Peptidase activities of the 20/26S proteasome and a novel protease in human brain

Journal of Neurochemistry

Volumn 84, Issue 2, 2003, Pages 392-396

  Vigouroux, Sophie ^a   Furukawa, Yoshiaki ^b   Farout, Luc ^a   Kish, Stephen J ^b   Briand, Marièle ^a   Briand, Yves ^a  

^a UNIVERSITÉ CLERMONT AUVERGNE   (France)

^b CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

Author keywords

Human brain; Neurodegenerative diseases; Peptidase; Protease; Proteasome

Indexed keywords

PEPTIDASE; PROTEASOME; PROTEINASE;

ALZHEIMER DISEASE; ARTICLE; BRAIN CELL; CARBOXY TERMINAL SEQUENCE; CATALYSIS; ENZYME ACTIVITY; HUMAN; HUMAN TISSUE; NERVE DEGENERATION; NEUROFIBRILLARY TANGLE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; TISSUE SPECIFICITY;

AGED; BLOTTING, WESTERN; BRAIN; BRAIN CHEMISTRY; CHROMATOGRAPHY, GEL; CYSTEINE ENDOPEPTIDASES; ENDOPEPTIDASES; ENZYME ACTIVATION; ENZYME INHIBITORS; FEMALE; HUMANS; MALE; MOLECULAR WEIGHT; MULTIENZYME COMPLEXES; PEPTIDE HYDROLASES; PRECIPITIN TESTS; PROTEASOME ENDOPEPTIDASE COMPLEX; REFERENCE VALUES;

EID: 0037266091     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.01534.x     Document Type: Article

References (13)

1. Adams J. and Stein R. (1996) Novel inhibitors of the proteasome and their therapeutic use in inflammation. Annu. Rep. Med. Chem. 31, 279-288.
2. Bradford M. M. (1976) A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
3. Chung K. K., Dawson V. L. and Dawson T. M. (2001) The role of the ubiquitin-proteasomal pathway in Parkinson's disease and other neurodegenerative disorders. Trends Neurosci. 24, 7-14.
4. Farout L., Lamare M. C., Cardozo C., Harrison M., Briand Y. and Briand M. (2000) Distribution of proteasomes and of five proteolytic activities in rat tissues. Arch. Biochem. Biophys. 374, 207-212.
5. Gregori L., Fuchs C., Figueiredo-Pereira M. E., Van Nostrand W. E. and Goldgaber D. (1995) Amyloid β-protein inhibits ubiquitin-dependent protein degradation in vitro. J. Biol. Chem. 270, 19702-19708.
6. Keller J. N., Hanni K. B. and Markesbery W. R. (2000) Impaired proteasome function in Alzheimer's disease. J. Neurochem. 75, 436-439.
7. Laemmli U.K. (1970) Cleavage of structural proteins during assembly of the head of bacteriophage T4. Nature 227, 680-685.
8. Lee D. H. and Goldberg A. L. (1996) Selective inhibitors of the proteasome-dependent and vacuolar pathways of protein degradation in Saccharomyces cerevisiae. J. Biol. Chem. 271, 27280-27284.
9. Leroy E., Boyer R., Auburger G., Leube B., Ulm G., Mezey E., Harta G., Brownstein M. J., Jonnalagada S., Chemova T., Deheji A., Lavedan C., Gasser T., Steinbach P. J., Wilkinson K. D. and Polymeropoulos M. H. (1998) The ubiquitin pathway in Parkinson's disease. Nature. 395, 451-452.
10. Lopez Salon M., Morelli L., Castano E. M., Soto E. F. and Pasquini J. M. (2000) Defective ubiquitination of cerebral proteins in Alzheimer's disease. J. Neurosci. Res. 62, 302-310.
11. McNaught K. and Jenner P. (2001) Proteasomal function is impaired in substantia nigra in Parkinson's disease. Neurosci. Lett. 297, 191-194.
12. Shimura H., Schlossmacher M. G., Hattori N., Frosch M. P., Trockenbacher A., Schneider R., Mizuno Y., Kosik K. S. and Selkoe D. J. (2001) Ubiquitination of a new form of α-synuclein by parkin from human brain: implications for Parkinson's disease. Science. 293, 263-269.
13. Towbin H., Staehelin T. and Gordon J. (1976) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl Acad. Sci. USA 76, 4350-4354.