiation by the helix-loop-helix protein Id-1. Mol Cell Biol 1995: 15: 3398-3404.
4. Hara E, Uzman A, Dimri P, Nehlin J D, Testori A, Campisi J. The helix-loop-helix protein Id-1 and a retinoblastoma protein binding mutant of SV40 T antigen synergize to reactive DNA synthesis in senescent human fibroblasts. Dev Genet 1996: 18: 161-172.
5. Alani R M, Hasskarl J, Grace M, Hernandez M C, Israel M A, Munger K. Immortalization of primary human keratinocytes by the helix-loop-helix protein, Id-1. Proc Natl Acad Sci USA 1999: 96: 9636-9641.
6. Norton J D, Atherton G T. Coupling of cell growth control and apoptosis functions of Id proteins. Mol Cell Biol 1998: 18: 2371-2381.
7. Nickoloff B J, Chaturvedi V, Bacon P, Qin J-Z, Denning M F, Diaz M O. Id-1 delays senescence but does not immortalize keratinocytes. J Biol Chem 2000: 275: 27501-27504.
8. Nickoloff B J, Basham T Y, Merigan T C, Morhenn V B. Antiproliferative effects of recombinant alpha and gamma interferons on cultured human keratinocytes. Laboratory Invest 1984: 51: 697-701.
9. Nickoloff B J, Mahrle G, Morhenn V B. The ultrastructural effects of recombinant gamma interferon on cultured human keratinocytes. J Ultrast Res 1986: 10: 17-21.
10. Saunders N A, Dahler A, Jones S, Smith R, Jetten A. Interferon-γ as a regulator of squamous differentiation. J Dermatol Sci 1996: 13: 98-106.
11. Wrone-Smith T, Johnson T, Nelson B et al. Discordant expression of Bcl-x and Bcl-2 by keratinocytes in-vitro and psoriatic keratinocytes in-vivo. Am J Pathol 1995: 146: 1079-1088.
12. Qin J-Z, Bacon P, Chaturvedi V, Nickoloff B J. Role of NF-κB activity in apoptotic response of keratinocytes mediated by interferon-γ, tumor necrosis factor-α, and tumor-necrosis-factor-related apoptosis-inducing ligand. J Invest Dermatol 2001: 117: 898-907.
13. Shiohara T, Moriya N. Epidermal T cells: Their functional role and disease relevance for dermatologists. J Invest Dermatol 1997: 109: 271-275.
14. Kim J, Modlin R L, Moy R L et al. IL-10 production in cutaneous basal and squamous cell carcinoma: A mechanism for evading the local T cell immune response. J Immunol 1995: 155: 2240-2244.
15. Ozawa H, Aiba S, Nakagawa R, Tagami H. Interferon-gamma inhibits antigen presentation by Langerhans cells for T helper type 1 cells by suppressing their CD80 (B7-1) expression. J Immunol 1996: 26: 648-652.
16. Taylor R S, Griffiths C E M, Brown M D, Swanson N A, Nickoloff B J. Constitutive absence and interferon-γ induced expression of adhesion molecules in basal cell carcinoma. J Am Acad Dermatol 1990: 22: 721-726.
17. Pentel M, Helm K, Maloney M M. Cell surface molecules in basal cell carcinoma. Dermatol Surg 1995: 21: 858-861.
18. Koog AJW, Tank B, Vuzeuski VD, Van Joost T, Prens EP. Expression of interferon-gamma receptors and interferon-gamma-induced upregulation of intercellular adhesion molecule-1 in basal cell carcinoma: Decreased expression of IFN-γR and shedding of ICAM-1 as a means to escape immune surveillance. J Pathol 1998: 184: 169-176.
19. Langlands K, Down GA, Kenley T. Id proteins are dynamically expressed in normal epidermis and dysregulated in squamous cell carcinoma. Cancer Res 2000: 60: 5929-5933.
20. Polsky D, Zuyung Young A, Busam KJ, Alani RM. The transcriptional repressor of p16/Ink4a, Id1, is upregulated in early melanomas. Cancer Res 2001: 61: 6008-6011.
21. Boukamp P, Petrussevska RT, Breitereutz D, Hornung J, Marhan A, Fusening NE. Normal keratinization in a spontaneously immortalized aneuploid human keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J Cell Biol 1998: 106: 761-777.
22. Mitra RS, Wrone-Smith T, Foreman KE, Nunez G, Nickoloff BJ. Apoptosis in keratinocytes is not dependent on induction of differentiation. Laboratory Invest 1997: 76: 99-107.
23. Griffiths CEM, Voorhees JJ, Nickoloff BJ. Gamma interferon induces different patterns of expression of HLA-DR and DQ and intercellular adhesion molecule-1 antigens. Br J Dermatol 1989: 120: 1-8.
24. Wice BM, Gordon JI. Forced expression of Id-1 in the adult mouse small intestinal epithelium is associated with development of adenomas. J Biol Chem 1998: 273: 25310-25319.
25. Israel MA, Hernandez MC, Florio M et al. Id gene expression as a key mediator of tumor cell biology. Cancer Res 1999: 59 (Suppl. 7): 1726S-1730S.
26. Lin CQ, Singh J, Murata K et al. A role for Id-1 in the aggressive phenotype and steroid hormone response of human breast cancer cells. Cancer Res 2000: 60: 1332-1340.
27. Maruyama H, Kleeff J, Wildi S et al. Id-I and Id-2 are overexpressed in pancreatic cancer na dysplastic lesion in chronic pancratitis. Am J Pathol 1999: 155: 815-822.
28. Kreider BJ, Benezra R, Rovera G, Kadesch T. Inhibition of myeloid differentiation by the Helix-Loop-Helix protein Id. Science 1992: 255: 1700-1702.
29. Jen Y, Weintraub H, Benezra R. Overexpression of Id protein inhibits the muscle differentiation program: In vivo association of Id with E2A proteins. Gene Dev 1992: 6: 1466-1479.
30. Nickoloff BJ, Mitra RS, Green J et al. Accessory cell function of keratinocytes from superantigens: Dependence on lymphocyte function-associated antigen/intercellular adhesion molecule-1 interaction. J Immunol 1993: 150: 2148-2159.
31. Yuspa Sh. The pathogenesis of squamous cell cancer: Lessons learned from studies of skin carcinogenesis. Cancer Res 1994: 54: 1178-1189.
32. Johnson R L, Rothman A L, Xie J, et al. Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science 1996: 272: 1668-1671.
33. Oro AE, Higgins KM, Hu Z, Bonifas JM, Epstein EH, Scott MP. Basal cell carcinomas in mice overexpressing Sonic Hedgehog. Science 1997: 276: 817-821.
34. Aszterbaum M, Epstein J, Oro A et al. Ultraviolet and ionizing radiation enhances the growth of BCCs and trichoblastomas in patched heterozygous knockout mice. Nature Med 1999: 5: 1285-1291.
35. Ruiz I, Altaba A. Gli proteins and Hedgehog signaling: Development and cancer. Trends Genet 1999: 15: 418-425.
36. Xie J, Murone M, Luoh S-M et al. Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature 1998: 391: 90-92.
37. Barrett TL, Smith KJ, Hodge JJ, Butler R, Hall FW, Skelton HG. Immunohistochemical nuclear staining for p53, PCNA, and Ki-67 in different histologic variants of basal cell carcinoma. J Am Acad Dermatol 1997: 37: 430-437.