Benzimidazole derivatives. 2. Synthesis and structure-activity relationships of new azabicyclic benzimidazole-4-carboxylic acid derivatives with affinity for serotoninergic 5-HT3 receptors

Journal of Medicinal Chemistry

Volumn 42, Issue 24, 1999, Pages 5020-5028

  López Rodríguez, María L ^a   Benhamú, Bellinda ^a   Morcillo, M José ^b   Tejada, Ignacio D ^a   Orensanz, Luis ^c   Alfaro, M José ^a   Martín, M Isabel ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b UNIVERSIDAD NACIONAL DE EDUCACIÓN A DISTANCIA   (Spain)

^c HOSPITAL RAMÓN Y CAJAL   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

(8 METHYL 8 AZABICYCLO[3.2.1]OCT 3 YL)BENZIMIDAZOLE 4 CARBOXYLIC ACID; (9 METHYL 9 AZABICYCLO[3.3.1]NON 3 YL)BENZIMIDAZOLE 4 CARBOXYLIC ACID; BENZIMIDAZOLE DERIVATIVE; GRANISETRON; N (1 AZABICYCLO[2.2.2]OCT 3 YL) 6 CHLORO 7 NITROBENZIMIDAZOLE 4 CARBOXAMIDE; N (1 AZABICYCLO[2.2.2]OCT 3 YL)BENZIMIDAZOLE 4 CARBOXAMIDE; N (1 AZABICYCLO[3.2.1]OCT 3 YL) 6 CHLOROBENZIMIDAZOLE 4 CARBOXAMIDE; ONDANSETRON; SEROTONIN 1A RECEPTOR; SEROTONIN 3 RECEPTOR; SEROTONIN 4 RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CHEMICAL REACTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CONFORMATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; GUINEA PIG; NONHUMAN; RAT; REACTION ANALYSIS; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; BENZIMIDAZOLES; CELL MEMBRANE; CEREBRAL CORTEX; ELECTRIC STIMULATION; GUINEA PIGS; ILEUM; MALE; MOLECULAR STRUCTURE; MUSCLE CONTRACTION; QUINUCLIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT3; SEROTONIN ANTAGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0041450131     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm991076c     Document Type: Article

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