Genetic analysis of morphological variants of Aspergillus parasiticus deficient in secondary metabolite production

Mycological Research

Volumn 107, Issue 7, 2003, Pages 831-840

  Kale, Shubha P ^a   Cary, Jeffrey W ^b   Baker, Craig ^c   Walker, Danya ^a   Bhatnagar, Deepak ^b   Bennett, Joan W ^c  

^a XAVIER UNIVERSITY OF LOUISIANA   (United States)

^b SOUTHERN REGIONAL RESEARCH CENTER   (United States)

^c Tulane University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FUNGUS; GENETIC ANALYSIS; SECONDARY METABOLITE;

ASPERGILLUS; ASPERGILLUS FLAVUS; ASPERGILLUS PARASITICUS; FUNGI;

EID: 0041423427     PISSN: 09537562     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0953756203007998     Document Type: Article

References (50)

1. Adams, T. H., Boylan, M. T. & Timberlake, W. E. (1988) brlA. is necessary and sufficient to direct conidiophore development in Aspergillus nidulans. Cell 54: 353-362.
2. Adams, T. H. & Yu, J. H. (1998) Coordinate control of secondary metabolite production and asexual sporulation in Aspergillus nidulans. Current Opinion in Microbiology 1: 674-677.
3. Adye, J. & Mateles, R. I. (1964) Incorporation of labeled compounds into aflatoxins. Biochemica et Biophysica Acta 86: 418-420.
4. Ball, C. (1982) Genetic approaches to overproduction of β-lactam antibiotics in eukaryotes. In Overproduction Microbial Products (V. Krumphanzl, B. Sityka & Z. Vanek, eds): 515-534. Academic Press, New York.
5. Bennett, J. W. (1979) Aflatoxins and anthraquinones from diploids of Aspergillus parasiticus. Journal of General Microbiology 113: 127-136.
6. Bhatnagar, D., Ehrlich, K. C. & Cleveland, T. E. (1992) Oxidation-reduction reactions in biosynthesis of secondary metabolites. In Handbook of Applied Mycology. Vol. 5. Mycotoxins in Ecological Systems (D. Bhatnagar, E. B. Lillehoj & D. K. Arora, eds): 255-286. Marcel Dekker, New York.
7. Bhatnagar, D., Ehrlich, K. C. & Cleveland, T. E. (2003) Molecular genetic analysis and regulation of aflatoxin biosynthesis. Applied Microbiology and Biotechnology 61: 83-93.
8. Bradshaw, R. E., Bennett, J. W. & Peberdy, J. F. (1983) Parasexual analysis of Aspergillus parasiticus. Journal of General Microbiology 129: 2117-2123.
9. Brown, D. W., Yu, J. H., Kelkar, H. S., Fernandes, M., Nesbitt, T. C., Keller, N. P., Adams, T. H. & Leonard, T. J. (1996) Twenty-five coregulated transcripts define a sterigmatocystin gene cluster in Aspergillus nidulans. Proceedings of the National Academy of Sciences, USA 93: 1418-1422.
10. Butchko, R. A. E., Adams, T. H. & Keller, N. P. (1999) Aspergillus nidulans mutants defective in stc gene cluster regulation. Genetics 153: 715-720.
11. Calvo, A. M., Wilson, R. A., Bok, J. W. & Keller, N. P. (2002) Relationship between secondary metabolism and fungal development. Microbiology and Molecular Biology Reviews 66: 447-459.
12. Cary, J. W. & Bhatnagar, D. (1995) Nucleotide sequence of a Aspergillus parasiticus gene strongly repressed by thiamine. Biochimica et Biophyica Acta 1261: 319-320.
13. Cary, J. W., Dyer, J. M., Ehrlich, K. C., Wright, M. S., Liang, S. H. & Linz, J. E. (2002) Molecular and functional characterization of a second copy of the aflatoxin regulatory gene, aflR-2, from Aspergillus parasiticus. Biochimica et Biophysica Acta 1576: 316-323.
14. Cary, J. W., Linz, J. E. & Bhatnagar, D. (2000) Aflatoxins: biological significance and regulation of biosynthesis. In Microbial Foodborne Diseases: mechanisms of pathogenesis and toxin synthesis (J. W. Cary, J. E. Linz & D. Bhatnagar, eds): 317-361. Technomic Publishing, Lancaster, PA.
