Molecular and structural basis of the specificity of a neutralizing acetylcholine receptor-mimicking antibody, using combined mutational and molecular modeling analyses

Journal of Biological Chemistry

Volumn 275, Issue 28, 2000, Pages 21578-21586

  Germain, Nathalie ^a   Mérienne, Karine ^a   Zinn Justin, Sophie ^a   Boulain, Jean Claude ^a   Ducancel, Frédéric ^a   Ménez, André ^a  

^a Commsrt a l'Ener Atom Saclay ^*  (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CHOLINERGIC RECEPTOR; EPITOPE; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; SNAKE VENOM;

ARTICLE; CHEMICAL STRUCTURE; MOLECULAR MODEL; MUTATION; PRIORITY JOURNAL;

AMINO ACID SUBSTITUTION; ANIMALS; ANTIBODIES, MONOCLONAL; ASPARTIC ACID; BINDING SITES; ENZYME-LINKED IMMUNOSORBENT ASSAY; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; NICOTINIC ANTAGONISTS; PROTEIN CONFORMATION; RECEPTORS, NICOTINIC; RECOMBINANT PROTEINS; SNAKE VENOMS; SNAKES; THERMODYNAMICS;

SERPENTES; VERTEBRATA;

EID: 0040949714     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M001794200     Document Type: Article

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