Apoptosis precedes detachment of germ cells from the seminiferous epithelium after hormone suppression by short-term oestradiol treatment of rats

International Journal of Andrology

Volumn 21, Issue 2, 1998, Pages 109-115

  Blanco Rodriguez J ^a   Martinez Garcia C ^a  

^a UNIVERSITY OF VALLADOLID   (Spain)

Author keywords

Apoptosis; Germ cells; Hormone suppression; Oestradiol; Spermatogenesis; Testis

Indexed keywords

DNA FRAGMENT; ESTRADIOL; ESTRADIOL BENZOATE; FOLLITROPIN; GONADOTROPIN; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL ADHESION; CONTROLLED STUDY; EPIDIDYMIS; EPITHELIUM CELL; GERM CELL; GONADOTROPIN RELEASE; HORMONE INHIBITION; INTRAMUSCULAR DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SEMINIFEROUS TUBULE; SEMINIFEROUS TUBULE EPITHELIUM; SPERMATOGENESIS;

ANIMALS; APOPTOSIS; CELL ADHESION; ESTRADIOL; FOLLICLE STIMULATING HORMONE; LUTEINIZING HORMONE; MALE; RATS; RATS, WISTAR; SEMINIFEROUS EPITHELIUM; SPERMATOGENESIS; SPERMATOZOA; TESTOSTERONE;

EID: 0031800442     PISSN: 01056263     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2605.1998.00109.x     Document Type: Article

References (46)