15. Chang, P. K., Cary, J. W., Bhatnagar, D., Cleveland, T. E., Bennett, J. W., Linz, J. E., Woloshuk, C. P. & Payne, G. (1993) Cloning and characterization of apa-2 gene associated with the regulation of aflatoxin biosynthesis. Applied and Environmental Microbiology 59: 3273-3279.
16. Cole, R. J. & Cox, R. H. (1981) Handbook of Toxic Fungal Metabolites. Academic Press, New York.
17. Couteaudier, Y., Viaud, M. & Riba, G. (1996) Genetic nature, stability, and improved virulence of hybrids from protoplast fusion in Beauveria. Microbial Ecology 32: 1-10.
18. Ehrlich, K. C., Cary, J. W. & Montalbano, B. G. (1999) Characterization of the promoter for the gene encoding the aflatoxin biosynthetic pathway regulatory protein, AFLR. Biochimica et Biophysica Acta 1444: 412-417.
19. Eaton, D. L. & Gallagher, E. P. (1994) Mechanisms of aflatoxin carcinogenesis. Annual Review of Pharmacology and Toxicology 34: 135-172.
20. Filtenborg, O., Frisvad, J. C. & Thrane, U. (1990) The significance of yeast extract composition on metabolite production in Penicillium. In Modern Concepts in Penicillium and Aspergillus Classification (R. A. Samson & J. I. Pitt, eds): 433-441. Plenum Press, New York.
21. Guzman-de-Pena, D., Aguirre, J. & Ruiz-Herrera, J. (1998) Correlation between the regulation of sterigmatocystin biosynthesis and sporulation in Emericella nidulans. Antonie van Leeuwenhoek 73: 199-205.
22. Hara, S., Fennell, D. I. & Hesseltine, C. W. (1974) Aflatoxin producing strains of Aspergillus flavus detected by fluorescence of agar medium under ultraviolet light. Applied Microbiology 27: 1118-1123.
23. Hastie, A. C. (1970) Benlate induced instability of Aspergillus diploids. Nature, London 226: 111.
24. Hicks, J. K., Shimizu, K. & Keller, N. P. (2002) Genetics and biosynthesis of aflatoxins and sterigmatocystin. In The Mycota. Vol. 11. Agricultural Applications (E. Kempken, ed.): 55-69. Springer-Verlag, Berlin.
25. Hicks, J. K., Yu, J. H., Keller, N. P. & Adams, T. H. (1997) Aspergillus sporulation and mycotoxin production both require inactivation of the FadA Gα protein-dependent signaling pathway. EMBO Journal 16: 4916-4923.
26. Horng, J. S., Chang, P. K., Pestka, J. J. & Linz, J. E. (1990) Development of a homologous transformation system for Aspergillus parasiticus with the gene encoding nitrate reductase. Molecular and General Genetics 224: 294-296.
27. Ishitani, C., Ikeda, Y. & Sakaguchi, K.-I. (1958) Hereditary variation and genetic recombination in koji-molds Aspergillus oryzae and Aspergillus sojae. Journal of General and Applied Microbiology 2: 401-430.
28. Jinks, J. L. (1963) Cytoplasmic inheritance in fungi. In Methodology in Basic Genetics (W. J. Burdette, ed.): 325-343. Holden-Day, San Francisco.
29. Kale, S. P. & Bennett, J. W. (1992) Strain instability in filamentous fungi. In Handbook of Applied Mycology. Vol. 5. Mycotoxins in Ecological Systems (D. Bhatnagar, E. B. Lillehoj & D. K. Arora, eds): 311-332. Marcel Dekker, New York.
30. Kale, S. P., Cary, J. W., Bhatnagar, D. & Bennett, J. W. (1994) Isolation and characterization of morphological variants of Aspergillus parasiticus deficient in secondary metabolite production. Mycological Research 98: 645-652.
31. Kale, S. P., Cary, J. W., Bhatnagar, D. & Bennett, J. W. (1996) Characterization of experimentally induced nonaflatoxigenic variant strains of Aspergillus parasiticus. Applied and Environmental Microbiology 62: 3399-3404.
32. Kiyohara, H., Watnabe, T., Imai, J., Takizawa, N., Hatta, T., Nagao, K. & Yamamoto, A. (1990) Intergenic hybridization between Monascus anka and Aspergillus oryzae by protoplast fusion. Applied Microbiology and Biotechnology 33: 671-676.
