Antigenic variations in the CD4 induced sites of the CCR5-tropic, pathogenic SHIV SF162P3 gp120 variants

Journal of Medical Primatology

Volumn 32, Issue 4-5, 2003, Pages 211-217

  Hsu, M ^a   Buckner, C ^a   Harouse, J ^a   Gettie, A ^a   Blanchard, J ^b   Robinson, J E ^c   Cheng Mayer, Cecilia ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b TULANE NATIONAL PRIMATE RESEARCH CENTER   (United States)

^c TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Antigenicity; CCR5; Clones; Envelope; SHIV

Indexed keywords

CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR5; EPITOPE; GLYCOPROTEIN GP 120; LUCIFERASE; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; VIRUS ENVELOPE PROTEIN;

AMINO ACID SUBSTITUTION; ANTIGENIC VARIATION; ARTICLE; BINDING SITE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNOMODULATION; IN VIVO STUDY; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN STRUCTURE; PROTEIN VARIANT; RECEPTOR BINDING; REPORTER GENE; RNA VIRUS INFECTION; SEQUENCE ANALYSIS; SIMIAN IMMUNODEFICIENCY VIRUS; VIRUS ENVELOPE; VIRUS GENE; VIRUS INFECTIVITY; VIRUS ISOLATION; VIRUS NEUTRALIZATION; VIRUS PATHOGENESIS; VIRUS STRAIN; VIRUS TRANSMISSION;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENIC VARIATION; ANTIGENS, CD4; BLOTTING, WESTERN; ENZYME-LINKED IMMUNOSORBENT ASSAY; HIV; HIV ENVELOPE PROTEIN GP120; HUMANS; LUCIFERASES; MOLECULAR SEQUENCE DATA; RECEPTORS, CCR5; SIMIAN IMMUNODEFICIENCY VIRUS;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; RNA VIRUSES; SIMIAE; SIMIAN IMMUNODEFICIENCY VIRUS; SIMIAN-HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0041471474     PISSN: 00472565     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0684.2003.00027.x     Document Type: Article

References (30)