1. Billig, H., Furuta, I., Rivier, C., Tapanainen, J., Parvinen, M. & Hsueh, J. W. (1995) Apoptosis in testis germ cells: developmental changes in gonadotropin dependence and localization to selective tubule stages. Endocrinology, 136, 5-12.
2. Blanco-Rodríguez, J. & Martínez-García, C. (1996a) Further observations on the early events that contribute to establishing the morphological pattern shown by the hormone suppressed testis. Tissue and Cell, 28, 387-399.
3. Blanco-Rodríguez, J. & Martínez-García, C. (1996b) Induction of apoptotic cell death in the seminiferous tubule of the adult rat testis: assessment of the germ cell types that exhibit the ability to enter apoptosis after hormone suppression by oestradiol treatment. International Journal of Andrology, 19, 237-247.
4. Brady-Kalnay, S. M., Rimm, D. L. & Tonks, N. K. (1995) Receptor protein tyrosine phosphatase PTPmu associates with cadherins and catenins in vivo. Journal of Cell Biology, 130, 977-986.
5. Bremner, W. J., Millar, M. R., Sharpe, R. M. & Saunders, P. T. (1994) Immunohistochemical localization of androgen receptors in the rat testis: evidence for stage-dependent expression and regulation by androgens. Endrocrinology, 135, 1227-1234.
6. Cameron, D. F. & Muffly, K. E. (1991) Hormonal regulation of spermatid binding. Journal of Cell Science, 100, 623-633.
7. Cameron, D. F., Muffly, K. E. & Nazian, S. J. (1993) Reduced testosterone during puberty results in a midspermiogenic lesion. Proceedings of the Society for Experimental Biology and Medicine, 202, 457-464.
8. Clermont, Y. & Harvey, S. C. (1967) Effects of hormones on spermatogenesis in the rat. Ciba Foundation Colloquia in Endocrinology, 16, 173-196.
9. Clermont, Y. & Morgentaler, H. (1995) Quantitative study of spermatogenesis in the hypophysectomized rat. Endocrinology, 57, 369-382.
10. Craig, S. W. & Johnson, R. P. (1996) Assembly of focal adhesions: progress, paradigms, and portents. Current Opinion in Cell Biology, 8, 74-85.
11. Dedhar, S. & Hanningan, G. E. (1996) Integrin cytoplasmic interactions and bidirectional transmembrane signalling. Current Opinion in Cell Biology, 8, 657-669.
12. Dym, M. & Madhwa Raj, H. G. (1977) Response of adult rat Sertoli cells and Leydig cells to depletion of luteinizing hormone and testosterone. Biology of Reproduction, 17, 676-696.
13. Frisch, S. & Francis, H. (1994) Disruption of epithelial cell-matrix interactions induces apoptosis. Journal of Cell Biology, 124, 619-626.
14. Ghosh, S., Bartke, A., Grasso, P., Reichert, L. E. & Russell, L. D. (1992) Structural manifestations of the rat Sertoli cell to hypophysectomy: a correlative morphometric and endocrine study. Endocrinology, 131, 485-497.
15. Gutkind, J. S. & Vitale-Cross, L. (1996) The pathway linking small GTP-binding proteins of the Rho family to cytoskeletal components and novel signaling kinase cascades. Seminars in Cellular and Development Biology, 7, 683-690.
16. Heckert, L. & Griswold, M. (1991) Expression of follicle-stimulating hormone receptor mRNA in rat testes and Sertoli cells. Molecular Endocrinology, 5, 670-677.
17. Henriksén, K., Hakovirta, H. & Parvinen, M. (1995) In-situ quantification of stage-specific apoptosis in the rat seminiferous epithelium: effects of short-term experimental cryptorchidism. International Journal of Andrology, 18, 256-262.
18. Hermistone, M. L. & Gordon, J. I. (1995) In vivo analysis of cadherin function in the mouse intestinal epithelium: essential roles in adhesion, maintenance of differentiation, and regulation of programmed cell death. Journal of Cell Biology, 129, 489-506.
19. Horwitz, A. F. & Hunter, T. (1996) Cell adhesion: integrating circuitry. Trends in Cell Biology, 6, 460-470.
20. Huber, O., Bierkamp, C. & Kemler, R. (1996) Cadherins and catenins in development. Current Opinion in Cell Biology, 8, 685-691.
21. Jégou, B. (1993) The Sertoli-Germ cell communication network in mammals. International Reviews of Cytology, 147, 25-96.
22. Jong, F. H., Uilenbroek, J. & Van der Molen, H. J. (1975) Oestradiol-17β, testosterone and gonadotrophins in oestradiol-17β treated intact adult male rats. Journal of Endocrinology, 65, 281-282.
23. Kangasniemi, M., Kaipia, A., Toppari, J., Perheentupa, A., Huhtaniemi, I. & Parvinen, M. (1990) Cellular regulation of follicle-stimulating hormone binding in rat seminiferous tubules. Journal of Andrology, 11, 336-343.
24. Kerr, J. B., Millar, M., Maddocks, S. & Sharpe, R. M. (1993) Stage-dependent changes in spermatogenesis and Sertoli cells in relation to the onset of spermatogenic failure following withdrawal of testosterone. Anatomical Record, 235, 547-559.
25. Kierszenbaum, A. L. (1994) Mammalian spermatogenesis in vivo and in vitro: a partnership of spermatogenic and somatic cell lineages. Endocrine Reviews, 15, 116-134.
26. Leung, P. C. & Steele, G. L. (1992) Intracellular signaling in the gonads. Endocrine Reviews, 13, 476-498.
27. Muffly, K. E., Nazian, S. J. & Cameron, D. F. (1994) Effects of follicle-stimulating hormone on the junction-related Sertoli cell cytoskeleton and daily sperm production in testosterone-treated hypophysectomized rats. Biology of Reproduction, 51, 158-166.
28. O'Donnell, L., McLachlan, R. I., Wreford, N. G., Kretser, D. M. & Robertson, D. M. (1996) Testosterone withdrawal promotes stage-specific detachment of round spermatids from the rat seminiferous epithelium. Biology of Reproduction, 55, 895-901.
29. Parsons, J. T. (1996) Integrin-mediated signaling: regulation by protein tyrosine kinases and small GTP-binding proteins. Current Opinion in Cell Biology, 8, 146-152.
30. Parvinen, M. (1982) Regulation of the seminiferous epithelium. Endocrine Reviews, 3, 404-417.
31. Russell, L. D. & Clermont, Y. (1977) Degeneration of germ cells in normal, hypophysectomized and hormone treated hypophysectomized rats. Anatomical Record, 187, 347-366.
32. Russell, L. D., Etllin, R. A., Sinha-Hikim, A. P. & Clegg, E. D. (1990) Histological and Histopathological Evaluation of the Testis. Cache River Press, Clearwater.
33. Russell, L. D., Malone, J. P. & Karpas, S. L. (1981) Morphological pattern elicited by agents affecting spermatogenesis by disruption of its hormonal stimulation. Tissue and Cell, 13, 369-380.
34. Sharpe, R. M., Fraser, H. M. & Ratnasooriya, W. D. (1988) Assessment of the role of Leydig cell products other than testosterone in spermatogenesis and fertility in adult rats. International Journal of Andrology, 11, 507-523.
35. Sharpe, R. M., Maddocks, S. & Kerr, J. B. (1990) Cell-cell interactions in the control of spermatogenesis as studied using Leydig cell destruction and testosterone replacement. American Journal of Anatomy, 188, 3-20.
36. Sinha-Hikim, A. P. & Swerdloff, R. S. (1993) Temporal and stage-specific changes in spennatogenesis of rat after gonadotropin deprivation by a potent gonadotropin-releasing hormone antagonist treatment. Endocrinology, 133, 2161-2170.
37. Sinha-Hikim, A. P., Wang, C., Leung, A. & Swerdloff, R. S. (1995) Involvement of apoptosis in the induction of germ cell degeneration in adult rats after gonadotropin-releasing hormone antagonist treatment. Endocrinology, 136, 2770-2775.
38. Skinner, M. K. (1991) Cell-cell interactions in the testis. Endocrine Reviews, 12, 45-77.
39. Steinberger, E. (1971) Hormonal control of mammalian spermatogenesis. Physiological Reviews, 51, 1-22.
40. Steinberger, E. & Duckett, G. E. (1967) Hormonal control of spermatogenesis. Journal of Reproduction and Fertility Supplement, 2, 75-87.
41. Streuli, M. (1996) Protein tyrosine phosphatases in signaling. Current Opinion in Cell Biology, 8, 182-188.
42. Symons, M. (1996) Rho family GTPases: the cytoskeleton and beyond. Trends in Biochemical Sciences, 21, 178-181.
43. Tapanainen, J. S., Tilly, J. L., Vihko, K. K. & Hsueh, A. J. W. (1993) Hormonal control of apoptotic cell death in the testis: gonadotropins and androgens as testicular cell survival factors. Molecular Endocrinology, 7, 643-650.
44. Tres, L. L. & Kierszenbaum, A. L. (1983) Viability of rat spermatogenic cells in vitro is facilitated by their coculture with Sertoli cells in serum-free honnone-supplemented medium. Proceedings of the National Academy of Sciences USA, 80, 3377-3381.
45. Vornberger, W., Prins, G., Musto, N. A. & Suarez-Quian, C. A. (1994) Androgen receptor distribution in rat testis: new implications for androgen regulation of spermatogenesis. Endocrinology, 134, 2307-2316.
46. Weber, J. E., Russell, L. D., Wong, V. & Peterson, R. N. (1983) Three-dimensional reconstruction of a rat stage V Sertoli cell: II. Morphometry of Sertoli-Sertoli and Sertoli-germ cell relationships. American Journal of Anatomy, 167, 163-179.