Characterization and modulation of EDHF-mediated relaxations in the rat isolated superior mesenteric arterial bed

British Journal of Pharmacology

Volumn 120, Issue 8, 1997, Pages 1431-1438

  McCulloch, Audrey I ^b   Bottrill, Fiona E ^a   Randall, Michael D ^b   Hiley, C Robin ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Carbachol; Clotrimazole; Cyclic GMP; Endothelium; Endothelium derived hyperpolarizing factor (EDHF); Mesenteric arterial bed; N(G) nitro L arginine methyl ester (L NAME); Nitric oxide; Potassium channels; Tetraethylammonium (TEA)

Indexed keywords

8 BROMO CYCLIC GMP; ACETYLCHOLINE; CARBACHOL; CLOTRIMAZOLE; CYTOCHROME P450 INHIBITOR; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; GLIBENCLAMIDE; INDOMETACIN; METHACHOLINE; METHOXAMINE; MUSCARINIC AGENT; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITROPRUSSIDE SODIUM; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM ION; PROSTAGLANDIN SYNTHASE INHIBITOR; TETRYLAMMONIUM;

ANIMAL EXPERIMENT; ARTERY DILATATION; ARTERY MUSCLE; ARTICLE; CONTROLLED STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SUPERIOR MESENTERIC ARTERY;

EID: 0030932957     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701066     Document Type: Article

References (40)