1. Albert J, Abrahamsson B, Nagy K, Aurelius E, Gaines H, Nystrom G, Fenyo EM: Rapid development of isolate-specific neutralizing antibodies after primary HIV-1 infection and consequent emergence of virus variants which resist neutralization by autologous sera. AIDS 4:107-112, 1990.
2. Cavacini L, Duval M, Robinson J, Posner M: Interactions of human antibodies, epitope exposure, antibody binding and neutralization of primary isolate HIV-1 virions. AIDS 16:2409-2417, 2002.
3. Cayabyab M, Karlsson GB, Etemad-Moghadam B, Hofman W, Steenbeke T, Halloran M, Fanton JW, Axthelm MK, Letvin NL, Sodroski J: Changes in human immunodeficiency virus type 1 envelope glycoproteins responsible for the pathogenicity of a multiply passaged simian-human immunodeficiency virus (SHIV-hxbc2). J Virol 73:976-984, 1999.
4. Chakrabarti LA, Ivanovic T, Cheng-Mayer C: Properties of the surface envelope glycoprotein associated with virulence of simian-human immunodeficiency virus SHIVSF33A molecular clones. J Virol 76:1588-1599, 2002.
5. Chan DC, Kim PS: HIV entry and its inhibition. Cell 93:681-684, 1998.
6. Cheng-Mayer C, Liu R, Landua NR, Stamatatos L: Macrophage tropism of human immunodeficiency virus type 1 and utilization of the CC-CKR5 coreceptor. J Virol 71:1657-1661, 1997.
7. Cheng-Mayer C, Quiroga M, Tung JW, Dina D, Levy JA: Viral determinants of human immunodeficiency virus type 1 T-cell or macrophage tropism, cytopathogenicity, and CD4 antigen modulation. J Virol 64:4390-4398, 1990.
8. Connor RI, Chen BK, Choe S, Landua NR: Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytes. Virology 206:935-944, 1995.
9. Connor RI, Sheridan KE, Ceradini D, Choe S, Landua NR: Change in coreceptor use correlates with disease progression in HIV-1-infected individuals. J Exp Med 185:621-628, 1997.
10. Etemad-Moghadam B, Sun Y, Nicholson EK, Fernandez M, Liou K, Gomila R, Lee J, Sodroski J: Envelope glycoprotein determinants of increased fusogenicity in a pathogenic simian-human immunodeficiency virus (SHIV-KB9) passaged in vivo. J Virol 74:4433-4440, 2000.
11. Etemad-Moghadam B, Sun Y, Nicholson EK, Karlsson GB, Schenten D, Sodroski J: Determinants of neutralization resistance in the envelope glycoproteins of simian-human immunodeficiency virus passaged in vivo. J Virol 73:8873-8879, 1999.
12. Harouse JM, Gettie A, Eshetu T, Tan RCH, Bohm R, Blanchard J, Baskin G, Cheng-Mayer C: Mucosal transmission and induction of simian AIDS by CCR5-specific SHIVSF162P3. J Virol 75:1990-1995, 2001.
13. Harouse JM, Gettie A, Tan RCH, Blanchard J, Cheng-Mayer C: Distinct pathogenic sequela in rhesus macaques infected with CCR5 or CXCR4 utilizing SHIVs. Science 284:816-819, 1999.
14. Harouse JM, Gettie A, Tan RCH, Eshetu T, Ratteree M, Blanchard J, Cheng-Mayer C: Pathogenic determinants of the mucosally transmissible CXCR4-specific SHIVSF33A2 map to env region. J AIDS 27:222-228, 2001.
15. SF33A variants in rhesus macaques. Virology 248:95-107, 1998.
16. Hsu M, Harouse JM, Gettie A, Buckner C, Blanchard J, Cheng-Mayer C: Increased mucosal transmission but not enhanced pathogenicity of the CCR5-tropic, simian AIDS-inducing simian/human immunodeficiency virus SHIVSF162P3 maps to envelope gp120. J Virol 77: 989-998, 2003.
17. Hung C-S, Vander Heyden N, Ratner L: Analysis of the critical domain in the V3 loop of human immunodeficiency virus type 1 gp120 involved in CCR5 utilization. J Virol 73:8216-8226, 1999.
18. Hwang SS, Boyle TJ, Lyerly HK, Cullen BR: Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1. Science 253:71-74, 1991.
19. Karlsson GB, Halloran M, Li J, Park IW, Gomila R, Reimann KA, Axthelm MK, Iliff SA, Letvin NL, Sodroski J: Characterization of molecularly cloned simian-human immunodeficiency viruses causing rapid CD4+ lymphocyte depletion in rhesus monkeys. J Virol 71:4218-4225, 1997.
20. Karlsson GB, Halloran M, Schenten D, Lee J, Racz P, Tenner-Racz K, Manola J, Gelman R, Etemad-Moghadam B, Desjardins E, Wyatt R, Gerard NP, Marcon L, Margolin D, Fanton J, Axthelm MK, Letvin NL, Sodroski J: The envelope glycoprotein ectodomains determine the efficiency of CD4+ T lymphocyte depletion in simian-human immunodeficiency virus-infected macaques. J Exp Med 188:1159-1171, 1998.
21. Kimata JT, Kuller L, Anderson DB, Dailey P, Overbaugh J: Emerging cytopathic and antigenic simian immunodeficiency virus variants influence AIDS progression. Nat Med 5:535-541, 1999.
22. Kwong PD, Wyatt R, Robinson J, Sweet RW, Sodroski J, Hendrickson WA: Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody. Nature 393:648-659, 1998.
23. Luciw PA, Pratt-Lowe E, Shaw KE, Levy JA, Cheng-Mayer C: Persistent infection of rhesus macaques with T-cell-line-tropic and macrophage-tropic clones of simian/human immunodeficiency viruses (SHIV). PNAS USA 92:7490-7494, 1995.
24. Reimann KA, Li JT, Voss G, Lekutis C, Tenner-Racz K, Racz P, Lin W, Montefiori DC, Lee-Parritz DE, Lu Y, Collman RG, Sodroski J, Letvin NL: An env gene derived from a primary human immunodeficiency virus type 1 isolate confers high in vivo replicative capacity to a chimeric simian/human immunodeficiency virus in rhesus monkeys. J Virol 70:3198-3206, 1996.
25. Rizzuto C, Sodroski J: Fine definition of a conserved CCR5-binding domain on the human immunodeficiency virus type 1 glycoprotein 120. AIDS Res Hum Retro 16:741-749, 2000.
26. Rizzuto CD, Wyatt R, Hernandez-Ramos N, Sun Y, Kwong PD, Hendrickson WA, Sodroski J: A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding. Science 280:1949-1953, 1998.
27. Thali M, Moore JP, Furman C, Charles M, Ho DD, Robinson J, Sodroski J: Characterization of conserved human immunodeficiency virus type 1 gp120 neutralization epitopes exposed upon gp120-CD4 binding. J Virol 67:3978-3988, 1993.
28. Wyatt R, Kwong PD, Desjardins E, Sweet RW, Robinson J, Hendrickson WA, Sodroski J: The antigenic structure of the HIV gp120 envelope glycoprotein. Nature 393:705-711, 1998.
29. Wyatt R, Moore J, Accola M, Desjardin E, Robinson J, Sodroski J: Involvement of the V1/V2 variable loop structure in the exposure of human immunodeficiency virus type 1 gp120 epitopes induced by receptor binding. J Virol 69:5723-5733, 1995.
30. Xiang S-H, Doka N, Choudhary RK, Sodroski J, Robinson JE: Characterization of CD4-induced epitopes on the HIV type 1 gp120 envelope glycoprotein recognized by neutralizing human monoclonal antibodies. AIDS Res Hum Retro 18:1207-1217, 2002.