The luteinizing hormone receptor: Influence of buffer composition on ligand binding and signaling of wild type and mutant receptors

Molecular and Cellular Endocrinology

Volumn 204, Issue 1-2, 2003, Pages 1-9

  Angelova, Krassimira ^a   Narayan, Prema ^a   Puett, David ^a  

^a UNIVERSITY OF GEORGIA   (United States)

Author keywords

Buffer effects on receptor function; Human chorionic gonadotropin; Kinetics of hormone binding; Luteinizing hormone receptor

Indexed keywords

AMINO ACID; BUFFER; CHORIONIC GONADOTROPIN; LUTEINIZING HORMONE RECEPTOR; SODIUM ION;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DISSOCIATION CONSTANT; EQUILIBRIUM CONSTANT; HORMONE RECEPTOR INTERACTION; IONIC STRENGTH; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR AFFINITY; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; SURFACE CHARGE; WILD TYPE;

EID: 0038783679     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(03)00155-2     Document Type: Article

References (29)

1. Alvarez C.A., Narayan P., Huang J., Puett D. Characterization of a region of the lutropin receptor extracellular domain near transmembrane helix 1 that is important in ligand-mediated signaling. Endocrinology. 140:1999;1775-1782.
2. Anderson T.T., Reichert L.E. Jr. Follitropin binding to receptors in testis: modulation by monovalent salts and divalent cations. J. Biol. Chem. 257:1982;11551-11557.
3. Angelova K., Puett D. Differential responses of an invariant region in the ectodomain of the three glycoprotein hormone receptors to mutagenesis and assay conditions. Endocrine. 19:2002;147-154.
4. Angelova K., Narayan P., Simon J.P., Puett D. Functional role of transmembrane helix 7 in the activation of the heptahelical lutropin receptor. Mol. Endocrinol. 14:2000;459-471.
5. Angelova K., Fanelli F., Puett D. A model for constitutive lutropin receptor activation based on molecular simulation and engineered mutations in transmembrane helices 6 and 7. J. Biol. Chem. 277:2002;32202-32213.
6. Ascoli M., Segaloff D.L. On the fates of receptor-bound human ovine luteinizing hormone and human choriogonadotropin in cultured Leydig tumor cells. Demonstration of similar rates of internalization. Endocrinology. 120:1987;1161-1172.
7. Ascoli M., Fanelli F., Segaloff D.L. The lutropin/choriogonadotropin receptor, a 2002 perspective. Endocr. Rev. 23:2002;141-174.
8. Bahl O.P. Chemistry of human chorionic gonadotropin. Li C.H. Hormonal Proteins and Peptides. 1:1973;171-199 Academic Press, New York.
9. Berman M.I., Thomas C.G. Jr, Manjunath P., Sairam M.R., Nayfeh S.N. The role of the carbohydrate moiety in thyrotropin action. Biochem. Biophys. Res. Commun. 133:1985;680-687.
10. Bhowmick N., Huang J., Puett D., Isaacs N.W., Lapthorn A.J. Determination of residues important in hormone binding to the extracellular domain of the LH/CG receptor by site-directed mutagenesis and modeling. Mol. Endocrinol. 10:1996;1147-1159.
11. + modulates the affinity of the lutropin/choriogonadotropin (LH/CG) receptor. J. Biol. Chem. 259:1984;15078-15084.
12. Cetani F., Tonacchera M., Vassart G. Differential effect of NaCl concentration on the constitutive activity of thyrotropin and luteinizing hormone/chorionic gonadotropin receptors. FEBS Lett. 378:1996;27-31.
13. Combarnous Y., Guillou F., Martinat N. Functional states of the luteinizing hormone/choriogonadotropin-receptor complex in rat Leydig cells. J. Biol. Chem. 261:1986;6868-6871.
14. Goffenberg S.I., Zhuravlev I.V. Regulation by cations of adenylate cyclase activity in chicken tissues. Biokhimiia. 53:1988;1214-1219.
15. Hattori M., Hachisu T., Shimohigashi Y., Wakabayashi K. Conformation of the beta subunit of deglycosylated human chorionic gonadotropin in the interaction at receptor sites. Mol. Cell. Endocrinol. 57:1988;17-23.
16. 2-adrenergic receptors by sodium. J. Biol. Chem. 265:1990;21590-21595.
17. Huang J., Puett D. Identification of two amino acid residues on the extracellular domain of the lutropin/choriogonadotropin receptor important in signaling. J. Biol. Chem. 270:1995;30023-30028.
18. Ketelslegers J.M., Knott G.D., Catt K.J. Kinetics of gonadotropin binding by receptors of the rat testis. Analysis by a nonlinear curve-fitting method. Biochemistry. 14:1975;3075-3083.
19. Liu G., Duranteau L., Carel J.-C., Monroe J., Doyle D.A., Shenker A. Leydig-cell tumors caused by an activating mutation of the gene encoding the luteinizing hormone receptor. New Engl. J. Med. 341:1999;1731-1736.
20. Manjunath P., Sairam M.R., Sairam J. Studies on pituitary follitropin. X. Biochemical, receptor binding and immunological properties of deglycosylated ovine hormone. Mol. Cell. Endocrinol. 28:1982;125-138.
21. Martin S., Botto J.-M., Vincent J.-P., Mazella J. Pivotal role of an aspartate residue in sodium sensitivity and coupling to G proteins of neurotensin receptors. Mol. Pharmacol. 55:1999;210-215.
22. Moyle W.R. Biochemistry of gonadotrophin receptors. Sinn C.A. Oxford Reviews of Reproductive Biology. 2:1980;123-204 Claredon Press, Oxford.
23. 2 receptor. Mol. Pharmacol. 60:2001;373-381.
24. Noland T.D., Puett D. Testicular membranes with improved stability of the gonadotropin receptor. Biochim. Biophys. Acta. 714:1982;226-233.
25. Quintana J., Wang H., Ascoli M. The regulation of the binding affinity of the luteinizing hormone/choriogonadotropin receptor by sodium ions is mediated by a highly conserved aspartate located in the second transmembrane domain of G protein-coupled receptors. Mol. Endocrinol. 7:1993;767-775.
26. Sairam M.R. Role of carbohydrates in glycoprotein hormone signal transduction. FASEB J. 3:1989;1915-1926.
27. Stavrou S.S., Zhu Y.-S., Cai L.-Q., Katz M.D., Herrera C., Defilio-Ricart M., Imperato-McGinley J. A novel mutation of the human luteinizing hormone receptor in 46XY and 46XX sisters. J. Clin. Endocrinol. Metab. 83:1998;2091-2098.
28. Tanford C. Physical Chemistry of Macromolecules. 1961;Wiley, New York.
29. Tramontano D., Ingbar S.H. Properties and regulation of the thyrotropin receptor in the FRTL5 rat thyroid cell line. Endocrinology. 118:1986;1945-1951.