33. Maramatsu, M. (1973) Preparation of RNA from animal cells. Methods in Cell Biology 7: 23-51.
34. Minto, R. E. & Townsend, C. A. (1997) Enzymology and molecular biology of aflatoxin biosynthesis. Chemical Reviews 97: 2537-2555.
35. Ogawa, K., Yoshida, N., Gesnara, W., Omumasaba, C. A. & Chamuswarng, C. (2000) Hybridization and breeding of the benomyl resistant mutant Trichoderma harziantum anatgonized to phytopathogenic fungi by protoplast fusion. Bioscience, Biotechnology and Biochemistry 64: 833-836.
36. Papa, K. E. (1976) Linkage groups in Aspergillus flavus. Mycologia 68: 159-165.
37. Papa, K. E. (1979) Genetics of Aspergillus flavus: complementation and mapping of aflatoxin mutants. Genetical Research 34: 1-9.
38. Papa, K. E. (1980) Dominant aflatoxin mutant of Aspergillus flavus. Journal of General Microbiology 118: 279-282.
39. Payne, G. A. & Brown, M. P. (1998) Genetics and physiology of aflatoxin biosynthesis. Annual Review of Phytopathology 36: 329-362.
40. Payne, G. A., Nystrom, G. J., Bhatnagar, D., Cleveland, T. E. & Woloshuk, C. P. (1993) Cloning of the afl-2 gene involved in aflatoxin biosynthesis from A. flavus. Applied and Environmental Microbiology 59: 156-162.
41. Roper, J. A. (1966) The parasexual cycle. In The Fungi: an advanced treatise. Vol. 2. The Fungal Organism (G. C. Ainsworth & A. S. Sussman, eds): 589-617. Academic Press, New York.
42. Scott, G. R., Marascalco, B. A. & Bennett, J. W. (1979) Parasexual analysis of aflatoxin and anthraquinone production in Aspergillus parasiticus. BIOS 1: 77-89.
43. Shimizu, K. & Keller, N. P. (2001) Genetic involvement of a cAMP- dependent protein kinase in a G protein signaling pathway regulating morphological and chemical transitions in Aspergillus nidulans. Genetics 157: 591-600.
44. Skory, C. D., Chang, P.-K., Cary, J. W. & Linz, J. E. (1992) Isolation and characterization of a gene from Aspergillus parasiticus associated with conversion of versicolorin A to sterigmatocystin in aflatoxin biosynthesis. Applied and Environmental Microbiology 58: 3527-3537.
45. Trail, F., Mahanti, N., Rarick, M., Mehigh, R., Liang, S. H., Zhou, R. & Linz, J. E. (1995) A physical and transcriptional map of an aflatoxin gene cluster in Aspergillus parasiticus and the functional disruption of a gene involved in the aflatoxin pathway. Applied and Environmental Microbiology 61: 2665-2673.
46. Walker, R. C. (1983) Official Methods and Recommended Practices of the American Oil Chemists Society. American Oil Chemists Society, Champaign, ILL.
47. Woloshuk, C. P., Foutz, K. R., Brewere, J. F., Bhatnagar, D., Cleveland, T. & Payne, G. A. (1995) Molecular characterization of the afl-1 locus in Aspergillus flavus. Applied and Environmental Microbiology 61: 3019-3023.
48. Yu, J. H., Butchko, R. A. E., Fernandes, M., Keller, N. P., Leonard, T. J. & Adams, T. H. (1996) Conservation of structure and function of the aflatoxin regulatory gene aflR from Aspergillus nidulans and A. flavus. Current Genetics 29: 549-555.
49. Yu, J., Chang, P. K., Cary, J. W., Wright, M., Bhatnagar, D., Cleveland, T. E., Payne, G. A. & Linz, J. E. (1995) Comparative mapping of aflatoxin pathway gene clusters in Aspergillus parasiticus and Aspergillus flavus. Applied and Environmental Microbiology 61: 2365-2371.
50. Zhou, R., Rasooly, R. & Linz, J. E. (2000) Isolation and analysis of fluP, a gene associated with hyphal growth and sporulation in Aspergillus parasiticus. Molecular and General Genetics 264: 514-520.