1. +]; a functional approach to separating EDHF- and EDNO-related mechanisms in perfused rat mesenteric arterial bed. J. Cardiovasc. Pharmacol., 21, 423-429.
2. BAUERSACHS, J., HECKER, M. & BUSSE, R. (1994). Display of the characteristics of endothelium-derived hyperpolarising factor by a cytochrome P450-derived arachidonic metabolite in the coronary microcirculation. Br. J. Pharmacol., 113, 1648-1553.
3. BOLTON, T.B. & CLAPP, L.H. (1986). Endothelial-dependent relaxant actions of carbachol and substance P in arterial smooth muscle. Br. J. Pharmacol., 87, 713-723.
4. BOLTON, T.B., LANG, R.J. & TAKEWAKI, T. (1984). Mechanisms of action of noradrenaline and carbachol on smooth muscle of guinea-pig anterior mesenteric artery. J. Physiol., 351, 549-572.
5. CAMPBELL, W.B., GEBREMEDHIM, D., PRATT, P.F. & HARDER, D.R. (1996). Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors. Circ. Res., 78, 415-423.
6. CHEN, G. & SUZUKI, H. (1990). Calcium dependency of the endothelium-dependent hyperpolarisation in smooth muscle cells of the rabbit carotid artery. J. Physiol., 421, 521-534.
7. CHEN, G. & SUZUKI, H. (1989). Some electrical properties of the endothelium-dependent hyperpolarisation recorded from rat arterial smooth muscle cells. J. Physiol., 410, 91-106.
8. CHEN, G., SUZUKI, H. & WESTON, A.H. (1988). Acetylcholine releases endothelium-derived hyperpolarizing factor and EDRF from rat blood vessels. Br. J. Pharmacol., 95, 1165-1174.
9. CHEN, G., YAMAMOTO, Y., MIWA, K. & SUZUKI, H. (1991). Hyperpolarisation of arterial smooth muscle induced by endothelial humoral substances. Am. J. Physiol., 260, H1888-H1892.
10. G-monomethyl-L-arginine of vasodilator effects of acetylcholine and methacholine in human forearm vasculature. Br. J. Pharmacol., 110, 736-738.
11. CORRIU, C., FELETOU, M., CANET, E. & VANHOUTTE, P.M. (1996). Inhibitor of the cytochrome P450-mono-oxygenase and endothelium-dependent hyperpolarization in the guinea-pig isolated carotid artery. Br. J. Pharmacol., 117, 607-610.
12. COWAN, C.L., PALACINO, J.J., NAJIBI, S. & COHEN, R.A. (1993). Potassium channel-mediated relaxation to acetylcholine in rabbit arteries. J. Pharmacol. Exp. Ther., 266, 1482-1489.
13. FELETOU, M. & VANHOUTTE, P.M. (1988). Endothelium-dependent hyperpolarisation of canine coronary smooth muscle. Br. J. Pharmacol., 93, 515-524.
14. FULTON, D., MAHBOUBI, K., MCGIFF, J.C. & QUILLEY, J. (1995). Cytochrome P450-dependent effects of bradykinin in the rat heart. Br. J. Pharmacol., 114, 99-102.
15. FURCHGOTT, R.F. & ZAWADZKI, J.V. (1980). The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature, 288, 373-376.
16. GARLAND, C.J. & MCPHERSON, G.A. (1992). Evidence that nitric oxide does not mediate the hyperpolarisation and relaxation to acetylcholine in the rat small mesenteric artery. Br. J. Pharmacol., 105, 429-435.
17. GARLAND, C.J., PLANE, F., KEMP, B.K. & COCKS, T.M. (1995). Endothelium-dependent hyperpolarization: a role in the control of vascular tone. Trends Pharmacol. Sci., 16, 23-30.
18. G-nitro-L-arginine in rat aorta. Eur. J. Pharmacol., 274, 25-32.
19. HECKER, M., BARA, A.T., BAUERSACHS, J. & BUSSE, R. (1994). Characterisation of endothelium-derived hyperpolarising factor as a cytochrome P450-derived arachidonic acid metabolite in mammals. J. Physiol., 481, 407-414.
20. JAISWAL, N., LAMBRECHT, G., MUTSCHLER, E., TACKE, R. & MALIK, K.U. (1991). Pharmacological characterisation of muscarinic receptors mediating relaxation and contraction in rabbit aorta. J. Pharmacol. Exp. Ther., 258, 842-850.
21. G-nitro-L-arginine in pulmonary hypertension. Br. J. Pharmacol., 116, 2457-2467.
22. KILPATRICK, E.V. & COCKS, T.M. (1994). Evidence for differential roles of nitric oxide (NO) and hyperpolarisation in endothelium-dependent relaxation of pig isolated coronary artery. Br. J. Pharmacol., 112, 557-565.
23. KOMORI, K. & SUZUKI, H. (1987). Electrical responses of smooth muscle cells during cholinergic vasodilatation in the rabbit saphenous artery. Circ. Res., 61, 586-593.
24. MCCULLOCH, A.I. & RANDALL, M.D. (1996a). Characterization of endothelium-dependent relaxations in the isolated perfused rat superior mesenteric arterial bed: the involvement of EDHF. Br. J. Pharmacol., 117, 229P.
25. MCCULLOCH, A.I. & RANDALL, M.D. (1996b). The modulation of EDHF activity by nitric oxide in the rat isolated superior mesenteric arterial bed. Br. J. Pharmacol., 119, 135P.
26. MCCULLOCH, A.I. & RANDALL, M.D. (1996c). Modulation of vasorelaxant responses to potassium channel openers by basal nitric oxide in the rat isolated superior mesenteric arterial bed. Br. J. Pharmacol., 117, 859-866.
27. + channel opened by cromakalim. Br. J. Pharmacol., 103, 1184-1190.
28. PALMER, R.M.J., FERRIGE, A.G. & MONCADA, S. (1987). Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature, 327, 524-526.
29. PARKINGTON, H.C., TONTA, M.A., COLEMAN, H.A. & TARE, M. (1995). Role of membrane potential in endothelium-dependent relaxation of guinea-pig coronary arterial smooth muscle. J. Physiol., 482, 469-480.
30. PARSONS, S.J.W., HILL, A., WALDRON, G.J., PLANE, F. & GARLAND, C.J. (1994). The relative importance of nitric oxide and nitric oxide-independent mechanisms in the acetylcholine-evoked dilatation of the rat mesenteric bed. Br. J. Pharmacol., 113, 1275-1280.
31. RANDALL, M.D., ALEXANDER, S.P.H., BENNETT, T., BOYD, E.A., FRY, J.R., GARDINER, S.M., KEMP, P.A., MCCULLOCH, A.I. & KENDALL, D.A. (1996). An endogenous cannabinoid as an endothelium-derived vasorelaxant. Biochem. Biophys. Res. Commun., 229, 114-120.
32. RANDALL, M.D. & HILEY, C.R. (1988). Effect of phenobarbitone pretreatment upon endothelium-dependent relaxation to acetylcholine in rat superior mesenteric arterial bed. Br. J. Pharmacol., 94, 977-983.
33. RANDALL, M.D. & MCCULLOCH, A.I. (1995). The involvement of ATP-sensitive potassium channels in β-adrenoceptor-mediated vasorelaxation in the rat isolated mesenteric arterial bed. Br. J. Pharmacol., 115, 607-612.
34. RUBANYI, G.M. MCKINNEY, M. & VANHOUTTE, P.M. (1987). Biphasic release of endothelium-derived relaxing factor(s) by acetylcholine from perfused canine femoral arteries. J. Pharmacol. Exp. Ther., 240, 802-808.
35. TARE, M., PARKINGTON, H.C., COLEMAN, H.A., NEILD, T.O. & DUSTING, G.J. (1990). Hyperpolarisation and relaxation of arterial smooth muscle caused by nitric oxide derived from the endothelium. Nature, 346, 69-71.
36. TAYLOR, S.G., SOUTHERTON, J.S., WESTON, A.H. & BAKER, J.R.J. (1988). Endothelium-dependent effects of acetylcholine in rat aorta: a comparison with sodium nitroprusside and cromakalim. Br. J. Pharmacol., 94, 853-863.
37. TAYLOR, S.G. & WESTON, A.H. (1988). Endothelium-derived hyperpolarizing factor: a new endogenous inhibitor from vascular endothelium. Trends Pharmacol. Sci., 9, 272-274.
38. WALDRON, G.J. & GARLAND, C.J. (1994). Contribution of nitric oxide and change in membrane potential to acetycholine-induced relaxation in the rat small mesenteric artery. Br. J. Pharmacol., 112, 831-836.
39. + channels in vascular smooth muscle cells. Proc. Natl. Acad. Sci. U.S.A., 85, 9360-9364.
40. ZYGMUNT, P.M., EDWARDS, G., WESTON, A.H., DAVIES, S.C. & HÖGESTÄTT, E.D. (1996). Effects of cytochrome P450 inhibitors on EDHF-mediated relaxation in the rat hepatic artery. Br. J. Pharmacol., 118, 1147-1152.